Objective:To investigate the therapeutic effects and pharmacological mechanisms of Yishen Xingyang capsule(YXC)in oligoasthenospermia(OA)rats.Methods:Forty-eight male SpragueeDawley rats were randomly divided into eig...Objective:To investigate the therapeutic effects and pharmacological mechanisms of Yishen Xingyang capsule(YXC)in oligoasthenospermia(OA)rats.Methods:Forty-eight male SpragueeDawley rats were randomly divided into eight groups of six rats each:normal control(NC);model control(MC);three different positive drug(PD);and low-,medium-,and high-dose YXC groups.A rat model of OA was established by administering glucosides of Tripterygium wilfordii Hook.F(GTW).After YXC administration,penile erectile function was observed.The epididymis,blood,and testes of the rats were harvested for analysis of sperm quality,sex hormone levels,mitochondrial membrane potential,and the transforming growth factor(TGF)-b1/Smad signaling pathway.Results:Compared with that in the MC group,penile erectile function in the YXC groups and three PD groups increased(all P<.01).Moreover,sperm quality in the YXC groups and three PD groups improved(all P<.001).The levels of testosterone,follicle stimulating hormone,and luteinizing hormone in the three PD and YXC groups increased(all P<.05).The mitochondrial membrane potential in the three PD and YXC groups significantly improved(all P<.001).Furthermore,the YXC and three PD groups showed decreased TGF-b1 expression(all P<.05)compared with the MC group.The high-dose YXC group and three PD groups improved Smad2 and Smad4 expression(all P<.05).Conclusion:YXC improved penile erectile function and sperm quality in OA rats,and the underlying mechanism included increase in sex hormones,inhibition of sperm apoptosis,and regulation of the TGFb1/Smad signaling pathway.Meanwhile,this study provides a new effective drug option for the treatment of OA,which is beneficial to male reproductive health and social harmony.展开更多
新石器—青铜时代自然环境波动变化对农业发展的影响一直备受关注。荥阳盆地是中华文明起源和早期农业发展的重要区域之一。但目前荥阳盆地新石器—青铜时代农业时空演化格局与水文地貌环境变迁的关系尚不清楚。本文基于两处详细测年的...新石器—青铜时代自然环境波动变化对农业发展的影响一直备受关注。荥阳盆地是中华文明起源和早期农业发展的重要区域之一。但目前荥阳盆地新石器—青铜时代农业时空演化格局与水文地貌环境变迁的关系尚不清楚。本文基于两处详细测年的湖沼地层,集成已有湖沼地层年代、高程数据,重建了荥阳盆地新石器—青铜时代4个时间节点(~8000 a BP、~6000 a BP、~4500 a BP和~3600 a BP)的湖沼水域分布;再结合已有植物浮选资料,探讨了农业时空分布格局与水文地貌环境的耦合关系。结果显示:①在~8000 a BP,荥阳盆地湖泊广布,并于~6000 a BP达到鼎盛。盆地湖泊在~4500 a BP明显萎缩,至~3600 a BP,盆地中大的湖泊不断萎缩并分解为数个小湖泊。②新石器—青铜时代荥阳盆地形成了以粟、黍、稻为主的农业结构。整个新石器—青铜时代,盆地周边山地丘陵区多为粟黍为主的旱作农业模式,在冲积平原区则存在粟黍旱作与稻作的混合模式。但在冲积平原与周边山地丘陵交接地段,不同时期农作物结构存在旱作与旱稻混作模式的变化。结合已有荥阳盆地周边地区气候重建资料,发现仰韶文化时期是荥阳盆地全新世湖泊分布范围最广的时段,不仅在平原区,临近平原的山地丘陵及部分黄土台地上也有水稻的种植,是新石器—青铜时代稻分布范围最广的阶段。因此,荥阳盆地新石器—青铜时代的水文地貌环境格局明显影响了区域农业发展。展开更多
为进一步理解末次冰消期以来东亚夏季风(EASM)变化的时空特征,特别是中原地区全新世EASM的时空格局及其驱动机制,在AMS14C年代的支持下,本文基于荥阳盆地湖相-湿地相剖面的正构烷烃和沉积学指标(粒度和总有机碳),重建了荥阳盆地~17.8 ca...为进一步理解末次冰消期以来东亚夏季风(EASM)变化的时空特征,特别是中原地区全新世EASM的时空格局及其驱动机制,在AMS14C年代的支持下,本文基于荥阳盆地湖相-湿地相剖面的正构烷烃和沉积学指标(粒度和总有机碳),重建了荥阳盆地~17.8 cal ka BP以来的气候与环境变化历史。重建结果表明,~17.8-~11.7 cal ka BP是草原环境下的黄土状堆积阶段。~11.7-~8.5 cal ka BP为湿地沉积时段,是森林和湿地扩展的时期。~8.5-~2.8 cal ka BP为湖泊存在时段,木本植物和水生植物丰度达到最高后波动降低。~2.8-~2.4 cal ka BP为湿地存在阶段,菌藻类和/或微生物、沉水浮游植物的烷烃贡献量很大。~2.4-~1.1 cal ka BP为草原环境下的黄土沉积时段。本文进一步基于荥阳盆地长链正构烷烃的平均碳链长(ACL_(27-33),简称ACL)和C_(27+29)/C_(31+33)比值,结合渑池盆地木本花粉百分含量和禾本科/(蒿属+藜科)比值,重建了中原地区全新世以来湿度变化,并与长江中下游地区和中国北方地区(指黄河以北地区)的全新世湿度序列进行了对比。对比结果显示,全新世中期的干旱时段(~7.0-~4.0 cal ka BP或~8.0-~5.0 cal ka BP)与长江中下游地区全新世中期的干旱时段基本对应。这一时段的干旱对应于厄尔尼诺-南方涛动(ENSO)强度的较低值(即La Nino态)时段和赤道西太平洋SST较高温时段。控制上述EASM影响区的中国中部地区全新世湿度空间格局的主要机制可能是ENSO状态以及由ENSO调控的亚热带西太平洋高压(WPSH)的南北向移动。展开更多
基金This study was funded by the Beijing University of Chinese Medicine(2018-zxfzjj-002)by the project of Beijing University of Chinese Medicine and Beijing Tong Ren Tang Company Limited Scientific Research Institute(2020071720310).
文摘Objective:To investigate the therapeutic effects and pharmacological mechanisms of Yishen Xingyang capsule(YXC)in oligoasthenospermia(OA)rats.Methods:Forty-eight male SpragueeDawley rats were randomly divided into eight groups of six rats each:normal control(NC);model control(MC);three different positive drug(PD);and low-,medium-,and high-dose YXC groups.A rat model of OA was established by administering glucosides of Tripterygium wilfordii Hook.F(GTW).After YXC administration,penile erectile function was observed.The epididymis,blood,and testes of the rats were harvested for analysis of sperm quality,sex hormone levels,mitochondrial membrane potential,and the transforming growth factor(TGF)-b1/Smad signaling pathway.Results:Compared with that in the MC group,penile erectile function in the YXC groups and three PD groups increased(all P<.01).Moreover,sperm quality in the YXC groups and three PD groups improved(all P<.001).The levels of testosterone,follicle stimulating hormone,and luteinizing hormone in the three PD and YXC groups increased(all P<.05).The mitochondrial membrane potential in the three PD and YXC groups significantly improved(all P<.001).Furthermore,the YXC and three PD groups showed decreased TGF-b1 expression(all P<.05)compared with the MC group.The high-dose YXC group and three PD groups improved Smad2 and Smad4 expression(all P<.05).Conclusion:YXC improved penile erectile function and sperm quality in OA rats,and the underlying mechanism included increase in sex hormones,inhibition of sperm apoptosis,and regulation of the TGFb1/Smad signaling pathway.Meanwhile,this study provides a new effective drug option for the treatment of OA,which is beneficial to male reproductive health and social harmony.
文摘新石器—青铜时代自然环境波动变化对农业发展的影响一直备受关注。荥阳盆地是中华文明起源和早期农业发展的重要区域之一。但目前荥阳盆地新石器—青铜时代农业时空演化格局与水文地貌环境变迁的关系尚不清楚。本文基于两处详细测年的湖沼地层,集成已有湖沼地层年代、高程数据,重建了荥阳盆地新石器—青铜时代4个时间节点(~8000 a BP、~6000 a BP、~4500 a BP和~3600 a BP)的湖沼水域分布;再结合已有植物浮选资料,探讨了农业时空分布格局与水文地貌环境的耦合关系。结果显示:①在~8000 a BP,荥阳盆地湖泊广布,并于~6000 a BP达到鼎盛。盆地湖泊在~4500 a BP明显萎缩,至~3600 a BP,盆地中大的湖泊不断萎缩并分解为数个小湖泊。②新石器—青铜时代荥阳盆地形成了以粟、黍、稻为主的农业结构。整个新石器—青铜时代,盆地周边山地丘陵区多为粟黍为主的旱作农业模式,在冲积平原区则存在粟黍旱作与稻作的混合模式。但在冲积平原与周边山地丘陵交接地段,不同时期农作物结构存在旱作与旱稻混作模式的变化。结合已有荥阳盆地周边地区气候重建资料,发现仰韶文化时期是荥阳盆地全新世湖泊分布范围最广的时段,不仅在平原区,临近平原的山地丘陵及部分黄土台地上也有水稻的种植,是新石器—青铜时代稻分布范围最广的阶段。因此,荥阳盆地新石器—青铜时代的水文地貌环境格局明显影响了区域农业发展。
文摘为进一步理解末次冰消期以来东亚夏季风(EASM)变化的时空特征,特别是中原地区全新世EASM的时空格局及其驱动机制,在AMS14C年代的支持下,本文基于荥阳盆地湖相-湿地相剖面的正构烷烃和沉积学指标(粒度和总有机碳),重建了荥阳盆地~17.8 cal ka BP以来的气候与环境变化历史。重建结果表明,~17.8-~11.7 cal ka BP是草原环境下的黄土状堆积阶段。~11.7-~8.5 cal ka BP为湿地沉积时段,是森林和湿地扩展的时期。~8.5-~2.8 cal ka BP为湖泊存在时段,木本植物和水生植物丰度达到最高后波动降低。~2.8-~2.4 cal ka BP为湿地存在阶段,菌藻类和/或微生物、沉水浮游植物的烷烃贡献量很大。~2.4-~1.1 cal ka BP为草原环境下的黄土沉积时段。本文进一步基于荥阳盆地长链正构烷烃的平均碳链长(ACL_(27-33),简称ACL)和C_(27+29)/C_(31+33)比值,结合渑池盆地木本花粉百分含量和禾本科/(蒿属+藜科)比值,重建了中原地区全新世以来湿度变化,并与长江中下游地区和中国北方地区(指黄河以北地区)的全新世湿度序列进行了对比。对比结果显示,全新世中期的干旱时段(~7.0-~4.0 cal ka BP或~8.0-~5.0 cal ka BP)与长江中下游地区全新世中期的干旱时段基本对应。这一时段的干旱对应于厄尔尼诺-南方涛动(ENSO)强度的较低值(即La Nino态)时段和赤道西太平洋SST较高温时段。控制上述EASM影响区的中国中部地区全新世湿度空间格局的主要机制可能是ENSO状态以及由ENSO调控的亚热带西太平洋高压(WPSH)的南北向移动。
