Objective:To observe the clinical effect of knee-bitong prescription combined with platelet-rich plasma in the treatment of knee osteoarthritis in the middle stage.Methods:From May 2018 to January 2019,90 patients wit...Objective:To observe the clinical effect of knee-bitong prescription combined with platelet-rich plasma in the treatment of knee osteoarthritis in the middle stage.Methods:From May 2018 to January 2019,90 patients with moderate knee osteoarthritis(K-L classificationⅡandⅢ)with liver and kidney deficiency were admitted,and 45 patients were divided into experimental group and control group.The test group included 15 males and 30 females;aged 46 to 70(58.93±10.671)years;course of disease was 1 to 8 years(27.06±4.216)months;K-L classification:33 cases in gradeⅡand 12 cases in gradeⅢ.Jibitongfang Jianjian Granules is taken orally once a day,once in the morning and evening,14 days a course of treatment,and combined with platelet-rich plasma(2ml)articular cavity injection,once every 14 days,a total of two,14 days apart;control group male 12 There were 33 females aged 43-68(57.00±8.832)years old;the course of disease was 1-8 years(25.40±3.718)months;KL classification:36 cases of gradeⅡ,9 cases of gradeⅢ,and the control group were given platelet-rich plasma(2ml)Injection into the joint cavity,the treatment course and frequency are the same as the experimental group.Record and compare the VAS score,WOMAC score,matrix metalloproteinase-1 and interleukin-1βlevels of joint fluid before and after treatment for one month to evaluate the therapeutic effect.Results:All 90 cases were followed up without serious adverse reactions or other complications.The WOMAC scores of the experimental group and the control group before and after treatment were:106.40±47.962,116.13±41.151,55.13±22.022,62.67±26.232.The VAS scores of the two groups before and after treatment were:5.87±2.446,5.80±2.145,2.67±1.345,4.00±1.964.The levels of interleukin 1βin the test group and the control group before and after treatment were:78.33±7.227,76.60±7.069,25.73±3.239,31.13±5.743.The levels of matrix metalloproteinase-1 before and after treatment in the two groups were:2299.66±179.343,2206.66±194.235,1741.86±183.077,1762.46±192.097.Conclusion:The combination of platelet-rich plasma and knee-bitong decoction in the treatment of moderate knee osteoarthritis is better than platelet-rich plasma group in relieving knee pain,improving knee function and reducing the levels of interleukin-1βand matrix metalloproteinase-1 in joint fluid.And the side effects are small,it is worth clinical application.展开更多
文摘Objective:To observe the clinical effect of knee-bitong prescription combined with platelet-rich plasma in the treatment of knee osteoarthritis in the middle stage.Methods:From May 2018 to January 2019,90 patients with moderate knee osteoarthritis(K-L classificationⅡandⅢ)with liver and kidney deficiency were admitted,and 45 patients were divided into experimental group and control group.The test group included 15 males and 30 females;aged 46 to 70(58.93±10.671)years;course of disease was 1 to 8 years(27.06±4.216)months;K-L classification:33 cases in gradeⅡand 12 cases in gradeⅢ.Jibitongfang Jianjian Granules is taken orally once a day,once in the morning and evening,14 days a course of treatment,and combined with platelet-rich plasma(2ml)articular cavity injection,once every 14 days,a total of two,14 days apart;control group male 12 There were 33 females aged 43-68(57.00±8.832)years old;the course of disease was 1-8 years(25.40±3.718)months;KL classification:36 cases of gradeⅡ,9 cases of gradeⅢ,and the control group were given platelet-rich plasma(2ml)Injection into the joint cavity,the treatment course and frequency are the same as the experimental group.Record and compare the VAS score,WOMAC score,matrix metalloproteinase-1 and interleukin-1βlevels of joint fluid before and after treatment for one month to evaluate the therapeutic effect.Results:All 90 cases were followed up without serious adverse reactions or other complications.The WOMAC scores of the experimental group and the control group before and after treatment were:106.40±47.962,116.13±41.151,55.13±22.022,62.67±26.232.The VAS scores of the two groups before and after treatment were:5.87±2.446,5.80±2.145,2.67±1.345,4.00±1.964.The levels of interleukin 1βin the test group and the control group before and after treatment were:78.33±7.227,76.60±7.069,25.73±3.239,31.13±5.743.The levels of matrix metalloproteinase-1 before and after treatment in the two groups were:2299.66±179.343,2206.66±194.235,1741.86±183.077,1762.46±192.097.Conclusion:The combination of platelet-rich plasma and knee-bitong decoction in the treatment of moderate knee osteoarthritis is better than platelet-rich plasma group in relieving knee pain,improving knee function and reducing the levels of interleukin-1βand matrix metalloproteinase-1 in joint fluid.And the side effects are small,it is worth clinical application.
