300 grams ground beef 350 grams bread crumbs 2 eggs1 gram MSG2 grams salt10 grams (1 tbsp) cooking wine5 grams chopped spring onion5 grams chopped ginger10 grams (1 tbsp) cornslarch300 grams (3/5 cup) cooking oilMix g...300 grams ground beef 350 grams bread crumbs 2 eggs1 gram MSG2 grams salt10 grams (1 tbsp) cooking wine5 grams chopped spring onion5 grams chopped ginger10 grams (1 tbsp) cornslarch300 grams (3/5 cup) cooking oilMix ground beef with salt, MSG, cooking wine. chopped spring onion and ginger, and 5 grams of cornslarch. Beat eggs in a bowl.Make ground beef into three rolls, about 5 cm in diameter and 15 cm long. Place on a plate and steam until cooked. Coat the rolls in beaten egg and then in breadcrumbs.Heat oil in a wok. fry the rolls until brown. Cut the meat rolls into 3-cm sections, arrange on a plate, and serve.展开更多
Objective:To explore the antibacterial mechanism of the active components of Xiangsu powder through the network pharmacological approach.Methods:TCMSP database was used to search and obtain the active components of Xi...Objective:To explore the antibacterial mechanism of the active components of Xiangsu powder through the network pharmacological approach.Methods:TCMSP database was used to search and obtain the active components of Xiangsu powder and its corresponding action targets,and its network relationship was defined.Target points associated with antibacterial effect were searched in Genecards database,and core target genes of antibacterial effect were obtained by mnapping the target points..Finally,the GO biological process and KEGG metabolic pathway were analyzed in the DAVID database.Results:There were 129 active components,250 targets,and 66 biological processes(40 biological processes,13 molcular functions,13 cell compositions)and 35 related signaling pathways.Among theim,quercetin may be the main substance that plays a role in the drugs contained in Xiangsu powder,followed by flavonol kaempferol and favonoid luteolin.Antibacterial targets such as TNF,Casp3,PTGS2,ACTB,STAT1 and NFKB1 are mostly involved in antiviral,anti-inflammatory and immune pathways.It mainly plays a role in the hepatitis B pathway and tunor necrosis factor signaling pathway.Conclusion:Quercetin,kaempferol,luteolin and other active components in Xiangsu powder can participate in the action process of Toll-like receptor pathway,TNF signaling pathway and other pathways through acting on TNF,Casp3,PTGS2,etc.,and finally achieve the purpose of antibacterial.展开更多
Objective: to analyze the effect of modified Chaihu Xiangsu Decoction in treating patients with chronic superficial gastritis. Methods: the study included 94 patients with chronic superficial gastritis. The opening da...Objective: to analyze the effect of modified Chaihu Xiangsu Decoction in treating patients with chronic superficial gastritis. Methods: the study included 94 patients with chronic superficial gastritis. The opening date is May 2020 and the closing date is October 2021. After being randomly divided into observation group and control group. Add and subtract Chaihu Xiangsu Decoction in the observation group and conventional western medicine in the control group. Observe and compare the changes of gastrointestinal hormone levels and clinical symptom scores before and after treatment in the two groups, and evaluate and compare the overall curative effect and the occurrence of adverse reactions;At the same time, HAMA and HAMD scales were used for objective evaluation and comparative improvement. Results: after different treatments, compared with the control group, the HAMA and HAMD scores of the observation group decreased more significantly after the addition and subtraction of Chaihu xiangsu decoction. The results of measuring the levels of gastrin, motilin and other gastrointestinal hormones showed that the improvement of the observation group was better (p < 0.05). After treatment, the clinical symptom scores of both groups were lower than before treatment, and the symptom scores of the observation group were lower than those of the control group (P < 0.05). In terms of curative effect, the total effective rate of the observation group was higher than that of the control group, and the probability of adverse reactions was lower, the difference was statistically significant (p < 0.05). Conclusion: the modified Chaihu Xiangsu Decoction has a better therapeutic effect in the treatment of patients with chronic superficial gastritis. The improvement effect of anxiety and depression of patients is better, the recovery of gastrointestinal hormone level is more ideal, the improvement of symptoms is better, and the adverse reactions are less, which is more safe and worthy of wide promotion.展开更多
Background:This paper investigates the anti-tumor mechanism of action of Poria cocos on the basis of network pharmacology.Method:In this paper,we screen the potential active ingredients of Poria cocos by TCMSP and obt...Background:This paper investigates the anti-tumor mechanism of action of Poria cocos on the basis of network pharmacology.Method:In this paper,we screen the potential active ingredients of Poria cocos by TCMSP and obtain their corresponding targets with SwissTargetPrediction.The GeneCards and OMIM databases are used to screen the relevant pathogenic candidate targets in various tumor disease processes.Furthermore,we obtain Poria cocos-tumor common targets by taking the intersection of Poria cocos potential targets and candidate target groups.Subsequently,the protein-protein interaction network(PPI)of common target genes is mapped based on the STRING database,and the"drug-active component-target gene-disease"network is constructed with the help of Cytoscape3.7.2.Therefore,the core target genes are obtained.Finally,GO and pathway enrichment analysis of the core target genes are performed by Metascape and DAVID.Results:38 common targets and 7 core genes(ESR1,MAPK3,MAPK8,MTOR,PIK3CA,JAK2,and IL6)in Poria cocos-tumors are found.They play an anti-tumor role by regulating various classical pathways such as PI3K-Akt signaling pathway,mTOR signaling pathway,Prolactin signaling pathway,ErbB signaling pathway,Choline metabolism in cancer.Conclusion:The research reveals the effective anti-tumor function of Poria as a multi-component,multi-target and multi-pathway herbal medicine.展开更多
文摘300 grams ground beef 350 grams bread crumbs 2 eggs1 gram MSG2 grams salt10 grams (1 tbsp) cooking wine5 grams chopped spring onion5 grams chopped ginger10 grams (1 tbsp) cornslarch300 grams (3/5 cup) cooking oilMix ground beef with salt, MSG, cooking wine. chopped spring onion and ginger, and 5 grams of cornslarch. Beat eggs in a bowl.Make ground beef into three rolls, about 5 cm in diameter and 15 cm long. Place on a plate and steam until cooked. Coat the rolls in beaten egg and then in breadcrumbs.Heat oil in a wok. fry the rolls until brown. Cut the meat rolls into 3-cm sections, arrange on a plate, and serve.
基金This study was supported by Jiangxi Innovation and Entrepreneurship Training Program for College Students(S202010412079)Study on the design of mask for TCM epidemic prevention based on incense therapy.
文摘Objective:To explore the antibacterial mechanism of the active components of Xiangsu powder through the network pharmacological approach.Methods:TCMSP database was used to search and obtain the active components of Xiangsu powder and its corresponding action targets,and its network relationship was defined.Target points associated with antibacterial effect were searched in Genecards database,and core target genes of antibacterial effect were obtained by mnapping the target points..Finally,the GO biological process and KEGG metabolic pathway were analyzed in the DAVID database.Results:There were 129 active components,250 targets,and 66 biological processes(40 biological processes,13 molcular functions,13 cell compositions)and 35 related signaling pathways.Among theim,quercetin may be the main substance that plays a role in the drugs contained in Xiangsu powder,followed by flavonol kaempferol and favonoid luteolin.Antibacterial targets such as TNF,Casp3,PTGS2,ACTB,STAT1 and NFKB1 are mostly involved in antiviral,anti-inflammatory and immune pathways.It mainly plays a role in the hepatitis B pathway and tunor necrosis factor signaling pathway.Conclusion:Quercetin,kaempferol,luteolin and other active components in Xiangsu powder can participate in the action process of Toll-like receptor pathway,TNF signaling pathway and other pathways through acting on TNF,Casp3,PTGS2,etc.,and finally achieve the purpose of antibacterial.
文摘Objective: to analyze the effect of modified Chaihu Xiangsu Decoction in treating patients with chronic superficial gastritis. Methods: the study included 94 patients with chronic superficial gastritis. The opening date is May 2020 and the closing date is October 2021. After being randomly divided into observation group and control group. Add and subtract Chaihu Xiangsu Decoction in the observation group and conventional western medicine in the control group. Observe and compare the changes of gastrointestinal hormone levels and clinical symptom scores before and after treatment in the two groups, and evaluate and compare the overall curative effect and the occurrence of adverse reactions;At the same time, HAMA and HAMD scales were used for objective evaluation and comparative improvement. Results: after different treatments, compared with the control group, the HAMA and HAMD scores of the observation group decreased more significantly after the addition and subtraction of Chaihu xiangsu decoction. The results of measuring the levels of gastrin, motilin and other gastrointestinal hormones showed that the improvement of the observation group was better (p < 0.05). After treatment, the clinical symptom scores of both groups were lower than before treatment, and the symptom scores of the observation group were lower than those of the control group (P < 0.05). In terms of curative effect, the total effective rate of the observation group was higher than that of the control group, and the probability of adverse reactions was lower, the difference was statistically significant (p < 0.05). Conclusion: the modified Chaihu Xiangsu Decoction has a better therapeutic effect in the treatment of patients with chronic superficial gastritis. The improvement effect of anxiety and depression of patients is better, the recovery of gastrointestinal hormone level is more ideal, the improvement of symptoms is better, and the adverse reactions are less, which is more safe and worthy of wide promotion.
基金Fund project:Anhui University of Traditional Chinese Medicine Student Innovation and Entrepreneurship Project(No.202006170606)Natural Science Key Project of Anhui University of Traditional Chinese Medicine(No.2020zrzd15)National Natural Youth Science Foundation of China(No.81904062)。
文摘Background:This paper investigates the anti-tumor mechanism of action of Poria cocos on the basis of network pharmacology.Method:In this paper,we screen the potential active ingredients of Poria cocos by TCMSP and obtain their corresponding targets with SwissTargetPrediction.The GeneCards and OMIM databases are used to screen the relevant pathogenic candidate targets in various tumor disease processes.Furthermore,we obtain Poria cocos-tumor common targets by taking the intersection of Poria cocos potential targets and candidate target groups.Subsequently,the protein-protein interaction network(PPI)of common target genes is mapped based on the STRING database,and the"drug-active component-target gene-disease"network is constructed with the help of Cytoscape3.7.2.Therefore,the core target genes are obtained.Finally,GO and pathway enrichment analysis of the core target genes are performed by Metascape and DAVID.Results:38 common targets and 7 core genes(ESR1,MAPK3,MAPK8,MTOR,PIK3CA,JAK2,and IL6)in Poria cocos-tumors are found.They play an anti-tumor role by regulating various classical pathways such as PI3K-Akt signaling pathway,mTOR signaling pathway,Prolactin signaling pathway,ErbB signaling pathway,Choline metabolism in cancer.Conclusion:The research reveals the effective anti-tumor function of Poria as a multi-component,multi-target and multi-pathway herbal medicine.
