Among collagen members in the collagen superfamily,type XIX collagen has raised increasing interest in relation to its structural and biological roles.Type XIX collagen is a Fibril-Associated Collagen with Interrupted...Among collagen members in the collagen superfamily,type XIX collagen has raised increasing interest in relation to its structural and biological roles.Type XIX collagen is a Fibril-Associated Collagen with Interrupted Triple helices member,one main subclass of collagens in this superfamily.This collagen contains a triple helix composed of three polypeptide segments aligned in parallel and it is associated with the basement membrane zone in different tissues.The molecular structure of type XIX collagen consists of five collagenous domains,COL1 to COL5,interrupted by six non-collagenous domains,NCI to NC6.The most relevant domain by which this collagen exerts its biological roles is NCI domain that can be cleavage enzymatically to release matricryptins,exerting anti-tumor and anti-angiogenic effect in murine and human models of cancer.Under physiological conditions,type XIX collagen expression decreases after birth in different tissues although it is necessary to keep its basal levels,mainly in skeletal muscle and hippocampal and telencephalic interneurons in brain.Notwithstanding,in amyotrophic lateral sclerosis,altered transcript expression levels show a novel biological effect of this collagen beyond its structural role in basement membranes and its anti-tumor and anti-angiogenic properties.Type XIX collagen can exert a compensatory effect to ameliorate the disease progression under neurodegenerative conditions specific to amyotrophic lateral sclerosis in transgenic SOD1 G93 A mice and amyotrophic lateral sclerosis patients.This novel biological role highlights its nature as prognostic biomarker of disease progression in and as promising therapeutic target,paving the way to a more precise prognosis of amyotrophic lateral sclerosis.展开更多
There are many problems worth discussing in Li Bai’s Fifty-Nine Pre-Tang Style Poems(XIX),which can be named Lotus Flower Peak in Huashan Mountain(西岳莲花山).From ancient times to the present,interpreters have put f...There are many problems worth discussing in Li Bai’s Fifty-Nine Pre-Tang Style Poems(XIX),which can be named Lotus Flower Peak in Huashan Mountain(西岳莲花山).From ancient times to the present,interpreters have put forward different opinions on the theme,period,and writing place of the poem,but they have not provided reliable evidence.From the perspective of historical geography,this paper elaborates on“Lotus Flower Peak”or“Lotus Flower Mountain”(莲花峰或莲花山)and“Luoyang Chuan”(洛阳川)in the poem,and puts forward a series of viewpoints for the first time.Li Bai chose Huashan Mountain as the starting point of his journey to the mystical landscape because of the special location of Yuntai Peak.Its position is easy to observe from east to west,thus forming an eastward immortal route contrary to the western route of the rebels of An Lushan and Shi Siming(安史叛军).It shows great significance to the division of the poet’s personal life stages that Li Bai started to use the word“Luoyang Chuan”.There is a significant difference between this word and the pure word“Luoyang”when it combines the applied allusion of the An-Shi Rebellion.According to the research results,this poem may be written during this period from January in 756 A.D.to October in 757 A.D.The poet did not enter Tongguan in Shaanxi at all,let alone climbing Yuntai Peak in Huashan Mountain.In this poem,the real geographical position runs through the whole process,making the poet’s romantic fairy fantasy and the real historical record perfect integration,fully showing the poet’s judgment of the current situation and the course of his mind in the An-Shi rebellion.展开更多
3-Methylthio-5-hydroxy-1,2,4-triazine(1c)reacted with substituted benzenesulfonyl chloride to give 3-methylthio-5-oxy-1,2,4-triazin-6-yl pyridinium betaine(4)in anhydrous pyridine.But when NaOH/H_2O/CH_3COCH_3 or NaOH...3-Methylthio-5-hydroxy-1,2,4-triazine(1c)reacted with substituted benzenesulfonyl chloride to give 3-methylthio-5-oxy-1,2,4-triazin-6-yl pyridinium betaine(4)in anhydrous pyridine.But when NaOH/H_2O/CH_3COCH_3 or NaOH/CH_3OH were used as reactant and solvent,3-methylthio-4-substituted benzenesulfonyl-5-oxo-6-hydroxy-1,4,5,6-tetrahydro-1,2,4-triazine(6)or 1-tosyl-3-methylthio-5-oxo-6-methyloxy-1,4,5,6-tetrahydro-1,2,4-triazine(7)was obtained respectively.The above reactions show anomalous properties of nucleophilic attack on 6-carbon in 1,2,4-triazine ring.展开更多
基金supported by Institutode Salud Carlos Ⅲ(Grant PI17/00949)Fondo Europeode Desarrollo Regional(FEDER)“Una manera de hacer Europa” from the European Union+1 种基金Centrode Investigación Biomédicaen Redsobre Enfermedades Neurodegenerativas(CIBERNED-612)Fundación FEDER(Federación Espa?olade Enfermedades Raras),Consolidated Groupsfrom Gobiernode Aragón
文摘Among collagen members in the collagen superfamily,type XIX collagen has raised increasing interest in relation to its structural and biological roles.Type XIX collagen is a Fibril-Associated Collagen with Interrupted Triple helices member,one main subclass of collagens in this superfamily.This collagen contains a triple helix composed of three polypeptide segments aligned in parallel and it is associated with the basement membrane zone in different tissues.The molecular structure of type XIX collagen consists of five collagenous domains,COL1 to COL5,interrupted by six non-collagenous domains,NCI to NC6.The most relevant domain by which this collagen exerts its biological roles is NCI domain that can be cleavage enzymatically to release matricryptins,exerting anti-tumor and anti-angiogenic effect in murine and human models of cancer.Under physiological conditions,type XIX collagen expression decreases after birth in different tissues although it is necessary to keep its basal levels,mainly in skeletal muscle and hippocampal and telencephalic interneurons in brain.Notwithstanding,in amyotrophic lateral sclerosis,altered transcript expression levels show a novel biological effect of this collagen beyond its structural role in basement membranes and its anti-tumor and anti-angiogenic properties.Type XIX collagen can exert a compensatory effect to ameliorate the disease progression under neurodegenerative conditions specific to amyotrophic lateral sclerosis in transgenic SOD1 G93 A mice and amyotrophic lateral sclerosis patients.This novel biological role highlights its nature as prognostic biomarker of disease progression in and as promising therapeutic target,paving the way to a more precise prognosis of amyotrophic lateral sclerosis.
基金the periodic research result of the research project:Beijing Social Science Fund Project,“Research on The Yuan Dynasty Version of Li Taibai’s Poems With Supplementary Annotations by Classification,Collected by Zunjing Pavilion in Japan”(日本尊经阁藏元版《分类补注李太白诗》研究)(Serial Number 15WYC060)Moreover,it is also the periodic research result of the research project:Planning of Philosophy and Social Sciences in Guizhou Province in 2018-Individually Listed Studies of Chinese Ancient Civilization(贵州省2018年度哲学社会科学规划国学单列课题阶段性成果)“Research on the Compilation and Publication of the Anthology of Special Collections of the Works of Scholars of Song Dynasty in Song and Yuan Dynasties”(宋元时期宋人别集的编纂与刊刻研究)(Serial Number 18GZGX25).
文摘There are many problems worth discussing in Li Bai’s Fifty-Nine Pre-Tang Style Poems(XIX),which can be named Lotus Flower Peak in Huashan Mountain(西岳莲花山).From ancient times to the present,interpreters have put forward different opinions on the theme,period,and writing place of the poem,but they have not provided reliable evidence.From the perspective of historical geography,this paper elaborates on“Lotus Flower Peak”or“Lotus Flower Mountain”(莲花峰或莲花山)and“Luoyang Chuan”(洛阳川)in the poem,and puts forward a series of viewpoints for the first time.Li Bai chose Huashan Mountain as the starting point of his journey to the mystical landscape because of the special location of Yuntai Peak.Its position is easy to observe from east to west,thus forming an eastward immortal route contrary to the western route of the rebels of An Lushan and Shi Siming(安史叛军).It shows great significance to the division of the poet’s personal life stages that Li Bai started to use the word“Luoyang Chuan”.There is a significant difference between this word and the pure word“Luoyang”when it combines the applied allusion of the An-Shi Rebellion.According to the research results,this poem may be written during this period from January in 756 A.D.to October in 757 A.D.The poet did not enter Tongguan in Shaanxi at all,let alone climbing Yuntai Peak in Huashan Mountain.In this poem,the real geographical position runs through the whole process,making the poet’s romantic fairy fantasy and the real historical record perfect integration,fully showing the poet’s judgment of the current situation and the course of his mind in the An-Shi rebellion.
基金Director of the project supported by National Natural Science foundation of China.
文摘3-Methylthio-5-hydroxy-1,2,4-triazine(1c)reacted with substituted benzenesulfonyl chloride to give 3-methylthio-5-oxy-1,2,4-triazin-6-yl pyridinium betaine(4)in anhydrous pyridine.But when NaOH/H_2O/CH_3COCH_3 or NaOH/CH_3OH were used as reactant and solvent,3-methylthio-4-substituted benzenesulfonyl-5-oxo-6-hydroxy-1,4,5,6-tetrahydro-1,2,4-triazine(6)or 1-tosyl-3-methylthio-5-oxo-6-methyloxy-1,4,5,6-tetrahydro-1,2,4-triazine(7)was obtained respectively.The above reactions show anomalous properties of nucleophilic attack on 6-carbon in 1,2,4-triazine ring.
