Enriched by the-medium containingchitin and cell wall of Phizoctoniasolani AG-1,a bacterium X2-23 withhigher chitinase activity was isolatedfrom 166 chitinase-producing bacteria.It could distinctly inhibit the fungi
文摘Enriched by the-medium containingchitin and cell wall of Phizoctoniasolani AG-1,a bacterium X2-23 withhigher chitinase activity was isolatedfrom 166 chitinase-producing bacteria.It could distinctly inhibit the fungi
文摘目的探讨血清Mas相关G蛋白偶联受体X2(Mas-related G protein-coupled receptor X2,MRGPRX2)以及细胞因子白介素(interleukin,IL)-4、IL-5、IL-6、IL-13、IL-23、IL-33水平与慢性自发性荨麻疹(chronic spontaneous urticaria,CSU)的相关性。方法收集2021年2月至2023年9月在复旦大学附属华山医院皮肤科就诊的55例CSU患者及同期21例健康体检者的基本临床信息和实验室数据,并评估CSU患者的疾病活动度和严重程度。采集所有受试者的外周血,通过酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测MRGPRX2,用Luminex多重检测技术检测血清IL-4、IL-5、IL-6、IL-13、IL-23、IL-33水平。采用Spearman相关性分析评价CSU患者的生物标志物与其他参数的相关性,logistic回归分析CSU发生的影响因素。结果CSU组患者血清MRGPRX2水平高于对照组[2.41(0,11.51)ng/mL vs 0(0,2.86)ng/mL,P=0.015],IL-23水平高于对照组[0.09(0.04,0.56)pg/mL vs 0.05(0.03,0.08)pg/mL,P=0.033]。两组受试者其他细胞因子水平差异无统计学意义。重度和非重度CSU患者MRGPRX2及细胞因子水平差异无统计学意义。相关性分析结果显示,CSU患者的血清MRGPRX2水平与IL-4(r=0.345,P=0.010)、IL-6(r=0.395,P=0.003)水平正相关。Logistic回归分析显示,血清MRGPRX2≥0.055 ng/mL、IL-23≥0.135 pg/mL是CSU发生的独立危险因素(P<0.05)。结论CSU患者血清MRGPRX2和IL-23水平升高,二者可能参与CSU发病。
