Background: Recent studies indicate that C-X-C motif chemokine receptor 4(CXCR4) and its ligand, C-X-C motif chemokine ligand 12(CXCL12), stimulate expression of the cell cycle regulatory protein Cyclin D1 in neurofib...Background: Recent studies indicate that C-X-C motif chemokine receptor 4(CXCR4) and its ligand, C-X-C motif chemokine ligand 12(CXCL12), stimulate expression of the cell cycle regulatory protein Cyclin D1 in neurofibromatosis 1-associated malignant peripheral nerve sheath tumor(MPNST) cells and promote their proliferation. In this study, we measured the expression of CXCR4, CXCL12, and Cyclin D1 proteins in sporadic MPNST tissues from Chinese patients and investigated their prognostic values.Methods: CXCR4, CXCL12, and Cyclin D1 protein expression in samples from 58 Chinese patients with sporadic MPNST was assessed with immunohistochemical staining.Their prognostic values were evaluated with Kaplan-Meier analysis and a log-rank test. Multivariate Cox regression analysis was used to identify independent prognostic factors.Results: High expression of CXCR4, CXCL12, and Cyclin D1 was observed in 19(32.8%), 32(55.2%), and 16(27.6%)samples, respectively. CXCR4 expression was positively correlated with CXCL12 expression(r = 0.334, P = 0.010) and Cyclin D1 expression(r = 0.309, P = 0.018). Patients with high CXCR4 expression showed longer overall survival than those with low CXCR4 expression(χ~2 = 4.642, P = 0.031).Conclusion: High CXCR4 expression may define a specific subtype of sporadic MPNST with favorable prognosis.展开更多
In the X-C linkage grinding of non-circular parts,the computation and control method of contour error in polar coordinates platform is different with that in the XY coordinates platform.To solve this problem,the analy...In the X-C linkage grinding of non-circular parts,the computation and control method of contour error in polar coordinates platform is different with that in the XY coordinates platform.To solve this problem,the analysis of the definition and computation methods for contour error and track error in polar coordinates platform will be made.Through the relative lead-lag relation of the linkage axes in the grinding process,the range of the estimation contour error is narrowed and a contour error calculation model is constructed.Then the contour compensation controllers along contour error direction and trajectory tracking error direction are designed respectively,and the error compensation decoupling matrix of the X-C linkage axes is given as well.In the end of this paper,we take the machining of the cylinder contour in Wankel rotary piston engine as an example.A simulation experiment of contour error compensation control based on relative lead-lag quantity is made.The result shows that the designed contour compensation controller can increase the contour machining accuracy effectively.展开更多
基金supported by the National Nature Science Foundation of China(81372872 to Jilong Yang,81672650 to Ze Zhu,and 81402215 to Xiaoling Du)funds from the University Cancer Foundation via the Sister Institution Network Fund(to Jilong Yang)
文摘Background: Recent studies indicate that C-X-C motif chemokine receptor 4(CXCR4) and its ligand, C-X-C motif chemokine ligand 12(CXCL12), stimulate expression of the cell cycle regulatory protein Cyclin D1 in neurofibromatosis 1-associated malignant peripheral nerve sheath tumor(MPNST) cells and promote their proliferation. In this study, we measured the expression of CXCR4, CXCL12, and Cyclin D1 proteins in sporadic MPNST tissues from Chinese patients and investigated their prognostic values.Methods: CXCR4, CXCL12, and Cyclin D1 protein expression in samples from 58 Chinese patients with sporadic MPNST was assessed with immunohistochemical staining.Their prognostic values were evaluated with Kaplan-Meier analysis and a log-rank test. Multivariate Cox regression analysis was used to identify independent prognostic factors.Results: High expression of CXCR4, CXCL12, and Cyclin D1 was observed in 19(32.8%), 32(55.2%), and 16(27.6%)samples, respectively. CXCR4 expression was positively correlated with CXCL12 expression(r = 0.334, P = 0.010) and Cyclin D1 expression(r = 0.309, P = 0.018). Patients with high CXCR4 expression showed longer overall survival than those with low CXCR4 expression(χ~2 = 4.642, P = 0.031).Conclusion: High CXCR4 expression may define a specific subtype of sporadic MPNST with favorable prognosis.
基金supported by the Chinese National Natural Science Foundation under Grant(51375056)the Beijing Natural Science Foundation under Grant(3142009)the key of Beijing Natural Science Foundation under Grant(KZ201211232039)
文摘In the X-C linkage grinding of non-circular parts,the computation and control method of contour error in polar coordinates platform is different with that in the XY coordinates platform.To solve this problem,the analysis of the definition and computation methods for contour error and track error in polar coordinates platform will be made.Through the relative lead-lag relation of the linkage axes in the grinding process,the range of the estimation contour error is narrowed and a contour error calculation model is constructed.Then the contour compensation controllers along contour error direction and trajectory tracking error direction are designed respectively,and the error compensation decoupling matrix of the X-C linkage axes is given as well.In the end of this paper,we take the machining of the cylinder contour in Wankel rotary piston engine as an example.A simulation experiment of contour error compensation control based on relative lead-lag quantity is made.The result shows that the designed contour compensation controller can increase the contour machining accuracy effectively.
