The microstructure of single crystal superalloy is relatively simple,consisting primarily ofγdendrites andγ/γ′eutectics.During the directional solidification process of Ni-based single crystal superalloys,withdraw...The microstructure of single crystal superalloy is relatively simple,consisting primarily ofγdendrites andγ/γ′eutectics.During the directional solidification process of Ni-based single crystal superalloys,withdrawal rate is a critical parameter affecting the spatial distribution ofγ/γ′eutectic along gravity direction.The results show that theγ/γ′eutectic fraction of the upper platform surface is always higher than that of the lower one,regardless of withdrawal rate.As the withdrawal rate decreases,there is a significant increase inγ/γ′eutectic fraction on the upper surface,while it decreases on the lower surface.The upward accumulation ofγ/γ′eutectic becomes more severe as the withdrawal rate decreases.It is also found that the percentage of Al+Ta is positively correlated with theγ/γ′eutectic fraction.Thermo-solute convection of Al and Ta solutes in the solidification front is the prime reason for the non-uniform distribution of eutectic.The non-uniform distribution ofγ/γ′eutectic cannot be eliminated even after subsequent solution heat treatment,resulting in excess eutectic on the upper surface and thus leading to the scrapping of the blade.展开更多
BACKGROUND Psychotic disorders are characterized by both positive symptoms(hallucinations,delusions)and negative symptoms(emotional blunting,anhedonia)that impair daily functioning.While antipsychotic drugs and psycho...BACKGROUND Psychotic disorders are characterized by both positive symptoms(hallucinations,delusions)and negative symptoms(emotional blunting,anhedonia)that impair daily functioning.While antipsychotic drugs and psychological interventions are effective when addressing positive symptoms,treatment of negative symptoms remains an ongoing challenge.Mindfulness-based interventions(MBIs)have been shown to reduce negative psychotic symptoms.However,as negative psychotic symptoms are assessed as a sole entity rather than a sum of manifestations,the effect of MBIs remains unclear.AIM To examine the effects of MBI in addition to integrated rehabilitation treatment(IRT)for people experiencing psychosis on each of the negative psychotic symptoms.METHODS A randomized controlled clinical trial with preintervention and postintervention measures was designed.The main outcome variable was negative psychotic symptoms assessed through the seven subscales of the Spanish version of the positive and negative syndrome scale.Data were analyzed using a repeated measures analysis of variance and reliable change index calculation.RESULTS There were no statistical differences between groups at the preintervention assessment.Statistically significant differences were found after MBI for the time in emotional withdrawal(F=37.75,P<0.001,η2=0.437)and social withdrawal(F=37.75,P<0.001,η2=0.437).CONCLUSION MBI added to IRT reduced the lack of interest and involvement with affective commitment to daily life activities,and interest and engagement in social activities increased.These negative psychotic symptoms were not improved by IRT alone.展开更多
BACKGROUND 5-aminosalicylates(5-ASA)are the primary treatment for mild to moderate ulcerative colitis(UC).Maintenance therapy with 5-ASA has been shown to reduce both the risk of relapse and colorectal cancer.AIM To e...BACKGROUND 5-aminosalicylates(5-ASA)are the primary treatment for mild to moderate ulcerative colitis(UC).Maintenance therapy with 5-ASA has been shown to reduce both the risk of relapse and colorectal cancer.AIM To evaluate the outcomes of 5-ASA withdrawal due to non-adherence in UC patients while in remission on monotherapy.METHODS Adult patients with UC who were followed up between July 2019 and April 2025 were screened.Patients in remission receiving 5-ASA monotherapy who experienced treatment withdrawal due to non-adherence were included in this study.RESULTS Among 880 patients with UC,30(3.4%)had 5-ASA withdrawal due to nonadherence while in remission on monotherapy.Twelve patients(40%)had disease relapse after a median of 20 months.The rate of patients in remission was 89%in the first year,decreasing to 73%in the second year,and to 64%in the third year.There were no significant differences between patients with and without relapse in terms of demographics,disease extent,remission duration before 5-ASA withdrawal,previous medications,steroid dependence,5-ASA formulation,baseline inflammatory markers,or partial and endoscopic Mayo scores.Most patients(75%)who experienced relapse were successfully treated with 5-ASA monotherapy,while one-fourth of them required corticosteroids.No patients required biologic agents,hospitalization,or surgical intervention.CONCLUSION Intermittent therapy may be safe and feasible for UC patients,especially those in long-term remission,with treatment interruption up to one year considered acceptable.展开更多
The research explores the long-term connection between Greece’s agricultural output,with a focus on both crop and livestock production,and crucial environmental factors like water usage and energy consumption.Through...The research explores the long-term connection between Greece’s agricultural output,with a focus on both crop and livestock production,and crucial environmental factors like water usage and energy consumption.Through linear regression analysis,the study investigates how these factors affect agricultural value-added,providing insights into the sustainability and efficiency of Greece’s farming sector.The results show a significant(p<0.05)positive relationship between crop production and agricultural value-added,as well as the significant influence of water usage and energy consumption on the productivity of both crops and livestock.For livestock farming,the analysis revealed a weaker contribution to agricultural value-added at the national level,likely due to structural inefficiencies in the sector.While livestock production benefits significantly from water and energy inputs,it does not have as substantial an economic impact compared to crop production.This research contributes to the field of agricultural economics by offering a historical perspective on how resource management influences agricultural performance over time.It highlights the significance of sustainable practices,especially in areas like the periphery of Western Macedonia,which are shifting from conventional energy sources like lignite to renewable energy.The findings advocate for policies that promote water conservation,energy efficiency,and smart agriculture to enhance productivity and support regional development.展开更多
BACKGROUND Despite therapeutic benefits,discontinuation of tirzepatide is common in randomized controlled trials(RCTs)due to adverse events(AEs)and other causes.No previous systematic reviews have explored the reasons...BACKGROUND Despite therapeutic benefits,discontinuation of tirzepatide is common in randomized controlled trials(RCTs)due to adverse events(AEs)and other causes.No previous systematic reviews have explored the reasons for discontinuing tirzepatide in the RCTs.AIM To explore the reasons for permanent discontinuation of tirzepatide vs controls[placebo,insulin,and glucagon-like peptide-1 receptor agonists(GLP-1Ras)]in RCTs.METHODS Relevant RCTs were systematically searched using related terms through multiple databases such as MEDLINE(via PubMed),Scopus,Cochrane Central Register,and ClinicalTrials.gov from their inception until June 20,2024.RevMan web was used to conduct meta-analysis using random-effects models.Outcomes were presented as risk ratios(RR)with 95%confidence intervals(CI).RESULTS Seventeen RCTs(n=14645),mostly having low risks of bias,were analyzed.Compared to placebo,the risk of permanent discontinuation of the study drug was substantially lower with tirzepatide 10 mg(RR:0.69,95%CI:0.51-0.93,P=0.02)and similar with tirzepatide 5 mg(RR:0.74,95%CI:0.47-1.17,P=0.20)and 15 mg(RR:0.94,95%CI:0.68-1.31,P=0.71).Tirzepatide had identical discontinuation risks when compared to insulin at 5 mg(RR:0.96,95%CI:0.75-1.24,P=0.77)and 10 mg(RR:1.19,95%CI:0.77-1.82,P=0.44)doses,whereas such risk was higher with tirzepatide 15 mg than insulin(RR:1.31,95%CI:1.03-1.67,P=0.03).Compared to GLP-1RA,the permanent discontinuation risk was similar with tirzepatide 5 mg(RR:0.98,95%CI:0.70-1.37,P=0.90)but was higher with tirzepatide 10 mg(RR:1.40,95%CI:1.03-1.90,P=0.03)and 15 mg(RR:1.70,95%CI:1.27-2.27,P=0.0004).Tirzepatide,at all doses,had higher risks of AE-related discontinuation than insulin;such risks were only greater with higher doses of tirzepatide than with placebo or GLP-1RA.Discontinuation risk due to withdrawal by the study subjects was lower with tirzepatide than with placebo or insulin.Compared to the placebo,tirzepatide(all doses)conferred a lower risk of study drug discontinuation due to other causes not specifically mentioned.CONCLUSION The discontinuation risk is not higher in tirzepatide group than in the placebo arm.Many factors other than AEs led to drug discontinuation in the included RCTs.展开更多
This review examines the mechanisms of anxiety and depression in menopausal syndrome from an integrated physiological to psychological perspective.Fluctuations in estrogen and progesterone levels during menopause affe...This review examines the mechanisms of anxiety and depression in menopausal syndrome from an integrated physiological to psychological perspective.Fluctuations in estrogen and progesterone levels during menopause affect neurotransmitter systems(including serotonin,norepinephrine,and dopamine),hypothalamic-pituitary-adrenal axis function,inflammatory processes,and neurotrophic factor expression,collectively diminishing the resilience of emotional regulation neural circuits.Simultaneously,vasomotor symptoms(such as hot flashes and night sweats),sleep disruption,genetic susceptibility,and epigenetic modifications interact with mood disorders,while psychosocial factors(such as midlife stressors and role transitions)and cognitive factors(including negative schemas about aging,attentional bias toward threats,and difficulties in emotional regulation)further shape women’s experiences of menopausal changes.Clinical practice should adopt a biopsychosocial model,employing personalized multimodal approaches through hormone therapy,antidepressants,psychotherapy,and lifestyle adjustments,while future research should focus on developing biomarkers,utilizing advanced technologies,and developing targeted interventions to support women’s psychological wellbeing during menopause.展开更多
Using data from the 11th to 14th Five-Year Plan periods(2006-2025),this study applies a Difference-in-Differences(DID)approach to assess the impact of industrial policy withdrawal.Industries that have faced policy wit...Using data from the 11th to 14th Five-Year Plan periods(2006-2025),this study applies a Difference-in-Differences(DID)approach to assess the impact of industrial policy withdrawal.Industries that have faced policy withdrawal for over a decade are categorized as the treatment group,while consistently supported industries form the control group.The analysis examines how withdrawal affects firm total factor productivity(TFP)and investment behavior.The results show that policy withdrawal boosts firm TFP by reducing over-investment and improving the efficiency of R&D spending.This effect is particularly evident in industries with strong,competitive leading firms.Additionally,in regions with lower levels of marketization,timely policy withdrawal plays a key role in curbing over-investment.This study also highlights a dual effect of policy withdrawal:while it fosters corporate social responsibility,it may also encourage financial speculation.These findings suggest that the implementation of industrial policy should provide“timely assistance”over a limited timeframe rather than long-term support to well-established industries.As industries mature,policy support should be gradually reduced or phased out to avoid over-investment and enhance firm efficiency.展开更多
Underground salt cavern CO_(2) storage(SCCS)offers the dual benefits of enabling extensive CO_(2) storage and facilitating the utilization of CO_(2) resources while contributing the regulation of the carbon market.Its...Underground salt cavern CO_(2) storage(SCCS)offers the dual benefits of enabling extensive CO_(2) storage and facilitating the utilization of CO_(2) resources while contributing the regulation of the carbon market.Its economic and operational advantages over traditional carbon capture,utilization,and storage(CCUS)projects make SCCS a more cost-effective and flexible option.Despite the widespread use of salt caverns for storing various substances,differences exist between SCCS and traditional salt cavern energy storage in terms of gas-tightness,carbon injection,brine extraction control,long-term carbon storage stability,and site selection criteria.These distinctions stem from the unique phase change characteristics of CO_(2) and the application scenarios of SCCS.Therefore,targeted and forward-looking scientific research on SCCS is imperative.This paper introduces the implementation principles and application scenarios of SCCS,emphasizing its connections with carbon emissions,carbon utilization,and renewable energy peak shaving.It delves into the operational characteristics and economic advantages of SCCS compared with other CCUS methods,and addresses associated scientific challenges.In this paper,we establish a pressure equation for carbon injection and brine extraction,that considers the phase change characteristics of CO_(2),and we analyze the pressure during carbon injection.By comparing the viscosities of CO_(2) and other gases,SCCS’s excellent sealing performance is demonstrated.Building on this,we develop a long-term stability evaluation model and associated indices,which analyze the impact of the injection speed and minimum operating pressure on stability.Field countermeasures to ensure stability are proposed.Site selection criteria for SCCS are established,preliminary salt mine sites suitable for SCCS are identified in China,and an initial estimate of achievable carbon storage scale in China is made at over 51.8-77.7 million tons,utilizing only 20%-30%volume of abandoned salt caverns.This paper addresses key scientific and engineering challenges facing SCCS and determines crucial technical parameters,such as the operating pressure,burial depth,and storage scale,and it offers essential guidance for implementing SCCS projects in China.展开更多
Water-level reduction frequently occurs in deep reservoirs,but its effect on dissolved oxygen concentration is not well understood.In this study we used a well-established water qual-itymodel to illustrate effects of ...Water-level reduction frequently occurs in deep reservoirs,but its effect on dissolved oxygen concentration is not well understood.In this study we used a well-established water qual-itymodel to illustrate effects of water level dynamics on oxygen concentration in Rappbode Reservoir,Germany.We then systematically elucidated the potential of selectivewithdrawal to control hypoxia under changing water levels.Our results documented a gradual decrease of hypolimnetic oxygen concentration under decreasing water level,and hypoxia occurred when the initial level was lower than 410 m a.s.l(71 m relative to the reservoir bottom).We also suggested that changes of hypoxic region,under increasing hypolimnetic withdrawal discharge,followed a unimodal trajectory with themaximum hypoxic area projected under the discharge between 3 m^(3)/sec and 4 m^(3)/sec.Besides,our results illustrated the extent of hypoxia was most effectively inhibited if the withdrawal strategy was applied at the end of stratification with the outlet elevation at the deepest part of the reservoir.Moreover,hy-poxia can be totally avoided under a hybrid elevation withdrawal strategy using surface withdrawal during early and mid stratification,and deep withdrawal at the end of strat-ification.We further confirmed the decisive role of thermal structure in the formation of hypoxia under water-level reduction and withdrawal strategies.We believe the conclusions from this study can be applied to many deep waters in the temperate zone,and the results should guide stakeholders to mitigate negative impacts of hypoxia on aquatic ecosystems.展开更多
Despite the high efficiency of remote sensing methods for rapid and large-scale detection of subsidence phenomena,this technique has limitations such as atmospheric impact and temporal and spatial decorrelation that a...Despite the high efficiency of remote sensing methods for rapid and large-scale detection of subsidence phenomena,this technique has limitations such as atmospheric impact and temporal and spatial decorrelation that affect the accuracy of the results.This paper proposes a method based on an artificial neural network to improve the results of monitoring land subsidence due to groundwater overexploitation by radar interferometry in the Aliabad plain(Central Iran).In this regard,vertical ground deformations were monitored over 18 months using the Sentinel-1A SAR images.To model the land subsidence by a multilayer perceptron(MLP)artificial neural network,four parameters,including groundwater level,alluvial thickness,elastic modulus,and transmissivity have been applied.The model's generalizability was assessed using data derived for 144 days.According to the results,the neural network estimates the land subsidence at each ground point with an accuracy of 6.8 mm.A comparison between the predicted and actual values indicated a significant agreement.The MLP model can be used to improve the results of subsidence detection in the study area or other areas with similar characteristics.展开更多
Lateral intakes are common in rivers.The pump effciency and sediment deposition are determined by the local hydrodynamic characteristics and mainstream division width.The hydraulic characteristics of lateral withdrawa...Lateral intakes are common in rivers.The pump effciency and sediment deposition are determined by the local hydrodynamic characteristics and mainstream division width.The hydraulic characteristics of lateral withdrawal from inclined river slopes at different intake elevations should be investigated.Meanwhile,the division width exhibits significant vertical non-uniformity at an inclined river slope,which should be clarified.Hence,a three-dimensional(3-D)hydrodynamic and particle-tracking model was developed with the Open Source Field Operation and Manipulation(Open FOAM),and the model was validated with physical model tests for 90°lateral withdrawal from an inclined side bank.The flow fields,withdrawal sources,and division widths were investigated with different intake bottom elevations,withdrawal discharges,and main channel velocities.This study showed that under inclined side bank conditions,water entered the intake at an oblique angle,causing significant 3-D spiral flows in the intake rather than two-dimensional closed recirculation.A lower withdrawal discharge,a lower bottom elevation of the intake,or a higher main channel velocity could further strengthen this phenomenon.The average division width and turbulent kinetic energy were smaller under inclined side bank conditions than under vertical bank conditions.With a low intake bottom elevation,a low withdrawal discharge,or a high main channel velocity,the sources of lateral withdrawal were in similar ranges near the local inclined bank in the vertical direction.Under inclined slope conditions,sediment deposition near the intake entrance could be reduced,compared to that under vertical slope conditions.The results provide hydrodynamic and sediment references for engineering designs for natural rivers with inclined terrains.展开更多
The existing land supply mode of opencast mining is"land requisition first,then transfer",which lacks an effective recovery and withdrawal mechanism,and the reclaimed mining land is difficult to withdraw.Acc...The existing land supply mode of opencast mining is"land requisition first,then transfer",which lacks an effective recovery and withdrawal mechanism,and the reclaimed mining land is difficult to withdraw.According to the regular rules of coal opencast mining and the periodic characteristics of land use,this paper puts forward a new mode of temporary land use for coal opencast mining.It is conducive to im-proving the quality and scale of land use and reclamation utilization of opencast coal mining,and is of great significance for exploring and for-mulating reasonable land use policies for mineral resources development projects.展开更多
Background and Objective: With the popularity and widespread use of mobile phones, the effects of mobile phone dependence and addiction on individuals’ physical and mental health have attracted more and more attentio...Background and Objective: With the popularity and widespread use of mobile phones, the effects of mobile phone dependence and addiction on individuals’ physical and mental health have attracted more and more attention. The present study aims to analyze the current state of mobile phone addiction and its impact on sleep quality within the population, while also exploring the influence of related factors on sleep quality. Ultimately, this research will provide a scientific foundation for targeted intervention measures and strategies. Methods: A total of 253 permanent residents in Nanjing were randomly selected as study subjects. The Mobile Phone Addiction Index (MPAI) and Pittsburgh Sleep Quality Index (PSQI) were used to evaluate the degree of smartphone addiction and sleep quality of the study subjects. Body mass index (BMI) was measured according to standardized procedures. Independent sample t-test, Chi-square test, rank sum test and multiple linear regression were used to analyze the correlation between mobile phone addiction and sleep quality, and P Results: 117 people (46.2%) were addicted to mobile phones. Chi-square test showed that the rate of mobile phone addiction in drinking group was significantly higher than that in non-drinking group (P P P P P P P P P P Conclusion: Mobile phone addiction may lead to shorter sleep duration and reduce sleep efficiency. The withdrawal of mobile phone addiction may have a negative impact on sleep quality. According to the characteristics of the population, appropriate comprehensive intervention measures should be taken to build an effective evaluation system, so as to reduce the impact of mobile phone addiction and withdrawal problems on sleep and improve sleep quality.展开更多
This study aims to determine whether the involvement of prestigious attorneys in issuing companies affects withdrawals in the initial public offering(IPO)market.There is little evidence on how the involvement of famou...This study aims to determine whether the involvement of prestigious attorneys in issuing companies affects withdrawals in the initial public offering(IPO)market.There is little evidence on how the involvement of famous lawyers affects IPO withdrawal.The study considers a large dataset consisting of 24,312 IPOs that were either successful or withdrawn from 22 distinct IPO marketplaces between January 1995 and December 2019.We find that IPO issuers may benefit from engaging with reputed attorneys by leveraging exceptional legal or negotiating abilities as quality certification signals to reduce IPO investors’ex-ante uncertainty.Here,the objective is to protect their IPOs from withdrawal of at least by 22%.Multiple robustness tests validate the reliability of the results of this study.These findings have significant implications for researchers,legislators,investors,and issuers.展开更多
To examine whether there are sex differences in morphine dependence and its metabolism. Naloxone-precipitated withdrawal study was performed. Twenty rats were induced by naloxone 1 h after a single dose of morphine in...To examine whether there are sex differences in morphine dependence and its metabolism. Naloxone-precipitated withdrawal study was performed. Twenty rats were induced by naloxone 1 h after a single dose of morphine injection. The withdrawal syndromes were recorded and an HPLC-UV method was set up to quantify the plasma levels of morphine and morphine-3-glucuronide（M3G）. In the spontaneous withdrawal study, 97 rats were treated with progressive morphine for 28 d to develop physical dependence. The spontaneous withdrawal syndromes were recorded and plasma levels of morphine and M3G were determined after the last injection. No significant differences were observed in withdrawal syndrome of naloxone precipitating. More severe spontaneous withdrawal syndromes were produced by chronic morphine injection in male rats than in female rats（P0.05）. Higher maximum plasma concentration（Cmax） of morphine was measured in male rats than female rats, while female rats had higher Cmax of M3G than male rats in both acute and chronic morphine administration. Our results indicated that sex differences existed in withdrawal syndrome of morphine-dependent rats, and the pharmacokinetics of morphine showed sex difference by both acute and chronic administration. There might be a relationship between the severity of withdrawal syndrome and the plasma concentrations of morphine, M3G, and the ratio of morphine to M3G（M3G/MOR）.展开更多
Nb-16Si-24Ti-10Cr-2A1-2Hf alloy was directionally solidified with withdrawal rates of 1.2, 6, 18, 36 and 50 mrn/min and then heat treated at 1400, 1450 and 1500℃with withdrawal rate of 50 mm/min for 10 h. The effects...Nb-16Si-24Ti-10Cr-2A1-2Hf alloy was directionally solidified with withdrawal rates of 1.2, 6, 18, 36 and 50 mrn/min and then heat treated at 1400, 1450 and 1500℃with withdrawal rate of 50 mm/min for 10 h. The effects of withdrawal rate and heat treatment temperature on the microstructure were studied. The microstructure of directionally solidified alloy was composed of the primary NbsSi3, Nbss/NbsSi3 eutectic cells and Cr2Nb, which distribute paralleled to the growth direction. The microstructure becomes more refined with the increasing withdrawal rate, accompany with the evolution of eutectic cells morphology. After heat treatment, Nbss phase connects and forms a continuous matrix, and the Cr2Nb phase becomes smaller and distributes more dispersedly. After heat treatment at 1450 ℃ for 10 h, the alloy achieves balance between the optimization of microstructure and alleviation of solute segregation.展开更多
A nickel base single crystal （SC） superalloy was directionally solidified using liquid metal cooling （LMC） process at various withdrawal rates. The microstructure was refined as increasing the withdrawal rate from...A nickel base single crystal （SC） superalloy was directionally solidified using liquid metal cooling （LMC） process at various withdrawal rates. The microstructure was refined as increasing the withdrawal rate from 3 to 12 mm/min. However, higher withdrawal rate of 15 mm/min induced the formation of stray grains. Size and volume fraction of the eutectics were found to decrease with the increasing in withdrawal rate. After solution heat treatment at 1250℃, un-dissolved eutectic was observed in specimens. High temperature creep rupture life was observed to be very sensitive to the fraction of these remaining eutectics. Creep rupture tests at 1000℃/235 MPa showed that refined microstructure and low fraction of the remaining eutectic lead to significant improvement of the rupture life.展开更多
Located in a monsoon domain,East Asia suffers devastating natural hazards induced by anomalous monsoon behaviors.East Asian monsoon(EAM)research has traditionally been a high priority for the Chinese climate community...Located in a monsoon domain,East Asia suffers devastating natural hazards induced by anomalous monsoon behaviors.East Asian monsoon(EAM)research has traditionally been a high priority for the Chinese climate community and is particularly challenging in a changing climate where the global mean temperature has been rising.Recent advances in studies of the variabilities and mechanisms of the EAM are reviewed in this paper,focusing on the interannual to interdecadal time scales.Some new results have been achieved in understanding the behaviors of the EAM,such as the evolution of the East Asian summer monsoon(EASM),including both its onset and withdrawal over the South China Sea,the changes in the northern boundary activity of the EASM,or the transitional climate zone in East Asia,and the cycle of the EASM and the East Asian winter monsoon and their linkages.In addition,understanding of the mechanism of the EAM variability has improved in several aspects,including the impacts of different types of ENSO on the EAM,the impacts from the Indian Ocean and Atlantic Ocean,and the roles of mid-to high-latitude processes.Finally,some scientific issues regarding our understanding of the EAM are proposed for future investigation.展开更多
The global community has prepared for the withdrawal of the U.S. from the Paris Agreement since Donald Trump was elected as the president of the U.S. However, Trump's formal declaration of withdrawal still caused ...The global community has prepared for the withdrawal of the U.S. from the Paris Agreement since Donald Trump was elected as the president of the U.S. However, Trump's formal declaration of withdrawal still caused worldwide reaction. Trump will use the withdrawal to build his political reputation and to renegotiate the Paris Agreement despite its negative effects on the political credibility, international relationships, and potential long-term economic growth of the U.S. In general, the withdrawal of the U.S. from the Paris Agreement will not change the development of low-carbon technologies and the transformation trend of the global climate governance regime. However, the long-term goals and international cooperation on climate change will be affected by budget cuts in American climate change research and the cancelation of donations from the multilateral environmental fund of the U.S. If the Paris Agreement is renegotiated, the common but differentiated principle of responsibility of the United Nations Framework Convention on Climate Change will be challenged again. Nevertheless, climate change governance remains a main theme of future sustainable development. Instead of national governments, local governments and non-governmental organizations will develop strategies for technical innovation and emphasize pragmatic cooperation, thus expanding their roles in climate change governance. The capacity building on climate change research and public awareness should be enhanced as a long-term objective of global climate change governance.展开更多
基金Shenzhen Science and Technology Program(JSGG20220831092800001)。
文摘The microstructure of single crystal superalloy is relatively simple,consisting primarily ofγdendrites andγ/γ′eutectics.During the directional solidification process of Ni-based single crystal superalloys,withdrawal rate is a critical parameter affecting the spatial distribution ofγ/γ′eutectic along gravity direction.The results show that theγ/γ′eutectic fraction of the upper platform surface is always higher than that of the lower one,regardless of withdrawal rate.As the withdrawal rate decreases,there is a significant increase inγ/γ′eutectic fraction on the upper surface,while it decreases on the lower surface.The upward accumulation ofγ/γ′eutectic becomes more severe as the withdrawal rate decreases.It is also found that the percentage of Al+Ta is positively correlated with theγ/γ′eutectic fraction.Thermo-solute convection of Al and Ta solutes in the solidification front is the prime reason for the non-uniform distribution of eutectic.The non-uniform distribution ofγ/γ′eutectic cannot be eliminated even after subsequent solution heat treatment,resulting in excess eutectic on the upper surface and thus leading to the scrapping of the blade.
基金Supported by the R+D Project funded by the Spanish Ministry of Science and Innovation MCIN/AEI/10.13039/501100011033 and by FEDER,EU,No.PID2021-122987OA-I00.
文摘BACKGROUND Psychotic disorders are characterized by both positive symptoms(hallucinations,delusions)and negative symptoms(emotional blunting,anhedonia)that impair daily functioning.While antipsychotic drugs and psychological interventions are effective when addressing positive symptoms,treatment of negative symptoms remains an ongoing challenge.Mindfulness-based interventions(MBIs)have been shown to reduce negative psychotic symptoms.However,as negative psychotic symptoms are assessed as a sole entity rather than a sum of manifestations,the effect of MBIs remains unclear.AIM To examine the effects of MBI in addition to integrated rehabilitation treatment(IRT)for people experiencing psychosis on each of the negative psychotic symptoms.METHODS A randomized controlled clinical trial with preintervention and postintervention measures was designed.The main outcome variable was negative psychotic symptoms assessed through the seven subscales of the Spanish version of the positive and negative syndrome scale.Data were analyzed using a repeated measures analysis of variance and reliable change index calculation.RESULTS There were no statistical differences between groups at the preintervention assessment.Statistically significant differences were found after MBI for the time in emotional withdrawal(F=37.75,P<0.001,η2=0.437)and social withdrawal(F=37.75,P<0.001,η2=0.437).CONCLUSION MBI added to IRT reduced the lack of interest and involvement with affective commitment to daily life activities,and interest and engagement in social activities increased.These negative psychotic symptoms were not improved by IRT alone.
文摘BACKGROUND 5-aminosalicylates(5-ASA)are the primary treatment for mild to moderate ulcerative colitis(UC).Maintenance therapy with 5-ASA has been shown to reduce both the risk of relapse and colorectal cancer.AIM To evaluate the outcomes of 5-ASA withdrawal due to non-adherence in UC patients while in remission on monotherapy.METHODS Adult patients with UC who were followed up between July 2019 and April 2025 were screened.Patients in remission receiving 5-ASA monotherapy who experienced treatment withdrawal due to non-adherence were included in this study.RESULTS Among 880 patients with UC,30(3.4%)had 5-ASA withdrawal due to nonadherence while in remission on monotherapy.Twelve patients(40%)had disease relapse after a median of 20 months.The rate of patients in remission was 89%in the first year,decreasing to 73%in the second year,and to 64%in the third year.There were no significant differences between patients with and without relapse in terms of demographics,disease extent,remission duration before 5-ASA withdrawal,previous medications,steroid dependence,5-ASA formulation,baseline inflammatory markers,or partial and endoscopic Mayo scores.Most patients(75%)who experienced relapse were successfully treated with 5-ASA monotherapy,while one-fourth of them required corticosteroids.No patients required biologic agents,hospitalization,or surgical intervention.CONCLUSION Intermittent therapy may be safe and feasible for UC patients,especially those in long-term remission,with treatment interruption up to one year considered acceptable.
文摘The research explores the long-term connection between Greece’s agricultural output,with a focus on both crop and livestock production,and crucial environmental factors like water usage and energy consumption.Through linear regression analysis,the study investigates how these factors affect agricultural value-added,providing insights into the sustainability and efficiency of Greece’s farming sector.The results show a significant(p<0.05)positive relationship between crop production and agricultural value-added,as well as the significant influence of water usage and energy consumption on the productivity of both crops and livestock.For livestock farming,the analysis revealed a weaker contribution to agricultural value-added at the national level,likely due to structural inefficiencies in the sector.While livestock production benefits significantly from water and energy inputs,it does not have as substantial an economic impact compared to crop production.This research contributes to the field of agricultural economics by offering a historical perspective on how resource management influences agricultural performance over time.It highlights the significance of sustainable practices,especially in areas like the periphery of Western Macedonia,which are shifting from conventional energy sources like lignite to renewable energy.The findings advocate for policies that promote water conservation,energy efficiency,and smart agriculture to enhance productivity and support regional development.
文摘BACKGROUND Despite therapeutic benefits,discontinuation of tirzepatide is common in randomized controlled trials(RCTs)due to adverse events(AEs)and other causes.No previous systematic reviews have explored the reasons for discontinuing tirzepatide in the RCTs.AIM To explore the reasons for permanent discontinuation of tirzepatide vs controls[placebo,insulin,and glucagon-like peptide-1 receptor agonists(GLP-1Ras)]in RCTs.METHODS Relevant RCTs were systematically searched using related terms through multiple databases such as MEDLINE(via PubMed),Scopus,Cochrane Central Register,and ClinicalTrials.gov from their inception until June 20,2024.RevMan web was used to conduct meta-analysis using random-effects models.Outcomes were presented as risk ratios(RR)with 95%confidence intervals(CI).RESULTS Seventeen RCTs(n=14645),mostly having low risks of bias,were analyzed.Compared to placebo,the risk of permanent discontinuation of the study drug was substantially lower with tirzepatide 10 mg(RR:0.69,95%CI:0.51-0.93,P=0.02)and similar with tirzepatide 5 mg(RR:0.74,95%CI:0.47-1.17,P=0.20)and 15 mg(RR:0.94,95%CI:0.68-1.31,P=0.71).Tirzepatide had identical discontinuation risks when compared to insulin at 5 mg(RR:0.96,95%CI:0.75-1.24,P=0.77)and 10 mg(RR:1.19,95%CI:0.77-1.82,P=0.44)doses,whereas such risk was higher with tirzepatide 15 mg than insulin(RR:1.31,95%CI:1.03-1.67,P=0.03).Compared to GLP-1RA,the permanent discontinuation risk was similar with tirzepatide 5 mg(RR:0.98,95%CI:0.70-1.37,P=0.90)but was higher with tirzepatide 10 mg(RR:1.40,95%CI:1.03-1.90,P=0.03)and 15 mg(RR:1.70,95%CI:1.27-2.27,P=0.0004).Tirzepatide,at all doses,had higher risks of AE-related discontinuation than insulin;such risks were only greater with higher doses of tirzepatide than with placebo or GLP-1RA.Discontinuation risk due to withdrawal by the study subjects was lower with tirzepatide than with placebo or insulin.Compared to the placebo,tirzepatide(all doses)conferred a lower risk of study drug discontinuation due to other causes not specifically mentioned.CONCLUSION The discontinuation risk is not higher in tirzepatide group than in the placebo arm.Many factors other than AEs led to drug discontinuation in the included RCTs.
基金Supported by Zhejiang Provincial Medical and Health Science and Technology Program,No.2025KY196.
文摘This review examines the mechanisms of anxiety and depression in menopausal syndrome from an integrated physiological to psychological perspective.Fluctuations in estrogen and progesterone levels during menopause affect neurotransmitter systems(including serotonin,norepinephrine,and dopamine),hypothalamic-pituitary-adrenal axis function,inflammatory processes,and neurotrophic factor expression,collectively diminishing the resilience of emotional regulation neural circuits.Simultaneously,vasomotor symptoms(such as hot flashes and night sweats),sleep disruption,genetic susceptibility,and epigenetic modifications interact with mood disorders,while psychosocial factors(such as midlife stressors and role transitions)and cognitive factors(including negative schemas about aging,attentional bias toward threats,and difficulties in emotional regulation)further shape women’s experiences of menopausal changes.Clinical practice should adopt a biopsychosocial model,employing personalized multimodal approaches through hormone therapy,antidepressants,psychotherapy,and lifestyle adjustments,while future research should focus on developing biomarkers,utilizing advanced technologies,and developing targeted interventions to support women’s psychological wellbeing during menopause.
基金supported by the Major Project of the Beijing Social Science Fund“Research on Constructing a New Development Pattern and the Coordinated Development of the Beijing-Tianjin-Hebei Region”(20ZDA31).
文摘Using data from the 11th to 14th Five-Year Plan periods(2006-2025),this study applies a Difference-in-Differences(DID)approach to assess the impact of industrial policy withdrawal.Industries that have faced policy withdrawal for over a decade are categorized as the treatment group,while consistently supported industries form the control group.The analysis examines how withdrawal affects firm total factor productivity(TFP)and investment behavior.The results show that policy withdrawal boosts firm TFP by reducing over-investment and improving the efficiency of R&D spending.This effect is particularly evident in industries with strong,competitive leading firms.Additionally,in regions with lower levels of marketization,timely policy withdrawal plays a key role in curbing over-investment.This study also highlights a dual effect of policy withdrawal:while it fosters corporate social responsibility,it may also encourage financial speculation.These findings suggest that the implementation of industrial policy should provide“timely assistance”over a limited timeframe rather than long-term support to well-established industries.As industries mature,policy support should be gradually reduced or phased out to avoid over-investment and enhance firm efficiency.
基金supported by the National Natural Science Foundation of China(52074046,52122403,51834003,and 52274073)the Graduate Research and Innovation Foundation of Chongqing(CYB22023)+2 种基金the Chongqing Talents Plan for Young Talents(cstc2022ycjh-bgzxm0035)Hunan Institute of Engineering(21RC025 and XJ2005)Hunan Province Education Department(21B0664).
文摘Underground salt cavern CO_(2) storage(SCCS)offers the dual benefits of enabling extensive CO_(2) storage and facilitating the utilization of CO_(2) resources while contributing the regulation of the carbon market.Its economic and operational advantages over traditional carbon capture,utilization,and storage(CCUS)projects make SCCS a more cost-effective and flexible option.Despite the widespread use of salt caverns for storing various substances,differences exist between SCCS and traditional salt cavern energy storage in terms of gas-tightness,carbon injection,brine extraction control,long-term carbon storage stability,and site selection criteria.These distinctions stem from the unique phase change characteristics of CO_(2) and the application scenarios of SCCS.Therefore,targeted and forward-looking scientific research on SCCS is imperative.This paper introduces the implementation principles and application scenarios of SCCS,emphasizing its connections with carbon emissions,carbon utilization,and renewable energy peak shaving.It delves into the operational characteristics and economic advantages of SCCS compared with other CCUS methods,and addresses associated scientific challenges.In this paper,we establish a pressure equation for carbon injection and brine extraction,that considers the phase change characteristics of CO_(2),and we analyze the pressure during carbon injection.By comparing the viscosities of CO_(2) and other gases,SCCS’s excellent sealing performance is demonstrated.Building on this,we develop a long-term stability evaluation model and associated indices,which analyze the impact of the injection speed and minimum operating pressure on stability.Field countermeasures to ensure stability are proposed.Site selection criteria for SCCS are established,preliminary salt mine sites suitable for SCCS are identified in China,and an initial estimate of achievable carbon storage scale in China is made at over 51.8-77.7 million tons,utilizing only 20%-30%volume of abandoned salt caverns.This paper addresses key scientific and engineering challenges facing SCCS and determines crucial technical parameters,such as the operating pressure,burial depth,and storage scale,and it offers essential guidance for implementing SCCS projects in China.
基金supported by the German Research Founda-tion(DFG,grant RI 2040/4-1)the InventWater ITN(Inventive forecasting tools for adapting water quality management to a new climate)through the European Union’s Horizon 2020 research,innovation program under the Marie Skłodowska-Curie grant agreement No.956623 and UFZ Program Integra-tion Budget+3 种基金Chenxi Mi acknowledges the financial support from the National Natural Science Foundation of China(No.42107060)Liaoning Provincial Doctoral Research Startup Fund Project(No.2022-BS-174)supported by the“Xingliao Talents Plan”science and technology in-novation leading talents project of Liaoning Province(No.XLYC2002054)the National Key Research and Develop-ment Program of China(NO.2022YFF1301000-4).
文摘Water-level reduction frequently occurs in deep reservoirs,but its effect on dissolved oxygen concentration is not well understood.In this study we used a well-established water qual-itymodel to illustrate effects of water level dynamics on oxygen concentration in Rappbode Reservoir,Germany.We then systematically elucidated the potential of selectivewithdrawal to control hypoxia under changing water levels.Our results documented a gradual decrease of hypolimnetic oxygen concentration under decreasing water level,and hypoxia occurred when the initial level was lower than 410 m a.s.l(71 m relative to the reservoir bottom).We also suggested that changes of hypoxic region,under increasing hypolimnetic withdrawal discharge,followed a unimodal trajectory with themaximum hypoxic area projected under the discharge between 3 m^(3)/sec and 4 m^(3)/sec.Besides,our results illustrated the extent of hypoxia was most effectively inhibited if the withdrawal strategy was applied at the end of stratification with the outlet elevation at the deepest part of the reservoir.Moreover,hy-poxia can be totally avoided under a hybrid elevation withdrawal strategy using surface withdrawal during early and mid stratification,and deep withdrawal at the end of strat-ification.We further confirmed the decisive role of thermal structure in the formation of hypoxia under water-level reduction and withdrawal strategies.We believe the conclusions from this study can be applied to many deep waters in the temperate zone,and the results should guide stakeholders to mitigate negative impacts of hypoxia on aquatic ecosystems.
文摘Despite the high efficiency of remote sensing methods for rapid and large-scale detection of subsidence phenomena,this technique has limitations such as atmospheric impact and temporal and spatial decorrelation that affect the accuracy of the results.This paper proposes a method based on an artificial neural network to improve the results of monitoring land subsidence due to groundwater overexploitation by radar interferometry in the Aliabad plain(Central Iran).In this regard,vertical ground deformations were monitored over 18 months using the Sentinel-1A SAR images.To model the land subsidence by a multilayer perceptron(MLP)artificial neural network,four parameters,including groundwater level,alluvial thickness,elastic modulus,and transmissivity have been applied.The model's generalizability was assessed using data derived for 144 days.According to the results,the neural network estimates the land subsidence at each ground point with an accuracy of 6.8 mm.A comparison between the predicted and actual values indicated a significant agreement.The MLP model can be used to improve the results of subsidence detection in the study area or other areas with similar characteristics.
基金supported by the National Natural Science Foundation of China(Grant No.52379061)the Natural Science Foundation of Jiangsu Province(Grant No.BK20230099)the Key Laboratory of Water Grid Project and Regulation of Ministry of Water Resources(Grant No.QTKS0034W23292).
文摘Lateral intakes are common in rivers.The pump effciency and sediment deposition are determined by the local hydrodynamic characteristics and mainstream division width.The hydraulic characteristics of lateral withdrawal from inclined river slopes at different intake elevations should be investigated.Meanwhile,the division width exhibits significant vertical non-uniformity at an inclined river slope,which should be clarified.Hence,a three-dimensional(3-D)hydrodynamic and particle-tracking model was developed with the Open Source Field Operation and Manipulation(Open FOAM),and the model was validated with physical model tests for 90°lateral withdrawal from an inclined side bank.The flow fields,withdrawal sources,and division widths were investigated with different intake bottom elevations,withdrawal discharges,and main channel velocities.This study showed that under inclined side bank conditions,water entered the intake at an oblique angle,causing significant 3-D spiral flows in the intake rather than two-dimensional closed recirculation.A lower withdrawal discharge,a lower bottom elevation of the intake,or a higher main channel velocity could further strengthen this phenomenon.The average division width and turbulent kinetic energy were smaller under inclined side bank conditions than under vertical bank conditions.With a low intake bottom elevation,a low withdrawal discharge,or a high main channel velocity,the sources of lateral withdrawal were in similar ranges near the local inclined bank in the vertical direction.Under inclined slope conditions,sediment deposition near the intake entrance could be reduced,compared to that under vertical slope conditions.The results provide hydrodynamic and sediment references for engineering designs for natural rivers with inclined terrains.
文摘The existing land supply mode of opencast mining is"land requisition first,then transfer",which lacks an effective recovery and withdrawal mechanism,and the reclaimed mining land is difficult to withdraw.According to the regular rules of coal opencast mining and the periodic characteristics of land use,this paper puts forward a new mode of temporary land use for coal opencast mining.It is conducive to im-proving the quality and scale of land use and reclamation utilization of opencast coal mining,and is of great significance for exploring and for-mulating reasonable land use policies for mineral resources development projects.
文摘Background and Objective: With the popularity and widespread use of mobile phones, the effects of mobile phone dependence and addiction on individuals’ physical and mental health have attracted more and more attention. The present study aims to analyze the current state of mobile phone addiction and its impact on sleep quality within the population, while also exploring the influence of related factors on sleep quality. Ultimately, this research will provide a scientific foundation for targeted intervention measures and strategies. Methods: A total of 253 permanent residents in Nanjing were randomly selected as study subjects. The Mobile Phone Addiction Index (MPAI) and Pittsburgh Sleep Quality Index (PSQI) were used to evaluate the degree of smartphone addiction and sleep quality of the study subjects. Body mass index (BMI) was measured according to standardized procedures. Independent sample t-test, Chi-square test, rank sum test and multiple linear regression were used to analyze the correlation between mobile phone addiction and sleep quality, and P Results: 117 people (46.2%) were addicted to mobile phones. Chi-square test showed that the rate of mobile phone addiction in drinking group was significantly higher than that in non-drinking group (P P P P P P P P P P Conclusion: Mobile phone addiction may lead to shorter sleep duration and reduce sleep efficiency. The withdrawal of mobile phone addiction may have a negative impact on sleep quality. According to the characteristics of the population, appropriate comprehensive intervention measures should be taken to build an effective evaluation system, so as to reduce the impact of mobile phone addiction and withdrawal problems on sleep and improve sleep quality.
基金funded by the Taif University Researchers Taif University,Taif,Saudi Arabia.
文摘This study aims to determine whether the involvement of prestigious attorneys in issuing companies affects withdrawals in the initial public offering(IPO)market.There is little evidence on how the involvement of famous lawyers affects IPO withdrawal.The study considers a large dataset consisting of 24,312 IPOs that were either successful or withdrawn from 22 distinct IPO marketplaces between January 1995 and December 2019.We find that IPO issuers may benefit from engaging with reputed attorneys by leveraging exceptional legal or negotiating abilities as quality certification signals to reduce IPO investors’ex-ante uncertainty.Here,the objective is to protect their IPOs from withdrawal of at least by 22%.Multiple robustness tests validate the reliability of the results of this study.These findings have significant implications for researchers,legislators,investors,and issuers.
基金National Science and Technology Support Program of China(Grant No.2008BAI49B01)the National Basic Research Program of China(Grant No.2009CB522000)
文摘To examine whether there are sex differences in morphine dependence and its metabolism. Naloxone-precipitated withdrawal study was performed. Twenty rats were induced by naloxone 1 h after a single dose of morphine injection. The withdrawal syndromes were recorded and an HPLC-UV method was set up to quantify the plasma levels of morphine and morphine-3-glucuronide（M3G）. In the spontaneous withdrawal study, 97 rats were treated with progressive morphine for 28 d to develop physical dependence. The spontaneous withdrawal syndromes were recorded and plasma levels of morphine and M3G were determined after the last injection. No significant differences were observed in withdrawal syndrome of naloxone precipitating. More severe spontaneous withdrawal syndromes were produced by chronic morphine injection in male rats than in female rats（P0.05）. Higher maximum plasma concentration（Cmax） of morphine was measured in male rats than female rats, while female rats had higher Cmax of M3G than male rats in both acute and chronic morphine administration. Our results indicated that sex differences existed in withdrawal syndrome of morphine-dependent rats, and the pharmacokinetics of morphine showed sex difference by both acute and chronic administration. There might be a relationship between the severity of withdrawal syndrome and the plasma concentrations of morphine, M3G, and the ratio of morphine to M3G（M3G/MOR）.
基金Project(51101005)supported by the National Natural Science Foundation of China
文摘Nb-16Si-24Ti-10Cr-2A1-2Hf alloy was directionally solidified with withdrawal rates of 1.2, 6, 18, 36 and 50 mrn/min and then heat treated at 1400, 1450 and 1500℃with withdrawal rate of 50 mm/min for 10 h. The effects of withdrawal rate and heat treatment temperature on the microstructure were studied. The microstructure of directionally solidified alloy was composed of the primary NbsSi3, Nbss/NbsSi3 eutectic cells and Cr2Nb, which distribute paralleled to the growth direction. The microstructure becomes more refined with the increasing withdrawal rate, accompany with the evolution of eutectic cells morphology. After heat treatment, Nbss phase connects and forms a continuous matrix, and the Cr2Nb phase becomes smaller and distributes more dispersedly. After heat treatment at 1450 ℃ for 10 h, the alloy achieves balance between the optimization of microstructure and alleviation of solute segregation.
文摘A nickel base single crystal （SC） superalloy was directionally solidified using liquid metal cooling （LMC） process at various withdrawal rates. The microstructure was refined as increasing the withdrawal rate from 3 to 12 mm/min. However, higher withdrawal rate of 15 mm/min induced the formation of stray grains. Size and volume fraction of the eutectics were found to decrease with the increasing in withdrawal rate. After solution heat treatment at 1250℃, un-dissolved eutectic was observed in specimens. High temperature creep rupture life was observed to be very sensitive to the fraction of these remaining eutectics. Creep rupture tests at 1000℃/235 MPa showed that refined microstructure and low fraction of the remaining eutectic lead to significant improvement of the rupture life.
基金supported jointly by the National Key Research and Development Program(Grant No.2016YFA0600604)the National Natural Science Foundation of China(Grant No.41721004)+1 种基金the Chinese Academy of Sciences Key Research Program of Frontier Sciences(Grant No.QYZDY-SSW-DQC024)the Jiangsu Collaborative Innovation Center for Climate Change
文摘Located in a monsoon domain,East Asia suffers devastating natural hazards induced by anomalous monsoon behaviors.East Asian monsoon(EAM)research has traditionally been a high priority for the Chinese climate community and is particularly challenging in a changing climate where the global mean temperature has been rising.Recent advances in studies of the variabilities and mechanisms of the EAM are reviewed in this paper,focusing on the interannual to interdecadal time scales.Some new results have been achieved in understanding the behaviors of the EAM,such as the evolution of the East Asian summer monsoon(EASM),including both its onset and withdrawal over the South China Sea,the changes in the northern boundary activity of the EASM,or the transitional climate zone in East Asia,and the cycle of the EASM and the East Asian winter monsoon and their linkages.In addition,understanding of the mechanism of the EAM variability has improved in several aspects,including the impacts of different types of ENSO on the EAM,the impacts from the Indian Ocean and Atlantic Ocean,and the roles of mid-to high-latitude processes.Finally,some scientific issues regarding our understanding of the EAM are proposed for future investigation.
文摘The global community has prepared for the withdrawal of the U.S. from the Paris Agreement since Donald Trump was elected as the president of the U.S. However, Trump's formal declaration of withdrawal still caused worldwide reaction. Trump will use the withdrawal to build his political reputation and to renegotiate the Paris Agreement despite its negative effects on the political credibility, international relationships, and potential long-term economic growth of the U.S. In general, the withdrawal of the U.S. from the Paris Agreement will not change the development of low-carbon technologies and the transformation trend of the global climate governance regime. However, the long-term goals and international cooperation on climate change will be affected by budget cuts in American climate change research and the cancelation of donations from the multilateral environmental fund of the U.S. If the Paris Agreement is renegotiated, the common but differentiated principle of responsibility of the United Nations Framework Convention on Climate Change will be challenged again. Nevertheless, climate change governance remains a main theme of future sustainable development. Instead of national governments, local governments and non-governmental organizations will develop strategies for technical innovation and emphasize pragmatic cooperation, thus expanding their roles in climate change governance. The capacity building on climate change research and public awareness should be enhanced as a long-term objective of global climate change governance.
