Withaminimas A–F(1–6), six new withaphysalin-type withanolides were isolated from the aerial parts of Physalis minima L.. The structures of these compounds were elucidated through a variety of spectroscopic techniqu...Withaminimas A–F(1–6), six new withaphysalin-type withanolides were isolated from the aerial parts of Physalis minima L.. The structures of these compounds were elucidated through a variety of spectroscopic techniques including HR-MS, NMR, and ECD. Compound 1 belongs to rare 18-norwithanolides, and 2–3 were 13/14-secowithanolides. According to the traditional usage of P. minima, inhibitory effects on nitric oxide(NO) production in lipopolysaccaride-activated RAW264.7 macrophages were evaluated, and compounds 1–4 exhibited significant inhibitory effects with IC50 values among 3.91–18.46 μmol·L–1.展开更多
基金supported in part by the National Natural Science Foundation of China(No.81430092)the Outstanding Youth Fund of the Basic Research Program of Jiangsu Province(No.BK20160077)the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_15R63)
文摘Withaminimas A–F(1–6), six new withaphysalin-type withanolides were isolated from the aerial parts of Physalis minima L.. The structures of these compounds were elucidated through a variety of spectroscopic techniques including HR-MS, NMR, and ECD. Compound 1 belongs to rare 18-norwithanolides, and 2–3 were 13/14-secowithanolides. According to the traditional usage of P. minima, inhibitory effects on nitric oxide(NO) production in lipopolysaccaride-activated RAW264.7 macrophages were evaluated, and compounds 1–4 exhibited significant inhibitory effects with IC50 values among 3.91–18.46 μmol·L–1.
