To the Editor: Wilson's disease is an autosomal recessive genetic disease caused by ATP7B gene mutations and characterized by a copper metabolism disorder. Liver transplantation(LT) is a treatment option for the m...To the Editor: Wilson's disease is an autosomal recessive genetic disease caused by ATP7B gene mutations and characterized by a copper metabolism disorder. Liver transplantation(LT) is a treatment option for the most severe(life-threatening) cases of Wilson's disease. Because of donor shortages and high costs, pursuing simple, safe, and effective therapies has become a medical hotspot [1]. Numerous studies [1–6] have shown that stem cell transplantation in liver diseases can attenuate liver fibrosis, improve liver function, and alleviate clinical symptoms. Here, we reported a case of Wilson's disease with decompensated cirrhosis who was treated with menstrual blood derived-mesenchymal stem cells(Men-MSCs) transplantation.展开更多
基金supported by a grant from the National Key Re-search and Development Program of China (2018YFC20 0 050 0)。
文摘To the Editor: Wilson's disease is an autosomal recessive genetic disease caused by ATP7B gene mutations and characterized by a copper metabolism disorder. Liver transplantation(LT) is a treatment option for the most severe(life-threatening) cases of Wilson's disease. Because of donor shortages and high costs, pursuing simple, safe, and effective therapies has become a medical hotspot [1]. Numerous studies [1–6] have shown that stem cell transplantation in liver diseases can attenuate liver fibrosis, improve liver function, and alleviate clinical symptoms. Here, we reported a case of Wilson's disease with decompensated cirrhosis who was treated with menstrual blood derived-mesenchymal stem cells(Men-MSCs) transplantation.
