背景:近期研究表明,肠道菌群可能会影响肌萎缩侧索硬化症的发展进程,然而两者之间的因果关系尚不清楚。目的:利用孟德尔随机化方法探索肠道菌群与肌萎缩侧索硬化症之间的因果关系。方法:从IEU Open GWAS数据库(由英国布里斯托尔大学的...背景:近期研究表明,肠道菌群可能会影响肌萎缩侧索硬化症的发展进程,然而两者之间的因果关系尚不清楚。目的:利用孟德尔随机化方法探索肠道菌群与肌萎缩侧索硬化症之间的因果关系。方法:从IEU Open GWAS数据库(由英国布里斯托尔大学的英国医学研究委员会和遗传流行病学研究所开发,旨在提供与多种疾病相关的全基因组关联研究数据,为开放数据库)中分别获取肠道菌群和肌萎缩侧索硬化症的GWAS数据,以肠道菌群为暴露因素、肌萎缩侧索硬化症为结局变量,使用逆方差加权法、MR-Egger回归法、加权中位数法、加权模型法和简单模型法来探究两者之间的因果关系。使用敏感性分析检验孟德尔随机化结果的可靠性,使用反向孟德尔随机化分析进一步验证两者间的因果关系。结果与结论:(1)正向孟德尔随机化分析结果表明,6种肠道菌群与肌萎缩侧索硬化症之间存在因果关系,其中嗜胆菌属(β=0.206,OR=1.229)、毛螺菌属(β=0.288,OR=1.333)、马文-布莱恩特氏菌属(β=0.196,OR=1.216)、瘤胃球菌UCG010属(β=0.254,OR=1.289)和泰泽氏菌属3型(β=0.128,OR=1.136)可能是肌萎缩侧索硬化症的潜在危险因素,肠杆菌属(β=-0.203,OR=0.816)可能是肌萎缩侧索硬化症的保护因素;(2)在敏感性分析中,未发现显著的异质性和水平多效性(P均> 0.05),反向孟德尔随机化分析亦未揭示肠道菌群与肌萎缩侧索硬化症之间存在反向因果关系;(3)该研究结果不仅为肌萎缩侧索硬化症治疗提供了潜在的生物标志物,还为开发基于肠道菌群的新的干预治疗方案提供了理论依据,对中国基础医学研究具有一定的启示意义。展开更多
为解决低压台区用电信息采集系统面临的干扰、终端高功耗及广域覆盖不足等问题,设计了一种基于远距离无线电(Long Range Radio,LoRa)的3层广域低功耗通信架构,重点研究了基于LoRa的抗干扰传输、功耗管理及多网关覆盖等关键技术。研究结...为解决低压台区用电信息采集系统面临的干扰、终端高功耗及广域覆盖不足等问题,设计了一种基于远距离无线电(Long Range Radio,LoRa)的3层广域低功耗通信架构,重点研究了基于LoRa的抗干扰传输、功耗管理及多网关覆盖等关键技术。研究结果表明,该架构能够有效提升通信可靠性,显著降低终端能耗,并扩展网络覆盖范围,为突破低压台区通信瓶颈提供了可行方案。展开更多
The rapid increase in the publication of knowledge bases as linked open data （LOD） warrants serious consideration from all concerned, as this phenomenon will potentially scale exponentially. This paper will briefly ...The rapid increase in the publication of knowledge bases as linked open data （LOD） warrants serious consideration from all concerned, as this phenomenon will potentially scale exponentially. This paper will briefly describe the evolution of the LOD, the emerging world-wide semantic web （WWSW）, and explore the scalability and performance features Of the service oriented architecture that forms the foundation of the semantic technology platform developed at MIMOS Bhd., for addressing the challenges posed by the intelligent future internet. This paper＂ concludes with a review of the current status of the agriculture linked open data.展开更多
Web data extraction is to obtain valuable data from the tremendous information resource of the World Wide Web according to the pre - defined pattern. It processes and classifies the data on the Web. Formalization of t...Web data extraction is to obtain valuable data from the tremendous information resource of the World Wide Web according to the pre - defined pattern. It processes and classifies the data on the Web. Formalization of the procedure of Web data extraction is presented, as well as the description of crawling and extraction algorithm. Based on the formalization, an XML - based page structure description language, TIDL, is brought out, including the object model, the HTML object reference model and definition of tags. At the final part, a Web data gathering and querying application based on Internet agent technology, named Web Integration Services Kit (WISK) is mentioned.展开更多
With the advent of phasor measurement unit (PMU) technology, the grid observability has got a new dimension. This facet of technology helps in getting the real-time and dynamic scenario of the grid operations which wa...With the advent of phasor measurement unit (PMU) technology, the grid observability has got a new dimension. This facet of technology helps in getting the real-time and dynamic scenario of the grid operations which was a remote possibility some decades before. Achieving this level of observability puts us at an advantage of responding to the system faults with reduced response time, and helps in restoring the grid stability within fraction of second. This paper demonstrates the detailed fault characterization from the PMU inputs, after illustrations from various real-time examples and different faults occurred in India. This paper tries to shed some light on areas where the accurate fault characterization can help the operator in taking the right decision for reliable grid operations.展开更多
广域长距离高性能传输技术在中国“东数西算”工程构建全国一体化算力网背景下具备重要的战略价值。3个趋势对广域分布式算力协同范式提出新需求:对算力资源要求极高的人工智能(AI)大模型智能应用的兴起;高端高性能图形处理单元(GPU)芯...广域长距离高性能传输技术在中国“东数西算”工程构建全国一体化算力网背景下具备重要的战略价值。3个趋势对广域分布式算力协同范式提出新需求:对算力资源要求极高的人工智能(AI)大模型智能应用的兴起;高端高性能图形处理单元(GPU)芯片被禁运限制单中心算力资源;中国各地建设的算力集群形成算力分散分布态势。广域长距离高性能传输技术是上述新范式的关键技术。从支撑广域分布式算力协同新范式、技术路线、承载网络、研究难点、成本5个方面进行讨论,结合深圳到宁夏中卫2100 km实网实验结果,将现有远程直接内存访问(remote direct memory access,RDMA)技术基于广域全光网进行长距离优化的方案是短期内可行性高、成本低且利于开展研究的最佳方案之一,通过优化基于融合以太网的远程直接内存访问(RDMA over Converged Ethernet,RoCE)可以在广域全光网上实现“广域光数直达”逼近物理层通信性能指标。展开更多
文摘背景:近期研究表明,肠道菌群可能会影响肌萎缩侧索硬化症的发展进程,然而两者之间的因果关系尚不清楚。目的:利用孟德尔随机化方法探索肠道菌群与肌萎缩侧索硬化症之间的因果关系。方法:从IEU Open GWAS数据库(由英国布里斯托尔大学的英国医学研究委员会和遗传流行病学研究所开发,旨在提供与多种疾病相关的全基因组关联研究数据,为开放数据库)中分别获取肠道菌群和肌萎缩侧索硬化症的GWAS数据,以肠道菌群为暴露因素、肌萎缩侧索硬化症为结局变量,使用逆方差加权法、MR-Egger回归法、加权中位数法、加权模型法和简单模型法来探究两者之间的因果关系。使用敏感性分析检验孟德尔随机化结果的可靠性,使用反向孟德尔随机化分析进一步验证两者间的因果关系。结果与结论:(1)正向孟德尔随机化分析结果表明,6种肠道菌群与肌萎缩侧索硬化症之间存在因果关系,其中嗜胆菌属(β=0.206,OR=1.229)、毛螺菌属(β=0.288,OR=1.333)、马文-布莱恩特氏菌属(β=0.196,OR=1.216)、瘤胃球菌UCG010属(β=0.254,OR=1.289)和泰泽氏菌属3型(β=0.128,OR=1.136)可能是肌萎缩侧索硬化症的潜在危险因素,肠杆菌属(β=-0.203,OR=0.816)可能是肌萎缩侧索硬化症的保护因素;(2)在敏感性分析中,未发现显著的异质性和水平多效性(P均> 0.05),反向孟德尔随机化分析亦未揭示肠道菌群与肌萎缩侧索硬化症之间存在反向因果关系;(3)该研究结果不仅为肌萎缩侧索硬化症治疗提供了潜在的生物标志物,还为开发基于肠道菌群的新的干预治疗方案提供了理论依据,对中国基础医学研究具有一定的启示意义。
文摘众数作为密度函数的最大值点,能有效刻画数据的集中趋势且对异常值具有较强稳健性。然而,在实际应用中,观测数据常因个体失访、退出实验或研究终止等原因出现右删失现象,且数据之间往往具有相依关系。为此,针对宽相依(widely orthant dependent,WOD)这一包含独立、负相依及部分正相依结构的宽泛相依序列,在右删失机制下结合逆概率加权(inverse probability weighting,IPW)方法构造核密度估计量,并据此提出众数的非参数核估计。在紧集和Lipschitz连续等适当条件下,证明密度估计量的一致强相合性,并进一步得出众数估计量的强相合性及其收敛速度。数值模拟和实证分析结果表明,该估计方法在有限样本下表现出良好的估计性能和稳健性,验证其渐近理论性质与实际应用价值。
文摘为解决低压台区用电信息采集系统面临的干扰、终端高功耗及广域覆盖不足等问题,设计了一种基于远距离无线电(Long Range Radio,LoRa)的3层广域低功耗通信架构,重点研究了基于LoRa的抗干扰传输、功耗管理及多网关覆盖等关键技术。研究结果表明,该架构能够有效提升通信可靠性,显著降低终端能耗,并扩展网络覆盖范围,为突破低压台区通信瓶颈提供了可行方案。
文摘The rapid increase in the publication of knowledge bases as linked open data （LOD） warrants serious consideration from all concerned, as this phenomenon will potentially scale exponentially. This paper will briefly describe the evolution of the LOD, the emerging world-wide semantic web （WWSW）, and explore the scalability and performance features Of the service oriented architecture that forms the foundation of the semantic technology platform developed at MIMOS Bhd., for addressing the challenges posed by the intelligent future internet. This paper＂ concludes with a review of the current status of the agriculture linked open data.
基金Note:Contents discussed in this paper are part of a key project,No.2000-A31-01-04,sponsored by Ministry of Science and Technology of P.R.China
文摘Web data extraction is to obtain valuable data from the tremendous information resource of the World Wide Web according to the pre - defined pattern. It processes and classifies the data on the Web. Formalization of the procedure of Web data extraction is presented, as well as the description of crawling and extraction algorithm. Based on the formalization, an XML - based page structure description language, TIDL, is brought out, including the object model, the HTML object reference model and definition of tags. At the final part, a Web data gathering and querying application based on Internet agent technology, named Web Integration Services Kit (WISK) is mentioned.
文摘With the advent of phasor measurement unit (PMU) technology, the grid observability has got a new dimension. This facet of technology helps in getting the real-time and dynamic scenario of the grid operations which was a remote possibility some decades before. Achieving this level of observability puts us at an advantage of responding to the system faults with reduced response time, and helps in restoring the grid stability within fraction of second. This paper demonstrates the detailed fault characterization from the PMU inputs, after illustrations from various real-time examples and different faults occurred in India. This paper tries to shed some light on areas where the accurate fault characterization can help the operator in taking the right decision for reliable grid operations.
文摘广域长距离高性能传输技术在中国“东数西算”工程构建全国一体化算力网背景下具备重要的战略价值。3个趋势对广域分布式算力协同范式提出新需求:对算力资源要求极高的人工智能(AI)大模型智能应用的兴起;高端高性能图形处理单元(GPU)芯片被禁运限制单中心算力资源;中国各地建设的算力集群形成算力分散分布态势。广域长距离高性能传输技术是上述新范式的关键技术。从支撑广域分布式算力协同新范式、技术路线、承载网络、研究难点、成本5个方面进行讨论,结合深圳到宁夏中卫2100 km实网实验结果,将现有远程直接内存访问(remote direct memory access,RDMA)技术基于广域全光网进行长距离优化的方案是短期内可行性高、成本低且利于开展研究的最佳方案之一,通过优化基于融合以太网的远程直接内存访问(RDMA over Converged Ethernet,RoCE)可以在广域全光网上实现“广域光数直达”逼近物理层通信性能指标。
