Traditional digitizers for signal readout of PET detectors are based on commercial analog-to-digital converters(ADC).However,the cost and power consumption of an entire electronic readout system based on digitizers fo...Traditional digitizers for signal readout of PET detectors are based on commercial analog-to-digital converters(ADC).However,the cost and power consumption of an entire electronic readout system based on digitizers for a PET scanner are high.To address this problem,a soft-core ADC based on a field-programmable gate array(FPGA)was proposed.An FPGA-based ADC(FPGA-ADC)combines low loss and high performance.To achieve good performance,the FPGA-ADC requires three calibrations:time-to-digital converter(TDC)length calibration,TDC alignment calibration,and TDC-to-ADC calibration.A prototype front-end electronics based on FPGA-ADC was built to evaluate the performance of time-of-flight positron emission tomography(TOF PET)detectors.Each PET detector consists of a LYSO crystal single-ended coupled to a silicon photomultiplier(SiPM).The experimental results show that the full-width at half-maximum(FWHM)energy resolution for 511 keV gamma photons after saturation correction of the SiPM was 12.3%.The FWHM coincidence timing resolution(CTR)of the TOF PET detector with the readout of the front-end electronic prototype is 385.2 ps.FPGA-ADCbased front-end electronics are very promising for multichannel,low-cost,highly integrated,and power-efficient readout electronic systems for radiation detector applications.展开更多
目的分析2008—2024年老年性肌少症与线粒体相关性研究的现状、热点及发展趋势,为该领域的后续研究提供参考。方法检索2008年1月1日至2024年12月31日Web of Science核心合集数据库收录的老年性肌少症与线粒体相关性研究的文献,使用R 4....目的分析2008—2024年老年性肌少症与线粒体相关性研究的现状、热点及发展趋势,为该领域的后续研究提供参考。方法检索2008年1月1日至2024年12月31日Web of Science核心合集数据库收录的老年性肌少症与线粒体相关性研究的文献,使用R 4.2.0软件的Bibliometrix包对发文国家、合作网络、作者、机构、期刊、高被引文献、关键词和文献被引频次进行定量和可视化分析,并运用H指数分析作者的学术影响力。结果共纳入1219篇文献,2008—2024年发文量总体呈上升趋势。累计发文量排名前三位的国家分别是美国、中国和意大利;发文量排名前三位的期刊分别为Journal of Cachexia,Sarcopenia and Muscle、International Journal of Molecular Sciences和Experimental Gerontology;H指数排名前六位的作者分别为Marzettie E、Calvani R、Picca A、Van Remmen H、Leeuwenbugh C和Bernabel R;被引频次最高的文献是“Sarcopenia:agingrelated loss of muscle mass and function”;出现频次排名前五的关键词分别为skeletalmuscle、sarcopenia、oxidative stress、exercise和expression。结论老年性肌少症与线粒体相关性研究领域呈现良好的发展态势。未来需加强跨国家、跨机构和跨学科合作,可重点关注线粒体融合蛋白等对线粒体功能的影响,以及饮食和运动对老年性肌少症的干预作用等方面的探索。展开更多
基金supported by the Key R&D Program of Shandong Province(No.2023SFGC0101)Shandong Excellent Young Scientists Fund Program(Overseas)(No.2023HWYQ-047)+1 种基金the Natural Science Foundation of Shandong Province(No.ZR2022QA039)the National Natural Science Foundation of China(NSFC)(No.U2106202).
文摘Traditional digitizers for signal readout of PET detectors are based on commercial analog-to-digital converters(ADC).However,the cost and power consumption of an entire electronic readout system based on digitizers for a PET scanner are high.To address this problem,a soft-core ADC based on a field-programmable gate array(FPGA)was proposed.An FPGA-based ADC(FPGA-ADC)combines low loss and high performance.To achieve good performance,the FPGA-ADC requires three calibrations:time-to-digital converter(TDC)length calibration,TDC alignment calibration,and TDC-to-ADC calibration.A prototype front-end electronics based on FPGA-ADC was built to evaluate the performance of time-of-flight positron emission tomography(TOF PET)detectors.Each PET detector consists of a LYSO crystal single-ended coupled to a silicon photomultiplier(SiPM).The experimental results show that the full-width at half-maximum(FWHM)energy resolution for 511 keV gamma photons after saturation correction of the SiPM was 12.3%.The FWHM coincidence timing resolution(CTR)of the TOF PET detector with the readout of the front-end electronic prototype is 385.2 ps.FPGA-ADCbased front-end electronics are very promising for multichannel,low-cost,highly integrated,and power-efficient readout electronic systems for radiation detector applications.
文摘目的分析2008—2024年老年性肌少症与线粒体相关性研究的现状、热点及发展趋势,为该领域的后续研究提供参考。方法检索2008年1月1日至2024年12月31日Web of Science核心合集数据库收录的老年性肌少症与线粒体相关性研究的文献,使用R 4.2.0软件的Bibliometrix包对发文国家、合作网络、作者、机构、期刊、高被引文献、关键词和文献被引频次进行定量和可视化分析,并运用H指数分析作者的学术影响力。结果共纳入1219篇文献,2008—2024年发文量总体呈上升趋势。累计发文量排名前三位的国家分别是美国、中国和意大利;发文量排名前三位的期刊分别为Journal of Cachexia,Sarcopenia and Muscle、International Journal of Molecular Sciences和Experimental Gerontology;H指数排名前六位的作者分别为Marzettie E、Calvani R、Picca A、Van Remmen H、Leeuwenbugh C和Bernabel R;被引频次最高的文献是“Sarcopenia:agingrelated loss of muscle mass and function”;出现频次排名前五的关键词分别为skeletalmuscle、sarcopenia、oxidative stress、exercise和expression。结论老年性肌少症与线粒体相关性研究领域呈现良好的发展态势。未来需加强跨国家、跨机构和跨学科合作,可重点关注线粒体融合蛋白等对线粒体功能的影响,以及饮食和运动对老年性肌少症的干预作用等方面的探索。
