An innovative real-time monitoring method for surrounding rock damage based on microseismic time-lapse double-difference tomography is proposed for delayed dynamic damage identification and insufficient detection of a...An innovative real-time monitoring method for surrounding rock damage based on microseismic time-lapse double-difference tomography is proposed for delayed dynamic damage identification and insufficient detection of adverse geological conditions in deep-buried tunnel construction.The installation techniques for microseismic sensors were optimized by mounting sensors at bolt ends which significantly improves signal-to-noise ratio(SNR)and anti-interference capability compared to conventional borehole placement.Subsequently,a 3D wave velocity evolution model that incorporates construction-induced disturbances was established,enabling the first visualization of spatiotemporal variations in surrounding rock wave velocity.It finds significant wave velocity reduction near the tunnel face,with roof and floor damage zones extending 40–50 m;wave velocities approaching undisturbed levels at 15 m ahead of the working face and on the laterally undisturbed side;pronounced spatial asymmetry in wave velocity distribution—values on the left side exceed those on the right,with a clear stress concentration or transition zone located 10–15 m;and systematically lower velocities behind the face than in front,indicating asymmetric rock damage development.These results provide essential theoretical support and practical guidance for optimizing dynamic construction strategies,enabling real-time adjustment of support parameters,and establishing safety early warning systems in deep-buried tunnel engineering.展开更多
Objective:To evaluate the effectiveness of cardiac rehabilitation therapy in the treatment of patients with chronic heart failure(CHF).Methods:76 patients with CHF who were treated in the hospital from January 2023 to...Objective:To evaluate the effectiveness of cardiac rehabilitation therapy in the treatment of patients with chronic heart failure(CHF).Methods:76 patients with CHF who were treated in the hospital from January 2023 to December 2024 were selected and randomly divided into two groups using a random number table.The experimental group(38 patients)received cardiac rehabilitation therapy,while the reference group(38 patients)received conventional drug therapy.The total effective rate,cardiac function indicators,lung function indicators,and pulse wave velocity(PWV)were compared between the two groups.Results:The total effective rate was higher in the experimental group than in the reference group.After treatment,the cardiac and lung function indicators were better in the experimental group than in the reference group,and the PWV was lower in the experimental group(P<0.05).Conclusion:Cardiac rehabilitation therapy for patients with CHF can improve treatment efficacy,enhance cardiopulmonary function,and regulate PWV levels,with high professionalism and feasibility.展开更多
Shear wave velocity Vs is measured by the surface geophysical survey like MASW （multi-channel surface wave analysis） or RWM （refraction wave method） and by the subsurface method like PS logging. PS logging and RWM...Shear wave velocity Vs is measured by the surface geophysical survey like MASW （multi-channel surface wave analysis） or RWM （refraction wave method） and by the subsurface method like PS logging. PS logging and RWM are direct methods to derive shear wave velocity and MASW retrieves shear wave through the inversion of the surface wave. In this work, the effectiveness of surface methods （MASW and RWM） is compared with PS logging in determining shear wave velocity. For this purpose, shear wave velocity results Vs30 of 12 PS logging and MASW surveys conducted in Mymensingh Municipality in Bangladesh have been utilized. Additionally, the shear wave velocity results of three PS logging have been compared with the refraction profiles of RWM survey conducted in Rooppur nuclear power plant site in Bangladesh. The relative discrepancy between RWM and PS logging is found less （ranges from -3.92 to 0.93） compared to MASW and PS logging （＋/-0.88 to 33.92）. The correlation coefficient of Vs30 derived from RWM and PS logging is observed much better （0.60） compared to MASW and PS logging （0.40）. The result is good considering the lateral lithologic variability and inherent differences among techniques. It is evident from the comparison that the RWM can be used as a cost-effective alternative to traditional borehole PS logging method for Vs30 determination and thus the number of down-hole logging tests might be significantly reduced.展开更多
AIM:To investigate whether a noninvasive measurement of tissue strain has a potential usefulness for management of nonalcoholic steatohepatitis(NASH).METHODS:In total 26 patients,23 NASHs and 3 normal controls were en...AIM:To investigate whether a noninvasive measurement of tissue strain has a potential usefulness for management of nonalcoholic steatohepatitis(NASH).METHODS:In total 26 patients,23 NASHs and 3 normal controls were enrolled in this study.NASH was staged based on Brunt criterion.At a region of interest(ROI),a shear wave was evoked by implementing an acoustic radiation force impulse(ARFI),and the propagation velocity was quantif ied.RESULTS:Shear wave velocity(SWV) could be reproducibly quantified at all ROIs in all subjects except for 4 NASH cases,in which a reliable SWV value was not calculated at several ROIs.An average SWV of 1.34 ± 0.26 m/s in fibrous stage 0-1 was significantly slower than 2.20 ± 0.74 m/s and 2.90 ± 1.01 m/s in stages 3 and 4,respectively,but was not significantly different from 1.79 ± 0.78 m/s in stage 2.When a cutoff value was set at 1.47 m/s,receiver operating characteristic analysis showed significance to dissociate stages 3 and 4 from stage 0-1(P=0.0092) with sensitivity,specificity and area under curve of 100%,75% and 94.2%,respectively.In addition,the correlation between SWV and hyaluronic acid was significant(P<0.0001),while a tendency toward negative correlation was observed with serum albumin(P=0.053).CONCLUSION:The clinical implementation of ARFI provides noninvasive repeated evaluations of liver stiffness at an arbitrary position,which has the potential to shed new light on NASH management.展开更多
The great Wenchuan earthquake(Ms=8.0)in 2008 caused severe damage in the western part of the Chengdu Plain.Soil liquefaction was one of the major causes of damage in the plain areas,and proper evaluation of liquefacti...The great Wenchuan earthquake(Ms=8.0)in 2008 caused severe damage in the western part of the Chengdu Plain.Soil liquefaction was one of the major causes of damage in the plain areas,and proper evaluation of liquefaction potential is important in the definition of the seismic hazard facing a given region and post-earthquake reconstruction.In this paper,a simplified procedure is proposed for liquefaction assessment of sandy deposits using shear wave velocity(V),and soil liquefaction from the Banqiao School site was preliminarily investigated after the earthquake.Boreholes were made at the site and shear wave velocities were measured both by SASW and down-hole methods.Based on the in-situ soil information and V profiles,the liquefaction potential of this site was evaluated.The results are reasonably consistent with the actual field behavior observed after the earthquake,indicating that the proposed procedure is effective.The possible effects of gravel and fines contents on liquefaction of sandy soils were also briefly discussed.展开更多
The evaluation and design of stone column improvement ground for liquefaction mitigation is a challenging issue for the state of practice. In this paper, a shear wave velocity-based approach is proposed based on the w...The evaluation and design of stone column improvement ground for liquefaction mitigation is a challenging issue for the state of practice. In this paper, a shear wave velocity-based approach is proposed based on the well-defined correlations of liquefaction resistance （CRR）-shear wave velocity （V）-void ratio （e） of sandy soils, and the values of parameters in this approach are recommended for preliminary design purpose when site specific values are not available. The detailed procedures of pre- and post-improvement liquefaction evaluations and stone column design are given. According to this approach, the required level of ground improvement will be met once the target V of soil is raised high enough （i.e., no less than the critical velocity） to resist the given earthquake loading according to the CRR-V relationship, and then this requirement is transferred to the control of target void ratio （i.e., the critical e） according to the V-e relationship. As this approach relies on the densification of the surrounding soil instead of the whole improved ground and is conservative by nature, specific considerations of the densification mechanism and effect are given, and the effects of drainage and reinforcement of stone columns are also discussed. A case study of a thermal power plant in Indonesia is introduced, where the effectiveness of stone column improved ground was evaluated by the proposed V-based method and compared with the SPT-based evaluation. This improved ground performed well and experienced no liquefaction during subsequent strong earthquakes.展开更多
The present paper investigates the effect of fracturing degree on P-and S-wave velocities in rock.The deformation of intact brittle rocks under loading conditions is characterized by a microcracking procedure,which oc...The present paper investigates the effect of fracturing degree on P-and S-wave velocities in rock.The deformation of intact brittle rocks under loading conditions is characterized by a microcracking procedure,which occurs due to flaws in their microscopic structure and propagates through the intact rock,leading to shear fracture.This fracturing process is of fundamental significance as it affects the mechanical properties of the rock and hence the wave velocities.In order to determine the fracture mechanism and the effect of fracturing degree,samples were loaded at certain percentages of peak strength and ultrasonic wave velocity was recorded after every test.The fracturing degree was recorded on the outer surface of the sample and quantified by the use of the indices P;（traces of joints/m）,P;（traces of joints/m;） and P;（length of fractures/m;）.It was concluded that the wave velocity decreases exponentially with increasing fracturing degree.Additionally,the fracturing degree is described adequately with the proposed indices.Finally,other parameters concerning the fracture characteristics,rock type and scale influence were found to contribute to the velocity decay and need to be investigated further.展开更多
The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity （BaPWV） and ankle-bra- chial index （ABI） are known to be associated with ischemic cardiovascular a...The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity （BaPWV） and ankle-bra- chial index （ABI） are known to be associated with ischemic cardiovascular and cerebrovascular diseases, whether these measures predict the risk of ischemic cerebrovascular disease in diabetic patients remains unclear. 117 patients with type 2 diabetes were enrolled in this study. According to the results of head magnetic resonance imaging, the patients were divided into a diabetes-only group （n = 55） and a diabetes and ischemic stroke group （n = 62）. We then performed ABI and BaPWV examinations for all patients. Compared with the diabe- tes-only group, we found decreased ABI and increased BaPWV in the diabetes and ischemic stroke group. Multivariate logistic regression analyses revealed that BaPWV and ABI were risk factors for ischemic stroke in patients with type 2 diabetes. Our findings indicate that decreased ABI and increased BaPWV are objective indicators of increased risk of ischemic stroke in patients with type 2 diabetes.展开更多
Objective We aimed to clarify the association between estimated pulse wave velocity(ePWV)and the changes in ePWV with all-cause mortality among middle-aged and elderly Chinese.Methods Data were obtained from the China...Objective We aimed to clarify the association between estimated pulse wave velocity(ePWV)and the changes in ePWV with all-cause mortality among middle-aged and elderly Chinese.Methods Data were obtained from the China Health and Retirement Longitudinal Study(CHARLS)from 2011-2018.The ePWV was calculated using an equation that included age and mean blood pressure(MBP).The ΔePWV was assessed as the difference in ePWV between the first two waves.Cox proportional hazard models were used to determine the association between ePWV and ΔePWV with all-cause mortality after adjustment for potential confounders.Results Of 13,116 participants during a median follow-up of 7.0 years,1,356 deaths occurred.An increased ePWV was independently associated with all-cause mortality.The hazard ratio[95% confidence interval(CI)]for participants from the 1^(st)-4^(th) quartile groups was 1.00,1.69(1.31-2.18),3.09(2.44-3.91),and 8.54(6.78-10.75),respectively.Each standard deviation(SD)increment of ePWV increased the risk of all-cause mortality by 132%.Furthermore,theΔePWV was significantly associated with a 1.28-fold(95%CI,1.18-1.38)risk of all-cause mortality per SD increment.Conclusion This cohort study provided novel evidence from a Chinese population that an increased ePWV or progression of the ePWV was independently associated with all-cause mortality,which highlighted the importance of mitigating ePWV progression in clinical practice.展开更多
In this study,the micro-failure process and failure mechanism of a typical brittle rock under uniaxial compression are investigated via continuous real-time measurement of wave velocities.The experimental results indi...In this study,the micro-failure process and failure mechanism of a typical brittle rock under uniaxial compression are investigated via continuous real-time measurement of wave velocities.The experimental results indicate that the evolutions of wave velocities became progressively anisotropic under uniaxial loading due to the direction-dependent development of micro-damage.A wave velocity model considering the inner anisotropic crack evolution is proposed to accurately describe the variations of wave velocities during uniaxial compression testing.Based on which,the effective elastic parameters are inferred by a transverse isotropic constitutive model,and the evolutions of the crack density are inversed using a self-consistent damage model.It is found that the propagation of axial cracks dominates the failure process of brittle rock under uniaxial loading and oblique shear cracks develop with the appearance of macrocrack.展开更多
By utilizing wave velocity imaging technology,the uniaxial multi-stage loading test was conducted on siltstone to attain wave velocity imagings during rock fracture.Based on the time series parameters of acoustic emis...By utilizing wave velocity imaging technology,the uniaxial multi-stage loading test was conducted on siltstone to attain wave velocity imagings during rock fracture.Based on the time series parameters of acoustic emissions(AE),joint response characteristics of the velocity field and AE during rock fracture were analyzed.Moreover,the localization effect of damage during rock fracture was explored by applying wave velocity imagings.The experimental result showed that the wave velocity imagings enable three-dimensional(3-D)visualization of the extent and spatial position of damage to the rock.A damaged zone has a low wave velocity and a zone where the low wave velocity is concentrated tends to correspond to a severely damaged zone.AE parameters and wave velocity imagings depict the changes in activity of cracks during rock fracture from temporal and spatial perspectives,respectively:the activity of cracks is strengthened,and the rate of AE events increases during rock fracture;correspondingly,the low-velocity zones are gradually aggregated and their area gradually increases.From the wave velocity imagings,the damaged zones in rock were divided into an initially damaged zone,a progressively damaged zone,and a fractured zone.During rock fracture,the progressively damaged zone and the fractured zone both develop around the initially damaged zone,showing a typical localization effect of the damage.By capturing the spatial development trends of the progressively damaged zone and fractured zone in wave velocity imagings,the development of microfractures can be predicted,exerting practical significance for determining the position of the main fracture.展开更多
Fibulin-1(FBLN-1),an elastin-associated extracellular matrix protein,has been found in blood and may play a role in the pathophysiological processes leading to cardiovascular disease(CVD).We aimed to investigate the r...Fibulin-1(FBLN-1),an elastin-associated extracellular matrix protein,has been found in blood and may play a role in the pathophysiological processes leading to cardiovascular disease(CVD).We aimed to investigate the relationship between fibulin-1 levels and the risk of CVD by evaluating vascular age derived from the Framingham Heart Study and brachial-ankle Pulse Wave Velocity(baPWV)in patients with asymptomatic hyperuricemia(AHU).In total,66 patients with AHU and 66 gender-and age-matched healthy individuals were enrolled.The plasma fibulin-1 levels were measured by immunochemistry.Patients with AHU presented significantly higher vascular age[median(interquartile range):54(22)vs.48(14)years,P=0.01]and baPWV[mean±SD:1373±223 vs.1291±177 cm/s,P=0.02]than the healthy subjects;however,no significant difference was observed in the plasma fibulin-1 level between the patients with AHU and healthy subjects[median(interquartile range):4018(3838)vs.3099(3405)ng/mL,P=0.31].A correlation between fibulin-1 levels and baPWV was observed only in patients with AHU(r=0.29,P=0.02);and there was also a suggestively statistically significant correlation between fibulin-1 levels and vascular age(r=0.22,P=0.08).However,these associations were rendered insignificant after adjustments for potential confounders.In healthy subjects,no correlation was observed between fibulin-1 levels and CVD risk.This study reveals that plasma fibulin-1 levels may reflect the CVD risk in patients with AHU,but the relationship is not robust.展开更多
Excavation under complex geological conditions requires effective and accurate geological forward-prospecting to detect the unfavorable geological structure and estimate the classification of surround-ing rock in fron...Excavation under complex geological conditions requires effective and accurate geological forward-prospecting to detect the unfavorable geological structure and estimate the classification of surround-ing rock in front of the tunnel face.In this work,a forward-prediction method for tunnel geology and classification of surrounding rock is developed based on seismic wave velocity layered tomography.In particular,for the problem of strong multi-solution of wave velocity inversion caused by few ray paths in the narrow space of the tunnel,a layered inversion based on regularization is proposed.By reducing the inversion area of each iteration step and applying straight-line interface assumption,the convergence and accuracy of wave velocity inversion are effectively improved.Furthermore,a surrounding rock classification network based on autoencoder is constructed.The mapping relationship between wave velocity and classification of surrounding rock is established with density,Poisson’s ratio and elastic modulus as links.Two numerical examples with geological conditions similar to that in the field tunnel and a field case study in an urban subway tunnel verify the potential of the proposed method for practical application.展开更多
Imaging the wave velocity field surrounding a borehole while drilling is a promising and urgently needed approach for extending the exploration range of the borehole point.This paper develops a drilling process detect...Imaging the wave velocity field surrounding a borehole while drilling is a promising and urgently needed approach for extending the exploration range of the borehole point.This paper develops a drilling process detection(DPD)system consisting of a multifunctional sensor and a pilot geophone installed at the top of the drilling rod,geophones at the tunnel face,a laser rangefinder,and an onsite computer.A weighted adjoint-state first arrival travel time tomography method is used to invert the P-wave velocity field of rock mass while borehole drilling.A field experiment in the ongoing construction of a deep buried tunnel in southwestern China demonstrated the DPD system and the tomography method.Time-frequency analysis of typical borehole drilling detection data shows that the impact drilling source is a pulse-like seismic exploration wavelet.A velocity field of the rock mass in a triangular area defined by the borehole trajectory and geophone receiving line can be obtained.Both the borehole core and optical image validate the inverted P-wave velocity field.A numerical simulation of a checkerboard benchmark model is used to test the tomography method.The rapid convergence of the misfits and consistent agreement between the inverted and observed travel times validate the P-wave velocity imaging.展开更多
Soil shear wave velocity （SWV） is an important parameter in geotechnical engineering. To measure the soil SWV, three methods are generally used in China, including the single-hole method, cross-hole method and the s...Soil shear wave velocity （SWV） is an important parameter in geotechnical engineering. To measure the soil SWV, three methods are generally used in China, including the single-hole method, cross-hole method and the surface-wave technique. An optimized approach based on a correlation function for single-hole SWV measurement is presented in this paper. In this approach, inherent inconsistencies of the artificial methods such as negative velocities, and too-large and too-small velocities, are eliminated from the single-hole method, and the efficiency of data processing is improved. In addition, verification using the cross-hole method of upper measuring points shows that the proposed optimized approach yields high precision in signal processing.展开更多
Accurate determination of seismic velocity of the crust is important for understanding regional tectonics and crustal evolution of the Earth. We propose a stepwise joint linearized inversion method using surface wave ...Accurate determination of seismic velocity of the crust is important for understanding regional tectonics and crustal evolution of the Earth. We propose a stepwise joint linearized inversion method using surface wave dispersion, Rayleigh wave ZH ratio （i.e., ellipticity）, and receiver function data to better resolve 1D crustal shear wave velocity （Vs） structure. Surface wave dispersion and Rayleigh wave ZH ratio data are more sensitive to absolute variations of shear wave speed at depths, but their sensi- tivity kernels to shear wave speeds are different and complimentary. However, receiver function data are more sensitive to sharp velocity contrast （e.g., due to the existence of crustal interfaces） and Vp/Vs ratios. The stepwise inversion method takes advantages of the complementary sensitivities of each dataset to better constrain the Vs model in the crust. We firstly invert surface wave dispersion and ZH ratio data to obtain a 1D smooth absolute vs model and then incorporate receiver function data in the joint inver- sion to obtain a finer Vs model with better constraints on interface structures. Through synthetic tests, Monte Carlo error analyses, and application to real data, we demonstrate that the proposed joint inversion method can resolve robust crustal Vs structures and with little initial model dependency.展开更多
Objective To study the relation between serum calcium level and elevated BaPWV in Chinese subjects. Methods The relation between serum calcium level and elevated BaPWV was studied in 9 615 subjects. The mean value of...Objective To study the relation between serum calcium level and elevated BaPWV in Chinese subjects. Methods The relation between serum calcium level and elevated BaPWV was studied in 9 615 subjects. The mean value of left and right BaPWV was analyzed. BaPWV was defined as high when it was31 752.5 cm/s （the upper quartile） either side. Results The BaPWV and its elevated percentage progressively increased across the quartiles of the serum calcium level （P〈0.05）. The prevalence of elevated BaPWV was significantly higher in subjects of the second, third and highest quartiles than in those of the lowest quartile （26.9%, 28.4%, and 33.2%vs 23.7%, P=0.0116, P=0.0004, and P〈0.0001）. Logistic regression analysis revealed that the risk of elevated BaPWV was 1.32- fold higher in subjects of the highest quartile than in those of the lowest quartile （OR=1.32, 95%CI：1.08-1.60）. Conclusion The elevated serum calcium level is related to an elevated BaPWV and a higher risk of arterial stiffness, independent of conventional risk factors, in middle-aged and elderly Chinese subjects.展开更多
The correlations between shear wave velocity(SWV)calculated from virtual touch tissue imaging quantification(VTIQ)technique and histological prognostic factors of invasive ductal carcinoma was investigated.A total of ...The correlations between shear wave velocity(SWV)calculated from virtual touch tissue imaging quantification(VTIQ)technique and histological prognostic factors of invasive ductal carcinoma was investigated.A total of 76 breast tumors histologically confirmed as invasive ductal carcinomas were included in this study.SWV values were measured by VTIQ for each lesion preoperatively or prior to breast biopsy.The maximum values were recorded for statistical analysis.Medical records were reviewed to determine tumor size,histological grade,lymph node status and immunohistochemical results.Tumor subtypes were categorized as luminal A,luminal B,human epidermal growth factor receptor 2(HER2)positive and triple negative.The correlations between SWV and histological prognostic factors were analyzed.It was found that tumor size showed positive association with SWV(r=0.465,P<0.001).Larger tumors had significantly higher SWV than smaller ones(P=0.001).Histological grade 1 tumors had significantly lower SWV values than those with higher histological grade(P=0.015).The Ki67 expression,tumor subtypes and lymph node status showed no statistically significant correlations with SWV,although triple negative tumors and lymph node-positive tumors showed higher SWV values.It was concluded that tumor size was significantly associated with SWV.Higher histological grade was associated with increased SWV.There was no statistically significant correlations between SWV and other histological prognostic factors.展开更多
Objective: Using receiver operating characteristics (ROC) curve to evaluate the value of pulse wave velocity (PWV) in the diagnosis of coronary heart disease (CHD). Methods: By using coronary angiography as golden dia...Objective: Using receiver operating characteristics (ROC) curve to evaluate the value of pulse wave velocity (PWV) in the diagnosis of coronary heart disease (CHD). Methods: By using coronary angiography as golden diagnostic standard of CHD, 218 patients were divided into both CHD group (n=121) and non-CHD group (n = 97). All these patients received PWV test. The efficacy of PWV of each artery segments in the diagnosis of CHD was evaluated by ROC curve. The sensitivity and specificity were calculated with the golden diagnostic standard of CHD. Results:The PWV of right carotid to femoral artery (Rc-f), left carotid to femoral artery (Lc-f), right radial to carotid artery (Rc-r), left radial to carotid artery (Lc-r) in CHD group were significantly higher than that of non-CHD group (9. 31±1. 75 vs 7.60±1.59, P<0. 01; 9. 02±1.71 vs 7. 52±1.50, P<0. 01; 8. 69±1. 37 vs 8. 00±1. 27, P<0. 01; 8.52±1. 03 vs 8. 03±1. 2, P<0. 01 respectively). However, the PWV of both right and left femoral to ankle artery (Rf-a and Lf-a) had no significant differences between the two groups. We then compared the area under curve (AUC) of each ROC(AUCROC) of PWV of Rc-f, Lc-f Rc-r and Lc-r to evaluate their diagnostic efficacy for CHD. We found that AUCROC of Rc-f PWV was the biggest (AUCROC = 0. 818), at the peak point of its ROC curve, the PWV was 8. 32 m/s. PWV>8. 32 m/s of Rc-f could predict the presence of CHD with a sensitivity of 79% and specificity of 77%. Conclusion: The PWV of Rc-f, Lc-f, Rc-r, Lc-r are significantly higher in CHD group than that in non-CHD group, and PWV of Rc-f is the most accurate in the detection of CHD. The PWV>8. 32 m/s of RC-F is a valuable predictor of CHD.展开更多
Objective Brachial-ankle pulse wave velocity （baPWV） is widely used as a simple noninvasive measure of arterial softness. The aim of this study was to evaluate the usefulness of baPWV as a predictor of the carotid a...Objective Brachial-ankle pulse wave velocity （baPWV） is widely used as a simple noninvasive measure of arterial softness. The aim of this study was to evaluate the usefulness of baPWV as a predictor of the carotid artery atherosclerosis in the elderly. Methods A total of 721 elderly participants （mean ~ SD age, 70.3 -4- 5.6years） were enrolled in the current study. All participant underwent both baPWV measurement and B-mode ultrasound for the intima-media thickness. Carotid atherosclerosis （CAS） was defined as the present of carotid plaque or and/or intima media thickness for at least 1.1 mm. Results A multivariate logistic regression analysis reveals that age, sex, brachial-ankle pulse wave velocity, smoking and LDL-C level showed a significant correlation with the presence of CAS. The odds ratios of CAS associated with a 500cm/s increase of brachial-ankle pulse wave velocity were 2.378 [95% confidence interval, 1.36 to 4.00, P〈0.05], 3.733 [95% confidence interval, 1.729 to 8.058, P〈0.01], 4.438 [95% confidence interval, 1.659 to 11.803, P〈0.01]. The baPWV significantly correlated with IMT by bivariate correlation analysis （r=-0.39; p=0.001）. After adjusting for factors influencing, baPWV all the same correlated with IMT （r=-0.35; p=0.001）.Conclusion These results indicate that brachial-ankle PWV is an independent predictor of CAS in the elderly.It also means that the direct measurement of arterial stiffness by this simple method may be of great help for the evaluation of carotid artherosclerosis, at least in the elderly展开更多
基金support of the National Natural Science Foundation of China(No.52274176)the Guangdong Province Key Areas R&D Program(No.2022B0101070001)+5 种基金Chongqing Elite Innovation and Entrepreneurship Leading talent Project(No.CQYC20220302517)the Chongqing Natural Science Foundation Innovation and Development Joint Fund(No.CSTB2022NSCQ-LZX0079)the National Key Research and Development Program Young Scientists Project(No.2022YFC2905700)the Chongqing Municipal Education Commission“Shuangcheng Economic Circle Construction in Chengdu-Chongqing Area”Science and Technology Innovation Project(No.KJCX2020031)the Fundamental Research Funds for the Central Universities(No.2024CDJGF-009)the Key Project for Technological Innovation and Application Development in Chongqing(No.CSTB2025TIAD-KPX0029).
文摘An innovative real-time monitoring method for surrounding rock damage based on microseismic time-lapse double-difference tomography is proposed for delayed dynamic damage identification and insufficient detection of adverse geological conditions in deep-buried tunnel construction.The installation techniques for microseismic sensors were optimized by mounting sensors at bolt ends which significantly improves signal-to-noise ratio(SNR)and anti-interference capability compared to conventional borehole placement.Subsequently,a 3D wave velocity evolution model that incorporates construction-induced disturbances was established,enabling the first visualization of spatiotemporal variations in surrounding rock wave velocity.It finds significant wave velocity reduction near the tunnel face,with roof and floor damage zones extending 40–50 m;wave velocities approaching undisturbed levels at 15 m ahead of the working face and on the laterally undisturbed side;pronounced spatial asymmetry in wave velocity distribution—values on the left side exceed those on the right,with a clear stress concentration or transition zone located 10–15 m;and systematically lower velocities behind the face than in front,indicating asymmetric rock damage development.These results provide essential theoretical support and practical guidance for optimizing dynamic construction strategies,enabling real-time adjustment of support parameters,and establishing safety early warning systems in deep-buried tunnel engineering.
基金Study on the Efficacy and Safety of Hyperbaric Oxygen Therapy Combined with Exercise in Improving Heart Rate Variability in Patients with Stable Chronic Cardiac Insufficiency(Project No.:2023-E-49)。
文摘Objective:To evaluate the effectiveness of cardiac rehabilitation therapy in the treatment of patients with chronic heart failure(CHF).Methods:76 patients with CHF who were treated in the hospital from January 2023 to December 2024 were selected and randomly divided into two groups using a random number table.The experimental group(38 patients)received cardiac rehabilitation therapy,while the reference group(38 patients)received conventional drug therapy.The total effective rate,cardiac function indicators,lung function indicators,and pulse wave velocity(PWV)were compared between the two groups.Results:The total effective rate was higher in the experimental group than in the reference group.After treatment,the cardiac and lung function indicators were better in the experimental group than in the reference group,and the PWV was lower in the experimental group(P<0.05).Conclusion:Cardiac rehabilitation therapy for patients with CHF can improve treatment efficacy,enhance cardiopulmonary function,and regulate PWV levels,with high professionalism and feasibility.
文摘Shear wave velocity Vs is measured by the surface geophysical survey like MASW （multi-channel surface wave analysis） or RWM （refraction wave method） and by the subsurface method like PS logging. PS logging and RWM are direct methods to derive shear wave velocity and MASW retrieves shear wave through the inversion of the surface wave. In this work, the effectiveness of surface methods （MASW and RWM） is compared with PS logging in determining shear wave velocity. For this purpose, shear wave velocity results Vs30 of 12 PS logging and MASW surveys conducted in Mymensingh Municipality in Bangladesh have been utilized. Additionally, the shear wave velocity results of three PS logging have been compared with the refraction profiles of RWM survey conducted in Rooppur nuclear power plant site in Bangladesh. The relative discrepancy between RWM and PS logging is found less （ranges from -3.92 to 0.93） compared to MASW and PS logging （＋/-0.88 to 33.92）. The correlation coefficient of Vs30 derived from RWM and PS logging is observed much better （0.60） compared to MASW and PS logging （0.40）. The result is good considering the lateral lithologic variability and inherent differences among techniques. It is evident from the comparison that the RWM can be used as a cost-effective alternative to traditional borehole PS logging method for Vs30 determination and thus the number of down-hole logging tests might be significantly reduced.
文摘AIM:To investigate whether a noninvasive measurement of tissue strain has a potential usefulness for management of nonalcoholic steatohepatitis(NASH).METHODS:In total 26 patients,23 NASHs and 3 normal controls were enrolled in this study.NASH was staged based on Brunt criterion.At a region of interest(ROI),a shear wave was evoked by implementing an acoustic radiation force impulse(ARFI),and the propagation velocity was quantif ied.RESULTS:Shear wave velocity(SWV) could be reproducibly quantified at all ROIs in all subjects except for 4 NASH cases,in which a reliable SWV value was not calculated at several ROIs.An average SWV of 1.34 ± 0.26 m/s in fibrous stage 0-1 was significantly slower than 2.20 ± 0.74 m/s and 2.90 ± 1.01 m/s in stages 3 and 4,respectively,but was not significantly different from 1.79 ± 0.78 m/s in stage 2.When a cutoff value was set at 1.47 m/s,receiver operating characteristic analysis showed significance to dissociate stages 3 and 4 from stage 0-1(P=0.0092) with sensitivity,specificity and area under curve of 100%,75% and 94.2%,respectively.In addition,the correlation between SWV and hyaluronic acid was significant(P<0.0001),while a tendency toward negative correlation was observed with serum albumin(P=0.053).CONCLUSION:The clinical implementation of ARFI provides noninvasive repeated evaluations of liver stiffness at an arbitrary position,which has the potential to shed new light on NASH management.
基金National Basic Research Program of China(973 Project)Under Grant No.2007CB714203the Foundation for Seismological Researches,China Earthquake Administration Under Grant No.200808022+1 种基金the China Postdoctoral Science Foundation Under Grant No.20080430219,No.20081476the National Natural Science Foundation of China Under Grant No.50708095
文摘The great Wenchuan earthquake(Ms=8.0)in 2008 caused severe damage in the western part of the Chengdu Plain.Soil liquefaction was one of the major causes of damage in the plain areas,and proper evaluation of liquefaction potential is important in the definition of the seismic hazard facing a given region and post-earthquake reconstruction.In this paper,a simplified procedure is proposed for liquefaction assessment of sandy deposits using shear wave velocity(V),and soil liquefaction from the Banqiao School site was preliminarily investigated after the earthquake.Boreholes were made at the site and shear wave velocities were measured both by SASW and down-hole methods.Based on the in-situ soil information and V profiles,the liquefaction potential of this site was evaluated.The results are reasonably consistent with the actual field behavior observed after the earthquake,indicating that the proposed procedure is effective.The possible effects of gravel and fines contents on liquefaction of sandy soils were also briefly discussed.
基金National Natural Science Foundation of China under Grant No.51578501 and No.51127005the Foundation for the Author of National Excellent Doctoral Dissertation of P R China under Grant No.201160+3 种基金the Zhejiang Provincial Natural Science Foundation of China under Grant No.LR15E080001the National Basic Research Program of China(973 Project)under Grant No.2014CB047005the Fundamental Research Funds for the Central Universities under Grant No.2014FZA4016Zhejiang University K.P.Chao’s High Technology Development Foundation(2014)
文摘The evaluation and design of stone column improvement ground for liquefaction mitigation is a challenging issue for the state of practice. In this paper, a shear wave velocity-based approach is proposed based on the well-defined correlations of liquefaction resistance （CRR）-shear wave velocity （V）-void ratio （e） of sandy soils, and the values of parameters in this approach are recommended for preliminary design purpose when site specific values are not available. The detailed procedures of pre- and post-improvement liquefaction evaluations and stone column design are given. According to this approach, the required level of ground improvement will be met once the target V of soil is raised high enough （i.e., no less than the critical velocity） to resist the given earthquake loading according to the CRR-V relationship, and then this requirement is transferred to the control of target void ratio （i.e., the critical e） according to the V-e relationship. As this approach relies on the densification of the surrounding soil instead of the whole improved ground and is conservative by nature, specific considerations of the densification mechanism and effect are given, and the effects of drainage and reinforcement of stone columns are also discussed. A case study of a thermal power plant in Indonesia is introduced, where the effectiveness of stone column improved ground was evaluated by the proposed V-based method and compared with the SPT-based evaluation. This improved ground performed well and experienced no liquefaction during subsequent strong earthquakes.
文摘The present paper investigates the effect of fracturing degree on P-and S-wave velocities in rock.The deformation of intact brittle rocks under loading conditions is characterized by a microcracking procedure,which occurs due to flaws in their microscopic structure and propagates through the intact rock,leading to shear fracture.This fracturing process is of fundamental significance as it affects the mechanical properties of the rock and hence the wave velocities.In order to determine the fracture mechanism and the effect of fracturing degree,samples were loaded at certain percentages of peak strength and ultrasonic wave velocity was recorded after every test.The fracturing degree was recorded on the outer surface of the sample and quantified by the use of the indices P;（traces of joints/m）,P;（traces of joints/m;） and P;（length of fractures/m;）.It was concluded that the wave velocity decreases exponentially with increasing fracturing degree.Additionally,the fracturing degree is described adequately with the proposed indices.Finally,other parameters concerning the fracture characteristics,rock type and scale influence were found to contribute to the velocity decay and need to be investigated further.
文摘The incidence of ischemic stroke in patients with diabetes is increasing. While brachial-ankle pulse wave velocity （BaPWV） and ankle-bra- chial index （ABI） are known to be associated with ischemic cardiovascular and cerebrovascular diseases, whether these measures predict the risk of ischemic cerebrovascular disease in diabetic patients remains unclear. 117 patients with type 2 diabetes were enrolled in this study. According to the results of head magnetic resonance imaging, the patients were divided into a diabetes-only group （n = 55） and a diabetes and ischemic stroke group （n = 62）. We then performed ABI and BaPWV examinations for all patients. Compared with the diabe- tes-only group, we found decreased ABI and increased BaPWV in the diabetes and ischemic stroke group. Multivariate logistic regression analyses revealed that BaPWV and ABI were risk factors for ischemic stroke in patients with type 2 diabetes. Our findings indicate that decreased ABI and increased BaPWV are objective indicators of increased risk of ischemic stroke in patients with type 2 diabetes.
基金supported by the National Key R&D Program of China[2021YFC2500500]Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences[2021-I2M-1-010]+2 种基金the National Natural Science Foundation of China[82073658]the Taikang Yicai Public Health and Epidemic Control Fund[TKYC-GW-2020]the Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancers of the Chinese Academy of Medical Sciences[2019RU038]。
文摘Objective We aimed to clarify the association between estimated pulse wave velocity(ePWV)and the changes in ePWV with all-cause mortality among middle-aged and elderly Chinese.Methods Data were obtained from the China Health and Retirement Longitudinal Study(CHARLS)from 2011-2018.The ePWV was calculated using an equation that included age and mean blood pressure(MBP).The ΔePWV was assessed as the difference in ePWV between the first two waves.Cox proportional hazard models were used to determine the association between ePWV and ΔePWV with all-cause mortality after adjustment for potential confounders.Results Of 13,116 participants during a median follow-up of 7.0 years,1,356 deaths occurred.An increased ePWV was independently associated with all-cause mortality.The hazard ratio[95% confidence interval(CI)]for participants from the 1^(st)-4^(th) quartile groups was 1.00,1.69(1.31-2.18),3.09(2.44-3.91),and 8.54(6.78-10.75),respectively.Each standard deviation(SD)increment of ePWV increased the risk of all-cause mortality by 132%.Furthermore,theΔePWV was significantly associated with a 1.28-fold(95%CI,1.18-1.38)risk of all-cause mortality per SD increment.Conclusion This cohort study provided novel evidence from a Chinese population that an increased ePWV or progression of the ePWV was independently associated with all-cause mortality,which highlighted the importance of mitigating ePWV progression in clinical practice.
基金Projects(41502283,41772309)supported by the National Natural Science Foundation of ChinaProject(2017YFC1501302)supported by the National Key Research and Development Program of ChinaProject(2017ACA102)supported by the Major Program of Technological Innovation of Hubei Province,China。
文摘In this study,the micro-failure process and failure mechanism of a typical brittle rock under uniaxial compression are investigated via continuous real-time measurement of wave velocities.The experimental results indicate that the evolutions of wave velocities became progressively anisotropic under uniaxial loading due to the direction-dependent development of micro-damage.A wave velocity model considering the inner anisotropic crack evolution is proposed to accurately describe the variations of wave velocities during uniaxial compression testing.Based on which,the effective elastic parameters are inferred by a transverse isotropic constitutive model,and the evolutions of the crack density are inversed using a self-consistent damage model.It is found that the propagation of axial cracks dominates the failure process of brittle rock under uniaxial loading and oblique shear cracks develop with the appearance of macrocrack.
基金Projects(51774138,51804122,51904105)supported by the National Natural Science Foundation of ChinaProjects(E2021209148,E2021209052)supported by the Natural Science Foundation of Hebei Province,China。
文摘By utilizing wave velocity imaging technology,the uniaxial multi-stage loading test was conducted on siltstone to attain wave velocity imagings during rock fracture.Based on the time series parameters of acoustic emissions(AE),joint response characteristics of the velocity field and AE during rock fracture were analyzed.Moreover,the localization effect of damage during rock fracture was explored by applying wave velocity imagings.The experimental result showed that the wave velocity imagings enable three-dimensional(3-D)visualization of the extent and spatial position of damage to the rock.A damaged zone has a low wave velocity and a zone where the low wave velocity is concentrated tends to correspond to a severely damaged zone.AE parameters and wave velocity imagings depict the changes in activity of cracks during rock fracture from temporal and spatial perspectives,respectively:the activity of cracks is strengthened,and the rate of AE events increases during rock fracture;correspondingly,the low-velocity zones are gradually aggregated and their area gradually increases.From the wave velocity imagings,the damaged zones in rock were divided into an initially damaged zone,a progressively damaged zone,and a fractured zone.During rock fracture,the progressively damaged zone and the fractured zone both develop around the initially damaged zone,showing a typical localization effect of the damage.By capturing the spatial development trends of the progressively damaged zone and fractured zone in wave velocity imagings,the development of microfractures can be predicted,exerting practical significance for determining the position of the main fracture.
文摘Fibulin-1(FBLN-1),an elastin-associated extracellular matrix protein,has been found in blood and may play a role in the pathophysiological processes leading to cardiovascular disease(CVD).We aimed to investigate the relationship between fibulin-1 levels and the risk of CVD by evaluating vascular age derived from the Framingham Heart Study and brachial-ankle Pulse Wave Velocity(baPWV)in patients with asymptomatic hyperuricemia(AHU).In total,66 patients with AHU and 66 gender-and age-matched healthy individuals were enrolled.The plasma fibulin-1 levels were measured by immunochemistry.Patients with AHU presented significantly higher vascular age[median(interquartile range):54(22)vs.48(14)years,P=0.01]and baPWV[mean±SD:1373±223 vs.1291±177 cm/s,P=0.02]than the healthy subjects;however,no significant difference was observed in the plasma fibulin-1 level between the patients with AHU and healthy subjects[median(interquartile range):4018(3838)vs.3099(3405)ng/mL,P=0.31].A correlation between fibulin-1 levels and baPWV was observed only in patients with AHU(r=0.29,P=0.02);and there was also a suggestively statistically significant correlation between fibulin-1 levels and vascular age(r=0.22,P=0.08).However,these associations were rendered insignificant after adjustments for potential confounders.In healthy subjects,no correlation was observed between fibulin-1 levels and CVD risk.This study reveals that plasma fibulin-1 levels may reflect the CVD risk in patients with AHU,but the relationship is not robust.
基金The research work described herein was funded by the National Natural Science Foundation of China(Grant No.51922067)The Key Research and Development Plan of Shandong Province of China(Grant No.2020ZLYS01)Taishan Scholars Program of Shan-dong Province of China(Grant No.tsqn201909003).
文摘Excavation under complex geological conditions requires effective and accurate geological forward-prospecting to detect the unfavorable geological structure and estimate the classification of surround-ing rock in front of the tunnel face.In this work,a forward-prediction method for tunnel geology and classification of surrounding rock is developed based on seismic wave velocity layered tomography.In particular,for the problem of strong multi-solution of wave velocity inversion caused by few ray paths in the narrow space of the tunnel,a layered inversion based on regularization is proposed.By reducing the inversion area of each iteration step and applying straight-line interface assumption,the convergence and accuracy of wave velocity inversion are effectively improved.Furthermore,a surrounding rock classification network based on autoencoder is constructed.The mapping relationship between wave velocity and classification of surrounding rock is established with density,Poisson’s ratio and elastic modulus as links.Two numerical examples with geological conditions similar to that in the field tunnel and a field case study in an urban subway tunnel verify the potential of the proposed method for practical application.
基金the support of the National Natural Science Foundation of China(Nos.42207211,42202320 and 42172296)Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education,Tongji University(No.KLE-TJGE-G2304).
文摘Imaging the wave velocity field surrounding a borehole while drilling is a promising and urgently needed approach for extending the exploration range of the borehole point.This paper develops a drilling process detection(DPD)system consisting of a multifunctional sensor and a pilot geophone installed at the top of the drilling rod,geophones at the tunnel face,a laser rangefinder,and an onsite computer.A weighted adjoint-state first arrival travel time tomography method is used to invert the P-wave velocity field of rock mass while borehole drilling.A field experiment in the ongoing construction of a deep buried tunnel in southwestern China demonstrated the DPD system and the tomography method.Time-frequency analysis of typical borehole drilling detection data shows that the impact drilling source is a pulse-like seismic exploration wavelet.A velocity field of the rock mass in a triangular area defined by the borehole trajectory and geophone receiving line can be obtained.Both the borehole core and optical image validate the inverted P-wave velocity field.A numerical simulation of a checkerboard benchmark model is used to test the tomography method.The rapid convergence of the misfits and consistent agreement between the inverted and observed travel times validate the P-wave velocity imaging.
基金Pre-research Project of Yantai Unverity Under Project No. TM05B35Shandong Natural Science Foundation Under Project No. bs08003 Key Foundation of Ministry of Education Under Project No. 207062
文摘Soil shear wave velocity （SWV） is an important parameter in geotechnical engineering. To measure the soil SWV, three methods are generally used in China, including the single-hole method, cross-hole method and the surface-wave technique. An optimized approach based on a correlation function for single-hole SWV measurement is presented in this paper. In this approach, inherent inconsistencies of the artificial methods such as negative velocities, and too-large and too-small velocities, are eliminated from the single-hole method, and the efficiency of data processing is improved. In addition, verification using the cross-hole method of upper measuring points shows that the proposed optimized approach yields high precision in signal processing.
基金supported by the National Earthquake Science Experiment in Sichuan and Yunnan Provinces of China(#2016 CESE 0201)National Natural Science Foundation of China(#41574034)China National Special Fund for Earthquake Scientific Research in Public Interest(#201508008)
文摘Accurate determination of seismic velocity of the crust is important for understanding regional tectonics and crustal evolution of the Earth. We propose a stepwise joint linearized inversion method using surface wave dispersion, Rayleigh wave ZH ratio （i.e., ellipticity）, and receiver function data to better resolve 1D crustal shear wave velocity （Vs） structure. Surface wave dispersion and Rayleigh wave ZH ratio data are more sensitive to absolute variations of shear wave speed at depths, but their sensi- tivity kernels to shear wave speeds are different and complimentary. However, receiver function data are more sensitive to sharp velocity contrast （e.g., due to the existence of crustal interfaces） and Vp/Vs ratios. The stepwise inversion method takes advantages of the complementary sensitivities of each dataset to better constrain the Vs model in the crust. We firstly invert surface wave dispersion and ZH ratio data to obtain a 1D smooth absolute vs model and then incorporate receiver function data in the joint inver- sion to obtain a finer Vs model with better constraints on interface structures. Through synthetic tests, Monte Carlo error analyses, and application to real data, we demonstrate that the proposed joint inversion method can resolve robust crustal Vs structures and with little initial model dependency.
基金supported by the Key Laboratory for Endocrine and Metabolic Diseases,Ministry of Health(1994DP131044)National Nature Science Foundation of China(81170739,81170719,81222008,81370960)+3 种基金Shanghai New Excellent Youth Program(XYQ2011009)Shanghai Health Bureau(2011293)EFSD-CDS-Lilly Program for Collaborative Research between China and Europe(2011)Shanghai Shen Kang Hospital Development Center(SHDC12012301)
文摘Objective To study the relation between serum calcium level and elevated BaPWV in Chinese subjects. Methods The relation between serum calcium level and elevated BaPWV was studied in 9 615 subjects. The mean value of left and right BaPWV was analyzed. BaPWV was defined as high when it was31 752.5 cm/s （the upper quartile） either side. Results The BaPWV and its elevated percentage progressively increased across the quartiles of the serum calcium level （P〈0.05）. The prevalence of elevated BaPWV was significantly higher in subjects of the second, third and highest quartiles than in those of the lowest quartile （26.9%, 28.4%, and 33.2%vs 23.7%, P=0.0116, P=0.0004, and P〈0.0001）. Logistic regression analysis revealed that the risk of elevated BaPWV was 1.32- fold higher in subjects of the highest quartile than in those of the lowest quartile （OR=1.32, 95%CI：1.08-1.60）. Conclusion The elevated serum calcium level is related to an elevated BaPWV and a higher risk of arterial stiffness, independent of conventional risk factors, in middle-aged and elderly Chinese subjects.
基金grants from the Fundamental Research Funds for the Central Universities(No.2172015YGYL019)the Fundamental Research Funds for the Central Universities(No.2015LC021)+1 种基金National Natural Science Foundation of China(No.81000616)Hubei Key Laboratory of Molecular Imaging Research Funds(No.02.03.2015-149).
文摘The correlations between shear wave velocity(SWV)calculated from virtual touch tissue imaging quantification(VTIQ)technique and histological prognostic factors of invasive ductal carcinoma was investigated.A total of 76 breast tumors histologically confirmed as invasive ductal carcinomas were included in this study.SWV values were measured by VTIQ for each lesion preoperatively or prior to breast biopsy.The maximum values were recorded for statistical analysis.Medical records were reviewed to determine tumor size,histological grade,lymph node status and immunohistochemical results.Tumor subtypes were categorized as luminal A,luminal B,human epidermal growth factor receptor 2(HER2)positive and triple negative.The correlations between SWV and histological prognostic factors were analyzed.It was found that tumor size showed positive association with SWV(r=0.465,P<0.001).Larger tumors had significantly higher SWV than smaller ones(P=0.001).Histological grade 1 tumors had significantly lower SWV values than those with higher histological grade(P=0.015).The Ki67 expression,tumor subtypes and lymph node status showed no statistically significant correlations with SWV,although triple negative tumors and lymph node-positive tumors showed higher SWV values.It was concluded that tumor size was significantly associated with SWV.Higher histological grade was associated with increased SWV.There was no statistically significant correlations between SWV and other histological prognostic factors.
文摘Objective: Using receiver operating characteristics (ROC) curve to evaluate the value of pulse wave velocity (PWV) in the diagnosis of coronary heart disease (CHD). Methods: By using coronary angiography as golden diagnostic standard of CHD, 218 patients were divided into both CHD group (n=121) and non-CHD group (n = 97). All these patients received PWV test. The efficacy of PWV of each artery segments in the diagnosis of CHD was evaluated by ROC curve. The sensitivity and specificity were calculated with the golden diagnostic standard of CHD. Results:The PWV of right carotid to femoral artery (Rc-f), left carotid to femoral artery (Lc-f), right radial to carotid artery (Rc-r), left radial to carotid artery (Lc-r) in CHD group were significantly higher than that of non-CHD group (9. 31±1. 75 vs 7.60±1.59, P<0. 01; 9. 02±1.71 vs 7. 52±1.50, P<0. 01; 8. 69±1. 37 vs 8. 00±1. 27, P<0. 01; 8.52±1. 03 vs 8. 03±1. 2, P<0. 01 respectively). However, the PWV of both right and left femoral to ankle artery (Rf-a and Lf-a) had no significant differences between the two groups. We then compared the area under curve (AUC) of each ROC(AUCROC) of PWV of Rc-f, Lc-f Rc-r and Lc-r to evaluate their diagnostic efficacy for CHD. We found that AUCROC of Rc-f PWV was the biggest (AUCROC = 0. 818), at the peak point of its ROC curve, the PWV was 8. 32 m/s. PWV>8. 32 m/s of Rc-f could predict the presence of CHD with a sensitivity of 79% and specificity of 77%. Conclusion: The PWV of Rc-f, Lc-f, Rc-r, Lc-r are significantly higher in CHD group than that in non-CHD group, and PWV of Rc-f is the most accurate in the detection of CHD. The PWV>8. 32 m/s of RC-F is a valuable predictor of CHD.
文摘Objective Brachial-ankle pulse wave velocity （baPWV） is widely used as a simple noninvasive measure of arterial softness. The aim of this study was to evaluate the usefulness of baPWV as a predictor of the carotid artery atherosclerosis in the elderly. Methods A total of 721 elderly participants （mean ~ SD age, 70.3 -4- 5.6years） were enrolled in the current study. All participant underwent both baPWV measurement and B-mode ultrasound for the intima-media thickness. Carotid atherosclerosis （CAS） was defined as the present of carotid plaque or and/or intima media thickness for at least 1.1 mm. Results A multivariate logistic regression analysis reveals that age, sex, brachial-ankle pulse wave velocity, smoking and LDL-C level showed a significant correlation with the presence of CAS. The odds ratios of CAS associated with a 500cm/s increase of brachial-ankle pulse wave velocity were 2.378 [95% confidence interval, 1.36 to 4.00, P〈0.05], 3.733 [95% confidence interval, 1.729 to 8.058, P〈0.01], 4.438 [95% confidence interval, 1.659 to 11.803, P〈0.01]. The baPWV significantly correlated with IMT by bivariate correlation analysis （r=-0.39; p=0.001）. After adjusting for factors influencing, baPWV all the same correlated with IMT （r=-0.35; p=0.001）.Conclusion These results indicate that brachial-ankle PWV is an independent predictor of CAS in the elderly.It also means that the direct measurement of arterial stiffness by this simple method may be of great help for the evaluation of carotid artherosclerosis, at least in the elderly
