Psoriasis is a chronic inflammatory skin disease characterized by erythema,scaling,and skin thickening.Topical drug application is recommended as the first-line treatment.Many formulation strategies have been develope...Psoriasis is a chronic inflammatory skin disease characterized by erythema,scaling,and skin thickening.Topical drug application is recommended as the first-line treatment.Many formulation strategies have been developed and explored for enhanced topical psoriasis treatment.However,these preparations usually have low viscosity and limited retention on the skin surface,resulting in low drug delivery efficiency and poor patient satisfaction.In this study,we developed the first water-responsive gel(WRG),which has a distinct water-triggered liquid-to-gel phase transition property.Specifically,WRG was kept in a solution state in the absence of water,and the addition of water induced an immediate phase transition and resulted in a high viscosity gel.Curcumin was used as a model drug to investigate the potential of WRG in topical drug delivery against psoriasis.In vitro and in vivo data showed that WRG formulation could not only extend skin retention but also facilitate the drug permeating across the skin.In a mouse model of psoriasis,curcumin loaded WRG(CUR-WRG)effectively ameliorated the symptoms of psoriasis and exerted a potent anti-psoriasis effect by extending drug retention and facilitating drug penetration.Further mechanism study demonstrated that the anti-hyperplasia,anti-inflammation,anti-angiogenesis,anti-oxidation,and immunomodulation properties of curcumin were amplified by enhanced topical drug delivery efficiency.Notably,neglectable local or systemic toxicity was observed for CUR-WRG application.This study suggests that WRG is a promising formulation for topically psoriasis treatment.展开更多
Room-temperature phosphorescence(RTP)materials play a vital role in security domain due to their unique optical properties.However,most average lifetimes of available RTP materials remain less than 1 s in aqueous-phas...Room-temperature phosphorescence(RTP)materials play a vital role in security domain due to their unique optical properties.However,most average lifetimes of available RTP materials remain less than 1 s in aqueous-phase media,which is unfavorable to practical applications.Herein,an ex-situ covalent coupling strategy is proposed to fabricate liquid-phase long-lived RTP materials by combining SiO_(2)microspheres with the feather-derived carbon dots(CDs).Astonishingly,the aqueous dispersion of the resulting CDs@SiO_(2)microspheres exhibits a lifetime of up to 2.38 s with an absolute quantum yield of 22%.Moreover,the average lifetime of the solid CDs@SiO_(2)is as long as 3.04 s,which is superior to that of existing RTP carbon-based materials.The striking enhancements in the RTP of the CDs@SiO_(2)composites are mainly attributed to the immobilization of the formed Si–O–C covalent bonds and Si–O–Si rigid networks.The CDs@SiO_(2)composites were subsequently applied in the fields of information encryption and anti-fake.Interestingly,the CDs@SiO_(2)composites possess intriguing,reversible and stable optical properties,including water-responsive structural colors,blue fluorescence and cyan RTP,exhibiting excellent covert performance in applications of information encryption and decryption,and high-level anticounterfeiting.These findings provide not only a straightforward strategy for developing multiresponsive optical materials but also a more secure anticounterfeiting technology.展开更多
Conventional wound dressings only protect passively against bacterial infection.Emerging mechanically active adhesive dressings(AADs)are inspired by the active closure of embryonic wounds.It can promote wound healing ...Conventional wound dressings only protect passively against bacterial infection.Emerging mechanically active adhesive dressings(AADs)are inspired by the active closure of embryonic wounds.It can promote wound healing by actively con-tracting the wound bed.AADs meet the requirements of high toughness,stimulus-response,and dynamic adhesion proper-ties,which are challenging.Hence,we construct a water-responsive shape memory polyurea fibrous membrane(PU-fm)featuring favorable toughness,wet-adhesion,breathability,absorbency of four times its weight,and antibacterial.First,the water-toughened electrospun PU-fm is fabricated using a homemade polyurea(PU)elastomer with multistage hydrogen bond networks as a spinning solution.Furthermore,a Janus-structured polyurea-polydopamine-silver fibrous membrane(PU@PDA@Ag-fm)is engineered,integrating antibacterial properties without compromising mechanical robustness.It demonstrates strong adhesion to the skin,actively promotes wound contraction,and enables adaptive wrapping of tissues of varying sizes by the water-driven shape memory effect.Antibacterial tests and wound healing experiments indicate that the PU@PDA@Ag-fm has favorable antibacterial properties against Escherichia coli(E.coli)and accelerates the wound healing rate by 20%.For the first time,water-responsive shape memory PU-fm as the AADs is constructed,providing a new strategy for wound management.This can be extended to applications in other smart devices for biomedicine such as tendon repair,and bioelectronic interfaces.展开更多
基金This research was supported by National Natural Science Foundation of China(Grant No.81903551)Natural Science Foundation of Zhejiang Province(Grant No.LYY22H300001)+3 种基金Wenzhou Municipal Science and Technology Bureau(Grant No.ZY2019007)Zhejiang postdoctoral scientific research project(Grant No.ZJ2021024)Wenzhou Municipal Key Laboratory of Pediatric Pharmacy(Grant No.WZEY02)Excellent Young Scientist Training Program fund from Wenzhou Medical University.
文摘Psoriasis is a chronic inflammatory skin disease characterized by erythema,scaling,and skin thickening.Topical drug application is recommended as the first-line treatment.Many formulation strategies have been developed and explored for enhanced topical psoriasis treatment.However,these preparations usually have low viscosity and limited retention on the skin surface,resulting in low drug delivery efficiency and poor patient satisfaction.In this study,we developed the first water-responsive gel(WRG),which has a distinct water-triggered liquid-to-gel phase transition property.Specifically,WRG was kept in a solution state in the absence of water,and the addition of water induced an immediate phase transition and resulted in a high viscosity gel.Curcumin was used as a model drug to investigate the potential of WRG in topical drug delivery against psoriasis.In vitro and in vivo data showed that WRG formulation could not only extend skin retention but also facilitate the drug permeating across the skin.In a mouse model of psoriasis,curcumin loaded WRG(CUR-WRG)effectively ameliorated the symptoms of psoriasis and exerted a potent anti-psoriasis effect by extending drug retention and facilitating drug penetration.Further mechanism study demonstrated that the anti-hyperplasia,anti-inflammation,anti-angiogenesis,anti-oxidation,and immunomodulation properties of curcumin were amplified by enhanced topical drug delivery efficiency.Notably,neglectable local or systemic toxicity was observed for CUR-WRG application.This study suggests that WRG is a promising formulation for topically psoriasis treatment.
基金the National Natural Science Foundation of China(52173206)the Applied Foundation Frontier Project from Wuhan Science and Technology Bureau(2022013988065202)。
文摘Room-temperature phosphorescence(RTP)materials play a vital role in security domain due to their unique optical properties.However,most average lifetimes of available RTP materials remain less than 1 s in aqueous-phase media,which is unfavorable to practical applications.Herein,an ex-situ covalent coupling strategy is proposed to fabricate liquid-phase long-lived RTP materials by combining SiO_(2)microspheres with the feather-derived carbon dots(CDs).Astonishingly,the aqueous dispersion of the resulting CDs@SiO_(2)microspheres exhibits a lifetime of up to 2.38 s with an absolute quantum yield of 22%.Moreover,the average lifetime of the solid CDs@SiO_(2)is as long as 3.04 s,which is superior to that of existing RTP carbon-based materials.The striking enhancements in the RTP of the CDs@SiO_(2)composites are mainly attributed to the immobilization of the formed Si–O–C covalent bonds and Si–O–Si rigid networks.The CDs@SiO_(2)composites were subsequently applied in the fields of information encryption and anti-fake.Interestingly,the CDs@SiO_(2)composites possess intriguing,reversible and stable optical properties,including water-responsive structural colors,blue fluorescence and cyan RTP,exhibiting excellent covert performance in applications of information encryption and decryption,and high-level anticounterfeiting.These findings provide not only a straightforward strategy for developing multiresponsive optical materials but also a more secure anticounterfeiting technology.
基金supported by the National Key R&D Program of China(No.2022YFB3805700)National Natural Science Foundation of China(No.92271206).
文摘Conventional wound dressings only protect passively against bacterial infection.Emerging mechanically active adhesive dressings(AADs)are inspired by the active closure of embryonic wounds.It can promote wound healing by actively con-tracting the wound bed.AADs meet the requirements of high toughness,stimulus-response,and dynamic adhesion proper-ties,which are challenging.Hence,we construct a water-responsive shape memory polyurea fibrous membrane(PU-fm)featuring favorable toughness,wet-adhesion,breathability,absorbency of four times its weight,and antibacterial.First,the water-toughened electrospun PU-fm is fabricated using a homemade polyurea(PU)elastomer with multistage hydrogen bond networks as a spinning solution.Furthermore,a Janus-structured polyurea-polydopamine-silver fibrous membrane(PU@PDA@Ag-fm)is engineered,integrating antibacterial properties without compromising mechanical robustness.It demonstrates strong adhesion to the skin,actively promotes wound contraction,and enables adaptive wrapping of tissues of varying sizes by the water-driven shape memory effect.Antibacterial tests and wound healing experiments indicate that the PU@PDA@Ag-fm has favorable antibacterial properties against Escherichia coli(E.coli)and accelerates the wound healing rate by 20%.For the first time,water-responsive shape memory PU-fm as the AADs is constructed,providing a new strategy for wound management.This can be extended to applications in other smart devices for biomedicine such as tendon repair,and bioelectronic interfaces.
