Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a...Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a stroke.Their dynamic activation and polarization states are key factors that influence the disease process and treatment outcomes.This review article investigates the role of microglia in ischemic stroke and explores potential intervention strategies.Microglia exhibit a dynamic functional state,transitioning between pro-inflammatory(M1)and anti-inflammatory(M2)phenotypes.This duality is crucial in ischemic stroke,as it maintains a balance between neuroinflammation and tissue repair.Activated microglia contribute to neuroinflammation through cytokine release and disruption of the blood-brain barrier,while simultaneously promoting tissue repair through anti-inflammatory responses and regeneration.Key pathways influencing microglial activation include Toll-like receptor 4/nuclear factor kappa B,mitogen-activated protein kinases,Janus kinase/signal transducer and activator of transcription,and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathways.These pathways are targets for various experimental therapies aimed at promoting M2 polarization and mitigating damage.Potential therapeutic agents include natural compounds found in drugs such as minocycline,as well as traditional Chinese medicines.Drugs that target these regulatory mechanisms,such as small molecule inhibitors and components of traditional Chinese medicines,along with emerging technologies such as single-cell RNA sequencing and spatial transcriptomics,offer new therapeutic strategies and clinical translational potential for ischemic stroke.展开更多
This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although ...This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although the rural revitalization strategy has achieved significant results in improving residents’quality of life,promoting agricultural modernization,it still faces challenges such as severe loss of human resources,insufficient agricultural technological innovation,and backward infrastructure construction.In response to these challenges,this paper proposes optimization strategies from three aspects:strengthening rural education and talent team construction,promoting agricultural technology innovation and achievement transformation,and increasing investment in rural infrastructure construction.展开更多
Dove’s 2017 advertising incident,which sparked widespread debate regarding perceived cultural insensitivity,highlighted a disconnect between the brand’s“Real Beauty”positioning and public reception.In response,thi...Dove’s 2017 advertising incident,which sparked widespread debate regarding perceived cultural insensitivity,highlighted a disconnect between the brand’s“Real Beauty”positioning and public reception.In response,this study proposes a strategic digital recovery framework,including revised campaign content,transparent communication through social media,and data-driven customer segmentation based on diverse skincare needs and cultural backgrounds.A PESTLE analysis underscores the importance of digital transformation and rising social consciousness in brand management.Findings suggest that inclusive messaging,precision targeting,and omnichannel digital engagement are key to restoring brand trust and reputation in the digital landscape.展开更多
Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practic...Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practice show poor targeting,rapid drug clearance from the circulatory system,and low therapeutic efficiency.Therefore,in this review,we have first described the mechanisms underlying nerve regeneration,characterized the biomaterials used for drug delivery to facilitate nerve regeneration,and highlighted the functionalization strategies used for such drug-delivery systems.These systems mainly use natural and synthetic polymers,inorganic materials,and hybrid systems with advanced drug-delivery abilities,including nanoparticles,hydrogels,and scaffoldbased systems.Then,we focused on comparing the types of drug-delivery systems for neural regeneration as well as the mechanisms and challenges associated with targeted delivery of drugs to facilitate neural regeneration.Finally,we have summarized the clinical application research and limitations of targeted delivery of these drugs.These biomaterials and drug-delivery systems can provide mechanical support,sustained release of bioactive molecules,and enhanced intercellular contact,ultimately reducing cell apoptosis and enhancing functional recovery.Nevertheless,immune reactions,degradation regulation,and clinical translations remain major unresolved challenges.Future studies should focus on optimizing biomaterial properties,refining delivery precision,and overcoming translational barriers to advance these technologies toward clinical applications.展开更多
Four distinct coordination polymers(CPs)were successfully synthesized by altering solvent types and adjusting ligand concentrations,and their crystal structures were investigated.[Co(L)(FDCA)(H_(2)O)_(2)]·0.5H_(2...Four distinct coordination polymers(CPs)were successfully synthesized by altering solvent types and adjusting ligand concentrations,and their crystal structures were investigated.[Co(L)(FDCA)(H_(2)O)_(2)]·0.5H_(2)O(1)was synthesized as a 2D structure using Coas the metal source,methanol‑water(4∶6,V/V)as the solvent,and specific concentrations of 2,5‑furandicarboxylic acid(H_(2)FDCA)and 1,3,5‑triimidazole benzene(L).Adjusting to pure water and lowering the concentration of L yielded the 1D chain structure of[Co(HL)2(H_(2)O)_(2)](FDCA)_(2)·6H_(2)O(2).Using Cu(Ⅱ)as the metal source,methanol/water(9∶1,V/V)as the solvent,and specific concentrations of L and H2FDCA,the 1D chain structure of[Cu(L)(FDCA)(H_(2)O)]·2H_(2)O(3)was synthesized.Upon increasing the concentrations of L and H2FDCA,and switching the solvent to pure water,the 1D chain structure of[Cu(HL)_(2)(H_(2)O)_(2)](FDCA)_(2)·6H_(2)O(4)was obtained.This shows that changing the solvent and ligand concentrations can affect the structural changes of CPs.In addition,the solid‑state photoluminescence of CPs 1‑4 at room temperature was studied,and their morphological changes were observed via scanning electron microscopy.Density functional theory calculations revealed that the negative charge concentrates on the O and N atoms of the ligand,facilitating ligand‑metal ion coordination.CCDC:2403934,1;2403935,2;2403936,3;2403938,4.展开更多
Fifty-five-year-old Shi Yizhong never imagined fireflies could become the foundation of a serious business.In 2022,Longshan Village in Huzhou’s Wuxing District collaborated with a young entrepreneurial team to create...Fifty-five-year-old Shi Yizhong never imagined fireflies could become the foundation of a serious business.In 2022,Longshan Village in Huzhou’s Wuxing District collaborated with a young entrepreneurial team to create a firefly campsite-a natural attraction where visitors can observe these glowing insects in a preserved habitat.The site quickly drew waves of tourists,who shared their experience online,recouping its initial investment in just two years.展开更多
The discharge of micro-polluted water from sources such as agricultural runoff,urban stormwater,and treated effluents presents significant challenges to aquatic ecosystems.Constructed wetlands(CWs)have gained recog-ni...The discharge of micro-polluted water from sources such as agricultural runoff,urban stormwater,and treated effluents presents significant challenges to aquatic ecosystems.Constructed wetlands(CWs)have gained recog-nition as an eco-friendly solution for removing pollutants from various wastewater sources and are increasingly applied for micro-polluted water treatment.By reviewing 78 full-scale CW studies from Web of Science,it is summarized that the ranges of ammonium nitrogen(NH4+-N)concentrations in runoff,wastewater treatment plant effluent and polluted river were 0.1–6.6,0.3–12.3,and 0.2–41.1 mg/L,respectively.The ranges of ni-trate nitrogen concentrations were 0.2–14.2,0–5.7,and 0–2.6 mg/L,respectively.Removal efficiencies of CWs for micro-polluted water varied by CW types.The total nitrogen removal efficiencies for subsurface-flow CWs,free-water surface-flow CWs,and hybrid CWs ranged from 27.4%to 66.5%,16.8%to 89.8%,and 19.4%to 88.2%,respectively.The NH4+-N removal efficiencies ranged from 34.2%to 73.6%,38.4%to 89.4%and 13.5%to 94.2%,respectively.Additionally,other factors influencing contaminant removal efficiency such as hydraulic retention time,vegetation types,redox micro-environment and influent water quality were evaluated.Based on these findings,two strategies for improving the purification performance of CWs were proposed:the selection of incorporating electron donor substrates and the optimization of operation parameters.This paper serves as a synthesis of information to guide future research and full-scale CW applications in micro-polluted water treatment.展开更多
The iterative continuation task(ICT)requires English as a foreign language(EFL)learners to read a segment and write a continuation that aligns with the preceding segment of an English novel with successive turns,offer...The iterative continuation task(ICT)requires English as a foreign language(EFL)learners to read a segment and write a continuation that aligns with the preceding segment of an English novel with successive turns,offering exposure to diverse grammatical structures and opportunities for contextualized usage.Given the importance of integrating technology into second language(L2)writing and the critical role that grammar plays in L2 writing development,automated written corrective feedback provided by Grammarly has gained significant attention.This study investigates the impact of Grammarly on grammar learning strategies,grammar grit,and grammar competence among EFL college students engaged in ICT.This study employed a mixed-methods sequential exploratory design;56 participants were divided into an experimental group(n=28),receiving Grammarly feedback for ICT,and a control group(n=28),completing ICT without Grammarly feedback.Quantitative results revealed that both groups showed improvements in L2 grammar learning strategies,grit and competence.For the experimental group,significant differences were observed across all variables of L2 grammar learning strategies,grit,and competence between pre-and post-tests.For the control group,significant differences were only observed in the affective dimension of grammar learning strategies,Consistency of Interest(COI)of grammar grit,and grammar competence.However,the control group presented a significantly higher improvement in grammar competence.Qualitative analysis showed both positive and negative perceptions of Grammarly.The pedagogical implications of integrating Grammarly and ICT for L2 grammar development are discussed.展开更多
Conventional locking/release mechanisms often face challenges in aircraft wing separation processes,such as excessive impact loads and insufficient synchronization.These may cause structural damage to the airframe or ...Conventional locking/release mechanisms often face challenges in aircraft wing separation processes,such as excessive impact loads and insufficient synchronization.These may cause structural damage to the airframe or attitude instability,seriously compromising mission reliability.To address this engineering challenge,this paper proposes a multi-point low-impact locking/release mechanism based on the mobility model and energy conversion strategy.Through establishing a DOF constraint framework system,this paper systematically analyzes the energy transfer and conversion characteristics during the wing separation process,reveals the generation mechanism of impact loads,and conducts research on low-impact design based on energy conversion strategy.Building on this foundation,a single-point locking/release mechanism employing parallel trapezoidal key shaft structure was designed,which increases frictional contact time and reduces the energy release rate,thereby achieving low-impact characteristics.The mechanism's performance was validated through physical prototype development and systematic functional testing(including unlocking force,synchronization,and impact tests).Experimental results demonstrate:(1)Under 14 kN preload condition,the maximum unlocking force was only 92.54 N,showing a linear relationship with preload that satisfies the"strong-connection/weak-unlock"design requirement;(2)Wing separation was completed within 46 ms,with synchronization time difference among three separation mechanisms stably controlled within 12-14 ms,proving rapid and reliable operation;(3)The unlocking impact acceleration ranged between 26 and 73 g,below the 100 g design limit,confirming the effectiveness of the energy conversion strategy.The proposed low-impact locking/release mechanism design method based on energy conversion strategy resolves the traditional challenges of high impact and synchronization deficiencies.The synergistic optimization mechanism of"structural load reduction and performance improvement"provides a highly reliable technical solution for wing separable mechanisms while offering novel design insights for wing connection/separation systems engineering.展开更多
Using photoelectrocatalytic CO_(2) reduction reaction(CO_(2)RR)to produce valuable fuels is a fascinating way to alleviate environmental issues and energy crises.Bismuth-based(Bi-based)catalysts have attracted widespr...Using photoelectrocatalytic CO_(2) reduction reaction(CO_(2)RR)to produce valuable fuels is a fascinating way to alleviate environmental issues and energy crises.Bismuth-based(Bi-based)catalysts have attracted widespread attention for CO_(2)RR due to their high catalytic activity,selectivity,excellent stability,and low cost.However,they still need to be further improved to meet the needs of industrial applications.This review article comprehensively summarizes the recent advances in regulation strategies of Bi-based catalysts and can be divided into six categories:(1)defect engineering,(2)atomic doping engineering,(3)organic framework engineering,(4)inorganic heterojunction engineering,(5)crystal face engineering,and(6)alloying and polarization engineering.Meanwhile,the corresponding catalytic mechanisms of each regulation strategy will also be discussed in detail,aiming to enable researchers to understand the structure-property relationship of the improved Bibased catalysts fundamentally.Finally,the challenges and future opportunities of the Bi-based catalysts in the photoelectrocatalytic CO_(2)RR application field will also be featured from the perspectives of the(1)combination or synergy of multiple regulatory strategies,(2)revealing formation mechanism and realizing controllable synthesis,and(3)in situ multiscale investigation of activation pathways and uncovering the catalytic mechanisms.On the one hand,through the comparative analysis and mechanism explanation of the six major regulatory strategies,a multidimensional knowledge framework of the structure-activity relationship of Bi-based catalysts can be constructed for researchers,which not only deepens the atomic-level understanding of catalytic active sites,charge transport paths,and the adsorption behavior of intermediate products,but also provides theoretical guiding principles for the controllable design of new catalysts;on the other hand,the promising collaborative regulation strategies,controllable synthetic paths,and the in situ multiscale characterization techniques presented in this work provides a paradigm reference for shortening the research and development cycle of high-performance catalysts,conducive to facilitating the transition of photoelectrocatalytic CO_(2)RR technology from the laboratory routes to industrial application.展开更多
Following a magnitude M 7.9 earthquake that struck near Mandalay,Myanmar in March 2025,this study investigates the seismic damage inflicted upon the city’s municipal water supply system.The analysis focuses on the fa...Following a magnitude M 7.9 earthquake that struck near Mandalay,Myanmar in March 2025,this study investigates the seismic damage inflicted upon the city’s municipal water supply system.The analysis focuses on the failure characteristics of water facilities and pipelines,examines cross-system cascading effects,and proposes corresponding recovery strategies.The main findings are as follows:(1)The damage to water plant facilities,concentrated in ancillary structures and connections due to insufficient seismic measures,demonstrated significant intensity-dependence.Increased seismic intensity not only aggravated structural damage but also compromised core treatment processes,leading to deteriorated water quality.(2)Within the same seismic intensity zone,high-density polyethylene(HDPE)pipes exhibited a significantly lower damage occurrence rate than ductile iron(DI)pipes,highlighting the material’s substantial influence on seismic performance.Moreover,a strong positive correlation was observed between the overall pipeline network damage and the seismic intensity.The average damage rate in IntensityⅨzones was 6.84 times that of IntensityⅧzones.(3)A cascading failure,initiated by a power outage,led to water supply disruption,loss of emergency response capability,and elevated secondary risks.This strongly coupled cross-system effect resulted in significant spatiotemporal propagation of disaster impacts.(4)The post-earthquake recovery adopted a phased strategy that prioritized critical facilities.Actions involved rapidly restoring the core supply zone with temporary points,reinstating the water plant’s power supply,and deploying targeted technologies for efficient pipeline repair.The outcomes of this study are expected to provide critical support and a valuable reference for developing earthquake-resilient urban water supply systems.展开更多
Social capital in the form of social resources or social networks is one of the most important livelihood capital of farmers, which can increase the labor productivity of poor households and increase income. It is imp...Social capital in the form of social resources or social networks is one of the most important livelihood capital of farmers, which can increase the labor productivity of poor households and increase income. It is important to explore the reasons underlying the livelihood strategy choices of farmers from the perspective of social capital under China’s rural revitalization strategy. In this study, the Liangshan Yi Autonomous Prefecture, a povertystricken mountainous area in southwestern China, was selected as the case study area, and multivariable linear regression models were constructed to analyze the influence of social capital on livelihood strategies.The results are as follows:(1) Individual social capital had a positive effect on non-agricultural livelihood strategies. On average, with a one-unit increase in individual social capital, the ratio of farmers’ nonagricultural income to total productive income(Income_Rto) increased by 0.002% and 0.062%,respectively. Collective social capital, with the Peasant Economic Cooperation Organization(PECO) as the carrier, had a negative effect on the non-agricultural livelihood strategies of farmers;on average, with a oneunit increase in PECO, Income_Rto decreased by approximately 0.053%. However, this effect was only significant in the river valley area.(2) The income differences among the different livelihood strategy types were explained by the livelihood strategy choices of farmers. As non-agricultural work can bring more benefits, the labor force exhibited one-way migration from villages to cities, resulting in a lack of the subject of rural revitalization. It is necessary to implement effective measures to highlight the role of PECO in increasing agricultural income for farmers. Finally,based on the above conclusions,policy recommendations with respect to livelihood transformation of farmers and rural sustainable development are discussed.展开更多
Since confidence is fading and anxiety is increasing in the US,America’s China policy has become more radical. In the short term, the US has the upper hand and China is in a relatively passive position. In the medium...Since confidence is fading and anxiety is increasing in the US,America’s China policy has become more radical. In the short term, the US has the upper hand and China is in a relatively passive position. In the medium-and long-term, there will be more balance between them. This current strategic gambling between China and the US will be the major issue of international politics in the first half of the 21 st century and the most prominent external challenge China faces. China needs to make strategic adjustments but the gamble may be worthwhile in correcting imbalance in the international order and in the co-evolution of the two countries.展开更多
With the entry to WTO and development of IT, banks in China are adjusting their competitive strategies to meet the competition. Internet banking has become a kind of strategic choice to response to the entry to WTO. B...With the entry to WTO and development of IT, banks in China are adjusting their competitive strategies to meet the competition. Internet banking has become a kind of strategic choice to response to the entry to WTO. Based on relevantly selective reviews of literature of strategy theory and research, a model is developed to study banks' strategic response to entry to WTO. According to a survey of 192 sets of questionnaires, this study finds that external pressure, business strategy and perceived benefits of Internet banking would influence banks' perceived increase in Internet banking investment. And banks' perceived increase in Internet banking investment has no difference between big banks and small banks.展开更多
Building a technology alliance is the main strategy for the United States to maintain its scientific and technological hegemony under its technopolitical strategic framework.After Joe Biden took office,the United Stat...Building a technology alliance is the main strategy for the United States to maintain its scientific and technological hegemony under its technopolitical strategic framework.After Joe Biden took office,the United States implemented“small yard with high fences”strategy for scientific and technological competition,as the first step toward building a technology alliance.The main goal is to restrict the flow of strategic emerging technologies and factors of innovation to rival countries.展开更多
Aiming to reveal the university students＇ understanding in management as for the strategy and strategic management phenomena, this study accomplishes a phenomenographic research to assess the future managers＇ market...Aiming to reveal the university students＇ understanding in management as for the strategy and strategic management phenomena, this study accomplishes a phenomenographic research to assess the future managers＇ market perception. It was chosen university students in Management of a Portuguese University. We conclude that the strategy definitions obtained are an assembly of the diverse existing concepts. Concerning to strategic management it was perceived an approach with one of the main existing concepts. The findings raise interesting issues with respect to the difficulties felt by new managers in translating their theoretical definitions in real examples in the organizations.展开更多
The key argument of this conceptual paper is that the roots of a viable future for an organisation are found in a robust strategic architecture perspective.The theoretical baselines for the concepts associated with th...The key argument of this conceptual paper is that the roots of a viable future for an organisation are found in a robust strategic architecture perspective.The theoretical baselines for the concepts associated with this paper are linked to a variety of strategy theories.These include,but are not restricted to,institutional theory,strategic thinking relating to the positioning-based view(PBV)and resource-based view(RBV)respectively,entrepreneurial thinking,and innovation thinking.Strategy can be described as the collective,emerging pattern—based on strategic choices—an organisation consciously exhibits and executes over time to ensure its sustainable endurance by differentiating itself in unique ways to create and add value for stakeholders.Strategy is about explaining how an organisation wants to move forward and how it wants to advance the interests of stakeholders.A strategic landscape is the broad external and internal context of an organisation.An important part of strategy and the strategic landscape it operates in is how organisations define or“construct”their own“topography”or strategic architecture.A strategic architecture presents an organisation?s core logic for creating sustainable value,and therefore,forms the foundation of an organisation?s competitive potential in a specific context.This paper presents descriptions of the seven key buildings blocks that constitute a strategic architecture perspective for an organisation with an indication of strategy tools and frameworks that can be used to illuminate strategic possibilities,choices,and challenges to assist ongoing strategising praxis.The key features and assumptions associated with a strategic architecture perspective are discussed.A strategic architecture perspective assists leaders to work through the strategic complexity to arrive at simplicity in the form of clarity on external and internal strategic leverages,strategic aspirations,core strategic choices,plausible multiple scenarios,focused strategic goals,and success measurements to guide strategy execution and ongoing strategy renewal and innovations for proactive strategic decision-making through various dialogues with key stakeholders.展开更多
Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy sources.This paper proposes a wind-solar hybrid energy storage system(HESS)to ensure a stable supply grid for a longe...Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy sources.This paper proposes a wind-solar hybrid energy storage system(HESS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOC)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,respectively.MATLAB/Simulink was used for simulation test.The optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 yuan.Additionally,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations significantly.The proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.展开更多
In July 2021,Russia unveiled its new National Security Strategy,which is a considerably updated version compared with the previous one and hence presents several new features.For instance,it further stresses that secu...In July 2021,Russia unveiled its new National Security Strategy,which is a considerably updated version compared with the previous one and hence presents several new features.For instance,it further stresses that security should be prioritized over other aspects;it gives more attention to the chaotic aspects of order change in its assessment of the international situation;it highlights the threats from the West;and it places increased emphasis on domestic capacity building as a means for safeguarding national security.From the content of the new Strategy as well as Russia’s policies in recent years,the strategy of Russia for the foreseeable future can be generally characterized as inward-looking.Domestically,its policies will become more conservative;diplomatically,it will take up a defensive position;and economically,it will increasingly emphasize security and selfreliance.In other words,several issues that were previously overlooked will be given attention.However,strategic introversion does not mean that Russia will invest all its energy in defense.Instead,Russia will build up strength for changes that lie ahead.With the expected strategic introversion,Russia will fnd difculty in making breakthroughs in terms of its relations with the West;the China-Russia relations will continue on the path of steady development;and Russia will place greater importance to the balance of power among major countries.展开更多
基金supported by the National Natural Science Foundation of China,82471345(to LC)the Key Research and Development Program for Social Development by the Jiangsu Provincial Department of Science and Technology.No.BE2022668(to LC).
文摘Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a stroke.Their dynamic activation and polarization states are key factors that influence the disease process and treatment outcomes.This review article investigates the role of microglia in ischemic stroke and explores potential intervention strategies.Microglia exhibit a dynamic functional state,transitioning between pro-inflammatory(M1)and anti-inflammatory(M2)phenotypes.This duality is crucial in ischemic stroke,as it maintains a balance between neuroinflammation and tissue repair.Activated microglia contribute to neuroinflammation through cytokine release and disruption of the blood-brain barrier,while simultaneously promoting tissue repair through anti-inflammatory responses and regeneration.Key pathways influencing microglial activation include Toll-like receptor 4/nuclear factor kappa B,mitogen-activated protein kinases,Janus kinase/signal transducer and activator of transcription,and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathways.These pathways are targets for various experimental therapies aimed at promoting M2 polarization and mitigating damage.Potential therapeutic agents include natural compounds found in drugs such as minocycline,as well as traditional Chinese medicines.Drugs that target these regulatory mechanisms,such as small molecule inhibitors and components of traditional Chinese medicines,along with emerging technologies such as single-cell RNA sequencing and spatial transcriptomics,offer new therapeutic strategies and clinical translational potential for ischemic stroke.
文摘This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although the rural revitalization strategy has achieved significant results in improving residents’quality of life,promoting agricultural modernization,it still faces challenges such as severe loss of human resources,insufficient agricultural technological innovation,and backward infrastructure construction.In response to these challenges,this paper proposes optimization strategies from three aspects:strengthening rural education and talent team construction,promoting agricultural technology innovation and achievement transformation,and increasing investment in rural infrastructure construction.
文摘Dove’s 2017 advertising incident,which sparked widespread debate regarding perceived cultural insensitivity,highlighted a disconnect between the brand’s“Real Beauty”positioning and public reception.In response,this study proposes a strategic digital recovery framework,including revised campaign content,transparent communication through social media,and data-driven customer segmentation based on diverse skincare needs and cultural backgrounds.A PESTLE analysis underscores the importance of digital transformation and rising social consciousness in brand management.Findings suggest that inclusive messaging,precision targeting,and omnichannel digital engagement are key to restoring brand trust and reputation in the digital landscape.
基金the support from Base for Interdisciplinary Innovative Talent Training,Shanghai Jiao Tong UniversityYouth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine。
文摘Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practice show poor targeting,rapid drug clearance from the circulatory system,and low therapeutic efficiency.Therefore,in this review,we have first described the mechanisms underlying nerve regeneration,characterized the biomaterials used for drug delivery to facilitate nerve regeneration,and highlighted the functionalization strategies used for such drug-delivery systems.These systems mainly use natural and synthetic polymers,inorganic materials,and hybrid systems with advanced drug-delivery abilities,including nanoparticles,hydrogels,and scaffoldbased systems.Then,we focused on comparing the types of drug-delivery systems for neural regeneration as well as the mechanisms and challenges associated with targeted delivery of drugs to facilitate neural regeneration.Finally,we have summarized the clinical application research and limitations of targeted delivery of these drugs.These biomaterials and drug-delivery systems can provide mechanical support,sustained release of bioactive molecules,and enhanced intercellular contact,ultimately reducing cell apoptosis and enhancing functional recovery.Nevertheless,immune reactions,degradation regulation,and clinical translations remain major unresolved challenges.Future studies should focus on optimizing biomaterial properties,refining delivery precision,and overcoming translational barriers to advance these technologies toward clinical applications.
文摘Four distinct coordination polymers(CPs)were successfully synthesized by altering solvent types and adjusting ligand concentrations,and their crystal structures were investigated.[Co(L)(FDCA)(H_(2)O)_(2)]·0.5H_(2)O(1)was synthesized as a 2D structure using Coas the metal source,methanol‑water(4∶6,V/V)as the solvent,and specific concentrations of 2,5‑furandicarboxylic acid(H_(2)FDCA)and 1,3,5‑triimidazole benzene(L).Adjusting to pure water and lowering the concentration of L yielded the 1D chain structure of[Co(HL)2(H_(2)O)_(2)](FDCA)_(2)·6H_(2)O(2).Using Cu(Ⅱ)as the metal source,methanol/water(9∶1,V/V)as the solvent,and specific concentrations of L and H2FDCA,the 1D chain structure of[Cu(L)(FDCA)(H_(2)O)]·2H_(2)O(3)was synthesized.Upon increasing the concentrations of L and H2FDCA,and switching the solvent to pure water,the 1D chain structure of[Cu(HL)_(2)(H_(2)O)_(2)](FDCA)_(2)·6H_(2)O(4)was obtained.This shows that changing the solvent and ligand concentrations can affect the structural changes of CPs.In addition,the solid‑state photoluminescence of CPs 1‑4 at room temperature was studied,and their morphological changes were observed via scanning electron microscopy.Density functional theory calculations revealed that the negative charge concentrates on the O and N atoms of the ligand,facilitating ligand‑metal ion coordination.CCDC:2403934,1;2403935,2;2403936,3;2403938,4.
文摘Fifty-five-year-old Shi Yizhong never imagined fireflies could become the foundation of a serious business.In 2022,Longshan Village in Huzhou’s Wuxing District collaborated with a young entrepreneurial team to create a firefly campsite-a natural attraction where visitors can observe these glowing insects in a preserved habitat.The site quickly drew waves of tourists,who shared their experience online,recouping its initial investment in just two years.
基金supported by the Natural Science Foundation of China(No.52470105)the Young Taishan Scholars Program of Shandong Province(No.358202103017).
文摘The discharge of micro-polluted water from sources such as agricultural runoff,urban stormwater,and treated effluents presents significant challenges to aquatic ecosystems.Constructed wetlands(CWs)have gained recog-nition as an eco-friendly solution for removing pollutants from various wastewater sources and are increasingly applied for micro-polluted water treatment.By reviewing 78 full-scale CW studies from Web of Science,it is summarized that the ranges of ammonium nitrogen(NH4+-N)concentrations in runoff,wastewater treatment plant effluent and polluted river were 0.1–6.6,0.3–12.3,and 0.2–41.1 mg/L,respectively.The ranges of ni-trate nitrogen concentrations were 0.2–14.2,0–5.7,and 0–2.6 mg/L,respectively.Removal efficiencies of CWs for micro-polluted water varied by CW types.The total nitrogen removal efficiencies for subsurface-flow CWs,free-water surface-flow CWs,and hybrid CWs ranged from 27.4%to 66.5%,16.8%to 89.8%,and 19.4%to 88.2%,respectively.The NH4+-N removal efficiencies ranged from 34.2%to 73.6%,38.4%to 89.4%and 13.5%to 94.2%,respectively.Additionally,other factors influencing contaminant removal efficiency such as hydraulic retention time,vegetation types,redox micro-environment and influent water quality were evaluated.Based on these findings,two strategies for improving the purification performance of CWs were proposed:the selection of incorporating electron donor substrates and the optimization of operation parameters.This paper serves as a synthesis of information to guide future research and full-scale CW applications in micro-polluted water treatment.
文摘The iterative continuation task(ICT)requires English as a foreign language(EFL)learners to read a segment and write a continuation that aligns with the preceding segment of an English novel with successive turns,offering exposure to diverse grammatical structures and opportunities for contextualized usage.Given the importance of integrating technology into second language(L2)writing and the critical role that grammar plays in L2 writing development,automated written corrective feedback provided by Grammarly has gained significant attention.This study investigates the impact of Grammarly on grammar learning strategies,grammar grit,and grammar competence among EFL college students engaged in ICT.This study employed a mixed-methods sequential exploratory design;56 participants were divided into an experimental group(n=28),receiving Grammarly feedback for ICT,and a control group(n=28),completing ICT without Grammarly feedback.Quantitative results revealed that both groups showed improvements in L2 grammar learning strategies,grit and competence.For the experimental group,significant differences were observed across all variables of L2 grammar learning strategies,grit,and competence between pre-and post-tests.For the control group,significant differences were only observed in the affective dimension of grammar learning strategies,Consistency of Interest(COI)of grammar grit,and grammar competence.However,the control group presented a significantly higher improvement in grammar competence.Qualitative analysis showed both positive and negative perceptions of Grammarly.The pedagogical implications of integrating Grammarly and ICT for L2 grammar development are discussed.
文摘Conventional locking/release mechanisms often face challenges in aircraft wing separation processes,such as excessive impact loads and insufficient synchronization.These may cause structural damage to the airframe or attitude instability,seriously compromising mission reliability.To address this engineering challenge,this paper proposes a multi-point low-impact locking/release mechanism based on the mobility model and energy conversion strategy.Through establishing a DOF constraint framework system,this paper systematically analyzes the energy transfer and conversion characteristics during the wing separation process,reveals the generation mechanism of impact loads,and conducts research on low-impact design based on energy conversion strategy.Building on this foundation,a single-point locking/release mechanism employing parallel trapezoidal key shaft structure was designed,which increases frictional contact time and reduces the energy release rate,thereby achieving low-impact characteristics.The mechanism's performance was validated through physical prototype development and systematic functional testing(including unlocking force,synchronization,and impact tests).Experimental results demonstrate:(1)Under 14 kN preload condition,the maximum unlocking force was only 92.54 N,showing a linear relationship with preload that satisfies the"strong-connection/weak-unlock"design requirement;(2)Wing separation was completed within 46 ms,with synchronization time difference among three separation mechanisms stably controlled within 12-14 ms,proving rapid and reliable operation;(3)The unlocking impact acceleration ranged between 26 and 73 g,below the 100 g design limit,confirming the effectiveness of the energy conversion strategy.The proposed low-impact locking/release mechanism design method based on energy conversion strategy resolves the traditional challenges of high impact and synchronization deficiencies.The synergistic optimization mechanism of"structural load reduction and performance improvement"provides a highly reliable technical solution for wing separable mechanisms while offering novel design insights for wing connection/separation systems engineering.
基金supports from the National Natural Science Foundation of China(Grant Nos.12305372 and 22376217)the National Key Research&Development Program of China(Grant Nos.2022YFA1603802 and 2022YFB3504100)+1 种基金the projects of the key laboratory of advanced energy materials chemistry,ministry of education(Nankai University)key laboratory of Jiangxi Province for persistent pollutants prevention control and resource reuse(2023SSY02061)are gratefully acknowledged.
文摘Using photoelectrocatalytic CO_(2) reduction reaction(CO_(2)RR)to produce valuable fuels is a fascinating way to alleviate environmental issues and energy crises.Bismuth-based(Bi-based)catalysts have attracted widespread attention for CO_(2)RR due to their high catalytic activity,selectivity,excellent stability,and low cost.However,they still need to be further improved to meet the needs of industrial applications.This review article comprehensively summarizes the recent advances in regulation strategies of Bi-based catalysts and can be divided into six categories:(1)defect engineering,(2)atomic doping engineering,(3)organic framework engineering,(4)inorganic heterojunction engineering,(5)crystal face engineering,and(6)alloying and polarization engineering.Meanwhile,the corresponding catalytic mechanisms of each regulation strategy will also be discussed in detail,aiming to enable researchers to understand the structure-property relationship of the improved Bibased catalysts fundamentally.Finally,the challenges and future opportunities of the Bi-based catalysts in the photoelectrocatalytic CO_(2)RR application field will also be featured from the perspectives of the(1)combination or synergy of multiple regulatory strategies,(2)revealing formation mechanism and realizing controllable synthesis,and(3)in situ multiscale investigation of activation pathways and uncovering the catalytic mechanisms.On the one hand,through the comparative analysis and mechanism explanation of the six major regulatory strategies,a multidimensional knowledge framework of the structure-activity relationship of Bi-based catalysts can be constructed for researchers,which not only deepens the atomic-level understanding of catalytic active sites,charge transport paths,and the adsorption behavior of intermediate products,but also provides theoretical guiding principles for the controllable design of new catalysts;on the other hand,the promising collaborative regulation strategies,controllable synthetic paths,and the in situ multiscale characterization techniques presented in this work provides a paradigm reference for shortening the research and development cycle of high-performance catalysts,conducive to facilitating the transition of photoelectrocatalytic CO_(2)RR technology from the laboratory routes to industrial application.
基金National Key Research and Development Program of China under Grant No.2023YFC3805201Scientific Research Fund of Institute of Engineering Mechanics,China Earthquake Administration under Grant Nos.2024B29 and 2024B25。
文摘Following a magnitude M 7.9 earthquake that struck near Mandalay,Myanmar in March 2025,this study investigates the seismic damage inflicted upon the city’s municipal water supply system.The analysis focuses on the failure characteristics of water facilities and pipelines,examines cross-system cascading effects,and proposes corresponding recovery strategies.The main findings are as follows:(1)The damage to water plant facilities,concentrated in ancillary structures and connections due to insufficient seismic measures,demonstrated significant intensity-dependence.Increased seismic intensity not only aggravated structural damage but also compromised core treatment processes,leading to deteriorated water quality.(2)Within the same seismic intensity zone,high-density polyethylene(HDPE)pipes exhibited a significantly lower damage occurrence rate than ductile iron(DI)pipes,highlighting the material’s substantial influence on seismic performance.Moreover,a strong positive correlation was observed between the overall pipeline network damage and the seismic intensity.The average damage rate in IntensityⅨzones was 6.84 times that of IntensityⅧzones.(3)A cascading failure,initiated by a power outage,led to water supply disruption,loss of emergency response capability,and elevated secondary risks.This strongly coupled cross-system effect resulted in significant spatiotemporal propagation of disaster impacts.(4)The post-earthquake recovery adopted a phased strategy that prioritized critical facilities.Actions involved rapidly restoring the core supply zone with temporary points,reinstating the water plant’s power supply,and deploying targeted technologies for efficient pipeline repair.The outcomes of this study are expected to provide critical support and a valuable reference for developing earthquake-resilient urban water supply systems.
基金financial supports from the National Natural Science Foundation of China (Grant Nos. 41461040, 41601614, 41601176)the Fundamental Research Funds for the Central Universities (JBK2102018)the Sichuan Center for Rural Development Research (CR2107, Mechanism of Farmers’ Livelihoods on Ecological Security in Ethnic Regions in Sichuan Province)。
文摘Social capital in the form of social resources or social networks is one of the most important livelihood capital of farmers, which can increase the labor productivity of poor households and increase income. It is important to explore the reasons underlying the livelihood strategy choices of farmers from the perspective of social capital under China’s rural revitalization strategy. In this study, the Liangshan Yi Autonomous Prefecture, a povertystricken mountainous area in southwestern China, was selected as the case study area, and multivariable linear regression models were constructed to analyze the influence of social capital on livelihood strategies.The results are as follows:(1) Individual social capital had a positive effect on non-agricultural livelihood strategies. On average, with a one-unit increase in individual social capital, the ratio of farmers’ nonagricultural income to total productive income(Income_Rto) increased by 0.002% and 0.062%,respectively. Collective social capital, with the Peasant Economic Cooperation Organization(PECO) as the carrier, had a negative effect on the non-agricultural livelihood strategies of farmers;on average, with a oneunit increase in PECO, Income_Rto decreased by approximately 0.053%. However, this effect was only significant in the river valley area.(2) The income differences among the different livelihood strategy types were explained by the livelihood strategy choices of farmers. As non-agricultural work can bring more benefits, the labor force exhibited one-way migration from villages to cities, resulting in a lack of the subject of rural revitalization. It is necessary to implement effective measures to highlight the role of PECO in increasing agricultural income for farmers. Finally,based on the above conclusions,policy recommendations with respect to livelihood transformation of farmers and rural sustainable development are discussed.
文摘Since confidence is fading and anxiety is increasing in the US,America’s China policy has become more radical. In the short term, the US has the upper hand and China is in a relatively passive position. In the medium-and long-term, there will be more balance between them. This current strategic gambling between China and the US will be the major issue of international politics in the first half of the 21 st century and the most prominent external challenge China faces. China needs to make strategic adjustments but the gamble may be worthwhile in correcting imbalance in the international order and in the co-evolution of the two countries.
基金This work was supported by National Natural Science Fund of China (70102007/G0202)
文摘With the entry to WTO and development of IT, banks in China are adjusting their competitive strategies to meet the competition. Internet banking has become a kind of strategic choice to response to the entry to WTO. Based on relevantly selective reviews of literature of strategy theory and research, a model is developed to study banks' strategic response to entry to WTO. According to a survey of 192 sets of questionnaires, this study finds that external pressure, business strategy and perceived benefits of Internet banking would influence banks' perceived increase in Internet banking investment. And banks' perceived increase in Internet banking investment has no difference between big banks and small banks.
文摘Building a technology alliance is the main strategy for the United States to maintain its scientific and technological hegemony under its technopolitical strategic framework.After Joe Biden took office,the United States implemented“small yard with high fences”strategy for scientific and technological competition,as the first step toward building a technology alliance.The main goal is to restrict the flow of strategic emerging technologies and factors of innovation to rival countries.
文摘Aiming to reveal the university students＇ understanding in management as for the strategy and strategic management phenomena, this study accomplishes a phenomenographic research to assess the future managers＇ market perception. It was chosen university students in Management of a Portuguese University. We conclude that the strategy definitions obtained are an assembly of the diverse existing concepts. Concerning to strategic management it was perceived an approach with one of the main existing concepts. The findings raise interesting issues with respect to the difficulties felt by new managers in translating their theoretical definitions in real examples in the organizations.
文摘The key argument of this conceptual paper is that the roots of a viable future for an organisation are found in a robust strategic architecture perspective.The theoretical baselines for the concepts associated with this paper are linked to a variety of strategy theories.These include,but are not restricted to,institutional theory,strategic thinking relating to the positioning-based view(PBV)and resource-based view(RBV)respectively,entrepreneurial thinking,and innovation thinking.Strategy can be described as the collective,emerging pattern—based on strategic choices—an organisation consciously exhibits and executes over time to ensure its sustainable endurance by differentiating itself in unique ways to create and add value for stakeholders.Strategy is about explaining how an organisation wants to move forward and how it wants to advance the interests of stakeholders.A strategic landscape is the broad external and internal context of an organisation.An important part of strategy and the strategic landscape it operates in is how organisations define or“construct”their own“topography”or strategic architecture.A strategic architecture presents an organisation?s core logic for creating sustainable value,and therefore,forms the foundation of an organisation?s competitive potential in a specific context.This paper presents descriptions of the seven key buildings blocks that constitute a strategic architecture perspective for an organisation with an indication of strategy tools and frameworks that can be used to illuminate strategic possibilities,choices,and challenges to assist ongoing strategising praxis.The key features and assumptions associated with a strategic architecture perspective are discussed.A strategic architecture perspective assists leaders to work through the strategic complexity to arrive at simplicity in the form of clarity on external and internal strategic leverages,strategic aspirations,core strategic choices,plausible multiple scenarios,focused strategic goals,and success measurements to guide strategy execution and ongoing strategy renewal and innovations for proactive strategic decision-making through various dialogues with key stakeholders.
基金supported by a Horizontal Project on the Development of a Hybrid Energy Storage Simulation Model for Wind Power Based on an RT-LAB Simulation System(PH2023000190)the Inner Mongolia Natural Science Foundation Project and the Optimization of Exergy Efficiency of a Hybrid Energy Storage System with Crossover Control for Wind Power(2023JQ04).
文摘Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy sources.This paper proposes a wind-solar hybrid energy storage system(HESS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOC)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,respectively.MATLAB/Simulink was used for simulation test.The optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 yuan.Additionally,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations significantly.The proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.
文摘In July 2021,Russia unveiled its new National Security Strategy,which is a considerably updated version compared with the previous one and hence presents several new features.For instance,it further stresses that security should be prioritized over other aspects;it gives more attention to the chaotic aspects of order change in its assessment of the international situation;it highlights the threats from the West;and it places increased emphasis on domestic capacity building as a means for safeguarding national security.From the content of the new Strategy as well as Russia’s policies in recent years,the strategy of Russia for the foreseeable future can be generally characterized as inward-looking.Domestically,its policies will become more conservative;diplomatically,it will take up a defensive position;and economically,it will increasingly emphasize security and selfreliance.In other words,several issues that were previously overlooked will be given attention.However,strategic introversion does not mean that Russia will invest all its energy in defense.Instead,Russia will build up strength for changes that lie ahead.With the expected strategic introversion,Russia will fnd difculty in making breakthroughs in terms of its relations with the West;the China-Russia relations will continue on the path of steady development;and Russia will place greater importance to the balance of power among major countries.
