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Wake-Up Security:Effective Security ImprovementMechanism for Low Power Internet of Things 被引量:2
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作者 Sun-Woo Yun Na-Eun Park Il-Gu Lee 《Intelligent Automation & Soft Computing》 SCIE 2023年第9期2897-2917,共21页
As time and space constraints decrease due to the development of wireless communication network technology,the scale and scope of cyber-attacks targeting the Internet of Things(IoT)are increasing.However,it is difficu... As time and space constraints decrease due to the development of wireless communication network technology,the scale and scope of cyber-attacks targeting the Internet of Things(IoT)are increasing.However,it is difficult to apply high-performance security modules to the IoT owing to the limited battery,memory capacity,and data transmission performance depend-ing on the size of the device.Conventional research has mainly reduced power consumption by lightening encryption algorithms.However,it is difficult to defend large-scale information systems and networks against advanced and intelligent attacks because of the problem of deteriorating security perfor-mance.In this study,we propose wake-up security(WuS),a low-power security architecture that can utilize high-performance security algorithms in an IoT environment.By introducing a small logic that performs anomaly detection on the IoT platform and executes the security module only when necessary according to the anomaly detection result,WuS improves security and power efficiency while using a relatively high-complexity security module in a low-power environment compared to the conventional method of periodically exe-cuting a high-performance security module.In this study,a Python simulator based on the UNSW-NB15 dataset is used to evaluate the power consumption,latency,and security of the proposed method.The evaluation results reveal that the power consumption of the proposed WuS mechanism is approxi-mately 51.8%and 27.2%lower than those of conventional high-performance security and lightweight security modules,respectively.Additionally,the laten-cies are approximately 74.8%and 65.9%lower,respectively.Furthermore,the WuS mechanism achieved a high detection accuracy of approximately 96.5%or greater,proving that the detection efficiency performance improved by approximately 33.5%compared to the conventional model.The performance evaluation results for the proposed model varied depending on the applied anomaly-detection model.Therefore,they can be used in various ways by selecting suitable models based on the performance levels required in each industry. 展开更多
关键词 Internet of Things SECURITY anomaly detection low-power architecture energy efficiency wake-up security
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GROUND BOUNCING NOISE REDUCTION TECHNIQUE CONSIDERING WAKE-UP DELAY IN MTCMOS CIRCUITS 被引量:1
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作者 Tian Xi Wang Yu Dong Zaiwang 《Journal of Electronics(China)》 2011年第4期596-601,共6页
Multi-Threshold CMOS(MTCMOS) is an effective technique for controlling leakage power with low delay overhead.However the large magnitude of ground bouncing noise induced by the sleep to active mode transition may caus... Multi-Threshold CMOS(MTCMOS) is an effective technique for controlling leakage power with low delay overhead.However the large magnitude of ground bouncing noise induced by the sleep to active mode transition may cause signal integrity problem in MTCMOS circuits.We propose a methodology for reducing ground bouncing noise under the wake-up delay constraint.An improved two-stage parallel power gating structure that can suppress the ground bouncing noise through turn on sets of sleep transistors consecutively is proposed.The size of each sleep transistor is optimized by a novel sizing algorithm based on a simple discharging model.Simulation results show that the proposed techniques achieve at least 23% improvement in the product of the peak amplitude of ground bouncing noise and the wake-up time when compared with other existing techniques. 展开更多
关键词 Ground bouncing noise Multi-Threshold CMOS(MTCMOS) wake-up time Low leakage
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A 2.1 μA WAKE-UP CIRCUIT FOR CHINESE ETC SYSTEM
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作者 Zhu Wenrui Zhang Dandan +2 位作者 Gao Tongqiang Liu Fei Yang Haigang 《Journal of Electronics(China)》 2013年第3期308-312,共5页
This paper proposes a low power wake-up baseband circuit used in Chinese Electronic Toll Collection (ETC) system. To reduce the static power consumption, a low power biasing strategy is proposed. The proposed circuit ... This paper proposes a low power wake-up baseband circuit used in Chinese Electronic Toll Collection (ETC) system. To reduce the static power consumption, a low power biasing strategy is proposed. The proposed circuit is fabricated in TSMC 0.18 μm technology with an area of 0.09 mm 2 . Its current consumption is only 2.1 μA under 1.8 V power supply. It achieves a sensitivity of 0.95 mV at room temperature with a variation of only ±28% over -35℃ to 105℃. 展开更多
关键词 wake-up Electronic Toll Collection (ETC) Low Power
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RESEARCH AND APPLICATION OF LF WAKE-UP TECHNOLOGY TO MICRO-POWER ACTIVE RFID
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作者 CAO SHIHUA ZHAO FANG 《微计算机信息》 北大核心 2008年第2期232-234,共3页
Tags of micro-power active RFID system are usually supllied by cells battery,the power consumption is a crucial factor.The currently applied operating mode is of timing wake-up.In this paper,presented the method of LF... Tags of micro-power active RFID system are usually supllied by cells battery,the power consumption is a crucial factor.The currently applied operating mode is of timing wake-up.In this paper,presented the method of LF wake-up technology,discussed how to use it to solve the low-power problem of active RFID tag.Put forward the crucial electrocircuit and working program flow.Practices show that this solution is capable of solving the problem of low-power of active RFID. 展开更多
关键词 LF wake-up active RFID TAG MICRO-POWER
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A Low Power Non-Volatile LR-WPAN Baseband Processor with Wake-Up Identification Receiver
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作者 YU Shuangming FENG Peng WU Nanjian 《China Communications》 SCIE CSCD 2016年第1期33-46,共14页
The paper proposes a low power non-volatile baseband processor with wake-up identification(WUI) receiver for LR-WPAN transceiver.It consists of WUI receiver,main receiver,transmitter,non-volatile memory(NVM) and power... The paper proposes a low power non-volatile baseband processor with wake-up identification(WUI) receiver for LR-WPAN transceiver.It consists of WUI receiver,main receiver,transmitter,non-volatile memory(NVM) and power management module.The main receiver adopts a unified simplified synchronization method and channel codec with proactive Reed-Solomon Bypass technique,which increases the robustness and energy efficiency of receiver.The WUI receiver specifies the communication node and wakes up the transceiver to reduce average power consumption of the transceiver.The embedded NVM can backup/restore the states information of processor that avoids the loss of the state information caused by power failure and reduces the unnecessary power of repetitive computation when the processor is waked up from power down mode.The baseband processor is designed and verified on a FPGA board.The simulated power consumption of processor is 5.1uW for transmitting and 28.2μW for receiving.The WUI receiver technique reduces the average power consumption of transceiver remarkably.If the transceiver operates 30 seconds in every 15 minutes,the average power consumption of the transceiver can be reduced by two orders of magnitude.The NVM avoids the loss of the state information caused by power failure and energy waste caused by repetitive computation. 展开更多
关键词 LR-WPAN wake-up identification receiver synchronization non-volatile memory baseband processor digital integrated circuit low power chip design
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An Energy-Efficient Duty-Cycled Wake-Up Radio Protocol for Avoiding Overhearing in Wireless Sensor Networks
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作者 Jean Mickael Lebreton Somasekhar Kandukuri +1 位作者 Nour Murad Richard Lorion 《Wireless Sensor Network》 2016年第8期176-190,共15页
Wake-up radio (WuR) system is often presented as the best candidate for replacing traditional duty cycled Medium Access Control (MAC) protocols in Wireless Sensor Networks (WSNs). The Double Radio (DoRa) protocol is a... Wake-up radio (WuR) system is often presented as the best candidate for replacing traditional duty cycled Medium Access Control (MAC) protocols in Wireless Sensor Networks (WSNs). The Double Radio (DoRa) protocol is a new MAC protocol for in-band WuR system with addressing capabilities. While the DoRa protocol improves the WSNs energy efficiency, it still suffers from an overhearing problem when the WuR system is very often requested. The WuR wastes a noticeable amount of energy when overhearing to wake-up demand intended to other nodes, but it is neither measured nor solved in other works. In this paper, an adaptive duty-cycled DoRa (DC-DoRa) is then proposed to solve the overhearing problem. The primary concept of the work is to enable the WuR functionality before the node is addressed and to disable the WuR after the node sent data. Extensive simulations under OMNeT++ using real input parameters are then performed to show the significant energy-savings through the two protocols and the nearly suppression of overhearing with DC-DoRa. In fact, the mean power consumption is three-order below using the DoRa protocol compared to traditional MAC protocols. While overhearing can represent up to 93% of the WuR energy consumption with the DoRa protocol, it is reduced to only 1% with the DC-DoRa protocol. 展开更多
关键词 Wireless Sensor Networks wake-up Radio MAC Protocol Energy Efficiency Duty Cycling
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Esophageal nasopharyngeal catheter in the wake-up anesthesia of the brain function area operations
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作者 蔡铁良 《外科研究与新技术》 2011年第3期219-220,共2页
Objective To evaluate the feasibility and safety of the self developed sound outside the ventilation device-esophageal nasopharynx catheter in brain functional areas surgery applications. Methods 13 patients involved ... Objective To evaluate the feasibility and safety of the self developed sound outside the ventilation device-esophageal nasopharynx catheter in brain functional areas surgery applications. Methods 13 patients involved functional areas of brain surgery were chosed. After induction of general anesthesia,the catheters were placed in the esophagus,then connected to anesthesia machines to an external 展开更多
关键词 Esophageal nasopharyngeal catheter in the wake-up anesthesia of the brain function area operations area
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醒后卒中静脉溶栓患者预后影响因素及其预测模型构建
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作者 夏慧 姜爱钟 +4 位作者 林福军 张建明 周畅 任玲 张正生 《脑与神经疾病杂志》 2026年第2期85-90,共6页
目的分析醒后卒中静脉溶栓患者预后影响因素,并构建预测模型。方法回顾性纳入2023年1月至2025年1月东南大学附属中大医院收治的接受静脉溶栓治疗的醒后卒中患者193例,以治疗后90 d改良Rankin量表(mRS)评分分为预后良好组(mRS≤2分)、预... 目的分析醒后卒中静脉溶栓患者预后影响因素,并构建预测模型。方法回顾性纳入2023年1月至2025年1月东南大学附属中大医院收治的接受静脉溶栓治疗的醒后卒中患者193例,以治疗后90 d改良Rankin量表(mRS)评分分为预后良好组(mRS≤2分)、预后不良组(mRS>2分)。Logistic回归分析醒后卒中静脉溶栓患者预后影响因素,并建立Logistic回归方程模型,通过受试者工作作特征(ROC)曲线、校准曲线、决策曲线评价模型效能。结果Logistic回归分析结果显示,醒后卒中静脉溶栓患者预后的危险因素为年龄、美国国立卫生研究院卒中量表(NIHSS)评分、同型半胱氨酸(Hcy)、中性粒细胞与淋巴细胞比率(P<0.05)。根据变量回归系数构建Logistic回归预测模型,logit(P)=-26.404+0.064×年龄+0.671×NIHSS评分+2.326×中性粒细胞与淋巴细胞比率+0.325×Hcy。阈值取0.328时,约登指数最大值为0.880,此时模型预测醒后卒中静脉溶栓患者预后的ROC曲线下面积(AUC)为0.967。校正曲线、决策曲线分析预测模型具有良好一致性与净获益。结论在醒后卒中接受静脉溶栓治疗的患者中年龄、NIHSS评分、血清Hcy水平以及中性粒细胞与淋巴细胞比率是影响预后的关键危险因素。通过整合这些指标建立的Logistic回归预测模型具有良好的判别效能,能够为临床医师提供可靠的预后评估工具,指导个体化治疗决策的制定。 展开更多
关键词 醒后卒中 静脉溶栓 预后 预测模型
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Application of A-line autoregressive model with exogenous input index during the wake-up test in spinal surgery under propofol-remifentanil anaesthesia 被引量:1
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作者 YAO Wen-long WANG Xue-ren LI Bai-li GUI Ling-li ZHU Chang ZHANG Chuan-han 《Chinese Medical Journal》 SCIE CAS CSCD 2007年第11期1013-1016,共4页
Paraplegia is a rare but terrible complication following major spinal operation. Intraoperative monitoring should be used to detect the neurological compucauons early so that they can be surgically revised.1 The commo... Paraplegia is a rare but terrible complication following major spinal operation. Intraoperative monitoring should be used to detect the neurological compucauons early so that they can be surgically revised.1 The common procedures for spinal cord monitoring are intraoperative wake-up test and neurophysiological methods. The latter includes somatosensory evoked potentials (SSEP) and motor evoked potentials (MEP). The wake-up test has been routinely used to monitor voluntary motor function of the lower limbs during corrective spinal surgery. 展开更多
关键词 evoked potentials auditory spinal diseases PROPOFOL PIPERIDINES wake-up test
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A fully integrated CMOS super-regenerative wake-up receiver for EEG applications 被引量:2
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作者 毛怿奇 高同强 +2 位作者 许晓冬 杨海钢 蔡新霞 《Journal of Semiconductors》 EI CAS CSCD 2016年第9期82-87,共6页
A fully integrated super-regenerative wake-up receiver for wireless body area network applications is presented. The super-regeneration receiver is designed to receive OOK-modulated data from the base station. A low p... A fully integrated super-regenerative wake-up receiver for wireless body area network applications is presented. The super-regeneration receiver is designed to receive OOK-modulated data from the base station. A low power waveform generator is adopted both to provide a quench signal for VCO and to provide a clock signal for the digital module. The receiver is manufactured in 0.18 μm CMOS process and the active area is 0.67 mm^2.It achieves a sensitivity of -80 d Bm for 10^(-3)BER with a data rate of 200 kbps. The power consumption of the super-regenerative wake-up receiver is about 2.16 m W. 展开更多
关键词 super-regenerative receiver wake-up circuit EEG OOK CMOS
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基于振动唤醒与热疗的多功能智能睡枕装置的设计与实现
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作者 胡玉鑫 《自动化应用》 2026年第3期117-121,共5页
提出一种集成振动唤醒、温湿度监测、热敷理疗及头部保护功能的多功能睡枕装置。通过在睡枕本体内部设置振动器与振动控制传感器,结合电子显示屏实现定时振动唤醒,消除传统闹钟铃声对公共环境的干扰及健康隐患。同时,利用热敷控制器与... 提出一种集成振动唤醒、温湿度监测、热敷理疗及头部保护功能的多功能睡枕装置。通过在睡枕本体内部设置振动器与振动控制传感器,结合电子显示屏实现定时振动唤醒,消除传统闹钟铃声对公共环境的干扰及健康隐患。同时,利用热敷控制器与电热片组合实现颈项热敷,配合护头带与护目带的重力珠设计,提升睡眠舒适性与保健功能。实验数据表明,该装置的振动唤醒有效率达98.7%,热敷温度控制精度在±15℃范围内,用户满意度达到92.3%。 展开更多
关键词 振动唤醒 温湿度监测 热敷 智能睡枕 睡眠健康
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A baseband circuit for wake-up receivers with double-mode detection and enhanced sensitivity robustness 被引量:1
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作者 朱文锐 杨海钢 +3 位作者 高同强 刘飞 程小燕 张丹丹 《Journal of Semiconductors》 EI CAS CSCD 2013年第8期144-149,共6页
This paper proposes a baseband circuit for wake-up receivers with double-mode detection and enhanced sensitivity robustness for use in the electronic toll collection system.A double-mode detection method,including amp... This paper proposes a baseband circuit for wake-up receivers with double-mode detection and enhanced sensitivity robustness for use in the electronic toll collection system.A double-mode detection method,including amplitude detection and frequency detection,is proposed to reject interference and reduce false wake-ups.An improved closed-loop band-pass filter and a DC offset cancellation technique are also newly introduced to enhance the sensitivity robustness.The circuit is fabricated in TSMC 0.18μm 3.3 V CMOS technology with an area of 0.12 mm2.Measurement results show that the sensitivity is -54.5 dBm with only a±0.95 dBm variation from the 1.8 to 3.3 V power supply,and that the temperature variation of the sensitivity is±1.4 dBm from -50 to 100℃. The current consumption is 1.4 to 1.7μA under a 1.8 to 3.3 V power supply. 展开更多
关键词 wake-up receiver double-mode detection DC offset cancellation
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双侧猎人弓综合征致反复后循环梗死一例并文献复习
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作者 张隽 张欢 +4 位作者 王平平 王媛 杨亭 马青峰 吴隆飞 《中国脑血管病杂志》 北大核心 2025年第9期631-635,共5页
猎人弓综合征又称旋转性椎动脉闭塞综合征,是后循环梗死的罕见病因。作者报道1例双侧猎人弓综合征致反复后循环梗死的青年男性患者,经颈动脉超声证实,患者转颈时双侧椎动脉血流速度明显降低,头部高分辨率MR血管成像及头颈部CT血管成像... 猎人弓综合征又称旋转性椎动脉闭塞综合征,是后循环梗死的罕见病因。作者报道1例双侧猎人弓综合征致反复后循环梗死的青年男性患者,经颈动脉超声证实,患者转颈时双侧椎动脉血流速度明显降低,头部高分辨率MR血管成像及头颈部CT血管成像示左侧椎动脉V3段存在夹层,提示猎人弓综合征可因椎动脉反复挤压内膜受损继发血栓形成致动脉-动脉栓塞性梗死。作者报道了该患者诊治过程并复习相关文献,以期提高临床医师对该罕见综合征的认识。 展开更多
关键词 猎人弓综合征 椎动脉夹层 动脉-动脉栓塞性梗死 醒后卒中 后循环梗死
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阿替普酶静脉溶栓治疗对组织窗内醒后脑卒中患者影响研究
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作者 夏慧 姜爱钟 +3 位作者 童慧 刘文 焦慧 张正生 《世界临床药物》 2025年第12期1255-1262,共8页
目的探究阿替普酶静脉溶栓治疗组织窗内醒后脑卒中(wake-up stroke,WUS)的临床价值。方法选取2023年7月至2025年1月我院神经内科收治的WUS患者,随机分为3组,每组36例。对照组(C组)行常规药物治疗,标准剂量组(B组)行0.9 mg/kg阿替普酶静... 目的探究阿替普酶静脉溶栓治疗组织窗内醒后脑卒中(wake-up stroke,WUS)的临床价值。方法选取2023年7月至2025年1月我院神经内科收治的WUS患者,随机分为3组,每组36例。对照组(C组)行常规药物治疗,标准剂量组(B组)行0.9 mg/kg阿替普酶静脉溶栓治疗,小剂量组(A组)行0.6 mg/kg阿替普酶静脉溶栓治疗。对比各组美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、临床疗效、出血状况、凝血功能、血小板计数(platelet count,PLT)、转归状况及不良反应。结果治疗后24 h、7 d、14 d、30 d,A、B组NIHSS评分低于C组(均P<0.05);A、B组治疗总有效率均高于C组(均P<0.05)。治疗前和治疗后24 h、7 d,各组凝血酶原时间、活化部分凝血活酶时间、纤维蛋白原及PLT水平比较无显著差异(均P>0.05)。治疗后90 d,各组颅内、消化道及泌尿系统、口腔及皮肤黏膜出血率情况无显著差异(均P>0.05);A、B组转归良好率、改良Barthel指数评分、蒙特利尔认知评估量表评分均高于C组(均P<0.05);各组药物不良反应总发生率相比无显著差异(均P>0.05)。结论小剂量阿替普酶静脉溶栓治疗组织窗内WUS可达到与标准剂量类似疗效,明显改善神经功能,促进良好转归,并且对出血影响较小。 展开更多
关键词 醒后脑卒中 组织窗 阿替普酶 静脉溶栓 小剂量
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醒脑开窍、补肾健脾养心针法治疗儿童全面性发育迟缓的疗效研究 被引量:1
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作者 孙攀 赵云霞 +3 位作者 张杨萍 庞中良 高永强 朱登纳 《吉林中医药》 2025年第2期234-238,共5页
目的观察全面性发育迟缓患儿实施醒脑开窍、补肾健脾养心针法治疗的效果。方法选取GDD住院患儿82例,随机分为对照组和试验组,各41例,2组各脱落3例,最终2组各纳入38例。对照组行常规康复治疗,试验组在此基础上增加实施醒脑开窍、补肾健... 目的观察全面性发育迟缓患儿实施醒脑开窍、补肾健脾养心针法治疗的效果。方法选取GDD住院患儿82例,随机分为对照组和试验组,各41例,2组各脱落3例,最终2组各纳入38例。对照组行常规康复治疗,试验组在此基础上增加实施醒脑开窍、补肾健脾养心针法。对2组患儿治疗前后应用Gesell发育量表、Peabody 2运动发育评估量表、婴儿-初中生社会生活能力量表进行疗效评估。结果治疗后2组精细运动、大运动、语言、适应性、个人-社交发育商(developmental quotient,DQ)及精细运动商(fine motor quotient,FMQ)、粗大运动商(gross motor quotient,GMQ)、总体运动商(total motor quotient,TMQ)和自我管理、独立生活、作业操作、参加集体活动、运动、交往评分均较治疗前提高(P<0.05),试验组大运动、语言、适应性、个人-社交DQ及FMQ、GMQ、TMQ和自我管理、独立生活、作业操作、运动评分较对照组更高(P<0.05),而2组精细运动DQ和参加集体活动、交往评分比较不存在统计学差异(P>0.05)。结论醒脑开窍、补肾健脾养心针法可改善GDD患儿智力发育、运动功能及社会生活能力。 展开更多
关键词 全面性发育迟缓 儿童 醒脑开窍 补肾 健脾 养心 针刺
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一种16 nW低功耗0. 4 V低电压无线唤醒接收机
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作者 张宇航 韦保林 +2 位作者 韦雪明 徐卫林 段吉海 《微电子学》 北大核心 2025年第4期556-562,共7页
针对无线接收机的灵敏度与功耗折中问题,设计了一种超低功耗包络检波(ED)前置结构的唤醒接收机。在对该结构唤醒接收机的灵敏度制约机制进行分析的基础上,引入一个高输入阻抗的无源差分包络检波器代替传统有源包络检波器,对其进行优化设... 针对无线接收机的灵敏度与功耗折中问题,设计了一种超低功耗包络检波(ED)前置结构的唤醒接收机。在对该结构唤醒接收机的灵敏度制约机制进行分析的基础上,引入一个高输入阻抗的无源差分包络检波器代替传统有源包络检波器,对其进行优化设计,降低系统功耗的同时提高接收灵敏度。采用65 nm CMOS工艺设计,仿真结果表明:在0.4 V供电电压及434 MHz载波频率、数据速率为200 bits/s的OOK信号驱动下,唤醒接收机的功耗为16 nW,灵敏度为-68dBm,相比于其他文献,在功耗基本相当的情况下实现了44.7%的灵敏度提高,在灵敏度与FoM值基本相当的情况下实现了43.3%的功耗降低。 展开更多
关键词 唤醒接收机 超低功耗 包络检波器
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基于时频检测的水声唤醒系统设计与实现
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作者 王容 周跃海 +1 位作者 童峰 陈东升 《声学技术》 北大核心 2025年第4期522-529,共8页
通常水下声学设备需要在水下长时间布放,由于水下能源供应十分有限,降低系统能耗、延长设备工作时间成为一个重要问题。针对声信号在水下传输受到双重选择性衰落和背景噪声带来的正确触发率低和误触发问题,使用国产芯片GD32F4xx设计和... 通常水下声学设备需要在水下长时间布放,由于水下能源供应十分有限,降低系统能耗、延长设备工作时间成为一个重要问题。针对声信号在水下传输受到双重选择性衰落和背景噪声带来的正确触发率低和误触发问题,使用国产芯片GD32F4xx设计和实现了一套基于时频检测的水声设备唤醒系统,用于控制唤醒模式和工作模式的切换。该系统可实时采集和处理信号,并通过不同地址码实现不同设备的独立唤醒。海试结果表明,此水声设备唤醒系统在距离1 km、平均信噪比为30 dB条件下,平均唤醒成功率达95.2%,误唤醒率为0,即使在−6 dB低信噪比条件下仍有60%唤醒成功率。 展开更多
关键词 水声唤醒系统 前置放大滤波电路 时频检测算法 GD32F4xx系统
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急性缺血性卒中发病时间评估的研究进展
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作者 池琦 赵颖 +6 位作者 韩东倩 张锶琪 杜沛洁 董琬玥 徐安定 杨振国 孟珩 《中国卒中杂志》 北大核心 2025年第4期493-499,共7页
急性缺血性卒中超急性期治疗的重点是再灌注治疗,且再灌注治疗具有严格的时间依赖性。而醒后卒中患者由于发病时间不明确,其再灌注治疗决策面临挑战。本文对急性缺血性卒中患者发病时间评估的研究进展进行综述,涵盖了基于昼夜节律、影... 急性缺血性卒中超急性期治疗的重点是再灌注治疗,且再灌注治疗具有严格的时间依赖性。而醒后卒中患者由于发病时间不明确,其再灌注治疗决策面临挑战。本文对急性缺血性卒中患者发病时间评估的研究进展进行综述,涵盖了基于昼夜节律、影像学和人工智能的评估方法,分析了不同方法评估急性缺血性卒中患者发病时间的效能,以期为醒后卒中患者再灌注治疗的选择提供支持依据。 展开更多
关键词 急性缺血性卒中 醒后卒中 发病时间 影像学 人工智能
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磁共振成像指导急性缺血性脑卒中静脉溶栓治疗效果的真实世界研究 被引量:2
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作者 谈毅 祝丽红 +2 位作者 尹增维 侯舒喃 俞厚明 《中国全科医学》 北大核心 2025年第20期2508-2515,共8页
背景缺血性脑卒中有较高致残率和致死率,部分患者发病时间难以确认,对这部分患者的治疗较为重要。目的探索基层医院在缺少CT灌注情况下,对于发病时间不明的急性缺血性脑卒中患者利用磁共振成像(MRI)的弥散加权成像(DWI)-液体衰减反转恢... 背景缺血性脑卒中有较高致残率和致死率,部分患者发病时间难以确认,对这部分患者的治疗较为重要。目的探索基层医院在缺少CT灌注情况下,对于发病时间不明的急性缺血性脑卒中患者利用磁共振成像(MRI)的弥散加权成像(DWI)-液体衰减反转恢复(FLAIR)不匹配指导静脉溶栓的有效性和安全性。方法回顾性选取2020年3月—2024年2月在杭州市临安区第一人民医院治疗的460例急性缺血性脑卒中患者为研究对象。排除大血管闭塞性病变,选择最后看起来正常时间>4.5 h以及发现症状到启动治疗<4.5 h的不明发病时间急性缺血性脑卒中患者,经MRI评估存在DWI/FLAIR不匹配,接受静脉溶栓治疗者纳入溶栓组;在明确时间窗为4.5 h内或不明发病时间急性缺血性脑卒中患者存在DWI/FLAIR不匹配可以静脉溶栓治疗而拒绝静脉溶栓治疗者纳入对照组。收集临床结局指标,包括早期神经功能、24 h美国国立卫生研究院卒中量表(NIHSS)评分、出血性转化、症状性颅内出血(sICH)及90 d改良Rankin量表(mRS)评分、90 d死亡情况,并记录阿替普酶过敏反应、转入重症监护病房(ICU)情况。比较两组治疗的有效性和安全性。采用单变量分析及多因素Logistic回归模型分析早期神经功能改善的影响因素。结果研究最终纳入溶栓组83例,其中男性51例(61.4%),平均年龄(70.1±12.4)岁;对照组55例,其中男性32例(58.2%),平均年龄(70.6±13.4)岁。溶栓组患者基线NIHSS评分高于对照组,症状识别-就诊时间长于对照组(P<0.05)。溶栓组患者早期神经功能改善率[50.6%(42/83)]高于对照组[23.6%(13/55)](P<0.05);两组患者24 h NIHSS评分、出血性转化发生率、SICH发生率比较,差异无统计学意义(P>0.05)。男性和女性在早期神经功能改善方面比较,差异无统计学意义[溶栓组:男性26例(61.9%)、女性16例(38.1%),χ^(2)=0.008,P>0.05,对照组:男性6例(46.2%)、女性7例(53.8%),χ^(2)=1.012,P>0.05]。多因素Logistic回归分析结果显示,静脉溶栓是早期神经功能改善的影响因素(OR=2.891,95%CI=1.319~6.337,P=0.008)。调整变量后结果显示,院前通知联合静脉溶栓是早期神经功能改善的影响因素(OR=6.938,95%CI=3.120~15.427,P<0.001)。结论在轻中度缺血性脑卒中伴无大血管病变的情况下,基层卒中中心利用MRI指导静脉溶栓可为不明发病时间的缺血性脑卒中患者提供短期益处,且实施院前通知可能更有利于患者早期神经功能恢复。 展开更多
关键词 卒中 醒后卒中 不明发病时间卒中 静脉溶栓 院前通知 磁共振成像 观察性研究
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ALB/Hcy比值与醒后卒中患者预后及交感神经兴奋性的相关性
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作者 连红亮 王静 +2 位作者 周慧 王相斌 尤素伟 《中国实用神经疾病杂志》 2025年第12期1482-1487,共6页
目的探讨白蛋白(ALB)/同型半胱氨酸(Hcy)比值与醒后卒中患者交感神经兴奋性的相关性,以及二者对患者预后的预测价值。方法回顾性选取2022-03—2025-02邯郸市中心医院收治的167例醒后卒中患者为研究对象,根据28 d预后情况分为不良组(58例... 目的探讨白蛋白(ALB)/同型半胱氨酸(Hcy)比值与醒后卒中患者交感神经兴奋性的相关性,以及二者对患者预后的预测价值。方法回顾性选取2022-03—2025-02邯郸市中心医院收治的167例醒后卒中患者为研究对象,根据28 d预后情况分为不良组(58例)、良好组(109例)。比较2组基线资料及ALB/Hcy比值、交感神经兴奋性,分析ALB/Hcy比值与交感神经兴奋性的相关性,醒后卒中患者预后的影响因素,以及各指标对醒后卒中预后的预测价值。结果不良组ALB/Hcy比值低于良好组,血压变异性、心率变异性、血糖变异性、血儿茶酚胺异常占比高于良好组(P<0.05)。血压变异性、心率变异性、血糖变异性、血儿茶酚胺异常患者ALB/Hcy比值低于正常患者,且各指标与ALB/Hcy比值呈负相关(P<0.05)。ALB/Hcy比值、血压变异性、心率变异性、血糖变异性、血儿茶酚胺异常均是醒后卒中预后的相关影响因素(P<0.05)。ALB/Hcy比值、血压变异性、心率变异性、血糖变异性、血儿茶酚胺异常联合预测患者预后的AUC值高于各指标单独检测(P<0.05)。结论ALB/Hcy比值与醒后卒中患者交感神经兴奋性有一定相关性,二者联合可为临床预测患者预后提供一定参考。 展开更多
关键词 醒后卒中 白蛋白/同型半胱氨酸比值 交感神经 预后 相关性 预测价值
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