Experimental and analytical investigations on the residual strength of the stiffened LY12CZ aluminum alloy panels with widespread fatigue damage （WFD） are conducted. Nine stiffened LY12CZ aluminum alloy panels with ...Experimental and analytical investigations on the residual strength of the stiffened LY12CZ aluminum alloy panels with widespread fatigue damage （WFD） are conducted. Nine stiffened LY12CZ aluminum alloy panels with three different types of damage are tested for residual strength. Each specimen is pre-cracked at rivet holes by saw cuts and subjected to a monotonically increasing tensile load until failure is occurred and the failure load is recorded. The stress intensity factors at the tips of the lead crack and the adjacent WFD cracks of the stiffened aluminum alloy panels are calculated by compounding approach and finite element method （FEM） respectively. The residual strength of the stiffened panels with WFD is evaluated by the engineering method with plastic zone linkup criterion and the FEM with apparent fracture toughness criterion respectively. The predicted residual strength agrees well with the experiment results. It indicates that in engineering practice these methods can be used for residual strength evaluation with the acceptable accuracy. It can be seen from this research that WFD can significantly reduce the residual strength and the critical crack length of the stiffened panels with WFD. The effect of WFD crack length on residual strength is also studied.展开更多
The westem slope of the Okinawa trough has been considered to experience important methane seep activities. Abundant terrigenous sediments supply and widely developed normal faults make this area an ideal place for me...The westem slope of the Okinawa trough has been considered to experience important methane seep activities. Abundant terrigenous sediments supply and widely developed normal faults make this area an ideal place for methane production, methane fluids migration and associated anaerobic oxidation of methane.展开更多
BACKGROUND Osteomalacia(OM)is frequently confused with various musculoskeletal or other rheumatic diseases,especially in patients with adult-onset widespread musculoskeletal pain because of its low prevalence and non-...BACKGROUND Osteomalacia(OM)is frequently confused with various musculoskeletal or other rheumatic diseases,especially in patients with adult-onset widespread musculoskeletal pain because of its low prevalence and non-specific manifestations.AIM To facilitate the early diagnosis and etiology-specific treatment of adult-onset hypophosphatemic OM.METHODS A retrospective review of medical records was performed to screen adult patients who visited a physiatry locomotive medicine clinic(spine and musculoskeletal pain clinic)primarily presenting with widespread musculoskeletal pain at a single tertiary hospital between January 2011 and December 2019.We enrolled patients with hypophosphatemia,high serum bone-specific alkaline phosphatase levels,and at least one imaging finding suggestive of OM.RESULTS Eight patients with adult-onset hypophosphatemic OM were included.The back was the most common site of pain.Proximal dominant symmetric muscle weakness was observed in more than half of the patients.Bone scintigraphy was the most useful imaging modality for diagnosing OM because radiotracer uptake in OM showed characteristic patterns.Six patients were diagnosed with adefovir(ADV)-induced Fanconi syndrome,and the other two patients were diagnosed with tumor-induced OM and light-chain nephropathy,respectively.After phosphorus and vitamin D supplementation and treatment for the underlying etiologies,improvements in pain,muscle strength,and gait were observed in all patients.CONCLUSION Mechanical pain characteristics,hypophosphatemia,and distinctive bone scintigraphy patterns are the initial diagnostic indicators of adult-onset hypophosphatemic OM.ADV-induced Fanconi syndrome is the most common etiology of hypophosphatemic OM in hepatitis B virus-endemic countries.展开更多
Widespread species that inhabit diverse environments possess large population sizes and exhibit a high capacity for environmental adaptation,thus enabling range expansion.In contrast,narrow-range species are confined ...Widespread species that inhabit diverse environments possess large population sizes and exhibit a high capacity for environmental adaptation,thus enabling range expansion.In contrast,narrow-range species are confined to restricted geographical areas and are ecologically adapted to narrow environmental conditions,thus limiting their ability to expand into novel environments.However,the genomic mechanisms underlying the differentiation between closely related species with varying distribution ranges remain poorly understood.The Niviventer niviventer species complex(NNSC),consisting of highly abundant wild rats in Southeast Asia and China,offers an excellent opportunity to investigate these questions due to the presence of both widespread and narrow-range species that are phylogenetically closely related.In the present study,we combined ecological niche modeling with phylogenetic analysis,which suggested that sister species cannot be both widespread and dominant within the same geographical region.Moreover,by assessing heterozygosity,linkage disequilibrium decay,and Tajima's D analysis,we found that widespread species exhibited higher genetic diversity than narrow-range species.In addition,by exploring the“genomic islands of speciation”,we identified 13 genes in highly divergent regions that were shared by the two widespread species,distinguishing them from their narrow-range counterparts.Functional annotation analysis indicated that these genes are involved in nervous system development and regulation.The adaptive evolution of these genes likely played an important role in the speciation of these widespread species.展开更多
Widespread hotels represent a new Italian phenomenon still not much investigated, both on theoretical and empirical side, which cannot be ignored anymore. Indeed they meet the need to implement techniques and manageme...Widespread hotels represent a new Italian phenomenon still not much investigated, both on theoretical and empirical side, which cannot be ignored anymore. Indeed they meet the need to implement techniques and management tools which are able to improve the culture-tourism binomial. This would permit to transform into valid instruments of national economical development, the shared declaration of intents for which culture and tourism, especially in Italy and in this particular fragile period, represent even more the main strategic levers for the sustainable development. This article intends to describe the potentiality of these widespread hotels as innovations particularly suitable with trends recently emerged in tourism sector and outline the phenomenon pattern in ltaly with particular attention on Umbria region, in order to identify his main strength and weakness and some innovation to improve performance. To this end, it starts from the analysis of the national and international economic-managerial literature concerning in particular cultural and experienced trends shown in tourism. Then it introduces the main acquisitions about widespread hotels in Italy, updating and extending them through a desk survey based on indirect sources of various natures. Lastly, it describes the case of Umbria, analyzing more in depth making use of interviews with entrepreneurs/managers of hotels and based on a semi-structured questionnaire. The aspects of indeterminateness which were found, starting from the normative one, testify how the potentiality of the widespread hotels as far as regards the value creation for the enterprise itself and the territorial stakeholder, are still not properly understood and therefore used. It is clear that, therefore, new behaviors are needed for entrepreneurs and, most importantly, for local policy makers in order to create the conditions for the full success of these hospitality models.展开更多
As is known, widespread fatigue damage （WFD） is a common phenomenon of aging aircraft being a negative impact on safety and reliability. The current FAR 25. 571 （b） requires that ＂An LOV （ Limit of Validi- ty） ...As is known, widespread fatigue damage （WFD） is a common phenomenon of aging aircraft being a negative impact on safety and reliability. The current FAR 25. 571 （b） requires that ＂An LOV （ Limit of Validi- ty） must be established, during which it is demonstrated that widespread fatigue damage will not occur in the air- craft structures＂. The FAA issued AC 91-82A in August 2011 providing guidance on developing and implemen- ting a Fatigue Management Program （FMP） system to address in-service issues for metallic fatigue critical struc- tures. This action brings new challenges to aircraft manufacturers in China. This paper introduces the problem of widespread fatigue damage including the MSD（ multiple site damage） and MED（ multiple element damage） and the differences between them and the steps to establish the LOV/ELOV（ Extended limit of validity）. Authors in this paper is also proposing some management indicators to control WFD during the design phase and mainte- nance. Developing and implementing the management indicators to address WFD which are involved in the FMP system may provide guidance on the estimation and management to address WFD for present and future aircraft. Finally, some suggestions are put forward to provide the theoretical basis for large civil aircraft design and airwor- thiness.展开更多
WASHINGTON, DC, August 2, 2007 — The US-China Business Council (USCBC) today released the full analysis of US exports to China from all 435 districts in the US House of Representatives. "This report illustrates ...WASHINGTON, DC, August 2, 2007 — The US-China Business Council (USCBC) today released the full analysis of US exports to China from all 435 districts in the US House of Representatives. "This report illustrates the widespread benefits to the US economy that have resulted from growing US exports to China," said USCBC President John Frisbie. "The report also acts as a reminder to Congress to keep the benefits of trade in mind when crafting legislation that may affect the US-China commercial relationship," Frisbie continued.展开更多
Objective To create an unique new method of digital orthopedic surgery and widely apply to spinal surgery,treatment of bone and joint injuries,ligament reconstruction and repair,bone minor resection and reconstruction...Objective To create an unique new method of digital orthopedic surgery and widely apply to spinal surgery,treatment of bone and joint injuries,ligament reconstruction and repair,bone minor resection and reconstruction,serious bone and展开更多
Phenolic compounds,as well as other aromatic compounds,have been reported to be abundant in hadal trenches.Although high-throughput sequencing studies have hinted at the potential of hadal microbes to degrade these co...Phenolic compounds,as well as other aromatic compounds,have been reported to be abundant in hadal trenches.Although high-throughput sequencing studies have hinted at the potential of hadal microbes to degrade these compounds,direct microbiological,genetic and biochemical evidence under in situ pressures remain absent.Here,a microbial consortium and a pure culture of Pseudomonas,newly isolated from Mariana Trench sediments,efficiently degraded phenol under pressures up to 70 and 60 MPa,respectively,with concomitant increase in biomass.By analyzing a high-pressure(70 MPa)culture metatranscriptome,not only was the entire range of metabolic processes under high pressure generated,but also genes encod-ing complete phenol degradation via ortho-and meta-cleavage pathways were revealed.The isolate of Pseudomonas also contained genes encoding the complete degradation pathway.Six transcribed genes(dmpKLMNOP_(sed))were functionally identified to encode a multicomponent hydroxylase catalyzing the hydroxylation of phenol and its methylated derivatives by heterogeneous expression.In addition,key catabolic genes identified in the metatranscriptome of the high-pressure cultures and genomes of bacterial isolates were found to be all widely distributed in 22 published hadal microbial metagenomes.At microbiological,genetic,bioinformatics,and biochemical levels,this study found that microorganisms widely found in hadal trenches were able to effectively drive phenolic compound degradation under high hydrostatic pressures.This information will bridge a knowledge gap concerning the microbial aromatics degradation within hadal trenches.展开更多
The 6.8 magnitude earthquake in Dingri County,Xigaze,Southwest China’s Xizang Autonomous Region,is tugging at the hearts of all Chinese people and garnered widespread attention from the international community.Intern...The 6.8 magnitude earthquake in Dingri County,Xigaze,Southwest China’s Xizang Autonomous Region,is tugging at the hearts of all Chinese people and garnered widespread attention from the international community.International figures,including UN Secretary-General Antonio Guterres,Russian President Vladimir Putin,French President Emmanuel Macron,Serbian President Aleksandar Vucic,and Japanese Prime Minister Shigeru Ishiba,have extended their condolences to China.展开更多
With the support by the National Natural Science Foundation of China,and China Ocean Mineral Resources R&D Association,the research team led by Prof.Wang Fengping(王风平)from Shanghai JiaoTong University,in cooper...With the support by the National Natural Science Foundation of China,and China Ocean Mineral Resources R&D Association,the research team led by Prof.Wang Fengping(王风平)from Shanghai JiaoTong University,in cooperation with Prof.Li Meng from ShenZhen University,and Prof.Stefan M.Sievert from Woods Hole Oceanographic Institution,revealed the metabolic function of largely unknown sedi-展开更多
Dear Editor,Nicotinamide adenine dinucleotide(NAD+),a nucleotidecontaining metabolite,can be incorporated as an RNA 5′cap to form NAD^(+)-capped RNAs(NAD-RNAs),which have been identified in bacteria,yeast,mammalian c...Dear Editor,Nicotinamide adenine dinucleotide(NAD+),a nucleotidecontaining metabolite,can be incorporated as an RNA 5′cap to form NAD^(+)-capped RNAs(NAD-RNAs),which have been identified in bacteria,yeast,mammalian cells and Arabidopsis thaliana(Hu et al.,2021).Most NAD-RNAs are m RNAs encoded by the nuclear and mitochondrial genomes。展开更多
The authors regret having a mistake in the article title‘Incidental bilateral ovarian paraganglioma of uterine fibroid with widespread adenomyosis:A case report’and change it to‘Incidental bilateral ovarian paragan...The authors regret having a mistake in the article title‘Incidental bilateral ovarian paraganglioma of uterine fibroid with widespread adenomyosis:A case report’and change it to‘Incidental bilateral ovarian paraganglioma in the background of uterine fibroid and widespread adenomyosis:A case report’.The authors would like to apologise for any inconvenience caused.展开更多
With the support by the Major Program of the National Natural Science Foundation of China,a research group led by Prof.Shen Zhiqiang（沈志强）from Shanghai Astronomical Observatory,Chinese Academy of Sciences reports ...With the support by the Major Program of the National Natural Science Foundation of China,a research group led by Prof.Shen Zhiqiang（沈志强）from Shanghai Astronomical Observatory,Chinese Academy of Sciences reports the detection of widespread CH2OHCHO（glycolaldehyde） and展开更多
The Sept. 11 attacks on New York’s World Trade Center did more than destroy the twin towers and kill nearly 3,000 people, they also plunged New Yorkers into depression and shell shock at twice the normal rate for mos...The Sept. 11 attacks on New York’s World Trade Center did more than destroy the twin towers and kill nearly 3,000 people, they also plunged New Yorkers into depression and shell shock at twice the normal rate for most Americans, new research found. 最新调查发现,对纽约世贸中心发动的9·11袭击事件。展开更多
文摘Experimental and analytical investigations on the residual strength of the stiffened LY12CZ aluminum alloy panels with widespread fatigue damage （WFD） are conducted. Nine stiffened LY12CZ aluminum alloy panels with three different types of damage are tested for residual strength. Each specimen is pre-cracked at rivet holes by saw cuts and subjected to a monotonically increasing tensile load until failure is occurred and the failure load is recorded. The stress intensity factors at the tips of the lead crack and the adjacent WFD cracks of the stiffened aluminum alloy panels are calculated by compounding approach and finite element method （FEM） respectively. The residual strength of the stiffened panels with WFD is evaluated by the engineering method with plastic zone linkup criterion and the FEM with apparent fracture toughness criterion respectively. The predicted residual strength agrees well with the experiment results. It indicates that in engineering practice these methods can be used for residual strength evaluation with the acceptable accuracy. It can be seen from this research that WFD can significantly reduce the residual strength and the critical crack length of the stiffened panels with WFD. The effect of WFD crack length on residual strength is also studied.
基金supported by the National Natural Science Foundation of China(grant No.41306062)the Key Laboratory of Gas Hydrate Foundation(grant No.SHW [2014]-DX-04)
文摘The westem slope of the Okinawa trough has been considered to experience important methane seep activities. Abundant terrigenous sediments supply and widely developed normal faults make this area an ideal place for methane production, methane fluids migration and associated anaerobic oxidation of methane.
基金This study was approved by the Institutional Review Board of Samsung Medical Center(approval number:2020-09-027-001).
文摘BACKGROUND Osteomalacia(OM)is frequently confused with various musculoskeletal or other rheumatic diseases,especially in patients with adult-onset widespread musculoskeletal pain because of its low prevalence and non-specific manifestations.AIM To facilitate the early diagnosis and etiology-specific treatment of adult-onset hypophosphatemic OM.METHODS A retrospective review of medical records was performed to screen adult patients who visited a physiatry locomotive medicine clinic(spine and musculoskeletal pain clinic)primarily presenting with widespread musculoskeletal pain at a single tertiary hospital between January 2011 and December 2019.We enrolled patients with hypophosphatemia,high serum bone-specific alkaline phosphatase levels,and at least one imaging finding suggestive of OM.RESULTS Eight patients with adult-onset hypophosphatemic OM were included.The back was the most common site of pain.Proximal dominant symmetric muscle weakness was observed in more than half of the patients.Bone scintigraphy was the most useful imaging modality for diagnosing OM because radiotracer uptake in OM showed characteristic patterns.Six patients were diagnosed with adefovir(ADV)-induced Fanconi syndrome,and the other two patients were diagnosed with tumor-induced OM and light-chain nephropathy,respectively.After phosphorus and vitamin D supplementation and treatment for the underlying etiologies,improvements in pain,muscle strength,and gait were observed in all patients.CONCLUSION Mechanical pain characteristics,hypophosphatemia,and distinctive bone scintigraphy patterns are the initial diagnostic indicators of adult-onset hypophosphatemic OM.ADV-induced Fanconi syndrome is the most common etiology of hypophosphatemic OM in hepatitis B virus-endemic countries.
基金supported by the Guangdong Provincial Key R&D Program (2022B1111040001)the Second Tibetan Plateau Scientific Expedition and Research Program (2019QZKK0402/2019QZKK0501)National Natural Science Foundation of China (32170426)。
文摘Widespread species that inhabit diverse environments possess large population sizes and exhibit a high capacity for environmental adaptation,thus enabling range expansion.In contrast,narrow-range species are confined to restricted geographical areas and are ecologically adapted to narrow environmental conditions,thus limiting their ability to expand into novel environments.However,the genomic mechanisms underlying the differentiation between closely related species with varying distribution ranges remain poorly understood.The Niviventer niviventer species complex(NNSC),consisting of highly abundant wild rats in Southeast Asia and China,offers an excellent opportunity to investigate these questions due to the presence of both widespread and narrow-range species that are phylogenetically closely related.In the present study,we combined ecological niche modeling with phylogenetic analysis,which suggested that sister species cannot be both widespread and dominant within the same geographical region.Moreover,by assessing heterozygosity,linkage disequilibrium decay,and Tajima's D analysis,we found that widespread species exhibited higher genetic diversity than narrow-range species.In addition,by exploring the“genomic islands of speciation”,we identified 13 genes in highly divergent regions that were shared by the two widespread species,distinguishing them from their narrow-range counterparts.Functional annotation analysis indicated that these genes are involved in nervous system development and regulation.The adaptive evolution of these genes likely played an important role in the speciation of these widespread species.
文摘Widespread hotels represent a new Italian phenomenon still not much investigated, both on theoretical and empirical side, which cannot be ignored anymore. Indeed they meet the need to implement techniques and management tools which are able to improve the culture-tourism binomial. This would permit to transform into valid instruments of national economical development, the shared declaration of intents for which culture and tourism, especially in Italy and in this particular fragile period, represent even more the main strategic levers for the sustainable development. This article intends to describe the potentiality of these widespread hotels as innovations particularly suitable with trends recently emerged in tourism sector and outline the phenomenon pattern in ltaly with particular attention on Umbria region, in order to identify his main strength and weakness and some innovation to improve performance. To this end, it starts from the analysis of the national and international economic-managerial literature concerning in particular cultural and experienced trends shown in tourism. Then it introduces the main acquisitions about widespread hotels in Italy, updating and extending them through a desk survey based on indirect sources of various natures. Lastly, it describes the case of Umbria, analyzing more in depth making use of interviews with entrepreneurs/managers of hotels and based on a semi-structured questionnaire. The aspects of indeterminateness which were found, starting from the normative one, testify how the potentiality of the widespread hotels as far as regards the value creation for the enterprise itself and the territorial stakeholder, are still not properly understood and therefore used. It is clear that, therefore, new behaviors are needed for entrepreneurs and, most importantly, for local policy makers in order to create the conditions for the full success of these hospitality models.
文摘As is known, widespread fatigue damage （WFD） is a common phenomenon of aging aircraft being a negative impact on safety and reliability. The current FAR 25. 571 （b） requires that ＂An LOV （ Limit of Validi- ty） must be established, during which it is demonstrated that widespread fatigue damage will not occur in the air- craft structures＂. The FAA issued AC 91-82A in August 2011 providing guidance on developing and implemen- ting a Fatigue Management Program （FMP） system to address in-service issues for metallic fatigue critical struc- tures. This action brings new challenges to aircraft manufacturers in China. This paper introduces the problem of widespread fatigue damage including the MSD（ multiple site damage） and MED（ multiple element damage） and the differences between them and the steps to establish the LOV/ELOV（ Extended limit of validity）. Authors in this paper is also proposing some management indicators to control WFD during the design phase and mainte- nance. Developing and implementing the management indicators to address WFD which are involved in the FMP system may provide guidance on the estimation and management to address WFD for present and future aircraft. Finally, some suggestions are put forward to provide the theoretical basis for large civil aircraft design and airwor- thiness.
文摘WASHINGTON, DC, August 2, 2007 — The US-China Business Council (USCBC) today released the full analysis of US exports to China from all 435 districts in the US House of Representatives. "This report illustrates the widespread benefits to the US economy that have resulted from growing US exports to China," said USCBC President John Frisbie. "The report also acts as a reminder to Congress to keep the benefits of trade in mind when crafting legislation that may affect the US-China commercial relationship," Frisbie continued.
文摘Objective To create an unique new method of digital orthopedic surgery and widely apply to spinal surgery,treatment of bone and joint injuries,ligament reconstruction and repair,bone minor resection and reconstruction,serious bone and
基金supported by the National Natural Science Foundation of China(Grants 91951106,92051104)。
文摘Phenolic compounds,as well as other aromatic compounds,have been reported to be abundant in hadal trenches.Although high-throughput sequencing studies have hinted at the potential of hadal microbes to degrade these compounds,direct microbiological,genetic and biochemical evidence under in situ pressures remain absent.Here,a microbial consortium and a pure culture of Pseudomonas,newly isolated from Mariana Trench sediments,efficiently degraded phenol under pressures up to 70 and 60 MPa,respectively,with concomitant increase in biomass.By analyzing a high-pressure(70 MPa)culture metatranscriptome,not only was the entire range of metabolic processes under high pressure generated,but also genes encod-ing complete phenol degradation via ortho-and meta-cleavage pathways were revealed.The isolate of Pseudomonas also contained genes encoding the complete degradation pathway.Six transcribed genes(dmpKLMNOP_(sed))were functionally identified to encode a multicomponent hydroxylase catalyzing the hydroxylation of phenol and its methylated derivatives by heterogeneous expression.In addition,key catabolic genes identified in the metatranscriptome of the high-pressure cultures and genomes of bacterial isolates were found to be all widely distributed in 22 published hadal microbial metagenomes.At microbiological,genetic,bioinformatics,and biochemical levels,this study found that microorganisms widely found in hadal trenches were able to effectively drive phenolic compound degradation under high hydrostatic pressures.This information will bridge a knowledge gap concerning the microbial aromatics degradation within hadal trenches.
文摘The 6.8 magnitude earthquake in Dingri County,Xigaze,Southwest China’s Xizang Autonomous Region,is tugging at the hearts of all Chinese people and garnered widespread attention from the international community.International figures,including UN Secretary-General Antonio Guterres,Russian President Vladimir Putin,French President Emmanuel Macron,Serbian President Aleksandar Vucic,and Japanese Prime Minister Shigeru Ishiba,have extended their condolences to China.
文摘With the support by the National Natural Science Foundation of China,and China Ocean Mineral Resources R&D Association,the research team led by Prof.Wang Fengping(王风平)from Shanghai JiaoTong University,in cooperation with Prof.Li Meng from ShenZhen University,and Prof.Stefan M.Sievert from Woods Hole Oceanographic Institution,revealed the metabolic function of largely unknown sedi-
基金supported by the National Key Research and Development Program of China(2019YFA0903900)Guangdong Innovation Research Team Fund(2014ZT05S078)+1 种基金the National Natural Science Foundation of China(32000153)China Postdoctoral Science Foundation(2018M640822,2019T120753)。
文摘Dear Editor,Nicotinamide adenine dinucleotide(NAD+),a nucleotidecontaining metabolite,can be incorporated as an RNA 5′cap to form NAD^(+)-capped RNAs(NAD-RNAs),which have been identified in bacteria,yeast,mammalian cells and Arabidopsis thaliana(Hu et al.,2021).Most NAD-RNAs are m RNAs encoded by the nuclear and mitochondrial genomes。
文摘The authors regret having a mistake in the article title‘Incidental bilateral ovarian paraganglioma of uterine fibroid with widespread adenomyosis:A case report’and change it to‘Incidental bilateral ovarian paraganglioma in the background of uterine fibroid and widespread adenomyosis:A case report’.The authors would like to apologise for any inconvenience caused.
文摘With the support by the Major Program of the National Natural Science Foundation of China,a research group led by Prof.Shen Zhiqiang（沈志强）from Shanghai Astronomical Observatory,Chinese Academy of Sciences reports the detection of widespread CH2OHCHO（glycolaldehyde） and
文摘The Sept. 11 attacks on New York’s World Trade Center did more than destroy the twin towers and kill nearly 3,000 people, they also plunged New Yorkers into depression and shell shock at twice the normal rate for most Americans, new research found. 最新调查发现,对纽约世贸中心发动的9·11袭击事件。
