Multiple evanescent white dot syndrome(MEWDS)is an inflammatory fundus disease primarily affecting the outer retina.It is characterized by transient yellow-white dots on the outer retina.Although the exact pathogenesi...Multiple evanescent white dot syndrome(MEWDS)is an inflammatory fundus disease primarily affecting the outer retina.It is characterized by transient yellow-white dots on the outer retina.Although the exact pathogenesis remains unclear,the progress in multimodal imaging(MMI)has enhanced our understanding of MEWDS.Most cases of MEWDS are idiopathic,lacking a definite cause,and can spontaneously recover;these are what we term classic MEWDS.Consequently,MEWDS is often referred to as the“common cold of the retina”.Simultaneously,patients with other disorders may present with varying degrees of manifestations similar to MEWDS.The resemblance in clinical or imaging findings can lead to misdiagnosis and inappropriate treatment.These MEWDS-like presentations are actually caused by other systemic or ocular disorders with diverse mechanisms.Thus,they differ from classic MEWDS in certain aspects.Using the keywords“MEWDSlike”and“Secondary MEWDS”,we searched for all relevant studies published in the PubMed database from January 2021 to January 2024.Subsequently,we retrospectively summarized the clinical and imaging characteristics of MEWDS,along with the manifestations in other diseases that resembled those of MEWDS,and compared classic MEWDS with these similar presentations.Based on our review,we classified such similar presentations under other conditions into two categories and summarized their features for differential diagnosis.We recommend paying close attention to patients suspected of having MEWDS,as there may be more serious systemic or ocular disorders that require prompt treatment.展开更多
Objective This study aimed to evaluate the relationships of white blood cell(WBC)count,platelet(PLT)count,and PLT-to-WBC ratio(PWR)with muscle mass in Chinese older adults.Methods This cross-sectional analysis involve...Objective This study aimed to evaluate the relationships of white blood cell(WBC)count,platelet(PLT)count,and PLT-to-WBC ratio(PWR)with muscle mass in Chinese older adults.Methods This cross-sectional analysis involved 4,033 Chinese older adults aged≥65 years from the Healthy Ageing and Biomarkers Cohort Study.Muscle mass and total skeletal muscle mass index(TSMI)were measured by bioelectric impedance analysis.WBC,PLT,and PWR were measured using standard methods.Multivariate linear regression was used to examine the associations of WBC count,PLT count,and PWR with TSMI.Results High WBC count,PLT count,and PWR were associated with low TSMI,with coefficients of-0.0091(95%confidence interval[CI]:-0.0142 to-0.0041),-0.0119(95%CI:-0.0170 to-0.0068),and-0.0051(95%CI:-0.0102 to-0.0001).The associations between the three inflammatory indices and TSMI were linear.Stratified analyses indicated that the relationship between inflammatory markers and TSMI was more evident in male participants and in individuals aged<80 years than in their counterparts.Conclusion Elevated WBC count,PLT count,and PWR correlated with muscle mass loss.This study highlights the importance of regular monitoring of inflammatory markers as a potential strategy for the screening and management of sarcopenia in older adults.展开更多
In the workshop of Guangshan White Shark Card Clothing Co.,Ltd.,precision machines are meticulously crafting the tips of card clothing with millimeter-level accuracy.These seemingly tiny textile accessories play a cru...In the workshop of Guangshan White Shark Card Clothing Co.,Ltd.,precision machines are meticulously crafting the tips of card clothing with millimeter-level accuracy.These seemingly tiny textile accessories play a crucial role in the global cotton and chemical fiber industry chains.As China's textile industry encounters trade barriers in the process of globalization,this company specializing in card clothing manufacturing is striving to explore a differentiated path in overseas markets.展开更多
Obesity has become a global threat to health;however,the available drugs for treating obesity are limited.We investigated the anti-obesity effect of hydroxy-α-sanshool(HAS),an amide derived from the fruit of Zanthoxy...Obesity has become a global threat to health;however,the available drugs for treating obesity are limited.We investigated the anti-obesity effect of hydroxy-α-sanshool(HAS),an amide derived from the fruit of Zanthoxylum bungeanum,which promotes the management of obesity by triggering the browning of white adipose tissue(WAT)targeting the membrane receptor of transient receptor potential vanilloid 1(TRPV1).However,HAS easily undergoes configuration transformation and oxidative degradation.The short peptide CKGGRAKDC or adipose-targeting sequence(ATS)binds specifically to prohibitin on the surface of WAT cells and can be used as recognition assembly to enhance adipocyte targetability.Furthermore,mesoporous silica nanoparticles(MSNs)are widely used in drug delivery systems because of their large specific surface area and pore volume.Therefore,HAS-loaded adipose-targeted MSNs(MSNs-ATS)were developed to enhance the adipocyte targetability,safety,and efficacy of HAS,and tested on mature 3T3-L1 cells and obese mouse models.MSNs-ATS showed higher specificity for adipocyte targetability without obvious toxicity.HAS-loaded MSNs-ATS showed anti-obesity effects superior to those of HAS alone.In conclusion,we successfully developed adipocyte-targeted,HAS-loaded MSNs with good safety and anti-obesity effects.展开更多
Intracerebral hemorrhage is the most dangerous subtype of stroke,characterized by high mortality and morbidity rates,and frequently leads to significant secondary white matter injury.In recent decades,studies have rev...Intracerebral hemorrhage is the most dangerous subtype of stroke,characterized by high mortality and morbidity rates,and frequently leads to significant secondary white matter injury.In recent decades,studies have revealed that gut microbiota can communicate bidirectionally with the brain through the gut microbiota–brain axis.This axis indicates that gut microbiota is closely related to the development and prognosis of intracerebral hemorrhage and its associated secondary white matter injury.The NACHT,LRR,and pyrin domain-containing protein 3(NLRP3)inflammasome plays a crucial role in this context.This review summarizes the dysbiosis of gut microbiota following intracerebral hemorrhage and explores the mechanisms by which this imbalance may promote the activation of the NLRP3 inflammasome.These mechanisms include metabolic pathways(involving short-chain fatty acids,lipopolysaccharides,lactic acid,bile acids,trimethylamine-N-oxide,and tryptophan),neural pathways(such as the vagus nerve and sympathetic nerve),and immune pathways(involving microglia and T cells).We then discuss the relationship between the activated NLRP3 inflammasome and secondary white matter injury after intracerebral hemorrhage.The activation of the NLRP3 inflammasome can exacerbate secondary white matter injury by disrupting the blood–brain barrier,inducing neuroinflammation,and interfering with nerve regeneration.Finally,we outline potential treatment strategies for intracerebral hemorrhage and its secondary white matter injury.Our review highlights the critical role of the gut microbiota–brain axis and the NLRP3 inflammasome in white matter injury following intracerebral hemorrhage,paving the way for exploring potential therapeutic approaches.展开更多
As the population ages,the burden of age-related diseases becomes greater.Currently,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common form.However,it is becoming cle...As the population ages,the burden of age-related diseases becomes greater.Currently,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common form.However,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of cSVD.The term cSVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).展开更多
The charge carrier transport and recombination dynamics in the quantum dots-based light-emitting diodes(QLEDs)featuring multiple emitting layers(M-EMLs)has a great impact on the device performance.In this work,QLEDs b...The charge carrier transport and recombination dynamics in the quantum dots-based light-emitting diodes(QLEDs)featuring multiple emitting layers(M-EMLs)has a great impact on the device performance.In this work,QLEDs based on M-EMLs separated by polyethyleneimine ethoxylated(PEIE)layer with different stacking sequences of blue(B),green(G),and red(R)QDs layer were used to intuitively explore the injection,transportation and recombination processes of the charge carriers in QLEDs by using the time-resolved electroluminescence(TrEL)spectra.From the TrEL spectra mea-surements,green and red emissions were obtained first in the QLEDs with the EMLs sequences of G/PEIE/B/PEIE/R and B/PEIE/R/PEIE/G along the direction of light emission,respectively.While the QLEDs adopt EMLs sequences of B/PEIE/G/PEIE/R,the blue,green and red emissions were obtained nearly at the same time.The above phenomenon can be attributed to different charge carrier transmission and radiation recombination process in the EMLs due to different valence band offsets and conduction band offsets between R-,G-and B-QDs by using different sequences of EMLs.White emission with coordi-nates of(0.31,0.31)and correlated color temperature(CCT)of 5916 K was obtained in the QLEDs with the EMLs se-quences of B/PEIE/G/PEIE/R,which can be attributed to the relative uniform emission of B-,G-and R-QDs due to the effec-tive injection and radiation recombination of charge carriers in each of the EMLs.The above results have great significance for further understanding and improving the performance of QLEDs with M-EMLs.展开更多
Grape white rot caused by Coniella vitis is a global concern in the grape industry.pH regulation is essential for cell growth,reproductive processes and pathogenicity in phytopathogenic fungi.In this study,we observed...Grape white rot caused by Coniella vitis is a global concern in the grape industry.pH regulation is essential for cell growth,reproductive processes and pathogenicity in phytopathogenic fungi.In this study,we observed that the growth rate,spore production and virulence of C.vitis significantly declined in alkaline pH,as well as the suppressive effect on secretion of hydrolytic enzymes.Transcriptomic and metabolomic analyses were used to investigate the responses of C.vitis to acidic(pH 5),neutral(pH 7)and alkaline environments(pH 9).We identified 728,1,780 and 3,386 differentially expressed genes(DEGs)at pH 5,pH 7 and pH 9,when compared with the host pH(pH 3),and 2,122 differently expressed metabolites(DEMs)in negative and positive ion mode.Most DEGs were involved in carbohydrate metabolic process,transmembrane transport,tricarboxylic acid cycle,peptide metabolic process,amide biosynthetic process,and organic acid metabolic process.In addition,metabolomic analysis revealed ABC transporters,indole alkaloid biosynthesis,diterpenoid biosynthesis,and carotenoid biosynthesis pathways in response to the pH change.Furthermore,we found that the aspartate synthesis metabolic route associated with the TCA cycle is a key limiting factor for the growth and development of C.vitis in alkaline environments,and aspartate supplementation enables C.vitis to grow in alkaline environments.Plant cell wall-degrading enzymes(PCWDEs)could contribute to the pathogenicity,when C.vitis infected at pH 3.Importantly,aflatrem biosynthesis in acidic environment might contribute to the virulence of C.vitis and has a risk of causing human health problems due to its acute neurotoxic effects.展开更多
Peanut is a globally significant oil crop and economic resource,notable for its kernel containing over 50%oil content.White testa peanuts are highly valued for their superior nutritional profile,minimal pigmentation,a...Peanut is a globally significant oil crop and economic resource,notable for its kernel containing over 50%oil content.White testa peanuts are highly valued for their superior nutritional profile,minimal pigmentation,and superior oil clarity.Identification of genes controlling white testa color is crucial for advancing breeding programs and understanding the genetic mechanisms involved.A genetic mapping study was performed in peanut to identify genes controlling white testa color,a trait associated with desirable end-use quality traits in this oilseed crop.In an F_(2)population generated from a cross of a white-testa with a pink-testa cultivar,two recessive quantitative-trait loci controlling white testa were identified and finemapped to A02 and B02 chromosomes.Two homologous genes,Arahy.MP3D3D and Arahy.26781N,encoding bHLH transcriptional factors,were identified as candidates for the two loci.Reduced expression of these two genes likely suppresses anthocyanin biosynthesis.展开更多
Iron-based Prussian white(PW)materials have attracted considerable attention as promising cathodes for potassium-ion batteries(PIBs)due to their high capacity,easy preparation,and economic merits.However,the intrinsic...Iron-based Prussian white(PW)materials have attracted considerable attention as promising cathodes for potassium-ion batteries(PIBs)due to their high capacity,easy preparation,and economic merits.However,the intrinsic iron dissolution and uncontrollable cathode-electrolyte interface(CEI)formation in conventional organic electrolytes severely hinder their long-term cycling stability.Herein,we employ succinonitrile(SN),a bifunctional electrolyte additive,to suppress the iron dissolution and promote thin,uniform,and stable CEI formation of the PW cathode,thus improving its structural stability.Benefited from the coordination between the cyano groups in SN and iron atoms,this molecule can preferentially adsorb on the surface of PW to mitigate iron dissolution.SN also facilitates the decomposition of anions in potassium salt rather than organic solvents in electrolyte due to the attractive reaction between SN and anions.Consequently,the PW cathode with SN additive provides better electrochemical reversibility,showing capacity retention of 93.6%after 3000 cycles at 5C.In comparison,without SN,the capacity retention is only 87.4%after 1000 cycles under the same conditions.Moreover,the full cells of PW matched with commercial graphite(Gr)achieve stable cycling for 3500 cycles at a high rate of 20C,with an exceptional capacity decay of only 0.005%per cycle,surpassing the majority of recently reported results in literature.展开更多
On March 28,the white paper“Human Rights in Xizang in the New Era”was released.The white paper provides a comprehensive and systematic account of the remarkable achievements made in Xizang's human rights cause u...On March 28,the white paper“Human Rights in Xizang in the New Era”was released.The white paper provides a comprehensive and systematic account of the remarkable achievements made in Xizang's human rights cause under the leadership of the CPC's(Communist Party of China)strategy for governing Xizang in the new era,showcasing the development and progress of human rights in Xizang.展开更多
Previous studies have found associations between color discrimination deficits and cognitive impairments besides aging.However,investigations into the microstructural pathology of brain white matter(WM)associated with...Previous studies have found associations between color discrimination deficits and cognitive impairments besides aging.However,investigations into the microstructural pathology of brain white matter(WM)associated with these deficits remain limited.This study aimed to examine the microstructural characteristics of WM in the non-demented population with abnormal color discrimination,utilizing Neurite Orientation Dispersion and Density Imaging(NODDI),and to explore their correlations with cognitive functions and cognition-related plasma biomarkers.The tract-based spatial statistic analysis revealed significant differences in specific brain regions between the abnormal color discrimination group and the healthy controls,characterized by increased isotropic volume fraction and decreased neurite density index and orientation dispersion index.Further analysis of region-of-interest parameters revealed that the isotropic volume fraction in the bilateral anterior thalamic radiation,superior longitudinal fasciculus,cingulum,and forceps minor was significantly correlated with poorer performance on neuropsychological assessments and to varying degrees various cognition-related plasma biomarkers.These findings provide neuroimaging evidence that WM microstructural abnormalities in non-demented individuals with abnormal color discrimination are associated with cognitive dysfunction,potentially serving as early markers for cognitive decline.展开更多
Grape white rot is a fungal disease caused by Coniella diplodiella(Speg.)Sacc.that seriously affects fruit quality and yield;however,the underlying mechanism governing the plant response to C.diplodiella pathogens is ...Grape white rot is a fungal disease caused by Coniella diplodiella(Speg.)Sacc.that seriously affects fruit quality and yield;however,the underlying mechanism governing the plant response to C.diplodiella pathogens is still poorly understood.Here,we characterized a homeodomain(HD)transcription factor from grape(Vitis vinifera),VvOCP3,and demonstrated its signifcance in C.diplodiella resistance.Expression analysis showed that VvOCP3 expression was signifcantly down-regulated upon inoculation with C.diplodiella.Functional analysis with transient injection in grape berries and stable overexpression in grape calli demonstrated that VvOCP3 negatively regulates grape resistance to C.diplodiella.Further studies showed that VvOCP3 directly binds to the promoter of VvPR1(pathogenesis-related protein 1)and inhibits its expression,resulting in reduced resistance to C.diplodiella.In addition,VvOCP3 can interact with the type 2C protein phosphatase VvABI1,which is a negative modulator of the ABA signaling pathway.In summary,our findings suggest that VvOCP3 plays a crucial role in regulating white rot resistance in grape,and offer theoretical guidance for developing grape cultivars with enhanced C.diplodiella resistance by regulating the expression of VvOCP3.展开更多
This study examined the effect of dietary serine(Ser)on egg white quality,ovomucin content of laying hens fed low-gossypol cottonseed meal(LCSM)-based diet and sought to explore the regulatory mechanism underlying the...This study examined the effect of dietary serine(Ser)on egg white quality,ovomucin content of laying hens fed low-gossypol cottonseed meal(LCSM)-based diet and sought to explore the regulatory mechanism underlying the effects.A total of 288 Hy-Line Brown layers were randomly assigned into 3 treatments and respectively offered soybean meal(SBM)-based diet,LCSM-based diet,and LCSM-based diet supplemented with 0.435%L-Ser.Dietary Ser supplementation reversed the decrease in quality indices of albumen,including the proportion of thick albumen(P<0.05),thick-to-thin ratio(P<0.05),albumen height(P<0.05),Haugh unit(P<0.05),and apparent viscosity that were caused by LCSM intake.Also,dietary Ser supplementation mitigated the LCSM-induced reduction in ovomucin content of the albumen(P<0.05).FT-IR analysis of ovomucin revealed differences in second derivative spectra at 1,200-800 cm^(-1) between birds received SBM-and LCSM-based diets,meanwhile,the α-helix of ovomucin was decreased by LCSM but increased by Ser addition(P<0.05).Furthermore,Ser addition up-regulated the mRNA expression of β-ovomucin in magnum mucosa at 2 and 7.5 h post-oviposition(P<0.05).Ser mitigated the LCSMinduced impairment of magnum epithelium,increased goblet cell counts(P<0.05),and up-regulated the expression of occludin,mucin 2,and the relevant glycosyltransferases for O-glycosylation in magnum mucosa(P<0.05).Conclusively,the alleviating effect of Ser on declining albumen quality due to dietary LCSM,could be explained by the efficacy of Ser in regulating ovomucin synthesis.This regulation occurred at the levels of transcription and posttranscriptional O-glycosylation modification ofβ-ovomucin,while positive effect on magnum morphology and barrier function could also in part account for the ovomucin content.This would provide a promising research direction on the adoption of nutritional interventions for manipulation of egg white quality from perspectives of albumen protein synthesis.展开更多
The Chinese Opera Season 2025 and International Exhibition of Chinese Opera opened in Vienna,the capital of Austria,on the evening of April 5.As the opening performance of the Season,a traditional Wu Opera(a local ope...The Chinese Opera Season 2025 and International Exhibition of Chinese Opera opened in Vienna,the capital of Austria,on the evening of April 5.As the opening performance of the Season,a traditional Wu Opera(a local opera in Zhejiang Province)scene"the Legend of the White Snake"was performed at the Muth Theatre in Vienna,drawing enthusiastic responses.展开更多
Sodium fluoride(NaF)is a daily necessity consumed as the major ingredient of fluorinated drinking water,milk,salts,mouthwashes,toothpaste,and dentistry medications.However,the use of NaF products has also been associa...Sodium fluoride(NaF)is a daily necessity consumed as the major ingredient of fluorinated drinking water,milk,salts,mouthwashes,toothpaste,and dentistry medications.However,the use of NaF products has also been associated with increased fluoride anion distribution in the body,leading to hypertension.AIM This study evaluated the antihypertensive effect of sweet orange peels-enriched white melon seed protein concentrate(WSP)biscuit meal in eight-week-old albino rats exposed to NaF for 14 days.METHODS Forty-two(42)male Wistar albino rats were assigned at random into 7 groups of 6 rats per group(control group and six experimental groups).The experimental groups received various treatments that lasted for two weeks.Twenty-four hours after the last administration,hemodynamic parameters were evaluated,rats were sacrificed,blood samples were collected,and the heart was harvested.Blood serum was assessed for cardiac troponin I(cTnI),creatine kinase-MB(CK-MB),and lactate dehydrogenase(LDH).At the same time,the heart homogenate was assayed for angiotensin-1 converting enzyme(ACE)activity,proinflammatory cytokines,nitric oxide concentrations,and antioxidant status.Cardiac tissues were stained with Hematoxylin and Eosin,Masson’s Trichrome,and cTnI.Also,the safety of the WSP biscuit diet was evaluated.RESULTS Results obtained showed that NaF administration elevated the collagen content of cardiac tissues,activities of ACE,and concentrations of cTnI,CK-MB,LDH,tumor necrosis factor-alpha,and interleukin 1 beta,while there was a reduction in the concentration of nitric oxide and antioxidants;however,their alterations were significantly prevented in WSP-biscuit-fed rats.The WSP biscuit meal is safe for consumption and possesses dose-dependent antihypertensive ability at 10%and 20%inclusion.CONCLUSION The WSP biscuit diet may be recommended in diet formulation for the management of individuals or communities that are predisposed to NaF contaminations.展开更多
The continuous white light(CWL)covering the visible and near-infrared(NIR)regions can be observed in various absorptive media excited by continuous-wave(CW)lasers.It is valuable to stimulate more efforts in unravellin...The continuous white light(CWL)covering the visible and near-infrared(NIR)regions can be observed in various absorptive media excited by continuous-wave(CW)lasers.It is valuable to stimulate more efforts in unravelling the involved photophysical processes and exploring its potential applications in diverse fields.Here,we proved that the enhanced thermal-field can boost the CWL emission.Using rare earth(RE)ions(Pr^(3+),Er^(3+)and Yb^(3+))as the photothermally active centers in Y_(2)SiO_(5)phosphor,we reveal that absorbing more excitation energy and isolating the heat conduction can lead to rapid thermal field accumulation inside the material,thereby significantly reducing the excitation threshold and enhancing white light emission.Our results might have important implications for the understanding of thermally enhanced radiation and may facilitate the CWL commercial application in night vision,bioimaging,and non-destructive detection.展开更多
This article takes the theory of power space as an starting point for an in-depth comparison of the clan hall in White Deer Plains and the scaffold in The Scarlet Letter.In White Deer Plains,The clan hall,as the core ...This article takes the theory of power space as an starting point for an in-depth comparison of the clan hall in White Deer Plains and the scaffold in The Scarlet Letter.In White Deer Plains,The clan hall,as the core place of family activities,has a spatial layout that implies a hierarchy of power,and the taboos it represents relate to various aspects such as marriage and bloodline,and maintains the order of the clan through a variety of disciplinary mechanisms.The scaffold in The Scarlet Letter is located in the town’s central square and is a symbol of Puritan social power and moral discipline,behind which Puritan taboos influence people’s behaviors and public punishments are used to achieve the discipline of the people.The research reveals the similarities and differences between the two in terms of sources of power,modes of operation and influence,and opens up new horizons for cross-cultural literary studies.展开更多
文摘Multiple evanescent white dot syndrome(MEWDS)is an inflammatory fundus disease primarily affecting the outer retina.It is characterized by transient yellow-white dots on the outer retina.Although the exact pathogenesis remains unclear,the progress in multimodal imaging(MMI)has enhanced our understanding of MEWDS.Most cases of MEWDS are idiopathic,lacking a definite cause,and can spontaneously recover;these are what we term classic MEWDS.Consequently,MEWDS is often referred to as the“common cold of the retina”.Simultaneously,patients with other disorders may present with varying degrees of manifestations similar to MEWDS.The resemblance in clinical or imaging findings can lead to misdiagnosis and inappropriate treatment.These MEWDS-like presentations are actually caused by other systemic or ocular disorders with diverse mechanisms.Thus,they differ from classic MEWDS in certain aspects.Using the keywords“MEWDSlike”and“Secondary MEWDS”,we searched for all relevant studies published in the PubMed database from January 2021 to January 2024.Subsequently,we retrospectively summarized the clinical and imaging characteristics of MEWDS,along with the manifestations in other diseases that resembled those of MEWDS,and compared classic MEWDS with these similar presentations.Based on our review,we classified such similar presentations under other conditions into two categories and summarized their features for differential diagnosis.We recommend paying close attention to patients suspected of having MEWDS,as there may be more serious systemic or ocular disorders that require prompt treatment.
基金supported by the National Natural Science Foundation of China(grant nos.82025030,82222063,and 82388102)the National Key Research and Development Program of China(grant no.2023YFC3603400)。
文摘Objective This study aimed to evaluate the relationships of white blood cell(WBC)count,platelet(PLT)count,and PLT-to-WBC ratio(PWR)with muscle mass in Chinese older adults.Methods This cross-sectional analysis involved 4,033 Chinese older adults aged≥65 years from the Healthy Ageing and Biomarkers Cohort Study.Muscle mass and total skeletal muscle mass index(TSMI)were measured by bioelectric impedance analysis.WBC,PLT,and PWR were measured using standard methods.Multivariate linear regression was used to examine the associations of WBC count,PLT count,and PWR with TSMI.Results High WBC count,PLT count,and PWR were associated with low TSMI,with coefficients of-0.0091(95%confidence interval[CI]:-0.0142 to-0.0041),-0.0119(95%CI:-0.0170 to-0.0068),and-0.0051(95%CI:-0.0102 to-0.0001).The associations between the three inflammatory indices and TSMI were linear.Stratified analyses indicated that the relationship between inflammatory markers and TSMI was more evident in male participants and in individuals aged<80 years than in their counterparts.Conclusion Elevated WBC count,PLT count,and PWR correlated with muscle mass loss.This study highlights the importance of regular monitoring of inflammatory markers as a potential strategy for the screening and management of sarcopenia in older adults.
文摘In the workshop of Guangshan White Shark Card Clothing Co.,Ltd.,precision machines are meticulously crafting the tips of card clothing with millimeter-level accuracy.These seemingly tiny textile accessories play a crucial role in the global cotton and chemical fiber industry chains.As China's textile industry encounters trade barriers in the process of globalization,this company specializing in card clothing manufacturing is striving to explore a differentiated path in overseas markets.
基金supported by the Natural Science Foundation of Sichuan Province(No.2022NSFSC0720)Research Center for the Development of the Comprehensive Health Industry and Rural Revitalization of Sichuan TCM(No.DJKYB202306)State Administration of Traditional Chinese Medicine of Sichuan Province of China(No.2020HJZX001).
文摘Obesity has become a global threat to health;however,the available drugs for treating obesity are limited.We investigated the anti-obesity effect of hydroxy-α-sanshool(HAS),an amide derived from the fruit of Zanthoxylum bungeanum,which promotes the management of obesity by triggering the browning of white adipose tissue(WAT)targeting the membrane receptor of transient receptor potential vanilloid 1(TRPV1).However,HAS easily undergoes configuration transformation and oxidative degradation.The short peptide CKGGRAKDC or adipose-targeting sequence(ATS)binds specifically to prohibitin on the surface of WAT cells and can be used as recognition assembly to enhance adipocyte targetability.Furthermore,mesoporous silica nanoparticles(MSNs)are widely used in drug delivery systems because of their large specific surface area and pore volume.Therefore,HAS-loaded adipose-targeted MSNs(MSNs-ATS)were developed to enhance the adipocyte targetability,safety,and efficacy of HAS,and tested on mature 3T3-L1 cells and obese mouse models.MSNs-ATS showed higher specificity for adipocyte targetability without obvious toxicity.HAS-loaded MSNs-ATS showed anti-obesity effects superior to those of HAS alone.In conclusion,we successfully developed adipocyte-targeted,HAS-loaded MSNs with good safety and anti-obesity effects.
基金supported by the Guangdong Basic and Applied Basic Research Foundation,No.2023A1515030045(to HS)Presidential Foundation of Zhujiang Hospital of Southern Medical University,No.yzjj2022ms4(to HS)。
文摘Intracerebral hemorrhage is the most dangerous subtype of stroke,characterized by high mortality and morbidity rates,and frequently leads to significant secondary white matter injury.In recent decades,studies have revealed that gut microbiota can communicate bidirectionally with the brain through the gut microbiota–brain axis.This axis indicates that gut microbiota is closely related to the development and prognosis of intracerebral hemorrhage and its associated secondary white matter injury.The NACHT,LRR,and pyrin domain-containing protein 3(NLRP3)inflammasome plays a crucial role in this context.This review summarizes the dysbiosis of gut microbiota following intracerebral hemorrhage and explores the mechanisms by which this imbalance may promote the activation of the NLRP3 inflammasome.These mechanisms include metabolic pathways(involving short-chain fatty acids,lipopolysaccharides,lactic acid,bile acids,trimethylamine-N-oxide,and tryptophan),neural pathways(such as the vagus nerve and sympathetic nerve),and immune pathways(involving microglia and T cells).We then discuss the relationship between the activated NLRP3 inflammasome and secondary white matter injury after intracerebral hemorrhage.The activation of the NLRP3 inflammasome can exacerbate secondary white matter injury by disrupting the blood–brain barrier,inducing neuroinflammation,and interfering with nerve regeneration.Finally,we outline potential treatment strategies for intracerebral hemorrhage and its secondary white matter injury.Our review highlights the critical role of the gut microbiota–brain axis and the NLRP3 inflammasome in white matter injury following intracerebral hemorrhage,paving the way for exploring potential therapeutic approaches.
文摘As the population ages,the burden of age-related diseases becomes greater.Currently,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common form.However,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of cSVD.The term cSVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).
文摘The charge carrier transport and recombination dynamics in the quantum dots-based light-emitting diodes(QLEDs)featuring multiple emitting layers(M-EMLs)has a great impact on the device performance.In this work,QLEDs based on M-EMLs separated by polyethyleneimine ethoxylated(PEIE)layer with different stacking sequences of blue(B),green(G),and red(R)QDs layer were used to intuitively explore the injection,transportation and recombination processes of the charge carriers in QLEDs by using the time-resolved electroluminescence(TrEL)spectra.From the TrEL spectra mea-surements,green and red emissions were obtained first in the QLEDs with the EMLs sequences of G/PEIE/B/PEIE/R and B/PEIE/R/PEIE/G along the direction of light emission,respectively.While the QLEDs adopt EMLs sequences of B/PEIE/G/PEIE/R,the blue,green and red emissions were obtained nearly at the same time.The above phenomenon can be attributed to different charge carrier transmission and radiation recombination process in the EMLs due to different valence band offsets and conduction band offsets between R-,G-and B-QDs by using different sequences of EMLs.White emission with coordi-nates of(0.31,0.31)and correlated color temperature(CCT)of 5916 K was obtained in the QLEDs with the EMLs se-quences of B/PEIE/G/PEIE/R,which can be attributed to the relative uniform emission of B-,G-and R-QDs due to the effec-tive injection and radiation recombination of charge carriers in each of the EMLs.The above results have great significance for further understanding and improving the performance of QLEDs with M-EMLs.
基金supported by the Shandong Provincial Natural Science Foundation,China(ZR2021QC131)the Shandong Province Key Research and Development Plan,China(2022TZXD001102)+1 种基金the Shandong Province Demonstration Project for Model Construction in Rural Revitalization Service,China(2022DXAL0226)the Innovation Project of Shandong Academy of Agricultural Sciences,China(CXGC2023F15,CXGC2023A41,and CXGC2023A47)。
文摘Grape white rot caused by Coniella vitis is a global concern in the grape industry.pH regulation is essential for cell growth,reproductive processes and pathogenicity in phytopathogenic fungi.In this study,we observed that the growth rate,spore production and virulence of C.vitis significantly declined in alkaline pH,as well as the suppressive effect on secretion of hydrolytic enzymes.Transcriptomic and metabolomic analyses were used to investigate the responses of C.vitis to acidic(pH 5),neutral(pH 7)and alkaline environments(pH 9).We identified 728,1,780 and 3,386 differentially expressed genes(DEGs)at pH 5,pH 7 and pH 9,when compared with the host pH(pH 3),and 2,122 differently expressed metabolites(DEMs)in negative and positive ion mode.Most DEGs were involved in carbohydrate metabolic process,transmembrane transport,tricarboxylic acid cycle,peptide metabolic process,amide biosynthetic process,and organic acid metabolic process.In addition,metabolomic analysis revealed ABC transporters,indole alkaloid biosynthesis,diterpenoid biosynthesis,and carotenoid biosynthesis pathways in response to the pH change.Furthermore,we found that the aspartate synthesis metabolic route associated with the TCA cycle is a key limiting factor for the growth and development of C.vitis in alkaline environments,and aspartate supplementation enables C.vitis to grow in alkaline environments.Plant cell wall-degrading enzymes(PCWDEs)could contribute to the pathogenicity,when C.vitis infected at pH 3.Importantly,aflatrem biosynthesis in acidic environment might contribute to the virulence of C.vitis and has a risk of causing human health problems due to its acute neurotoxic effects.
基金supported by the Key Research and Development Program of China(2022YFD1200400)National Natural Science Foundation of China(32472041)+2 种基金the Project of the Development for High-quality Seed Industry of Hubei Province(HBZY2023B003)Key Research and Development Program of Hubei Province(2021BBA077)Innovation Program of the Chinese Academy of Agricultural Sciences(2024-2060299-089-031)。
文摘Peanut is a globally significant oil crop and economic resource,notable for its kernel containing over 50%oil content.White testa peanuts are highly valued for their superior nutritional profile,minimal pigmentation,and superior oil clarity.Identification of genes controlling white testa color is crucial for advancing breeding programs and understanding the genetic mechanisms involved.A genetic mapping study was performed in peanut to identify genes controlling white testa color,a trait associated with desirable end-use quality traits in this oilseed crop.In an F_(2)population generated from a cross of a white-testa with a pink-testa cultivar,two recessive quantitative-trait loci controlling white testa were identified and finemapped to A02 and B02 chromosomes.Two homologous genes,Arahy.MP3D3D and Arahy.26781N,encoding bHLH transcriptional factors,were identified as candidates for the two loci.Reduced expression of these two genes likely suppresses anthocyanin biosynthesis.
基金funding support from the Macao Science and Technology Development Fund(0013/2021/AMJ and 0082/2022/A2)support from the Multi-Year Research Grants(MYRG2022-00266-IAPME,and MYRG-GRG2023-00224-IAPME)provided by the Research&Development Office at the University of Macao+2 种基金the National Natural Science Foundation of China(52202328)the Shanghai Sailing Program(22YF1455500)the Shanghai Magnolia Talent Plan Pujiang Project(24PJD128)for their financial support。
文摘Iron-based Prussian white(PW)materials have attracted considerable attention as promising cathodes for potassium-ion batteries(PIBs)due to their high capacity,easy preparation,and economic merits.However,the intrinsic iron dissolution and uncontrollable cathode-electrolyte interface(CEI)formation in conventional organic electrolytes severely hinder their long-term cycling stability.Herein,we employ succinonitrile(SN),a bifunctional electrolyte additive,to suppress the iron dissolution and promote thin,uniform,and stable CEI formation of the PW cathode,thus improving its structural stability.Benefited from the coordination between the cyano groups in SN and iron atoms,this molecule can preferentially adsorb on the surface of PW to mitigate iron dissolution.SN also facilitates the decomposition of anions in potassium salt rather than organic solvents in electrolyte due to the attractive reaction between SN and anions.Consequently,the PW cathode with SN additive provides better electrochemical reversibility,showing capacity retention of 93.6%after 3000 cycles at 5C.In comparison,without SN,the capacity retention is only 87.4%after 1000 cycles under the same conditions.Moreover,the full cells of PW matched with commercial graphite(Gr)achieve stable cycling for 3500 cycles at a high rate of 20C,with an exceptional capacity decay of only 0.005%per cycle,surpassing the majority of recently reported results in literature.
文摘On March 28,the white paper“Human Rights in Xizang in the New Era”was released.The white paper provides a comprehensive and systematic account of the remarkable achievements made in Xizang's human rights cause under the leadership of the CPC's(Communist Party of China)strategy for governing Xizang in the new era,showcasing the development and progress of human rights in Xizang.
基金supported by the Joint Funds for Innovation of Science and Technology,Fujian Province(2021Y9037)a National Clinical Key Special Subject of China(21281003).
文摘Previous studies have found associations between color discrimination deficits and cognitive impairments besides aging.However,investigations into the microstructural pathology of brain white matter(WM)associated with these deficits remain limited.This study aimed to examine the microstructural characteristics of WM in the non-demented population with abnormal color discrimination,utilizing Neurite Orientation Dispersion and Density Imaging(NODDI),and to explore their correlations with cognitive functions and cognition-related plasma biomarkers.The tract-based spatial statistic analysis revealed significant differences in specific brain regions between the abnormal color discrimination group and the healthy controls,characterized by increased isotropic volume fraction and decreased neurite density index and orientation dispersion index.Further analysis of region-of-interest parameters revealed that the isotropic volume fraction in the bilateral anterior thalamic radiation,superior longitudinal fasciculus,cingulum,and forceps minor was significantly correlated with poorer performance on neuropsychological assessments and to varying degrees various cognition-related plasma biomarkers.These findings provide neuroimaging evidence that WM microstructural abnormalities in non-demented individuals with abnormal color discrimination are associated with cognitive dysfunction,potentially serving as early markers for cognitive decline.
基金funded by the National Natural Science Foundation of China(31972368)the China Agriculture Research System(CARS-29-yc-6)+1 种基金the Major Agricultural Science Projects of Liaoning Province,China(2023JH1/10200004)the Science and Technology Program of Shenyang,China(23-410-2-03)。
文摘Grape white rot is a fungal disease caused by Coniella diplodiella(Speg.)Sacc.that seriously affects fruit quality and yield;however,the underlying mechanism governing the plant response to C.diplodiella pathogens is still poorly understood.Here,we characterized a homeodomain(HD)transcription factor from grape(Vitis vinifera),VvOCP3,and demonstrated its signifcance in C.diplodiella resistance.Expression analysis showed that VvOCP3 expression was signifcantly down-regulated upon inoculation with C.diplodiella.Functional analysis with transient injection in grape berries and stable overexpression in grape calli demonstrated that VvOCP3 negatively regulates grape resistance to C.diplodiella.Further studies showed that VvOCP3 directly binds to the promoter of VvPR1(pathogenesis-related protein 1)and inhibits its expression,resulting in reduced resistance to C.diplodiella.In addition,VvOCP3 can interact with the type 2C protein phosphatase VvABI1,which is a negative modulator of the ABA signaling pathway.In summary,our findings suggest that VvOCP3 plays a crucial role in regulating white rot resistance in grape,and offer theoretical guidance for developing grape cultivars with enhanced C.diplodiella resistance by regulating the expression of VvOCP3.
基金financially supported by the National Natural Science Foundation of China(32072774)the China Postdoctoral Science Foundation(2023M733822)+2 种基金the Beijing Innovation Consortium of Agriculture Research System(BAIC04),Chinathe earmarked fund for CARS National System for Layer Production Technology,China(CARS-40)the Agricultural Science and Technology Innovation Program(ASTIP)of the Chinese Academy of Agricultural Sciences。
文摘This study examined the effect of dietary serine(Ser)on egg white quality,ovomucin content of laying hens fed low-gossypol cottonseed meal(LCSM)-based diet and sought to explore the regulatory mechanism underlying the effects.A total of 288 Hy-Line Brown layers were randomly assigned into 3 treatments and respectively offered soybean meal(SBM)-based diet,LCSM-based diet,and LCSM-based diet supplemented with 0.435%L-Ser.Dietary Ser supplementation reversed the decrease in quality indices of albumen,including the proportion of thick albumen(P<0.05),thick-to-thin ratio(P<0.05),albumen height(P<0.05),Haugh unit(P<0.05),and apparent viscosity that were caused by LCSM intake.Also,dietary Ser supplementation mitigated the LCSM-induced reduction in ovomucin content of the albumen(P<0.05).FT-IR analysis of ovomucin revealed differences in second derivative spectra at 1,200-800 cm^(-1) between birds received SBM-and LCSM-based diets,meanwhile,the α-helix of ovomucin was decreased by LCSM but increased by Ser addition(P<0.05).Furthermore,Ser addition up-regulated the mRNA expression of β-ovomucin in magnum mucosa at 2 and 7.5 h post-oviposition(P<0.05).Ser mitigated the LCSMinduced impairment of magnum epithelium,increased goblet cell counts(P<0.05),and up-regulated the expression of occludin,mucin 2,and the relevant glycosyltransferases for O-glycosylation in magnum mucosa(P<0.05).Conclusively,the alleviating effect of Ser on declining albumen quality due to dietary LCSM,could be explained by the efficacy of Ser in regulating ovomucin synthesis.This regulation occurred at the levels of transcription and posttranscriptional O-glycosylation modification ofβ-ovomucin,while positive effect on magnum morphology and barrier function could also in part account for the ovomucin content.This would provide a promising research direction on the adoption of nutritional interventions for manipulation of egg white quality from perspectives of albumen protein synthesis.
文摘The Chinese Opera Season 2025 and International Exhibition of Chinese Opera opened in Vienna,the capital of Austria,on the evening of April 5.As the opening performance of the Season,a traditional Wu Opera(a local opera in Zhejiang Province)scene"the Legend of the White Snake"was performed at the Muth Theatre in Vienna,drawing enthusiastic responses.
文摘Sodium fluoride(NaF)is a daily necessity consumed as the major ingredient of fluorinated drinking water,milk,salts,mouthwashes,toothpaste,and dentistry medications.However,the use of NaF products has also been associated with increased fluoride anion distribution in the body,leading to hypertension.AIM This study evaluated the antihypertensive effect of sweet orange peels-enriched white melon seed protein concentrate(WSP)biscuit meal in eight-week-old albino rats exposed to NaF for 14 days.METHODS Forty-two(42)male Wistar albino rats were assigned at random into 7 groups of 6 rats per group(control group and six experimental groups).The experimental groups received various treatments that lasted for two weeks.Twenty-four hours after the last administration,hemodynamic parameters were evaluated,rats were sacrificed,blood samples were collected,and the heart was harvested.Blood serum was assessed for cardiac troponin I(cTnI),creatine kinase-MB(CK-MB),and lactate dehydrogenase(LDH).At the same time,the heart homogenate was assayed for angiotensin-1 converting enzyme(ACE)activity,proinflammatory cytokines,nitric oxide concentrations,and antioxidant status.Cardiac tissues were stained with Hematoxylin and Eosin,Masson’s Trichrome,and cTnI.Also,the safety of the WSP biscuit diet was evaluated.RESULTS Results obtained showed that NaF administration elevated the collagen content of cardiac tissues,activities of ACE,and concentrations of cTnI,CK-MB,LDH,tumor necrosis factor-alpha,and interleukin 1 beta,while there was a reduction in the concentration of nitric oxide and antioxidants;however,their alterations were significantly prevented in WSP-biscuit-fed rats.The WSP biscuit meal is safe for consumption and possesses dose-dependent antihypertensive ability at 10%and 20%inclusion.CONCLUSION The WSP biscuit diet may be recommended in diet formulation for the management of individuals or communities that are predisposed to NaF contaminations.
基金supported by the National Natural Science Foundation of China(12104336,U20A20211,62075152,12004274)Fundamental Research Program of Shanxi Province(20210302124162)。
文摘The continuous white light(CWL)covering the visible and near-infrared(NIR)regions can be observed in various absorptive media excited by continuous-wave(CW)lasers.It is valuable to stimulate more efforts in unravelling the involved photophysical processes and exploring its potential applications in diverse fields.Here,we proved that the enhanced thermal-field can boost the CWL emission.Using rare earth(RE)ions(Pr^(3+),Er^(3+)and Yb^(3+))as the photothermally active centers in Y_(2)SiO_(5)phosphor,we reveal that absorbing more excitation energy and isolating the heat conduction can lead to rapid thermal field accumulation inside the material,thereby significantly reducing the excitation threshold and enhancing white light emission.Our results might have important implications for the understanding of thermally enhanced radiation and may facilitate the CWL commercial application in night vision,bioimaging,and non-destructive detection.
文摘This article takes the theory of power space as an starting point for an in-depth comparison of the clan hall in White Deer Plains and the scaffold in The Scarlet Letter.In White Deer Plains,The clan hall,as the core place of family activities,has a spatial layout that implies a hierarchy of power,and the taboos it represents relate to various aspects such as marriage and bloodline,and maintains the order of the clan through a variety of disciplinary mechanisms.The scaffold in The Scarlet Letter is located in the town’s central square and is a symbol of Puritan social power and moral discipline,behind which Puritan taboos influence people’s behaviors and public punishments are used to achieve the discipline of the people.The research reveals the similarities and differences between the two in terms of sources of power,modes of operation and influence,and opens up new horizons for cross-cultural literary studies.
