Background:There is overwhelming evidence that periodontal disease and dental caries affect the majority of populations and that western culture and lifestyle may have a profound influence on oral health,especially in...Background:There is overwhelming evidence that periodontal disease and dental caries affect the majority of populations and that western culture and lifestyle may have a profound influence on oral health,especially in adults.The present study was performed to determine the effect of westernization on the oral health of college students of Udaipur City,Rajasthan.Methods:A descriptive cross-sectional study was conducted among students attending various professional and non-professional bachelor's degree colleges of Udaipur City,Rajasthan,India,from March 2013 to May 2013.Eight hundred students were selected based on a two-stage random sampling procedure.Westernization was assessed by a self-administered structured questionnaire.Periodontal status,dental caries status and malocclusion were assessed according to World Health Organization(WHO) criteria(1997).Statistical analysis was performed using Chi-square and Multivariate logistic regression.The confidence level and level of significance were set at 95% and 5%,respectively.Results:The present study suggested that adverse habits,listening to English music and preferring English food had a significant association with dental caries and periodontal diseases.Malocclusion also showed a significant relationship with consuming English food for snacks and desserts.Multivariate analysis revealed a significantly greater odds ratio(OR) for periodontal disease and dental caries among those who preferred English food for lunch.Conclusion:Based on the results of the present study,there is an association between westernization and oral health.展开更多
The differences between modernization and westernization are am biguous,since they share a dialectical relationship. In addition we can best express these differences from an affirm ative point of view and a negative ...The differences between modernization and westernization are am biguous,since they share a dialectical relationship. In addition we can best express these differences from an affirm ative point of view and a negative point of view. Affirm atively,westernization stem s from Europe,and the core of modernization is the western civilization. It was the occident that completed the modernization process,and the progress of the world modernization is the expansion of the occidental modern civilization. Negatively,modernization is a value free concept,and the westernization or Europeanization is a concept with strong value orientation. Although modernization stems from Europe,the occidental civilization is not created by westerners alone. Instead,it comes from the long developm ent and integration of human civilization. The mode of the occidental modernization is not completed yet and needs more explorations and adjustm ents. It seem s that the modernization process is the global expansion of the occidental modern civilization,but as the scale of modernization grows,it will involve more countries with more different characteristics,and it will become further and further from the westernization or Europeanization.展开更多
Abstract China used to have great urban rural disparity in socioeconomic development. Since the late 1980s, rapid socioeconomic development and urbanization have been taking place in rural settings. It is epidemiologi...Abstract China used to have great urban rural disparity in socioeconomic development. Since the late 1980s, rapid socioeconomic development and urbanization have been taking place in rural settings. It is epidemiologically established that cancer scale and profile will transit as economy prospers and urbanization develops. However, there are few published studies reporting what changes are undergoing in cancer pattern in Chinese rural settings. Population-based tumor registration data collected by us in urban Shijiazhuang city (available for 2,374,827 people in 2012) and in rural Shexian County (available for 408,995 people since 2000) were used for urban rural comparison of age standardized incidence rate (ASIR) of westernization-related cancers in 2012, and the trend of biennial ASIR of these cancers for 2000-2015 in Shexian County was examined following a decade of rapid socioeconomic development and urbanization. From 1988-2015, the Gross Domestic Product per Capita (GDP) in rural Shexian County increased from 860 to 3000 US$, and urbanization rate from 22.4% to 54.8%. The biennial ASIRs of lung, colorectal, gallbladder cancer and leukemia in both sexes, and that of breast, ovary, thyroid, and kidney cancer in women increased significantly from 2000 - 2015. The increase from 2000-2001 to 2014-2015 in man and women for lung cancer was from 15.9 to 34.7 per 105 (P = 0.05) and 9.6 to 16.7 (P = 0.00), for colorectal cancer from 6.6 to 15.9 (P = 0.00) and 4.0 to 11.7 (P = 0.00), for gallbladder cancer from 0.1 to 2.4 (P = 0.00) and 0.3 to 2.7 (P = 0.00), for leukemia from 2.8 to 7.7 (P = 0.00) and 2.3 to 6.2 (P = 0.00);and in women for cancer of breast from 2.8 to 17.3 (P = 0.00), kidney from 0.2 to 2.4 (P = 0.00), ovary from 0.2 to 4.3 (P = 0.00), and thyroid from 0.2 to 4.2 (P = 0.00). Notwithstanding these increases, their ASIRs in 2012 in Shexian County were still significantly lower than that in Shijiazhuang city. Westernization-related cancer is increasing rapidly in rural China. Comprehensive measures are needed to strengthen prevention to ensure sustainable development.展开更多
Nowadays,the word globalization has become a most exposed word in contexts of economy,culture and politics.Among the three fields,economic globalization has been paid more attention to.In this article,the author inten...Nowadays,the word globalization has become a most exposed word in contexts of economy,culture and politics.Among the three fields,economic globalization has been paid more attention to.In this article,the author intends to discuss the issue of cultural globalization.In detail,he wants to analyze the impacts of cultural globalization in the making of contemporary Chinese culture.First,the author discussed that the cultural globalization is mostly cultural westernization.Second,he explained that cultural westernization is not a monster to Chinese and the construction of modern Chinese culture.Thirdly and lastly,by discussing some significances of western culture,the author suggested those significances of western culture are valuable to be absorbed in the making of Chinese culture great again.展开更多
In this study,based on MERRA-2 reanalysis data and a multi-algorithm integrated atmospheric river(AR)iden-tification method,the authors reveal the cross-seasonal regulation mechanism of El Niño-Southern Oscillati...In this study,based on MERRA-2 reanalysis data and a multi-algorithm integrated atmospheric river(AR)iden-tification method,the authors reveal the cross-seasonal regulation mechanism of El Niño-Southern Oscillation(ENSO)on winter-spring AR activities in East Asia.The results show that ENSO asymmetrically modulates AR ac-tivity through teleconnection and hysteresis effects,and has significant enhancement/inhibition effects on ARs in different regions.At the onset of El Niño,enhanced southwesterly flow at the western edge of the western Pacific subtropical high(WPSH)leads to enhanced AR activity in the western Pacific,and anomalous southerly winds in the Indian Ocean promote northward transport of water vapor in the Arabian Sea and Bay of Bengal.With a three-month lag,the weakening and eastward retreat of the WPSH weakens the low-latitude AR activity,but persistent southerly winds in the Bay of Bengal maintain the AR activity over Southwest China.The mid-to high-latitude AR response exhibits delayed dynamics,initially dominated by the synergistic effect of the southward deviation of the upper-air rapids and the low-level convergence(double-rapid-flow effect)and later modulated by the Pacific-North American teleconnection(PNA)-triggered East Asian ridge,which enhances the precipitation efficiency through prolonged frontal activity and enhanced cold-warm airmass convergence.Overall,El Niño promotes the development of low-and midlatitude AR activity in East Asia,while La Niña promotes(maritime continental)AR activity in the tropics.This study establishes the“ENSO teleconnection→circulation adjust-ment→East Asian AR response”chain,revealing a cross-seasonal lagged response mechanisms of East Asian AR activity,and provides a theoretical basis for winter and spring climate prediction and extreme precipitation forecasting.展开更多
Corrigendum:Epalrestat protects against diabetic peripheral neuropathy by alleviating oxidative stress and inhibiting polyol pathway https://doi.org/10.4103/NRR.NRR-D-25-00562 In the article titled“Epalrestat protect...Corrigendum:Epalrestat protects against diabetic peripheral neuropathy by alleviating oxidative stress and inhibiting polyol pathway https://doi.org/10.4103/NRR.NRR-D-25-00562 In the article titled“Epalrestat protects against diabetic peripheral neuropathy by alleviating oxidative stress and inhibiting polyol pathway,”published on pages 345-351 in Issue 2,Volume 11 of Neural Regeneration Research(Li et al.,2016),the Western blot bands in Figure 2A are incorrect.展开更多
1 Introduction The history of medicine in modern China has frequently been framed through a lens of“Westernization”,in which traditional Chinese medicine(TCM)is portrayed as grad-ually yielding to modern Western med...1 Introduction The history of medicine in modern China has frequently been framed through a lens of“Westernization”,in which traditional Chinese medicine(TCM)is portrayed as grad-ually yielding to modern Western medicine.Such a binary framework,however,oversimplifies the intricate realities of medical encounters in China.展开更多
Chinese modernization transcends the conventional concept of modernization,as the Chinese wisdom behind it inspires innovative development.FOR a long time,many people have equated modernization with Westernization.Thi...Chinese modernization transcends the conventional concept of modernization,as the Chinese wisdom behind it inspires innovative development.FOR a long time,many people have equated modernization with Westernization.This long held prejudice has proven false in the face of Chinese modernization.展开更多
INTRODUCTION.Depressive disorders are mental illnesses that seriously affect public health.There are approximately 320 million patients with depression worldwide,accounting for 4.4% of the total disease burden.1Depres...INTRODUCTION.Depressive disorders are mental illnesses that seriously affect public health.There are approximately 320 million patients with depression worldwide,accounting for 4.4% of the total disease burden.1Depression leads to social and occupational impairment,diminished quality of life and an elevated risk of death by suicide.展开更多
The Pamir Plateau,at the northwestern margin of the Tibetan Plateau,is a key region for investigating continental collision and plateau uplifting.To probe its deep structure,we collected seismic data from 263 stations...The Pamir Plateau,at the northwestern margin of the Tibetan Plateau,is a key region for investigating continental collision and plateau uplifting.To probe its deep structure,we collected seismic data from 263 stations across 11 research projects.We applied cross-correlation to noise data and extracted surface wave dispersion data from cross-correlation functions.The extracted dispersion data were subsequently inverted using a 3-D transdimensional Bayesian inversion method(rj-3 DMcMC).The inversion result reveals several crustal low-velocity zones(LVZs).Their formation is likely related to crustal thickening,the exposure of gneiss domes,and thicker sedimentary sequences compared to surrounding areas.In the lower crust and upper mantle,the LVZs in southern Pamir and southeastern Karakoram evolve into high-velocity zones,which expand northeastward with increasing depth.This suggests northward underthrusting of the Indian Plate.We also analyzed the Moho using both the standard deviation of S-wave velocity and the S-wave velocity structure.Results show that significant variations in velocity standard deviation reliably delineate the Moho interface.展开更多
BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s...BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s syndrome,among others.The pathogenesis of these diseases is related to the abnormal activation and regulatory imbalance of the immune system.The prevalence and morbidity of rheumatic immune diseases are high,imposing a significant burden on patients'quality of life and socio-economic costs.Currently,the treatment of rheumatic immune diseases mainly relies on Western medicine,such as non-steroidal anti-inflammatory drugs,glucocorticoids,disease-modifying antirheumatic drugs,and biologics.However,the therapeutic effects of Western medicine are not ideal,some patients poorly respond or are resistant to Western medicine,and long-term use often causes various adverse reactions.AIM To systematically evaluate the efficacy and safety of Tripterygium wilfordii gly-cosides tablets combined with Western medicine in the treatment of patients with rheumatic immune diseases.METHODS This study conducted a meta-analysis to systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases.Chinese and English databases were searched for randomized controlled trials(RCTs)on the treatment of rheumatic immune diseases with Tripterygium wilfordii glycosides tablets combined with Western medicine.The quality of the included studies was assessed using the Cochrane risk of bias assessment tool.Meta-analysis was performed using RevMan 5.4 software.RESULTS The meta-analysis included 11 RCTs involving 1026 patients with rheumatic immune diseases.The combined treatment significantly reduced the risk of disease recurrence(relative risk=1.07,95%confidence interval:1.01-1.15,P<0.05)and showed no significant heterogeneity(I2=0%,P=0.53),indicating that Tripterygium wilfordii glycosides tablets combined with Western medicine is an effective method to reduce the possibility of postoperative recurrence in patients with rheumatic immune diseases.However,due to the limited number and quality of the studies included,these results should be interpreted with caution.CONCLUSION Tripterygium wilfordii glycosides tablets combined with Western medicine is an effective and safe treatment option for patients with rheumatic immune diseases and can be considered a clinical choice.However,more high-quality research is needed to validate this conclusion and provide more solid evidence for clinical practice.展开更多
BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and countries.AIM To analyze the burden of MD i...BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and countries.AIM To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging challenges.METHODS We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to 2021.Statistical methods included age-standardisation and uncertainty analysis to address variations in population structure and data completeness.RESULTS Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age groups.Depressive and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum disorders.Australia,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the lowest.Additionally,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk factors.CONCLUSION This study highlights the significant burden of MD in the WPR,with variations by age,gender,and nation.The coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.展开更多
文摘Background:There is overwhelming evidence that periodontal disease and dental caries affect the majority of populations and that western culture and lifestyle may have a profound influence on oral health,especially in adults.The present study was performed to determine the effect of westernization on the oral health of college students of Udaipur City,Rajasthan.Methods:A descriptive cross-sectional study was conducted among students attending various professional and non-professional bachelor's degree colleges of Udaipur City,Rajasthan,India,from March 2013 to May 2013.Eight hundred students were selected based on a two-stage random sampling procedure.Westernization was assessed by a self-administered structured questionnaire.Periodontal status,dental caries status and malocclusion were assessed according to World Health Organization(WHO) criteria(1997).Statistical analysis was performed using Chi-square and Multivariate logistic regression.The confidence level and level of significance were set at 95% and 5%,respectively.Results:The present study suggested that adverse habits,listening to English music and preferring English food had a significant association with dental caries and periodontal diseases.Malocclusion also showed a significant relationship with consuming English food for snacks and desserts.Multivariate analysis revealed a significantly greater odds ratio(OR) for periodontal disease and dental caries among those who preferred English food for lunch.Conclusion:Based on the results of the present study,there is an association between westernization and oral health.
文摘The differences between modernization and westernization are am biguous,since they share a dialectical relationship. In addition we can best express these differences from an affirm ative point of view and a negative point of view. Affirm atively,westernization stem s from Europe,and the core of modernization is the western civilization. It was the occident that completed the modernization process,and the progress of the world modernization is the expansion of the occidental modern civilization. Negatively,modernization is a value free concept,and the westernization or Europeanization is a concept with strong value orientation. Although modernization stems from Europe,the occidental civilization is not created by westerners alone. Instead,it comes from the long developm ent and integration of human civilization. The mode of the occidental modernization is not completed yet and needs more explorations and adjustm ents. It seem s that the modernization process is the global expansion of the occidental modern civilization,but as the scale of modernization grows,it will involve more countries with more different characteristics,and it will become further and further from the westernization or Europeanization.
文摘Abstract China used to have great urban rural disparity in socioeconomic development. Since the late 1980s, rapid socioeconomic development and urbanization have been taking place in rural settings. It is epidemiologically established that cancer scale and profile will transit as economy prospers and urbanization develops. However, there are few published studies reporting what changes are undergoing in cancer pattern in Chinese rural settings. Population-based tumor registration data collected by us in urban Shijiazhuang city (available for 2,374,827 people in 2012) and in rural Shexian County (available for 408,995 people since 2000) were used for urban rural comparison of age standardized incidence rate (ASIR) of westernization-related cancers in 2012, and the trend of biennial ASIR of these cancers for 2000-2015 in Shexian County was examined following a decade of rapid socioeconomic development and urbanization. From 1988-2015, the Gross Domestic Product per Capita (GDP) in rural Shexian County increased from 860 to 3000 US$, and urbanization rate from 22.4% to 54.8%. The biennial ASIRs of lung, colorectal, gallbladder cancer and leukemia in both sexes, and that of breast, ovary, thyroid, and kidney cancer in women increased significantly from 2000 - 2015. The increase from 2000-2001 to 2014-2015 in man and women for lung cancer was from 15.9 to 34.7 per 105 (P = 0.05) and 9.6 to 16.7 (P = 0.00), for colorectal cancer from 6.6 to 15.9 (P = 0.00) and 4.0 to 11.7 (P = 0.00), for gallbladder cancer from 0.1 to 2.4 (P = 0.00) and 0.3 to 2.7 (P = 0.00), for leukemia from 2.8 to 7.7 (P = 0.00) and 2.3 to 6.2 (P = 0.00);and in women for cancer of breast from 2.8 to 17.3 (P = 0.00), kidney from 0.2 to 2.4 (P = 0.00), ovary from 0.2 to 4.3 (P = 0.00), and thyroid from 0.2 to 4.2 (P = 0.00). Notwithstanding these increases, their ASIRs in 2012 in Shexian County were still significantly lower than that in Shijiazhuang city. Westernization-related cancer is increasing rapidly in rural China. Comprehensive measures are needed to strengthen prevention to ensure sustainable development.
文摘Nowadays,the word globalization has become a most exposed word in contexts of economy,culture and politics.Among the three fields,economic globalization has been paid more attention to.In this article,the author intends to discuss the issue of cultural globalization.In detail,he wants to analyze the impacts of cultural globalization in the making of contemporary Chinese culture.First,the author discussed that the cultural globalization is mostly cultural westernization.Second,he explained that cultural westernization is not a monster to Chinese and the construction of modern Chinese culture.Thirdly and lastly,by discussing some significances of western culture,the author suggested those significances of western culture are valuable to be absorbed in the making of Chinese culture great again.
基金supported by the National Natural Science Foundation of China[grant number 41830964]the Natural Science Foundation of Hunan Province[grant number 2023JJ40666]。
文摘In this study,based on MERRA-2 reanalysis data and a multi-algorithm integrated atmospheric river(AR)iden-tification method,the authors reveal the cross-seasonal regulation mechanism of El Niño-Southern Oscillation(ENSO)on winter-spring AR activities in East Asia.The results show that ENSO asymmetrically modulates AR ac-tivity through teleconnection and hysteresis effects,and has significant enhancement/inhibition effects on ARs in different regions.At the onset of El Niño,enhanced southwesterly flow at the western edge of the western Pacific subtropical high(WPSH)leads to enhanced AR activity in the western Pacific,and anomalous southerly winds in the Indian Ocean promote northward transport of water vapor in the Arabian Sea and Bay of Bengal.With a three-month lag,the weakening and eastward retreat of the WPSH weakens the low-latitude AR activity,but persistent southerly winds in the Bay of Bengal maintain the AR activity over Southwest China.The mid-to high-latitude AR response exhibits delayed dynamics,initially dominated by the synergistic effect of the southward deviation of the upper-air rapids and the low-level convergence(double-rapid-flow effect)and later modulated by the Pacific-North American teleconnection(PNA)-triggered East Asian ridge,which enhances the precipitation efficiency through prolonged frontal activity and enhanced cold-warm airmass convergence.Overall,El Niño promotes the development of low-and midlatitude AR activity in East Asia,while La Niña promotes(maritime continental)AR activity in the tropics.This study establishes the“ENSO teleconnection→circulation adjust-ment→East Asian AR response”chain,revealing a cross-seasonal lagged response mechanisms of East Asian AR activity,and provides a theoretical basis for winter and spring climate prediction and extreme precipitation forecasting.
文摘Corrigendum:Epalrestat protects against diabetic peripheral neuropathy by alleviating oxidative stress and inhibiting polyol pathway https://doi.org/10.4103/NRR.NRR-D-25-00562 In the article titled“Epalrestat protects against diabetic peripheral neuropathy by alleviating oxidative stress and inhibiting polyol pathway,”published on pages 345-351 in Issue 2,Volume 11 of Neural Regeneration Research(Li et al.,2016),the Western blot bands in Figure 2A are incorrect.
文摘1 Introduction The history of medicine in modern China has frequently been framed through a lens of“Westernization”,in which traditional Chinese medicine(TCM)is portrayed as grad-ually yielding to modern Western medicine.Such a binary framework,however,oversimplifies the intricate realities of medical encounters in China.
文摘Chinese modernization transcends the conventional concept of modernization,as the Chinese wisdom behind it inspires innovative development.FOR a long time,many people have equated modernization with Westernization.This long held prejudice has proven false in the face of Chinese modernization.
基金funded by the Construction Project of the"Flagship"Department of Chinese and Western Medicine Coordination(LiuL/2024-221)the 2024 Medical Service and Security Capacity Improvement Project(National Clinical Key Specialty Construction)(LiuL/Huwei Medical/2024-65)+5 种基金the Shanghai Traditional Chinese Medicine Standardization Project(LiuL/No.2023JSP03)the Shanghai Key Discipline Construction Project of Traditional Chinese Medicine(Clinical)(LiuL/2024-No.3)the Shanghai Technical Standardization Management and Promotion Project(LiuL/No.SHDC22023212)the Shanghai Municipal Health Commission Traditional Chinese Medicine Research Project(2022)(LiuL/No.2022Cx004)Clinical research project of Shanghai Health Commission-Youth Project(LW/No.20214Y0056)Shanghai Institute of Traditional Chinese Medicine for Mental Health(LW/No.SZB2023201).
文摘INTRODUCTION.Depressive disorders are mental illnesses that seriously affect public health.There are approximately 320 million patients with depression worldwide,accounting for 4.4% of the total disease burden.1Depression leads to social and occupational impairment,diminished quality of life and an elevated risk of death by suicide.
基金supported by the National Natural Science Foundation of China(Grant No.42174126)the Alliance of International Science Organizations(ANSO)Project(Grant No.ANSO-CR-PP2022-04)+1 种基金the Deep Earth Probe and Mineral Resources Exploration National Science and Technology Major Project(Grant Nos.2024ZD1002206,2024ZD1002201)Key R&D Program of Xinjiang Uyghur Autonomous Region(Grant No.2024B03013-2)。
文摘The Pamir Plateau,at the northwestern margin of the Tibetan Plateau,is a key region for investigating continental collision and plateau uplifting.To probe its deep structure,we collected seismic data from 263 stations across 11 research projects.We applied cross-correlation to noise data and extracted surface wave dispersion data from cross-correlation functions.The extracted dispersion data were subsequently inverted using a 3-D transdimensional Bayesian inversion method(rj-3 DMcMC).The inversion result reveals several crustal low-velocity zones(LVZs).Their formation is likely related to crustal thickening,the exposure of gneiss domes,and thicker sedimentary sequences compared to surrounding areas.In the lower crust and upper mantle,the LVZs in southern Pamir and southeastern Karakoram evolve into high-velocity zones,which expand northeastward with increasing depth.This suggests northward underthrusting of the Indian Plate.We also analyzed the Moho using both the standard deviation of S-wave velocity and the S-wave velocity structure.Results show that significant variations in velocity standard deviation reliably delineate the Moho interface.
文摘BACKGROUND Rheumatic immune diseases are a group of chronic inflammatory diseases charac-terized by joint and systemic multi-organ involvement,including rheumatoid arthritis,systemic lupus erythematosus,and Sjogren’s syndrome,among others.The pathogenesis of these diseases is related to the abnormal activation and regulatory imbalance of the immune system.The prevalence and morbidity of rheumatic immune diseases are high,imposing a significant burden on patients'quality of life and socio-economic costs.Currently,the treatment of rheumatic immune diseases mainly relies on Western medicine,such as non-steroidal anti-inflammatory drugs,glucocorticoids,disease-modifying antirheumatic drugs,and biologics.However,the therapeutic effects of Western medicine are not ideal,some patients poorly respond or are resistant to Western medicine,and long-term use often causes various adverse reactions.AIM To systematically evaluate the efficacy and safety of Tripterygium wilfordii gly-cosides tablets combined with Western medicine in the treatment of patients with rheumatic immune diseases.METHODS This study conducted a meta-analysis to systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases.Chinese and English databases were searched for randomized controlled trials(RCTs)on the treatment of rheumatic immune diseases with Tripterygium wilfordii glycosides tablets combined with Western medicine.The quality of the included studies was assessed using the Cochrane risk of bias assessment tool.Meta-analysis was performed using RevMan 5.4 software.RESULTS The meta-analysis included 11 RCTs involving 1026 patients with rheumatic immune diseases.The combined treatment significantly reduced the risk of disease recurrence(relative risk=1.07,95%confidence interval:1.01-1.15,P<0.05)and showed no significant heterogeneity(I2=0%,P=0.53),indicating that Tripterygium wilfordii glycosides tablets combined with Western medicine is an effective method to reduce the possibility of postoperative recurrence in patients with rheumatic immune diseases.However,due to the limited number and quality of the studies included,these results should be interpreted with caution.CONCLUSION Tripterygium wilfordii glycosides tablets combined with Western medicine is an effective and safe treatment option for patients with rheumatic immune diseases and can be considered a clinical choice.However,more high-quality research is needed to validate this conclusion and provide more solid evidence for clinical practice.
基金Supported by National Key Research and Development Program of China,No.2022YFC3600903Key Discipline Project under Shanghai's Three-Year Action Plan for Strengthening the Public Health System(2023-2025),No.GWVI-11.1-44.
文摘BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and countries.AIM To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging challenges.METHODS We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to 2021.Statistical methods included age-standardisation and uncertainty analysis to address variations in population structure and data completeness.RESULTS Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age groups.Depressive and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum disorders.Australia,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the lowest.Additionally,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk factors.CONCLUSION This study highlights the significant burden of MD in the WPR,with variations by age,gender,and nation.The coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.
