Wireless capsule endoscopy(WCE)has the potential to fully replace conventional wired counterparts for its low invasiveness.Recent studies have attempted to expand the functions of capsules toward this goal.However,lim...Wireless capsule endoscopy(WCE)has the potential to fully replace conventional wired counterparts for its low invasiveness.Recent studies have attempted to expand the functions of capsules toward this goal.However,limitations in space and energy supply have resulted in the inability to perform multiple diagnostic and treatment tasks using a single capsule.In this study,we developed a dual-functional capsule robot(DFCR)for drug delivery and tissue biopsy based on magnetic torsion spring technology.The delivery module was shown to rotate the push rod with a thrust of 894 mN to release approximately 0.3 mL of semisolid drug.The biopsy module used a built-in blade to cut tissue with a shear stress of 22.87 MPa,producing a sample of approximately 1.8 mm3.Additionally,a five-degree-of-freedom permanent magnet drive system was developed.By adjusting the strength of the unidirectional magnetic field generated by an external magnet,the capsule can be wirelessly controlled to sequentially trigger the two functions.Ex vivo tests on porcine stomachs confirmed the feasibility of the prototype capsule(12 mm in diameter and 45 mm in length)in active movement,medication,and tissue biopsy.The newly developed DFCR further expands the clinical application prospects of WCE robots in minimally invasive surgery.展开更多
The wireless capsule endoscope,as a small electronic device,has conquered some limitations of traditional wired diagnosing tools,such as the uncomfortableness of the cables for the patient and the inability to examine...The wireless capsule endoscope,as a small electronic device,has conquered some limitations of traditional wired diagnosing tools,such as the uncomfortableness of the cables for the patient and the inability to examine the very convoluted small intestine section.However,this technique is still encountering a lot of practical challenges and is looking for feasible improvements.This work investigates the RF performance of the wireless capsule endoscope system by studying the electromagnetic(EM) wave propagation within the human body.A wireless capsule endoscopy transmission channel model is constructed to serve the purpose of investigating signal attenuations according to the relative position between the transmitter and the receiver.Within 300-500 MHz,the S_(21) results are regular and do not display any sudden changes,which allows a suitable expression to be derived for S_(21) in terms of frequency and offset.The results provide useful information for capsule localization.展开更多
Wireless capsule endoscopes (WCEs) have been used widely to detect abnormalities inside regions of the small intestine that are not accessible when using traditional endoscopy techniques. However, an experienced clini...Wireless capsule endoscopes (WCEs) have been used widely to detect abnormalities inside regions of the small intestine that are not accessible when using traditional endoscopy techniques. However, an experienced clinician must spend an average of 2 hours to view and analyze the approximately 60,000 images produced during one examination. Therefore, developing a computeraided system for processing WCE images is crucial. This paper proposes a novel method used for detecting bleeding and ulcers in WCE images. This approach involves using color features to determine the status of the small intestine. The experimental results revealed that the proposed scheme is promising in detecting bleeding and ulcer regions.展开更多
Due to rapid development in Artificial Intelligence(AI)and Deep Learning(DL),it is difficult to maintain the security and robustness of these techniques and algorithms due to emergence of novel term adversary sampling...Due to rapid development in Artificial Intelligence(AI)and Deep Learning(DL),it is difficult to maintain the security and robustness of these techniques and algorithms due to emergence of novel term adversary sampling.Such technique is sensitive to these models.Thus,fake samples cause AI and DL model to produce diverse results.Adversarial attacks that successfully implemented in real world scenarios highlight their applicability even further.In this regard,minor modifications of input images cause“Adversarial Attacks”that altered the performance of competing attacks dramatically.Recently,such attacks and defensive strategies are gaining lot of attention by the machine learning and security researchers.Doctors use different kinds of technologies to examine the patient abnormalities including Wireless Capsule Endoscopy(WCE).However,using WCE it is very difficult for doctors to detect an abnormality within images since it takes enough time while inspection and deciding abnormality.As a result,it took weeks to generate patients test report,which is tiring and strenuous for them.Therefore,researchers come out with the solution to adopt computerized technologies,which are more suitable for the classification and detection of such abnormalities.As far as the classification is concern,the adversarial attacks generate problems in classified images.Now days,to handle this issue machine learning is mainstream defensive approach against adversarial attacks.Hence,this research exposes the attacks by altering the datasets with noise including salt and pepper and Fast Gradient Sign Method(FGSM)and then reflects that how machine learning algorithms work fine to handle these noises in order to avoid attacks.Results obtained on the WCE images which are vulnerable to adversarial attack are 96.30%accurate and prove that the proposed defensive model is robust when compared to competitive existing methods.展开更多
The distribution of rDNA was visualized in interphase nuclei of tumor promoter treated human lymphocytes in comparison with the mltogen Phytoheamagglutinin (PHA) effects by using an in situ hybridization fluorescent m...The distribution of rDNA was visualized in interphase nuclei of tumor promoter treated human lymphocytes in comparison with the mltogen Phytoheamagglutinin (PHA) effects by using an in situ hybridization fluorescent method. The procedure involves biotinylated rDNA as the probe and FITC-avidin as detection system. Silver (Ag) staining was used to visualize nucleoli. In the interphase nuclei of most of the nonstimulated control lymphocytes, only one small Ag-stained nucleolus could be seen. The in situ hybridization, however, revealed one to several agglomerations of rDNA fluorescent spots. With tumor promoting herb extract WCE (40 μg/ml) or TPA (60 ng/ ml) treatment, the Interphase nucleoli increased slightly in number with the morphology alteration into larger, reticular or compact granular types. Ag-stained particles also increased in number. The number of the in situ hybridization rDNA fluorescent spots and dots increased markedly and largereticulate formations of numerous rDNA spots were seen. This phenomenum resembles to the changes in PHA stimulated lymphocytes. Statistic analysized data showed signifcant difference between control and drug- treated cells. These results indicate that transcriptionally activated rDNA and amplification of total rDNA was induced by the used tumor promoters.展开更多
2014年4月30日至5月3日，“第12届世界子宫内膜异位症会议（World Congress On Endometriosis，WCE）”在巴西圣保罗市召开，来自全世界68个国家的1300位学者和30个学术团体参会，中国较前有更多的代表参加并在大会发言及壁报展示。本...2014年4月30日至5月3日，“第12届世界子宫内膜异位症会议（World Congress On Endometriosis，WCE）”在巴西圣保罗市召开，来自全世界68个国家的1300位学者和30个学术团体参会，中国较前有更多的代表参加并在大会发言及壁报展示。本次大会集中体现了3年来全世界关于子宫内膜异位症（内异症）诊治观念的更新、技术的进展以及对未来研究的展望。展开更多
基金supported by the National Natural Science Foundation of China(No.52105072)Zhejiang Provincial Natural Science Foundation of China(No.LZ24E050004)+2 种基金Jiangsu Provincial Outstanding Youth Program(No.BK20230072)a grant from Suzhou Industrial Foresight and Key Core Technology Project(No.SYC2022044)grants from Jiangsu Qinglan Project and Jiangsu 333 High-level Talents.
文摘Wireless capsule endoscopy(WCE)has the potential to fully replace conventional wired counterparts for its low invasiveness.Recent studies have attempted to expand the functions of capsules toward this goal.However,limitations in space and energy supply have resulted in the inability to perform multiple diagnostic and treatment tasks using a single capsule.In this study,we developed a dual-functional capsule robot(DFCR)for drug delivery and tissue biopsy based on magnetic torsion spring technology.The delivery module was shown to rotate the push rod with a thrust of 894 mN to release approximately 0.3 mL of semisolid drug.The biopsy module used a built-in blade to cut tissue with a shear stress of 22.87 MPa,producing a sample of approximately 1.8 mm3.Additionally,a five-degree-of-freedom permanent magnet drive system was developed.By adjusting the strength of the unidirectional magnetic field generated by an external magnet,the capsule can be wirelessly controlled to sequentially trigger the two functions.Ex vivo tests on porcine stomachs confirmed the feasibility of the prototype capsule(12 mm in diameter and 45 mm in length)in active movement,medication,and tissue biopsy.The newly developed DFCR further expands the clinical application prospects of WCE robots in minimally invasive surgery.
基金Project (BK20131183) supported by the Natural Science Foundation of Jiangsu Province,ChinaProjects (RDF-14-03-24,RDF-14-02-48) supported by Research Development Fund of Xi’an Jiaotong-Liverpool University,China
文摘The wireless capsule endoscope,as a small electronic device,has conquered some limitations of traditional wired diagnosing tools,such as the uncomfortableness of the cables for the patient and the inability to examine the very convoluted small intestine section.However,this technique is still encountering a lot of practical challenges and is looking for feasible improvements.This work investigates the RF performance of the wireless capsule endoscope system by studying the electromagnetic(EM) wave propagation within the human body.A wireless capsule endoscopy transmission channel model is constructed to serve the purpose of investigating signal attenuations according to the relative position between the transmitter and the receiver.Within 300-500 MHz,the S_(21) results are regular and do not display any sudden changes,which allows a suitable expression to be derived for S_(21) in terms of frequency and offset.The results provide useful information for capsule localization.
文摘Wireless capsule endoscopes (WCEs) have been used widely to detect abnormalities inside regions of the small intestine that are not accessible when using traditional endoscopy techniques. However, an experienced clinician must spend an average of 2 hours to view and analyze the approximately 60,000 images produced during one examination. Therefore, developing a computeraided system for processing WCE images is crucial. This paper proposes a novel method used for detecting bleeding and ulcers in WCE images. This approach involves using color features to determine the status of the small intestine. The experimental results revealed that the proposed scheme is promising in detecting bleeding and ulcer regions.
基金This work was supported by“Human Resources Program in Energy Technology”of the Korea Institute of Energy Technology Evaluation and Planning(KETEP),granted financial resources from the Ministry of Trade,Industry&Energy,Republic of Korea.(No.20204010600090).
文摘Due to rapid development in Artificial Intelligence(AI)and Deep Learning(DL),it is difficult to maintain the security and robustness of these techniques and algorithms due to emergence of novel term adversary sampling.Such technique is sensitive to these models.Thus,fake samples cause AI and DL model to produce diverse results.Adversarial attacks that successfully implemented in real world scenarios highlight their applicability even further.In this regard,minor modifications of input images cause“Adversarial Attacks”that altered the performance of competing attacks dramatically.Recently,such attacks and defensive strategies are gaining lot of attention by the machine learning and security researchers.Doctors use different kinds of technologies to examine the patient abnormalities including Wireless Capsule Endoscopy(WCE).However,using WCE it is very difficult for doctors to detect an abnormality within images since it takes enough time while inspection and deciding abnormality.As a result,it took weeks to generate patients test report,which is tiring and strenuous for them.Therefore,researchers come out with the solution to adopt computerized technologies,which are more suitable for the classification and detection of such abnormalities.As far as the classification is concern,the adversarial attacks generate problems in classified images.Now days,to handle this issue machine learning is mainstream defensive approach against adversarial attacks.Hence,this research exposes the attacks by altering the datasets with noise including salt and pepper and Fast Gradient Sign Method(FGSM)and then reflects that how machine learning algorithms work fine to handle these noises in order to avoid attacks.Results obtained on the WCE images which are vulnerable to adversarial attack are 96.30%accurate and prove that the proposed defensive model is robust when compared to competitive existing methods.
文摘The distribution of rDNA was visualized in interphase nuclei of tumor promoter treated human lymphocytes in comparison with the mltogen Phytoheamagglutinin (PHA) effects by using an in situ hybridization fluorescent method. The procedure involves biotinylated rDNA as the probe and FITC-avidin as detection system. Silver (Ag) staining was used to visualize nucleoli. In the interphase nuclei of most of the nonstimulated control lymphocytes, only one small Ag-stained nucleolus could be seen. The in situ hybridization, however, revealed one to several agglomerations of rDNA fluorescent spots. With tumor promoting herb extract WCE (40 μg/ml) or TPA (60 ng/ ml) treatment, the Interphase nucleoli increased slightly in number with the morphology alteration into larger, reticular or compact granular types. Ag-stained particles also increased in number. The number of the in situ hybridization rDNA fluorescent spots and dots increased markedly and largereticulate formations of numerous rDNA spots were seen. This phenomenum resembles to the changes in PHA stimulated lymphocytes. Statistic analysized data showed signifcant difference between control and drug- treated cells. These results indicate that transcriptionally activated rDNA and amplification of total rDNA was induced by the used tumor promoters.
文摘2014年4月30日至5月3日，“第12届世界子宫内膜异位症会议（World Congress On Endometriosis，WCE）”在巴西圣保罗市召开，来自全世界68个国家的1300位学者和30个学术团体参会，中国较前有更多的代表参加并在大会发言及壁报展示。本次大会集中体现了3年来全世界关于子宫内膜异位症（内异症）诊治观念的更新、技术的进展以及对未来研究的展望。
