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Vulvar sarcomas: A 25 plus-year experience from Queensland
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作者 Ian S. C. Jones Alex Crandon Karen Sanday 《Open Journal of Obstetrics and Gynecology》 2013年第1期37-40,共4页
Objective: To review the characteristics of cases of vulvar sarcomas (VS) referred to the Queensland Centre for Gynaecological Cancer (QCGC) between mid 1984 and mid 2012. Methods: VS case data from QCGC were reviewed... Objective: To review the characteristics of cases of vulvar sarcomas (VS) referred to the Queensland Centre for Gynaecological Cancer (QCGC) between mid 1984 and mid 2012. Methods: VS case data from QCGC were reviewed and analysed using the computer software Statistical Package for the Social Sciences (SPSS) 11.0. Results: Of the nine cases three died of their disease, one died of ovarian cancer and five are still alive and disease free. The mean age at diagnosis was 54.8 years. Time from onset of symptoms to diagnosis averaged one month. All diagnoses were confirmed histologically. The most common presenting complaint was a lump. Treatment in all but one case involved surgical excision, one case had chemotherapy alone and two cases had surgery followed by radiotherapy. Conclusions: To talk of five year survival for patients with such a rare cancer, so many histological types with variable cell differentiation plus the unknown of when sarcomatous cells metastasize from even early FIGO staged lesions is in our opinion taking generalisation to far. A multidisciplinary approach to management achieves the best results for each individual and pooling multicentre data will improve our understanding of this rare disease and benefit future patients. 展开更多
关键词 vulvar sarcoma Diagnosis Management OUTCOME FOLLOW Up
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Misdiagnosed myeloid sarcoma of the vulva 被引量:3
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作者 HE Yi LI Xu-dong +3 位作者 HUANG Ying WANG Dong-ning HU Yuan HUANG Ren-wei 《Chinese Medical Journal》 SCIE CAS CSCD 2013年第5期984-985,共2页
A 25-year-old woman presented with a lump in the vulva associated with progressive difficulty in urination that had persisted for approximately half a year. A diagnosis of Bartholin's abscess had been made in another... A 25-year-old woman presented with a lump in the vulva associated with progressive difficulty in urination that had persisted for approximately half a year. A diagnosis of Bartholin's abscess had been made in another hospital. Incision revealed no pus and ultrasonography showed a solid lesion in the left vulva. Partial excision of the tumor was implemented and histopathology showed a small round cell tumor. There were no other significant findings in her present or past medical history. She was admitted to our hospital with vulvar cancer. On gynecological examination, a 7 cm × 6 cm finn, hard, painless mass was found in the left labium majora. The right labium was inflamed but painless. 展开更多
关键词 sarcoma myeloid vulvar neoplasms LEUKEMIA
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外阴近端型上皮样肉瘤临床病理特征及预后分析
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作者 袁华 王亚希 +2 位作者 李宁 吴令英 姚洪文 《中华肿瘤防治杂志》 北大核心 2024年第22期1393-1398,共6页
目的回顾性分析外阴上皮样肉瘤(ES)患者的临床病理特征、治疗及预后情况,为临床诊治该类疾病提供参考。方法收集2003-01-01-2020-01-31中国医学科学院肿瘤医院经病理确诊并接受治疗的13例外阴ES患者临床资料,患者发病年龄28~65岁,中位... 目的回顾性分析外阴上皮样肉瘤(ES)患者的临床病理特征、治疗及预后情况,为临床诊治该类疾病提供参考。方法收集2003-01-01-2020-01-31中国医学科学院肿瘤医院经病理确诊并接受治疗的13例外阴ES患者临床资料,患者发病年龄28~65岁,中位发病年龄46岁。分析外阴ES患者发病年龄、临床表现、肿瘤大小、分期等。运用Kaplan-Meier法绘制生存曲线,计算生存率。结果根据国际妇产科协会(FIGO)2009分期标准,Ⅰ期8例(61.5%),Ⅱ期4例(30.8%),Ⅲ期1例(7.7%)。10例患者为本院初治,其中9例患者接受手术治疗,其中8例(8/9)患者接受外阴局部扩大切除术、1例(1/9)患者接受外阴广泛切除;8例(8/9)患者接受腹股沟淋巴结清除,1例(1/8)患者出现腹股沟淋巴结转移。5例(5/9)患者术后接受化疗,均未接受辅助放疗。中位随访时间为112.7个月(4.5~174.8)个月。10例初治患者5年和10年无进展生存率分别为67.5%和54.0%。5年和10年总生存率均为78.8%。共4例复发患者在我院治疗,均接受复发减瘤手术。结论外阴ES易发生于绝经前女性。大部分患者以触及外阴肿物就诊。根治性手术是主要治疗方式,辅助放化疗的作用仍需进一步探讨。 展开更多
关键词 外阴上皮样肉瘤 临床病理特征 预后 手术治疗
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外阴上皮样肉瘤的临床分析 被引量:2
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作者 孙力 吴令英 +2 位作者 李晓光 白萍 张宏图 《中华肿瘤杂志》 CAS CSCD 北大核心 2010年第12期935-938,共4页
目的 探讨外阴上皮样肉瘤的临床特点、诊断治疗方法及预后.方法 对我院收治的4例和文献报道资料完整的16例外阴上皮样肉瘤患者进行回顾性分析.结果 20例外阴上皮样肉瘤患者年龄23~80岁,中位年龄36岁.肿物直径为1~10 cm,中位数为5.1 cm... 目的 探讨外阴上皮样肉瘤的临床特点、诊断治疗方法及预后.方法 对我院收治的4例和文献报道资料完整的16例外阴上皮样肉瘤患者进行回顾性分析.结果 20例外阴上皮样肉瘤患者年龄23~80岁,中位年龄36岁.肿物直径为1~10 cm,中位数为5.1 cm.免疫组化检测结果显示,20例外阴上皮样肉瘤患者vimentin阳性,19例CK阳性,16例EMA阳性.10例患者行双侧或同侧腹股沟淋巴结清扫,3例未行腹股沟淋巴结清扫.术后7例患者未补充治疗,13例患者行术后放疗和(或)化疗.20例外阴上皮样肉瘤患者中,无复发及转移11例(55.0%),腹股沟淋巴结转移治疗后存活2例(10.0%),死亡7例(35.0%).早期患者(Ⅰ~Ⅱ期)的中位生存时间(21个月)高于晚期患者(6个月,P<0.05).10例行双侧或同侧腹股沟淋巴结清扫患者的中位生存时间为11.5个月,3例未行腹股沟淋巴结清扫患者的中位生存时间为6个月,差异无统计学意义(P=0.086).结论 外阴上皮样肉瘤误诊率较高,确诊时需要结合免疫组化检查,诊断上皮样肉瘤的标记性蛋白为vimentin、EMA和CK.外阴上皮样肉瘤的有效治疗方法为局部广泛切除加双侧腹股沟淋巴结清扫,手术切缘至少2 cm,化疗和放疗的疗效尚不确切. 展开更多
关键词 外阴肿瘤 肉瘤 诊断 治疗 预后
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外阴粒细胞肉瘤一例临床病理分析并文献复习 被引量:3
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作者 方三高 王巍伟 赵燕 《肿瘤研究与临床》 CAS 2017年第12期824-828,共5页
目的 探讨外阴粒细胞肉瘤(GS)的临床病理特征、诊断与鉴别诊断.方法 对泰州市人民医院1例外阴GS的临床表现、组织学特点及免疫组织化学进行综合分析并复习相关文献.结果 患者75岁,因发现无痛性外阴肿物而入院,B型超声显示左侧大阴唇... 目的 探讨外阴粒细胞肉瘤(GS)的临床病理特征、诊断与鉴别诊断.方法 对泰州市人民医院1例外阴GS的临床表现、组织学特点及免疫组织化学进行综合分析并复习相关文献.结果 患者75岁,因发现无痛性外阴肿物而入院,B型超声显示左侧大阴唇等回声区,内部回声不均匀.大体切面实性,鱼肉状,边界不清.光学显微镜下观察片层状恶性肿瘤细胞弥漫分布,小至中等大小,胞质少,核圆形或椭圆形,染色质细腻,核分裂多见;免疫组织化学肿瘤细胞表达髓过氧化物酶(MPO)、CD43、溶菌酶和CD117.结论 外阴GS非常罕见,仅凭形态学易误诊为淋巴瘤、尤文肉瘤、小细胞癌等,掌握其病理形态并正确诊断对患者的合理治疗和预后具有重要意义. 展开更多
关键词 外阴肿瘤 肉瘤 髓样 病理学 临床 诊断 鉴别
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