Organic semiconductor materials have shown unique advantages in the development of optoelectronic devices due to their ease of preparation,low cost,lightweight,and flexibility.In this work,we explored the application ...Organic semiconductor materials have shown unique advantages in the development of optoelectronic devices due to their ease of preparation,low cost,lightweight,and flexibility.In this work,we explored the application of the organic semiconductor Y6-1O single crystal in photodetection devices.Firstly,Y6-1O single crystal material was prepared on a silicon substrate using solution droplet casting method.The optical properties of Y6-1O material were characterized by polarized optical microscopy,fluorescence spectroscopy,etc.,confirming its highly single crystalline performance and emission properties in the near-infrared region.Phototransistors based on Y6-1O materials with different thicknesses were then fabricated and tested.It was found that the devices exhibited good visible to near-infrared photoresponse,with the maximum photoresponse in the near-infrared region at 785 nm.The photocurrent on/off ratio reaches 10^(2),and photoresponsivity reaches 16 mA/W.It was also found that the spectral response of the device could be regulated by gate voltage as well as the material thickness,providing important conditions for optimizing the performance of near-infrared photodetectors.This study not only demonstrates the excellent performance of organic phototransistors based on Y6-1O single crystal material in near-infrared detection but also provides new ideas and directions for the future development of infrared detectors.展开更多
To construct high-performance aqueous ammonium-ion full batteries,(NH_(4))_(2)V_(6)O_(16)·1.5H_(2)O(NVO)nanoribbon cathodes were prepared by pH-regulated hydrothermal synthesis.Anodes were prepared by growing the...To construct high-performance aqueous ammonium-ion full batteries,(NH_(4))_(2)V_(6)O_(16)·1.5H_(2)O(NVO)nanoribbon cathodes were prepared by pH-regulated hydrothermal synthesis.Anodes were prepared by growing the active material polyaniline(PANI)on carbon cloth.The assembled NVO//PANI full cells exhibit a reversible capacity of 109.5 mA·h/g at a current density of 1.0 A/g and a high energy density of 23 W·h/kg.The ammonium-ion intercalation/extraction mechanism is primarily governed by the pseudocapacitance behavior.These results indicate that NVO is a potential candidate as a cathode material for aqueous ammonium-ion batteries.展开更多
Boron suboxide(B_(6)O)is recognized as a superhard material with a low mass density,high resistance to chemical wear,and excellent wear resistance.Despite its desirable properties,the limited fracture tough-ness of B_...Boron suboxide(B_(6)O)is recognized as a superhard material with a low mass density,high resistance to chemical wear,and excellent wear resistance.Despite its desirable properties,the limited fracture tough-ness of B_(6)O restricts its application in industrial contexts.This study presents the structural and me-chanical characterization of B_(6)O-SiC nanocomposites,which were synthesized via a high-pressure high-temperature sintering process of B_(6)O powders and SiC whiskers.The sintering process induced fragmen-tation of SiC whiskers,resulting in the homogenous distribution of SiC fragments within the B_(6)O matrix.An increase in SiC content was observed to decrease the composite’s hardness,while initially reducing then enhancing its toughness.The nanocomposites containing 20 wt%and 30 wt%SiC whiskers exhibited significant improvements in fracture toughness,averaging 6.5 MPa m^(1/2)and 7.0 MPa m^(1/2),respectively-approximately threefold the toughness of polycrystalline B_(6)O-while sustaining high hardness values of 36.3 GPa and 35.6 GPa on average.Microstructural analyses revealed that the composites’superior me-chanical performance is due to the presence of strong grain boundaries,as well as a high density of nan-otwins and stacking faults.The findings demonstrate a viable method for producing B_(6)O-based nanocom-posites with enhanced hardness and toughness,potentially expanding their industrial applicability.展开更多
BACKGROUND Centromere protein A(CENPA)exhibits an increased expression level in primary human rectal cancer tissues,but its role has not been investigated.AIM To clarify the specific role and mechanism of CENPA in rec...BACKGROUND Centromere protein A(CENPA)exhibits an increased expression level in primary human rectal cancer tissues,but its role has not been investigated.AIM To clarify the specific role and mechanism of CENPA in rectal cancer progression.METHODS CENPA protein expression in rectal cancer tissues and cell lines were detected.CENPA was overexpressed and knocked down in SW837 and SW480 cells,and proliferation,invasion,apoptosis and epithelial-mesenchymal transition(EMT)marker protein levels were examined.O6-methylguanine DNA methyltransferase(MGMT)promoter methylation was assessed with methylation-specific poly-merase chain reaction.Co-immunoprecipitation assay verified the interaction between MGMT and protein tyrosine phosphatase nonreceptor type 4(PTPN4).SW837 cells with CENPA knockdown were injected subcutaneously into mice,and tumor growth was examined.RESULTS CENPA was upregulated in rectal cancer tissues and cell lines.CENPA overex-pression promoted proliferation,invasion and EMT,and inhibited apoptosis in rectal cancer cells.Whereas CENPA knockdown showed the opposite results.Moreover,CENPA inhibited MGMT expression by promoting DNA methyltrans-ferase 1-mediated MGMT promoter methylation.MGMT knockdown abolished the CENPA knockdown-mediated inhibition of rectal cancer cell progression.MGMT increased PTPN4 protein stability by inhibiting PTPN4 ubiquitination degradation via competing with ubiquitin-conjugating enzyme E2O for interacting with PTPN4.PTPN4 knockdown abolished the inhibitory effects of MGMT overexpression on rectal cancer cell progression.Moreover,CENPA knockdown inhibited xenograft tumor growth in vivo.CONCLUSION CENPA knockdown inhibited rectal cancer cell growth and attenuated xenograft tumor growth through regulating the MGMT/PTPN4 axis.展开更多
Here we report that the presence of MgCO_(3) stimulates the extracellular polymeric substance (EPS) secretion of Microcystis Aeruginosa (M. Aeruginosa). This stimulation led to a significant reduction in the total con...Here we report that the presence of MgCO_(3) stimulates the extracellular polymeric substance (EPS) secretion of Microcystis Aeruginosa (M. Aeruginosa). This stimulation led to a significant reduction in the total concentration of NH_(4)^(+)‒N by more than 86%, and effective recovery of PO_(4)^(3-)‒P within three days from concentrated wastewater (WW), although the secreted EPS inhibited the conversion of MgCO_(3) to specific crystal forms (MgNH4PO4.6H2O or MgHPO4.7H2O). Moreover, with an increase in PO_(4)^(3-) concentration in WW, these crystals appeared, thus the removal of NH_(4)^(+)‒N and PO_(4)^(3-)‒P nutrients can be attributed to the combined effect of M. Aeruginosa and MgCO_(3). We used Surface-Enhanced Raman Spectroscopy (SERS) combined with X-ray Diffraction (XRD), Field Emission Scanning Electron Microscopy with Energy-Dispersive X-ray Spectroscopy (FESEM-EDS), and X-ray Photoelectron Spectroscopy (XPS) to investigate the mechanism for competitive interactions between M. Aeruginosa and MgCO_(3) in removing NH_(4)^(+)‒N and PO_(4)^(3-)‒P. We identified that the bound EPS accumulated amorphous Mg–P–O dense particles on M. Aeruginosa, while soluble EPS, containing –COOH groups of humic-like substances decreased the pH of the solution and coordinated with Mg^(2+) ions. Therefore, both secreted bound and soluble EPS play a vital role in hindering the transformation of Mg^(2+) ions or MgCO_(3) to MgNH4PO4.6H2O or MgHPO4.7H2O crystals within WW, and they enhanced M. Aeruginosa 's ability in absorbing nutrients of NH_(4)^(+)‒N and PO_(4)^(3-)‒P. This mechanism plays a crucial role in the efficient recovery of NH_(4)^(+)‒N and PO_(4)^(3-)‒P from concentrated wastewater sources such as aerobically or anaerobically digested effluent from various sources like agriculture, livestock, and domestic wastewaters.展开更多
[目的]探讨MUC16蛋白的硫酸化O型连接糖对食管鳞癌细胞的迁移作用。[方法]TCGA数据库分析MUC16在食管癌组织中的表达水平。过表达或敲低MUC16后,划痕实验检测食管鳞癌细胞KYSE-30的迁移水平。过表达或敲低CHST4后,Lectin blot和Alcian b...[目的]探讨MUC16蛋白的硫酸化O型连接糖对食管鳞癌细胞的迁移作用。[方法]TCGA数据库分析MUC16在食管癌组织中的表达水平。过表达或敲低MUC16后,划痕实验检测食管鳞癌细胞KYSE-30的迁移水平。过表达或敲低CHST4后,Lectin blot和Alcian blue染色检测食管鳞癌细胞中MUC16的O型连接糖硫酸化水平以及食管鳞癌细胞的迁移水平,LC-ESI-MS检测MUC16的O型连接糖类型。[结果]相比于食管正常组织,食管癌组织中MUC16和CHST4的表达水平较高(0.78±0.13 vs 0.09±0.02;0.43±0.08 vs 0.07±0.02,P<0.05)。过表达MUC16后,食管鳞癌细胞的迁移水平显著上升;敲低MUC16后,食管鳞癌细胞的迁移水平显著下降。敲低CHST4后,MUC16 O型连接糖的硫酸化水平显著下降,食管鳞癌细胞的迁移水平显著下降;过表达CHST4后,MUC16 O型连接糖的硫酸化水平显著上升,食管鳞癌细胞的迁移水平显著上升。食管鳞癌细胞在m/z 813和1121处发现了含有GlcNAc-6-O-硫酸的低聚糖,而敲低CHST4后硫酸化的低聚糖水平降低。[结论]CHST4介导的MUC16蛋白O型连接糖硫酸化对食管鳞癌细胞的迁移具有促进作用(1.00±0.05 vs 1.83±0.12)。展开更多
基金Supported by the National Key Research and Development Program of China(2021YFB2012601)National Natural Science Foundation of China(12204109)+1 种基金Science and Technology Innovation Plan of Shanghai Science and Technology Commission(21JC1400200)Higher Education Indus⁃try Support Program of Gansu Province(2022CYZC-06)。
文摘Organic semiconductor materials have shown unique advantages in the development of optoelectronic devices due to their ease of preparation,low cost,lightweight,and flexibility.In this work,we explored the application of the organic semiconductor Y6-1O single crystal in photodetection devices.Firstly,Y6-1O single crystal material was prepared on a silicon substrate using solution droplet casting method.The optical properties of Y6-1O material were characterized by polarized optical microscopy,fluorescence spectroscopy,etc.,confirming its highly single crystalline performance and emission properties in the near-infrared region.Phototransistors based on Y6-1O materials with different thicknesses were then fabricated and tested.It was found that the devices exhibited good visible to near-infrared photoresponse,with the maximum photoresponse in the near-infrared region at 785 nm.The photocurrent on/off ratio reaches 10^(2),and photoresponsivity reaches 16 mA/W.It was also found that the spectral response of the device could be regulated by gate voltage as well as the material thickness,providing important conditions for optimizing the performance of near-infrared photodetectors.This study not only demonstrates the excellent performance of organic phototransistors based on Y6-1O single crystal material in near-infrared detection but also provides new ideas and directions for the future development of infrared detectors.
基金supported by the National Natural Science Foundation of China(Nos.52171200,52371211)the Changsha Special Project,China(No.kh2301006)。
文摘To construct high-performance aqueous ammonium-ion full batteries,(NH_(4))_(2)V_(6)O_(16)·1.5H_(2)O(NVO)nanoribbon cathodes were prepared by pH-regulated hydrothermal synthesis.Anodes were prepared by growing the active material polyaniline(PANI)on carbon cloth.The assembled NVO//PANI full cells exhibit a reversible capacity of 109.5 mA·h/g at a current density of 1.0 A/g and a high energy density of 23 W·h/kg.The ammonium-ion intercalation/extraction mechanism is primarily governed by the pseudocapacitance behavior.These results indicate that NVO is a potential candidate as a cathode material for aqueous ammonium-ion batteries.
基金supported by the Natural Science Foundation of Hebei Province of China(E2022203109)the National Natural Sci-ence Foundation of China(Grant No.52202049,52103322)+5 种基金the Natural Science Foundation of Jiangxi Province of China(Grant No.20202BAB214010)the Open Funds of the State Key Laboratory of Metastable Materials Science and Technology(Grant No.201906)Ganzhou Science and Technology Project(Grant No.202060)the Program of Qingjiang Excellent Young Talents,Jiangxi Univer-sity of Science and Technology(JXUSTQJYX2020002)China Post-doctoral Science Foundation(2023M731866)the Macao Young Scholars Program(AM2021015).
文摘Boron suboxide(B_(6)O)is recognized as a superhard material with a low mass density,high resistance to chemical wear,and excellent wear resistance.Despite its desirable properties,the limited fracture tough-ness of B_(6)O restricts its application in industrial contexts.This study presents the structural and me-chanical characterization of B_(6)O-SiC nanocomposites,which were synthesized via a high-pressure high-temperature sintering process of B_(6)O powders and SiC whiskers.The sintering process induced fragmen-tation of SiC whiskers,resulting in the homogenous distribution of SiC fragments within the B_(6)O matrix.An increase in SiC content was observed to decrease the composite’s hardness,while initially reducing then enhancing its toughness.The nanocomposites containing 20 wt%and 30 wt%SiC whiskers exhibited significant improvements in fracture toughness,averaging 6.5 MPa m^(1/2)and 7.0 MPa m^(1/2),respectively-approximately threefold the toughness of polycrystalline B_(6)O-while sustaining high hardness values of 36.3 GPa and 35.6 GPa on average.Microstructural analyses revealed that the composites’superior me-chanical performance is due to the presence of strong grain boundaries,as well as a high density of nan-otwins and stacking faults.The findings demonstrate a viable method for producing B_(6)O-based nanocom-posites with enhanced hardness and toughness,potentially expanding their industrial applicability.
基金This study was reviewed and approved by the Ethic Committee of Medical College of Henan Vocational University of Science and Technology(Approval No.HVUYL414101416920231017001)all participants signed a written informed consent.
文摘BACKGROUND Centromere protein A(CENPA)exhibits an increased expression level in primary human rectal cancer tissues,but its role has not been investigated.AIM To clarify the specific role and mechanism of CENPA in rectal cancer progression.METHODS CENPA protein expression in rectal cancer tissues and cell lines were detected.CENPA was overexpressed and knocked down in SW837 and SW480 cells,and proliferation,invasion,apoptosis and epithelial-mesenchymal transition(EMT)marker protein levels were examined.O6-methylguanine DNA methyltransferase(MGMT)promoter methylation was assessed with methylation-specific poly-merase chain reaction.Co-immunoprecipitation assay verified the interaction between MGMT and protein tyrosine phosphatase nonreceptor type 4(PTPN4).SW837 cells with CENPA knockdown were injected subcutaneously into mice,and tumor growth was examined.RESULTS CENPA was upregulated in rectal cancer tissues and cell lines.CENPA overex-pression promoted proliferation,invasion and EMT,and inhibited apoptosis in rectal cancer cells.Whereas CENPA knockdown showed the opposite results.Moreover,CENPA inhibited MGMT expression by promoting DNA methyltrans-ferase 1-mediated MGMT promoter methylation.MGMT knockdown abolished the CENPA knockdown-mediated inhibition of rectal cancer cell progression.MGMT increased PTPN4 protein stability by inhibiting PTPN4 ubiquitination degradation via competing with ubiquitin-conjugating enzyme E2O for interacting with PTPN4.PTPN4 knockdown abolished the inhibitory effects of MGMT overexpression on rectal cancer cell progression.Moreover,CENPA knockdown inhibited xenograft tumor growth in vivo.CONCLUSION CENPA knockdown inhibited rectal cancer cell growth and attenuated xenograft tumor growth through regulating the MGMT/PTPN4 axis.
基金supported by Cultivating Fund Project of Hubei Hongshan Laboratory(2022hspy002).
文摘Here we report that the presence of MgCO_(3) stimulates the extracellular polymeric substance (EPS) secretion of Microcystis Aeruginosa (M. Aeruginosa). This stimulation led to a significant reduction in the total concentration of NH_(4)^(+)‒N by more than 86%, and effective recovery of PO_(4)^(3-)‒P within three days from concentrated wastewater (WW), although the secreted EPS inhibited the conversion of MgCO_(3) to specific crystal forms (MgNH4PO4.6H2O or MgHPO4.7H2O). Moreover, with an increase in PO_(4)^(3-) concentration in WW, these crystals appeared, thus the removal of NH_(4)^(+)‒N and PO_(4)^(3-)‒P nutrients can be attributed to the combined effect of M. Aeruginosa and MgCO_(3). We used Surface-Enhanced Raman Spectroscopy (SERS) combined with X-ray Diffraction (XRD), Field Emission Scanning Electron Microscopy with Energy-Dispersive X-ray Spectroscopy (FESEM-EDS), and X-ray Photoelectron Spectroscopy (XPS) to investigate the mechanism for competitive interactions between M. Aeruginosa and MgCO_(3) in removing NH_(4)^(+)‒N and PO_(4)^(3-)‒P. We identified that the bound EPS accumulated amorphous Mg–P–O dense particles on M. Aeruginosa, while soluble EPS, containing –COOH groups of humic-like substances decreased the pH of the solution and coordinated with Mg^(2+) ions. Therefore, both secreted bound and soluble EPS play a vital role in hindering the transformation of Mg^(2+) ions or MgCO_(3) to MgNH4PO4.6H2O or MgHPO4.7H2O crystals within WW, and they enhanced M. Aeruginosa 's ability in absorbing nutrients of NH_(4)^(+)‒N and PO_(4)^(3-)‒P. This mechanism plays a crucial role in the efficient recovery of NH_(4)^(+)‒N and PO_(4)^(3-)‒P from concentrated wastewater sources such as aerobically or anaerobically digested effluent from various sources like agriculture, livestock, and domestic wastewaters.
文摘[目的]探讨MUC16蛋白的硫酸化O型连接糖对食管鳞癌细胞的迁移作用。[方法]TCGA数据库分析MUC16在食管癌组织中的表达水平。过表达或敲低MUC16后,划痕实验检测食管鳞癌细胞KYSE-30的迁移水平。过表达或敲低CHST4后,Lectin blot和Alcian blue染色检测食管鳞癌细胞中MUC16的O型连接糖硫酸化水平以及食管鳞癌细胞的迁移水平,LC-ESI-MS检测MUC16的O型连接糖类型。[结果]相比于食管正常组织,食管癌组织中MUC16和CHST4的表达水平较高(0.78±0.13 vs 0.09±0.02;0.43±0.08 vs 0.07±0.02,P<0.05)。过表达MUC16后,食管鳞癌细胞的迁移水平显著上升;敲低MUC16后,食管鳞癌细胞的迁移水平显著下降。敲低CHST4后,MUC16 O型连接糖的硫酸化水平显著下降,食管鳞癌细胞的迁移水平显著下降;过表达CHST4后,MUC16 O型连接糖的硫酸化水平显著上升,食管鳞癌细胞的迁移水平显著上升。食管鳞癌细胞在m/z 813和1121处发现了含有GlcNAc-6-O-硫酸的低聚糖,而敲低CHST4后硫酸化的低聚糖水平降低。[结论]CHST4介导的MUC16蛋白O型连接糖硫酸化对食管鳞癌细胞的迁移具有促进作用(1.00±0.05 vs 1.83±0.12)。
