C,N,S-tridoped TiO2 hollow spheres （labeled as C,N,S-THs） were synthesized using carbon spheres as template and C,N,S-tridoped TiO2 nanoparticles as building blocks. The structure and physicochemical properties of t...C,N,S-tridoped TiO2 hollow spheres （labeled as C,N,S-THs） were synthesized using carbon spheres as template and C,N,S-tridoped TiO2 nanoparticles as building blocks. The structure and physicochemical properties of the catalysts were characterized by X- ray diffraction （XRD）, scanning electron microscopy （SEM）, UV-Vis diffuse reflectance spectrum （DRS）, N2 adsorption-desorption isotherms, X-ray photoelectron spectroscopy （XPS） and Photoluminescence emission spectroscopy （PL）. The results showed that the hollow spheres had average diameter of about 200 nm and the shell thickness was about 20 nm. The tridoped TiO2 hollow spheres exhibited strong absorption in the visible-light region. C,N,S-tridoped could narrow the band gap of the THs by mixing the orbit O 2p with C 2p, N 2p and S 3p orbits and shift its optical response from ultraviolet （UV） to the visible-light region. PL analysis indicated that the electron-hole recombination rate of TiO2 hollow spheres had been effectively inhibited when doped with C, N and S elements. The photocatalytic activities of the samples were evaluated for the degradation of X-3B （Reactive Brilliant Red dye, C.I. Reactive Red 2） aqueous solution under visible-light （λ 〉 420 nm） irradiation. It was found that the C,N,S-tridoped TiO2 hollow spheres indicated higher photocatalytic activity than commercial P25 and the undoped counterpart photocatalyst.展开更多
Defect sites on oxide semiconductors play a crucial role in promoting photocatalytiperformance and mod-ulating the bandgap structure of photocatalysts.However,the role of interfacial coordinatively unsatu-rated defect...Defect sites on oxide semiconductors play a crucial role in promoting photocatalytiperformance and mod-ulating the bandgap structure of photocatalysts.However,the role of interfacial coordinatively unsatu-rated defect sites between metal and oxide in photocatalysis is still under debate.So,we designed an experiment to probe the role of interfacial coordinatively unsaturated defect sites.In this work,a se-ries of Ti/TiO_(2) photocatalysts with varying concentrations of interfacial Ti^(3+)sites were prepared through an epitaxial growth method under hydrothermal conditions.Through experimental and computational investigations,the roles of interfacial defect sites were discussed in detail.On the one hand,the inter-facial coordinatively unsaturated Ti^(3+)sites could act as visible-light-responsive sites in photocatalytic reactions due to the overlap and hybridization of multiple electronic orbitals.On the other hand,the Ti/TiO_(2) interface exhibited a certain degree of metallic character near the Fermi level because of the par-tial delocalization and redistribution of electrons,facilitating the charge migration and separation across the metal-oxide interface.Consequently,the obtained Ti/TiO_(2) catalysts showed notably enhanced charge transfer efficiency and visible light photocatalytic activity compared to their pristine counterparts.This work may provide a new perspective to interfacial defect engineering in classic metal/oxide heterojunc-tion photocatalysts and figure a more precise direction to synthesize higher effective photocatalysts for environmental governance.展开更多
Constructing nanocomposites that combine the advantages of composite materials,nanomaterials,and interfaces has been regarded as an important strategy to improve the photocatalytic activity of TiO2.In this study,2D‐2...Constructing nanocomposites that combine the advantages of composite materials,nanomaterials,and interfaces has been regarded as an important strategy to improve the photocatalytic activity of TiO2.In this study,2D‐2D TiO2 nanosheet/layered WS2(TNS/WS2)heterojunctions were prepared via a hydrothermal method.The structure and morphology of the photocatalysts were systematically characterized.Layered WS2(~4 layers)was wrapped on the surface of TiO2 nanosheets with a plate‐to‐plate stacked structure and connected with each other by W=O bonds.The as‐prepared TNS/WS2 heterojunctions showed higher photocatalytic activity for the degradation of RhB under visible‐light irradiation,than pristine TiO2 nanosheets and layered WS2.The improvement of photocatalytic activity was primarily attributed to enhanced charge separation efficiency,which originated from the perfect 2D‐2D nanointerfaces and intimate interfacial contacts between TiO2 nanosheets and layered WS2.Based on experimental results,a double‐transfer photocatalytic mechanism for the TNS/WS2 heterojunctions was proposed and discussed.This work provides new insights for synthesizing highly efficient and environmentally stable photocatalysts by engineering the surface heterojunctions.展开更多
Integrating the advantages of Bi and Cr elements in the bandgap engineering of metal oxides, a visible-light-responsive photocatalyst Bi1.5Cr0.5WO6 is successfully constructed and initially applied in water decontamin...Integrating the advantages of Bi and Cr elements in the bandgap engineering of metal oxides, a visible-light-responsive photocatalyst Bi1.5Cr0.5WO6 is successfully constructed and initially applied in water decontamination. The combination of UV-vis diffuses reflectance and the Mott-Schottky curve from electrochemical testing can be used to determine the conduction band and valence band of Bi1.5Cr0.5WO6 to be about –1.26 and 1.42 V, respectively. The location of energy band structure indicates that the superoxide free radical can be produced in Bi1.5Cr0.5WO6 photocatalytic system without hydroxyl group. This speculation is also confirmed by ESR experiment and active radical species scavenging experiments. In addition, the best photocatalytic performance of Bi1.5Cr0.5WO6 obtained under 180 ℃ is attributed to the smallest impedance and the strongest electronic migration capability.展开更多
Controllable liquid manipulation is of paramount scientific and technological importance in various fields,such as the chemical industry,biomedicine,and agricultural production.Magnetic actuation,characterized by rapi...Controllable liquid manipulation is of paramount scientific and technological importance in various fields,such as the chemical industry,biomedicine,and agricultural production.Magnetic actuation,characterized by rapid,contactless,and environmentally benign operation,has emerged as a promising approach for precise liquid control.However,conventional magnetic strategies typically govern droplet movement on open surfaces,facing limitations such as restricted liquid volumes,uncertain flow paths,and inevitable evaporation,thereby constraining their broader practical applications.Recently,a variety of magneticdriven strategies have been developed to dynamically regulate liquids within enclosed spaces,especially through physicochemical mechanisms.These approaches provide efficient control over liquid behavior by leveraging magnetically induced chemical changes,structural deformations,and dragging motions,opening new opportunities for flexible and versatile fluid management.This review explores the design and mechanisms of magneto-responsive confined interfaces for the manipulation of nonmagnetic liquids,highlighting key advancements and potential applications including liquid valves,liquid mixing,liquid flow regulation,and liquid pumping.Finally,the existing challenges and future prospects in this field are presented.展开更多
A novel[3]rotaxane,featuring two hydrogen-bonded aramide azo-macrocycles mechanically interlocked on a dumbbell with distinct recognition sites,a secondary dialkylammonium(AM)unit and a 4,4'-bipyridinium(BP)unit,h...A novel[3]rotaxane,featuring two hydrogen-bonded aramide azo-macrocycles mechanically interlocked on a dumbbell with distinct recognition sites,a secondary dialkylammonium(AM)unit and a 4,4'-bipyridinium(BP)unit,has been synthesized.This multi-stimuli-responsive[3]rotaxane exhibits unique molecular motion,with the macrocycles shuttling along the axle in response to acid-base reactions,temperature changes,solvent variations,and light irradiation.The molecular shuttle and reversibility were investigated by^(1)H NMR,2D NOESY,HRESI-MS,and UV-vis spectroscopy.This study provides a rare example of a higher order rotaxane with multi-stimuli responsiveness,highlighting its potential for multi-state control over the motion of interlocked rings on an axle.The ability to manipulate the molecular motion of the macrocycles through various external triggers offers insights for future developments in molecular machinery and adaptive materials.展开更多
The tumor microenvironment(TME)-activatable probes have proven effective in enhancing the signalto-background ratio(SBR)for precise fluorescence imaging in tumor diagnosis.However,many fluorophores have suboptimal emi...The tumor microenvironment(TME)-activatable probes have proven effective in enhancing the signalto-background ratio(SBR)for precise fluorescence imaging in tumor diagnosis.However,many fluorophores have suboptimal emission spectra and a short Stokes shift,which may lead to overlap with bioautofluorescence,excitation,and emission spectra,limiting their use in intraoperative guidance.Herein,aγ-glutathione(GSH)responsive near-infrared(NIR)BODIPY probe,named“Pro-Dye”was synthesized with a large Stokes shift of 91 nm.The Pro-Dye can be rapidly and specifically activated by high concentrations of GSH both in solution and inside cancer cells,while remaining inactive in normal cells(Human umbilical vein endothelial cells,HUVECs).The Pro-Dye was further encapsulated by 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol)-5000(DSPE-PEG5000)to form Pro-Dye nanoparticles(NPs),making it water-dispersible for in vivo application.In vivo fluorescence imaging demonstrated that Pro-Dye NPs can accumulate at the tumor and exhibit an improved SBR compared to the“alwayson”probe(Dye NPs).Moreover,the tumor can be precisely resected under the real-time guidance of fluorescence imaging of Pro-Dye NPs,showing a well-defined tumor margin.展开更多
Rapid and ultrasensitive detection of pathogen-associated biomarkers is vital for the early diagnosis and therapy of bacterial infections.Herein,we developed a close-packed and ordered Au@AgPt array coupled with a cas...Rapid and ultrasensitive detection of pathogen-associated biomarkers is vital for the early diagnosis and therapy of bacterial infections.Herein,we developed a close-packed and ordered Au@AgPt array coupled with a cascade triggering strategy for surface-enhanced Raman scattering(SERS)and colorimetric identification of the Staphylococcus aureus biomarker micrococcal nuclease(MNase)in serum samples.The trimetallic Au@AgPt nanozymes can catalyze the oxidation of 3,3’,5,5’-tetramethylbenzidine(TMB)molecules to SERS-enhanced oxidized TMB(oxTMB),accompanied by the color change from colorless to blue.In the presence of S.aureus,the secreted MNase preferentially cut the nucleobase AT-rich regions of DNA sequences on magnetic beads(MBs)to release alkaline phosphatase(ALP),which subsequently mediated the oxTMB reduction for inducing the colorimetric/SERS signal fade away.Using this“on-to-off”triggering strategy,the target S.aureus can be recorded in a wide linear range with a limit of detection of 38 CFU/mL in the colorimetric mode and 6 CFU/mL in the SERS mode.Meanwhile,the MNase-mediated strategy characterized by high specificity and sensitivity successfully discriminated between patients with sepsis(n=7)and healthy participants(n=3),as well as monitored the prognostic progression of the disease(n=2).Overall,benefiting from highly active and dense“hot spot”substrate,MNase-mediated cascade response strategy,and colorimetric/SERS dual-signal output,this methodology will offer a promising avenue for the early diagnosis of S.aureus infection.展开更多
Microneedle(MN)patches could be a promising treatment for diabetic foot ulcers that plague thousands of people worldwide.While reducing skin resistance or increasing driving force can accelerate the efficiency of tran...Microneedle(MN)patches could be a promising treatment for diabetic foot ulcers that plague thousands of people worldwide.While reducing skin resistance or increasing driving force can accelerate the efficiency of transdermal drug delivery with conventional MN patches,it can create toxic chemical residues or require the help of additional devices.Herein,a thermo-responsive microneedles patch(TMN)with high biocompatibility without additional equipment is proposed.The TMN consisted of a bilayer microneedles composed of sodium alginate(SA)-g-poly(N-isopropylacrylamide)layer(SA-g-PNIPAM)loaded with sucrose octasulfate sodium salt(SOS)and hyaluronic acid layer and a polycaprolactone/chitosan nanofiber membrane loading with tetracycline hydrochloride(TH)and SOS.PNIPAM accelerates drug release by extruding the drug through a volumetric phase transition in response to temperature changes,and TH and SOS promote wound healing by inhibiting bacterial growth and promoting vascular regeneration and epithelial formation.The results showed that the drug release of TMN was significantly faster,with the drug release rate of more than 80% in the 10th h,and the antibacterial rate of TMN could reach 800%.In addition,TMN had good biocompatibility and good healing effects in vivo,which may be helpful for the design of multifunctional dressings in the future.展开更多
Strong polyelectrolyte brushes(SPBs)play an important role in enabling material surface functionalization due to their unique stimuli-responsive properties.Although the unexpected pH responsiveness of SPBs has been re...Strong polyelectrolyte brushes(SPBs)play an important role in enabling material surface functionalization due to their unique stimuli-responsive properties.Although the unexpected pH responsiveness of SPBs has been revealed in the past ten years,it is still unclear if the pH-responsive properties of SPBs are affected by the brush thickness.In this study,we employed the positively charged poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride(PMETAC)and negatively charged sodium poly(styrenesulfonate)(NaPSS)brushes as model systems to explore the effect of thickness on the pH-responsive properties of SPBs.The results demonstrate that the pH-responsive properties of SPBs manifest different dependences on the brush thickness.Specifically,for both PMETAC and NaPSS brushes,the pH-responsive hydration and stiffness are influenced by the thickness,and the pH-responsive wettability and adhesion are almost unaffected by the thickness.This work not only provides a clear understanding of the relationship between the brush thickness and the pH responsiveness of SPBs,but also offers a new method to control the pH-responsive properties of SPBs.展开更多
Superhydrophobic/superhydrophilic antifouling materials are widely used to solve the severe water pollution and bio-adhesion of marine equipment.However,conventional antifouling materials rely on the static superwetta...Superhydrophobic/superhydrophilic antifouling materials are widely used to solve the severe water pollution and bio-adhesion of marine equipment.However,conventional antifouling materials rely on the static superwettability of surfaces,which suffer from poorly sustained antifouling effects.Inspired by the unique dynamic antifouling strategies of Calliphora Vicina wing surface based on the hydrophobic micro-cilia arrays,a Biomimetic Magnetic-Responsive Antifouling Surface(BMRAS)is designed and fabricated using a method combining UV lithography and an inverse molding.The BMRAS is coated by high-aspect-ratio micro-cilia,which are filled with synthesized magnetic Fe3O4 nanoparticles.The bioinspired hydrophobic micro-cilia arrays endow the BMRAS with excellent intrinsic superhydrophobicity,benefiting from the high-aspect-ratio feature and roughness effect.Remarkably,the static contact angle is more than 156.9±1.6°and the rolling angle is less than 2.3±0.3°.The synthesized magnetic nanomaterials play a key role in implementing dynamic antifouling strategies.On the one hand,the surface tension can be adjusted as required under magnetically controlled oscillations.On the other hand,the doping of magnetic nanomaterials can enhance mechanical properties and reduce capillary force-induced aggregation of high-aspect-ratio micro-cilia.The antifouling tests demonstrate that the chemically modified micro-cilia can effectively expel gravels under the stimulation of an external magnetic field and enable the BMRAS to achieve dynamic self-cleaning.Specifically,0.17 g gravel distributed on BMRAS can be completely cleaned up within 0.296 s,which improved by 14.2%compared with the flat materials.This work provides a brief and effective strategy for designing dynamic antifouling surfaces with excellent physicochemical durability and great potential value in the applications of marine fouling.展开更多
Prostate cancer(PCa)is characterized by high incidence and propensity for easy metastasis,presenting significant challenges in clinical diagnosis and treatment.Tumor microenvironment(TME)-responsive nanomaterials prov...Prostate cancer(PCa)is characterized by high incidence and propensity for easy metastasis,presenting significant challenges in clinical diagnosis and treatment.Tumor microenvironment(TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy.Considering that tumor-derived alkaline phosphatase(ALP)is over-expressed in metastatic PCa,it makes a great chance to develop a theranostics system with ALP responsive in the TME.Herein,an ALP-responsive aggregationinduced emission luminogens(AIEgens)nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa.The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence,and enhanced accumulation and prolonged retention period at the tumor site.In terms of detection,the fluorescence(FL)/computed tomography(CT)/magnetic resonance(MR)multi-mode imaging effect of nanoprobe was significantly improved post-aggregation,enabling precise diagnosis through the amalgamation of multiple imaging modes.Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis,and enhanced FL imaging technology can achieve“intraoperative visual navigation”,showing its potential application value in clinical tumor detection and surgical guidance.In terms of treatment,AMNF showed strong absorption in the near infrared region after aggregation,which improved the photothermal treatment effect.Overall,our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.展开更多
Diabetic liver injury is a widespread complication of diabetes and carries a high risk to liver function.Therefore,early diagnosis of diabetic liver injury is of great significance for providing quality of life for di...Diabetic liver injury is a widespread complication of diabetes and carries a high risk to liver function.Therefore,early diagnosis of diabetic liver injury is of great significance for providing quality of life for diabetic patients.Most of the activated dual-modal probes are usually activated by single factor stimulation,which greatly reduces the diagnostic accuracy of liver injury.Here,a novel cysteine(Cys)/homocysteine(Hcy)and viscosity-enhanced dual-modal probe DAL was developed for the first time to monitor diabetic liver injury and its repair process.In the presence of Cys/Hcy,the near-infrared fluorescence(NIRF)and photoacoustic(PA)signals of the probe DAL were activated,with further signal enhancement in high viscosity environments.This Cys/Hcy and viscosity cascade probe exhibits heightened sensitivity and enhanced anti-interference capabilities,contributing to the advancement of liver injury diagnosis accuracy.In addition,the probe DAL shows exceptional mitochondrial targeting ability,enabling sensitive monitoring of Cys/Hcy and viscosity alterations within mitochondria.Based on NIRF/PA dual-modal imaging technology,the probe was successfully used for the first time in a mouse diabetic liver injury model to evaluate the extent of liver damage and the repair process by tracking the levels of Cys/Hcy and viscosity.Therefore,the two-factor activated dual-modal probe developed in this study provides a powerful instrument for accurate diagnosis and efficacy evaluation of complications related to diabetes.展开更多
In deep oil reservoir development,enhanced oil recovery(EOR)techniques encounter significant challenges under high-temperature and high-salinity conditions.Traditional profile-control agents often fail to maintain sta...In deep oil reservoir development,enhanced oil recovery(EOR)techniques encounter significant challenges under high-temperature and high-salinity conditions.Traditional profile-control agents often fail to maintain stable blocking under extreme conditions and exhibit poor resistance to high temperature and high salinity.This study develops a functionalized nanographite system(the MEGO system)with superior high-temperature dispersibility and thermosalinity-responsive capability through polyether amine(PEA)grafting and noncovalent interactions with disodium naphthalene sulfonate(DNS)molecules.The grafted PEA and DNS provide steric hindrance and electrostatic repulsion,enhancing thermal and salinity resistance.After ten days of aggregation,the MEGO system forms stable particle aggregates(55.51-61.80 lm)that are suitable for deep reservoir migration and profile control.Both experiments and simulations reveal that particle size variations are synergistically controlled by temperature and salt ions(Na^(+),Ca^(2+),and Mg^(2+)).Compared with monovalent ions,divalent ions promote nanographite aggregation more strongly through double-layer compression and bridging effects.In core displacement experiments,the MEGO system demonstrated superior performance in reservoirs with permeabilities ranging from 21.6 to 103 mD.The aggregates formed within the pore throats significantly enhanced flow resistance,expanded the sweep volume,and increased the overall oil recovery to 56.01%.This research indicates that the MEGO system holds excellent potential for EOR in deep oil reservoirs.展开更多
Glycyrrhetinic acid(GA)sheds new light on liver-targeted therapy due to high-specific accumulation to GA receptors in liver,however,the limitation of commonly used macromolecular GA modification approaches as well as ...Glycyrrhetinic acid(GA)sheds new light on liver-targeted therapy due to high-specific accumulation to GA receptors in liver,however,the limitation of commonly used macromolecular GA modification approaches as well as the application gap across various vector have constrained its use.In this study,we proposed a novel perspective to break out,disulfide bonds(SS)were employed as linkage to facilitate GA modification,which allowed further connections with various carriers,while provided additional glutathione(GSH)-responsive property.The superiority of GA-disulfide conjunction was validated using mesoporous silica nanoparticles(MSN)as model carriers,chemotherapeutic drug(doxorubicin)and photosensitizer(indocyanine green)were loaded into MSN-SS-GA to further achieve chemo-photothermal synergistic anti-tumor therapy.Based on results from multiple evaluations,the GA-disulfide drafted MSN(DI/MSN-SS-GA)demonstrated expected liver tumor targeting effect and exhibited GSH-stimuli release property to reduce preleakage.Taken together,this study presents an effective chemo-photothermal therapy for liver cancer(88.26%),offers a potential,robust and straightforward strategy on GA application for enhancing liver targeting therapy.展开更多
Rapid advances in thermal management technology and the increasing need for multi-energy conversion have placed stringent energy efficiency requirements on next-generation shape-stable composite phase change materials...Rapid advances in thermal management technology and the increasing need for multi-energy conversion have placed stringent energy efficiency requirements on next-generation shape-stable composite phase change materials(PCMs).Magnetically-responsive phase change thermal storage materials are considered an emerging concept for energy storage systems,enabling PCMs to perform unprecedented functions(such as green energy utilization,magnetic thermotherapy,drug release,etc.).The combination of multifunctional magnetic nanomaterials and PCMs is a milestone in the creation of advanced multifunctional composite PCMs.However,a timely and comprehensive review of composite PCMs based on magnetic nanoparticle modification is still missing.Herein,we furnish an exhaustive exposition elucidating the cutting-edge advancements in magnetically responsive composite PCMs.We delve deeply into the multifarious roles assumed by distinct nanoparticles within composite PCMs of varying dimensions,meticulously scrutinizing the intricate interplay between their architectures and thermophysical attributes.Moreover,we prognosticate future research trajectories,delineate alternative stratagems,and illuminate prospective avenues.This review is intended to stimulate broader academic interest in interdisciplinary fields and provide valuable insights into the development of next-generation magnetically-responsive composite PCMs.展开更多
Control crosslink network and chain connectivity are essential to develop shape memory polymers(SMPs)with high shape memory capabilities,adjustable response temperature,and satisfying mechanistical properties.In this ...Control crosslink network and chain connectivity are essential to develop shape memory polymers(SMPs)with high shape memory capabilities,adjustable response temperature,and satisfying mechanistical properties.In this study,novel poly(ε-caprolactone)(PCL)-poly(2-vinyl)ethylene glycol(PVEG)copolymers bearing multi-pendant vinyl groups is synthesized by branched-selective allylic etherification polymerization of vinylethylene carbonate(VEC)with linear and tetra-arm PCLs under a synergistic catalysis of palladium complex and boron reagent.Facile thiol-ene photo-click reaction of PCL-PVEG copolymers with multifunctional thiols can rapidly access a serious crosslinked SMPs with high shape memory performance.The thermal properties,mechanical properties and response temperature of the obtained SMPs are tunable by the variation of PCL prepolymers,vinyl contents and functionality of thiols.Moreover,high elastic modulus in the rubbery plateau region can be maintained effectively owing to high-density topological networks of the PCL materials.In addition,the utility of the present SMPs is further demonstrated by the post-functionalization via thiol-ene photo-click chemistry.展开更多
Tumor microenvironment-responsive drug self-delivery systems utilize tumor microenvironment-responsive chemical bonds to link anti-tumor drugs,exploiting the hydrophilic and hydrophobic properties of different drugs t...Tumor microenvironment-responsive drug self-delivery systems utilize tumor microenvironment-responsive chemical bonds to link anti-tumor drugs,exploiting the hydrophilic and hydrophobic properties of different drugs to form amphiphilic prodrug molecules with self-assembly characteristics.Upon stimulation by specific factors in the tumor microenvironment,these amphiphilic prodrug molecules can release drugs at precise sites within the tumor.These strategies significantly increase the drug concentration at the tumor site while effectively reducing the damage of anti-cancer drugs to normal tissues.Owing to the advanced delivery strategies such as synergistic administration and controlled drug release,tumor microenvironment-responsive drug self-delivery systems hold great potential for treating malignant tumors with multidrug resistance(MDR).At the same time,the stimulus-reactivity of metal complexes provides an important opportunity to design site-specific prodrugs that can maximize therapeutic efficacy while minimizing adverse side effects of metal drugs.This innovative drug design complements the tumor microenvironment-responsive self-delivery system,providing more feasible therapeutic strategies and possibilities in the field of cancer therapy and drug delivery.This work provides a comprehensive review of recent advancements in drug self-delivery systems,offering insights into their potential applications in cancer therapy and MDR reversal.展开更多
Background:Nonsuicidal self-injury(NSSI)in adolescents with depression disorders often exhibits addictive patterns,potentially linked to serum beta-endorphin levels and neural reward responsiveness.Beta-endorphin,invo...Background:Nonsuicidal self-injury(NSSI)in adolescents with depression disorders often exhibits addictive patterns,potentially linked to serum beta-endorphin levels and neural reward responsiveness.Beta-endorphin,involved in reward processing,alongside dysregulated neural reward pathways,may reinforce self-injurious behaviors,highlighting the need to explore these mechanisms.Methods:Adolescents(aged 12-17 years)with depression disorders were divided into an NSSI group(21 subjects)and a control group(11 subjects)according to inclusion criteria.Serum beta-endorphin concentration was measured using the enzyme-linked immunosorbent assay method.The Addiction Factor Scale was used to assess addiction levels.Statistical analyses were con-ducted using SPSS 25.0.The oxygenated hemoglobin response signal was detected using functional near-infrared spectroscopy.Analyses were performed using NIRS_KIT 2.0.Results:Compared with the control group,the NSSI group exhibited lower serum beta-endorphin concentration.Additionally,85.7%of those in the NSSI group displayed addictive behaviors,and serum beta-endorphin concentration was negatively correlated with the Addiction Factor Scale score.The reward task activated channels 17,20,and 21(corresponding to the dorsolateral prefrontal cortex[PFC]and frontopolar PFC)in the gain condition and channels 20 and 21 in the loss condition.The oxygenated hemoglobin concentration of the differential waveform(Δ[oxy-Hb])of channel 12(corresponding to the frontopolar PFC)correlated positively with the Addiction Factor Scale score and negatively with the serum beta-endorphin concentration.展开更多
Maxillofacial trauma is an infection and oxidative stress-induced damage to maxillofacial area related cells.Increasing evidences have suggested that therapeutic strategies with controllable anti-infective and anti-in...Maxillofacial trauma is an infection and oxidative stress-induced damage to maxillofacial area related cells.Increasing evidences have suggested that therapeutic strategies with controllable anti-infective and anti-inflammatory capabilities hold great potentials in the clinical treatment of maxillofacial trauma.Herein,we reported an infectious microenvironment responsive bimetallic sulfide(FeCuS_(x),FCS)combining with near infrared(NIR)irradiation for maxillofacial trauma therapy.In cellular levels,FCS exhibited the most efficient antioxidant and anti-inflammatory,cell migration,and angiogenesis behaviors through down-regulating the inflammatory factor(iNOS)expression level,up-regulating anti-inflammatory factors(Arg^(-1)and TGF-β)expression level,inducing macrophages M2 polarization(CD86down-regulation and CD206 up-regulation),and promoting tissue repair factors(CD31)expression level.Besides,it presented the excellent antibacterial ability of Escherichia coli(99.74%)and MRSA(99.78%)for FCS+NIR.Significantly,it also confirmed that FCS+NIR presented the excellent functions of inhibiting wound infections,decreasing wound inflammation,as well as promoting trauma tissue repairing.Altogether,it had developed the strategy of FCS+NIR for the synergistic enhancement of infectious maxillofacial trauma healing,could also serve as a promising therapeutic strategy for the treatment of infectious diseases.展开更多
基金supported by the National Natural Science Foundation of China(No.51172043)the Doctor Research Starting Fund of Jinling Institute of Technology(No.JITB-201307)the Social Developing Program of Jiangsu Province(No.BE2011797)
文摘C,N,S-tridoped TiO2 hollow spheres （labeled as C,N,S-THs） were synthesized using carbon spheres as template and C,N,S-tridoped TiO2 nanoparticles as building blocks. The structure and physicochemical properties of the catalysts were characterized by X- ray diffraction （XRD）, scanning electron microscopy （SEM）, UV-Vis diffuse reflectance spectrum （DRS）, N2 adsorption-desorption isotherms, X-ray photoelectron spectroscopy （XPS） and Photoluminescence emission spectroscopy （PL）. The results showed that the hollow spheres had average diameter of about 200 nm and the shell thickness was about 20 nm. The tridoped TiO2 hollow spheres exhibited strong absorption in the visible-light region. C,N,S-tridoped could narrow the band gap of the THs by mixing the orbit O 2p with C 2p, N 2p and S 3p orbits and shift its optical response from ultraviolet （UV） to the visible-light region. PL analysis indicated that the electron-hole recombination rate of TiO2 hollow spheres had been effectively inhibited when doped with C, N and S elements. The photocatalytic activities of the samples were evaluated for the degradation of X-3B （Reactive Brilliant Red dye, C.I. Reactive Red 2） aqueous solution under visible-light （λ 〉 420 nm） irradiation. It was found that the C,N,S-tridoped TiO2 hollow spheres indicated higher photocatalytic activity than commercial P25 and the undoped counterpart photocatalyst.
基金financialy supported by the National Key Research and Development Plan of China (No.2016YFC0209305)the Science and Technology Plans of Tianjin (No.18PTZWHZ00180)+1 种基金the Major National Science and Technology Projects (No.2017ZX07106001)the Tianjin Development Program for Innovation and Entrepreneurship。
文摘Defect sites on oxide semiconductors play a crucial role in promoting photocatalytiperformance and mod-ulating the bandgap structure of photocatalysts.However,the role of interfacial coordinatively unsatu-rated defect sites between metal and oxide in photocatalysis is still under debate.So,we designed an experiment to probe the role of interfacial coordinatively unsaturated defect sites.In this work,a se-ries of Ti/TiO_(2) photocatalysts with varying concentrations of interfacial Ti^(3+)sites were prepared through an epitaxial growth method under hydrothermal conditions.Through experimental and computational investigations,the roles of interfacial defect sites were discussed in detail.On the one hand,the inter-facial coordinatively unsaturated Ti^(3+)sites could act as visible-light-responsive sites in photocatalytic reactions due to the overlap and hybridization of multiple electronic orbitals.On the other hand,the Ti/TiO_(2) interface exhibited a certain degree of metallic character near the Fermi level because of the par-tial delocalization and redistribution of electrons,facilitating the charge migration and separation across the metal-oxide interface.Consequently,the obtained Ti/TiO_(2) catalysts showed notably enhanced charge transfer efficiency and visible light photocatalytic activity compared to their pristine counterparts.This work may provide a new perspective to interfacial defect engineering in classic metal/oxide heterojunc-tion photocatalysts and figure a more precise direction to synthesize higher effective photocatalysts for environmental governance.
基金supported by the National High Technology Research and Development Program of China(863 Program,2012AA063504)the National Natural Science Foundation of China(U1407116,21511130020,21276193)the Tianjin Municipal Natural Science Foundation(13JCZDJC35600)~~
文摘Constructing nanocomposites that combine the advantages of composite materials,nanomaterials,and interfaces has been regarded as an important strategy to improve the photocatalytic activity of TiO2.In this study,2D‐2D TiO2 nanosheet/layered WS2(TNS/WS2)heterojunctions were prepared via a hydrothermal method.The structure and morphology of the photocatalysts were systematically characterized.Layered WS2(~4 layers)was wrapped on the surface of TiO2 nanosheets with a plate‐to‐plate stacked structure and connected with each other by W=O bonds.The as‐prepared TNS/WS2 heterojunctions showed higher photocatalytic activity for the degradation of RhB under visible‐light irradiation,than pristine TiO2 nanosheets and layered WS2.The improvement of photocatalytic activity was primarily attributed to enhanced charge separation efficiency,which originated from the perfect 2D‐2D nanointerfaces and intimate interfacial contacts between TiO2 nanosheets and layered WS2.Based on experimental results,a double‐transfer photocatalytic mechanism for the TNS/WS2 heterojunctions was proposed and discussed.This work provides new insights for synthesizing highly efficient and environmentally stable photocatalysts by engineering the surface heterojunctions.
基金financially supported by the Natural Science Foundation of Fujian province(2016J05042,2015J01057,2018J01439)Open Fund of State Key Laboratory of Photocatalysis on Energy and Environment(SKLPEE-KF201505)+3 种基金Scientific Project of Putian Science and Technology Bureau(2016S1001)Science and Technology Project of Fujian Provincial Department of Education(JA15444)the Projects of Putian University(2015065,2015081)Program for New Century Excellent Talents in Fujian Province University
文摘Integrating the advantages of Bi and Cr elements in the bandgap engineering of metal oxides, a visible-light-responsive photocatalyst Bi1.5Cr0.5WO6 is successfully constructed and initially applied in water decontamination. The combination of UV-vis diffuses reflectance and the Mott-Schottky curve from electrochemical testing can be used to determine the conduction band and valence band of Bi1.5Cr0.5WO6 to be about –1.26 and 1.42 V, respectively. The location of energy band structure indicates that the superoxide free radical can be produced in Bi1.5Cr0.5WO6 photocatalytic system without hydroxyl group. This speculation is also confirmed by ESR experiment and active radical species scavenging experiments. In addition, the best photocatalytic performance of Bi1.5Cr0.5WO6 obtained under 180 ℃ is attributed to the smallest impedance and the strongest electronic migration capability.
基金supported by the National Natural Science Foundation of China(Nos.52025132,U24A20205,52303373,21621091,22021001,and 22121001)the China Postdoctoral Science Foundation(No.2024M763174)+2 种基金the 111 Project(Nos.B17027,B16029)the Natural Science Foundation of Fujian Province of China(No.2022J02059)the New Cornerstone Science Foundation through the Xplorer Prize。
文摘Controllable liquid manipulation is of paramount scientific and technological importance in various fields,such as the chemical industry,biomedicine,and agricultural production.Magnetic actuation,characterized by rapid,contactless,and environmentally benign operation,has emerged as a promising approach for precise liquid control.However,conventional magnetic strategies typically govern droplet movement on open surfaces,facing limitations such as restricted liquid volumes,uncertain flow paths,and inevitable evaporation,thereby constraining their broader practical applications.Recently,a variety of magneticdriven strategies have been developed to dynamically regulate liquids within enclosed spaces,especially through physicochemical mechanisms.These approaches provide efficient control over liquid behavior by leveraging magnetically induced chemical changes,structural deformations,and dragging motions,opening new opportunities for flexible and versatile fluid management.This review explores the design and mechanisms of magneto-responsive confined interfaces for the manipulation of nonmagnetic liquids,highlighting key advancements and potential applications including liquid valves,liquid mixing,liquid flow regulation,and liquid pumping.Finally,the existing challenges and future prospects in this field are presented.
基金supported by the National Natural Science Foundation of China(No.22271202 to L.Yuan,No.22201193 to X.Li)the Sichuan Science and Technology Program(No.2023NSFSC0109 to X.Li)+2 种基金the Fundamental Research Funds for the Central Universities and the Hundred Talent Program of Sichuan University(No.YJ2021158 to X.Li)Sichuan University Interdisciplinary Innovation Fund(X.Li)Open Project of State Key Laboratory of Supramolecular Structure and Materials(No.SKLSSM2024037)。
文摘A novel[3]rotaxane,featuring two hydrogen-bonded aramide azo-macrocycles mechanically interlocked on a dumbbell with distinct recognition sites,a secondary dialkylammonium(AM)unit and a 4,4'-bipyridinium(BP)unit,has been synthesized.This multi-stimuli-responsive[3]rotaxane exhibits unique molecular motion,with the macrocycles shuttling along the axle in response to acid-base reactions,temperature changes,solvent variations,and light irradiation.The molecular shuttle and reversibility were investigated by^(1)H NMR,2D NOESY,HRESI-MS,and UV-vis spectroscopy.This study provides a rare example of a higher order rotaxane with multi-stimuli responsiveness,highlighting its potential for multi-state control over the motion of interlocked rings on an axle.The ability to manipulate the molecular motion of the macrocycles through various external triggers offers insights for future developments in molecular machinery and adaptive materials.
基金supported by the Natural Science Foundation of Shaanxi Province(Nos.2023-YBSF-270,2024SF-ZDCYL-02-08)Fundamental Research Funds for the Central Universities(No.xzy022024033)+2 种基金Horizontal Project of the First Affiliated Hospital of Xi’an Jiaotong University(No.202304174)supported by the Opening Project of Structural Optimization and Application of Functional Molecules Key Laboratory of Sichuan Province(No.2023GNFZ-03)The Key Laboratory for Screening and Diagnosis of Maternal and Child Genetic Disease of Health Commission of Jiangxi Province.
文摘The tumor microenvironment(TME)-activatable probes have proven effective in enhancing the signalto-background ratio(SBR)for precise fluorescence imaging in tumor diagnosis.However,many fluorophores have suboptimal emission spectra and a short Stokes shift,which may lead to overlap with bioautofluorescence,excitation,and emission spectra,limiting their use in intraoperative guidance.Herein,aγ-glutathione(GSH)responsive near-infrared(NIR)BODIPY probe,named“Pro-Dye”was synthesized with a large Stokes shift of 91 nm.The Pro-Dye can be rapidly and specifically activated by high concentrations of GSH both in solution and inside cancer cells,while remaining inactive in normal cells(Human umbilical vein endothelial cells,HUVECs).The Pro-Dye was further encapsulated by 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol)-5000(DSPE-PEG5000)to form Pro-Dye nanoparticles(NPs),making it water-dispersible for in vivo application.In vivo fluorescence imaging demonstrated that Pro-Dye NPs can accumulate at the tumor and exhibit an improved SBR compared to the“alwayson”probe(Dye NPs).Moreover,the tumor can be precisely resected under the real-time guidance of fluorescence imaging of Pro-Dye NPs,showing a well-defined tumor margin.
基金supported by the National Natural Science Foundation of China(Grant Nos.:82373833,22177039,and 82304438)the National Key Research and Development Program of China(Grant No.:2021YFC2300400)Guangdong Basic and Applied Basic Research Foundation,China(Grant Nos.:2024A1515012204,2022A1515010300,and 2022A1515110618).
文摘Rapid and ultrasensitive detection of pathogen-associated biomarkers is vital for the early diagnosis and therapy of bacterial infections.Herein,we developed a close-packed and ordered Au@AgPt array coupled with a cascade triggering strategy for surface-enhanced Raman scattering(SERS)and colorimetric identification of the Staphylococcus aureus biomarker micrococcal nuclease(MNase)in serum samples.The trimetallic Au@AgPt nanozymes can catalyze the oxidation of 3,3’,5,5’-tetramethylbenzidine(TMB)molecules to SERS-enhanced oxidized TMB(oxTMB),accompanied by the color change from colorless to blue.In the presence of S.aureus,the secreted MNase preferentially cut the nucleobase AT-rich regions of DNA sequences on magnetic beads(MBs)to release alkaline phosphatase(ALP),which subsequently mediated the oxTMB reduction for inducing the colorimetric/SERS signal fade away.Using this“on-to-off”triggering strategy,the target S.aureus can be recorded in a wide linear range with a limit of detection of 38 CFU/mL in the colorimetric mode and 6 CFU/mL in the SERS mode.Meanwhile,the MNase-mediated strategy characterized by high specificity and sensitivity successfully discriminated between patients with sepsis(n=7)and healthy participants(n=3),as well as monitored the prognostic progression of the disease(n=2).Overall,benefiting from highly active and dense“hot spot”substrate,MNase-mediated cascade response strategy,and colorimetric/SERS dual-signal output,this methodology will offer a promising avenue for the early diagnosis of S.aureus infection.
基金supported by the Joint Funds of National Natural Science Foundation of China(No.U22A20162)the Natural Science Foundation of Hebei Province of China(No.C2021202002)+1 种基金the National Natural Science Foundation of China(No.52271245),the Natural Science Foundation of Tianjin(No.21JCQNJC01280)the financial support from the Danish Council for Independent Research(9040-00219B),European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement ENSIGN(Project ID:101086226),L4DNANO(Project ID:101086227).
文摘Microneedle(MN)patches could be a promising treatment for diabetic foot ulcers that plague thousands of people worldwide.While reducing skin resistance or increasing driving force can accelerate the efficiency of transdermal drug delivery with conventional MN patches,it can create toxic chemical residues or require the help of additional devices.Herein,a thermo-responsive microneedles patch(TMN)with high biocompatibility without additional equipment is proposed.The TMN consisted of a bilayer microneedles composed of sodium alginate(SA)-g-poly(N-isopropylacrylamide)layer(SA-g-PNIPAM)loaded with sucrose octasulfate sodium salt(SOS)and hyaluronic acid layer and a polycaprolactone/chitosan nanofiber membrane loading with tetracycline hydrochloride(TH)and SOS.PNIPAM accelerates drug release by extruding the drug through a volumetric phase transition in response to temperature changes,and TH and SOS promote wound healing by inhibiting bacterial growth and promoting vascular regeneration and epithelial formation.The results showed that the drug release of TMN was significantly faster,with the drug release rate of more than 80% in the 10th h,and the antibacterial rate of TMN could reach 800%.In addition,TMN had good biocompatibility and good healing effects in vivo,which may be helpful for the design of multifunctional dressings in the future.
基金financially supported by the National Natural Science Foundation of China(Nos.22273098,52033001 and 22303032)the Key Project of Anhui Province Science and Technology Innovation Platform(No.S202305a12020030)+1 种基金the Science and Technology Program Project of Zhejiang Province,China(No.2025ZY01057)partially carried out at the USTC Center for Micro and Nanoscale Research and Fabrication。
文摘Strong polyelectrolyte brushes(SPBs)play an important role in enabling material surface functionalization due to their unique stimuli-responsive properties.Although the unexpected pH responsiveness of SPBs has been revealed in the past ten years,it is still unclear if the pH-responsive properties of SPBs are affected by the brush thickness.In this study,we employed the positively charged poly[2-(methacryloyloxy)ethyl]trimethylammonium chloride(PMETAC)and negatively charged sodium poly(styrenesulfonate)(NaPSS)brushes as model systems to explore the effect of thickness on the pH-responsive properties of SPBs.The results demonstrate that the pH-responsive properties of SPBs manifest different dependences on the brush thickness.Specifically,for both PMETAC and NaPSS brushes,the pH-responsive hydration and stiffness are influenced by the thickness,and the pH-responsive wettability and adhesion are almost unaffected by the thickness.This work not only provides a clear understanding of the relationship between the brush thickness and the pH responsiveness of SPBs,but also offers a new method to control the pH-responsive properties of SPBs.
基金supported by the National Key Research and Development Program of China(2023YFB4605700)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.52021003)+4 种基金the National Outstanding Youth Science Fund Project of National Natural Science Foundation of China(No.52222509)the Natural Science Foundation of Jilin Province(No.20220101220JC)the Defense Industrial Technology Development Program(JCKY2023130C001)Changbai Talents Plan of Jilin Province“Fundamental Research Funds for the Central Universities”.
文摘Superhydrophobic/superhydrophilic antifouling materials are widely used to solve the severe water pollution and bio-adhesion of marine equipment.However,conventional antifouling materials rely on the static superwettability of surfaces,which suffer from poorly sustained antifouling effects.Inspired by the unique dynamic antifouling strategies of Calliphora Vicina wing surface based on the hydrophobic micro-cilia arrays,a Biomimetic Magnetic-Responsive Antifouling Surface(BMRAS)is designed and fabricated using a method combining UV lithography and an inverse molding.The BMRAS is coated by high-aspect-ratio micro-cilia,which are filled with synthesized magnetic Fe3O4 nanoparticles.The bioinspired hydrophobic micro-cilia arrays endow the BMRAS with excellent intrinsic superhydrophobicity,benefiting from the high-aspect-ratio feature and roughness effect.Remarkably,the static contact angle is more than 156.9±1.6°and the rolling angle is less than 2.3±0.3°.The synthesized magnetic nanomaterials play a key role in implementing dynamic antifouling strategies.On the one hand,the surface tension can be adjusted as required under magnetically controlled oscillations.On the other hand,the doping of magnetic nanomaterials can enhance mechanical properties and reduce capillary force-induced aggregation of high-aspect-ratio micro-cilia.The antifouling tests demonstrate that the chemically modified micro-cilia can effectively expel gravels under the stimulation of an external magnetic field and enable the BMRAS to achieve dynamic self-cleaning.Specifically,0.17 g gravel distributed on BMRAS can be completely cleaned up within 0.296 s,which improved by 14.2%compared with the flat materials.This work provides a brief and effective strategy for designing dynamic antifouling surfaces with excellent physicochemical durability and great potential value in the applications of marine fouling.
基金supported by Natural Science Foundation of Jilin Province(No.SKL202302002)Key Research and Development project of Jilin Provincial Science and Technology Department(No.20210204142YY)+2 种基金The Science and Technology Development Program of Jilin Province(No.2020122256JC)Beijing Kechuang Medical Development Foundation Fund of China(No.KC2023-JX-0186BQ079)Talent Reserve Program(TRP),the First Hospital of Jilin University(No.JDYY-TRP-2024007)。
文摘Prostate cancer(PCa)is characterized by high incidence and propensity for easy metastasis,presenting significant challenges in clinical diagnosis and treatment.Tumor microenvironment(TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy.Considering that tumor-derived alkaline phosphatase(ALP)is over-expressed in metastatic PCa,it makes a great chance to develop a theranostics system with ALP responsive in the TME.Herein,an ALP-responsive aggregationinduced emission luminogens(AIEgens)nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa.The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence,and enhanced accumulation and prolonged retention period at the tumor site.In terms of detection,the fluorescence(FL)/computed tomography(CT)/magnetic resonance(MR)multi-mode imaging effect of nanoprobe was significantly improved post-aggregation,enabling precise diagnosis through the amalgamation of multiple imaging modes.Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis,and enhanced FL imaging technology can achieve“intraoperative visual navigation”,showing its potential application value in clinical tumor detection and surgical guidance.In terms of treatment,AMNF showed strong absorption in the near infrared region after aggregation,which improved the photothermal treatment effect.Overall,our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.
基金financially supported by the National Natural Science Foundation of China(Nos.21877048,22077048,and 22277014)Guangxi Natural Science Foundation(Nos.2021GXNSFDA075003,AD21220061)the Startup Fund of Guangxi University(No.A3040051003).
文摘Diabetic liver injury is a widespread complication of diabetes and carries a high risk to liver function.Therefore,early diagnosis of diabetic liver injury is of great significance for providing quality of life for diabetic patients.Most of the activated dual-modal probes are usually activated by single factor stimulation,which greatly reduces the diagnostic accuracy of liver injury.Here,a novel cysteine(Cys)/homocysteine(Hcy)and viscosity-enhanced dual-modal probe DAL was developed for the first time to monitor diabetic liver injury and its repair process.In the presence of Cys/Hcy,the near-infrared fluorescence(NIRF)and photoacoustic(PA)signals of the probe DAL were activated,with further signal enhancement in high viscosity environments.This Cys/Hcy and viscosity cascade probe exhibits heightened sensitivity and enhanced anti-interference capabilities,contributing to the advancement of liver injury diagnosis accuracy.In addition,the probe DAL shows exceptional mitochondrial targeting ability,enabling sensitive monitoring of Cys/Hcy and viscosity alterations within mitochondria.Based on NIRF/PA dual-modal imaging technology,the probe was successfully used for the first time in a mouse diabetic liver injury model to evaluate the extent of liver damage and the repair process by tracking the levels of Cys/Hcy and viscosity.Therefore,the two-factor activated dual-modal probe developed in this study provides a powerful instrument for accurate diagnosis and efficacy evaluation of complications related to diabetes.
基金supported by the General Program of the National Natural Science Foundation of China(52074335)the National Key Research and Development Program of China(2022YFE0129900 and 2019YFA0708700)+1 种基金the Fundamental Research Funds for the Central Universities(23CX07003A)the Special Funding Program for the Operational Expenses of National Research Institutions(SKLDOG2024-ZYRC-01).
文摘In deep oil reservoir development,enhanced oil recovery(EOR)techniques encounter significant challenges under high-temperature and high-salinity conditions.Traditional profile-control agents often fail to maintain stable blocking under extreme conditions and exhibit poor resistance to high temperature and high salinity.This study develops a functionalized nanographite system(the MEGO system)with superior high-temperature dispersibility and thermosalinity-responsive capability through polyether amine(PEA)grafting and noncovalent interactions with disodium naphthalene sulfonate(DNS)molecules.The grafted PEA and DNS provide steric hindrance and electrostatic repulsion,enhancing thermal and salinity resistance.After ten days of aggregation,the MEGO system forms stable particle aggregates(55.51-61.80 lm)that are suitable for deep reservoir migration and profile control.Both experiments and simulations reveal that particle size variations are synergistically controlled by temperature and salt ions(Na^(+),Ca^(2+),and Mg^(2+)).Compared with monovalent ions,divalent ions promote nanographite aggregation more strongly through double-layer compression and bridging effects.In core displacement experiments,the MEGO system demonstrated superior performance in reservoirs with permeabilities ranging from 21.6 to 103 mD.The aggregates formed within the pore throats significantly enhanced flow resistance,expanded the sweep volume,and increased the overall oil recovery to 56.01%.This research indicates that the MEGO system holds excellent potential for EOR in deep oil reservoirs.
基金funded by Research Project of Department of Education of Liaoning Province(No.LJKMZ20221363,China)。
文摘Glycyrrhetinic acid(GA)sheds new light on liver-targeted therapy due to high-specific accumulation to GA receptors in liver,however,the limitation of commonly used macromolecular GA modification approaches as well as the application gap across various vector have constrained its use.In this study,we proposed a novel perspective to break out,disulfide bonds(SS)were employed as linkage to facilitate GA modification,which allowed further connections with various carriers,while provided additional glutathione(GSH)-responsive property.The superiority of GA-disulfide conjunction was validated using mesoporous silica nanoparticles(MSN)as model carriers,chemotherapeutic drug(doxorubicin)and photosensitizer(indocyanine green)were loaded into MSN-SS-GA to further achieve chemo-photothermal synergistic anti-tumor therapy.Based on results from multiple evaluations,the GA-disulfide drafted MSN(DI/MSN-SS-GA)demonstrated expected liver tumor targeting effect and exhibited GSH-stimuli release property to reduce preleakage.Taken together,this study presents an effective chemo-photothermal therapy for liver cancer(88.26%),offers a potential,robust and straightforward strategy on GA application for enhancing liver targeting therapy.
基金financially supported by the National Natural Science Foundation of China(No.51902025).
文摘Rapid advances in thermal management technology and the increasing need for multi-energy conversion have placed stringent energy efficiency requirements on next-generation shape-stable composite phase change materials(PCMs).Magnetically-responsive phase change thermal storage materials are considered an emerging concept for energy storage systems,enabling PCMs to perform unprecedented functions(such as green energy utilization,magnetic thermotherapy,drug release,etc.).The combination of multifunctional magnetic nanomaterials and PCMs is a milestone in the creation of advanced multifunctional composite PCMs.However,a timely and comprehensive review of composite PCMs based on magnetic nanoparticle modification is still missing.Herein,we furnish an exhaustive exposition elucidating the cutting-edge advancements in magnetically responsive composite PCMs.We delve deeply into the multifarious roles assumed by distinct nanoparticles within composite PCMs of varying dimensions,meticulously scrutinizing the intricate interplay between their architectures and thermophysical attributes.Moreover,we prognosticate future research trajectories,delineate alternative stratagems,and illuminate prospective avenues.This review is intended to stimulate broader academic interest in interdisciplinary fields and provide valuable insights into the development of next-generation magnetically-responsive composite PCMs.
基金financially supported by the National Natural Science Foundation of China(No.22171182)Sichuan Tianfu Emei Plan.
文摘Control crosslink network and chain connectivity are essential to develop shape memory polymers(SMPs)with high shape memory capabilities,adjustable response temperature,and satisfying mechanistical properties.In this study,novel poly(ε-caprolactone)(PCL)-poly(2-vinyl)ethylene glycol(PVEG)copolymers bearing multi-pendant vinyl groups is synthesized by branched-selective allylic etherification polymerization of vinylethylene carbonate(VEC)with linear and tetra-arm PCLs under a synergistic catalysis of palladium complex and boron reagent.Facile thiol-ene photo-click reaction of PCL-PVEG copolymers with multifunctional thiols can rapidly access a serious crosslinked SMPs with high shape memory performance.The thermal properties,mechanical properties and response temperature of the obtained SMPs are tunable by the variation of PCL prepolymers,vinyl contents and functionality of thiols.Moreover,high elastic modulus in the rubbery plateau region can be maintained effectively owing to high-density topological networks of the PCL materials.In addition,the utility of the present SMPs is further demonstrated by the post-functionalization via thiol-ene photo-click chemistry.
基金supported by the National Natural Science Foundation of China(No.21907059)Shandong Province Chinese Medicine Science and Technology Development Project(No.M-2022258)+1 种基金the Young Scientist Development Foundation of Shandong First Medical University(No.202201-002)the Academic Promotion Program of Shandong First Medical University(Nos.2019LJ003 and 2019QL011).
文摘Tumor microenvironment-responsive drug self-delivery systems utilize tumor microenvironment-responsive chemical bonds to link anti-tumor drugs,exploiting the hydrophilic and hydrophobic properties of different drugs to form amphiphilic prodrug molecules with self-assembly characteristics.Upon stimulation by specific factors in the tumor microenvironment,these amphiphilic prodrug molecules can release drugs at precise sites within the tumor.These strategies significantly increase the drug concentration at the tumor site while effectively reducing the damage of anti-cancer drugs to normal tissues.Owing to the advanced delivery strategies such as synergistic administration and controlled drug release,tumor microenvironment-responsive drug self-delivery systems hold great potential for treating malignant tumors with multidrug resistance(MDR).At the same time,the stimulus-reactivity of metal complexes provides an important opportunity to design site-specific prodrugs that can maximize therapeutic efficacy while minimizing adverse side effects of metal drugs.This innovative drug design complements the tumor microenvironment-responsive self-delivery system,providing more feasible therapeutic strategies and possibilities in the field of cancer therapy and drug delivery.This work provides a comprehensive review of recent advancements in drug self-delivery systems,offering insights into their potential applications in cancer therapy and MDR reversal.
基金supported by the National Natural Science Foundation of China(No.82260878)Guizhou Medical University Affiliated Hospital Doctoral Research Initiation Fund Project(gyfybsky-2021-44)+3 种基金Guizhou Provincial Science and Technology Plan Project(Qiankehe Achievements LC[2022]014)High-level Innovative Talents Cultivation Program of Guizhou Province(QianKeHe[2016]5679)Province Guiyang City Science and Technology Projects,Zhu Subjects Contract([2022]4-2-5)Guizhou Science and Technology Planning Project(QianKeHe[2020]4Y198).
文摘Background:Nonsuicidal self-injury(NSSI)in adolescents with depression disorders often exhibits addictive patterns,potentially linked to serum beta-endorphin levels and neural reward responsiveness.Beta-endorphin,involved in reward processing,alongside dysregulated neural reward pathways,may reinforce self-injurious behaviors,highlighting the need to explore these mechanisms.Methods:Adolescents(aged 12-17 years)with depression disorders were divided into an NSSI group(21 subjects)and a control group(11 subjects)according to inclusion criteria.Serum beta-endorphin concentration was measured using the enzyme-linked immunosorbent assay method.The Addiction Factor Scale was used to assess addiction levels.Statistical analyses were con-ducted using SPSS 25.0.The oxygenated hemoglobin response signal was detected using functional near-infrared spectroscopy.Analyses were performed using NIRS_KIT 2.0.Results:Compared with the control group,the NSSI group exhibited lower serum beta-endorphin concentration.Additionally,85.7%of those in the NSSI group displayed addictive behaviors,and serum beta-endorphin concentration was negatively correlated with the Addiction Factor Scale score.The reward task activated channels 17,20,and 21(corresponding to the dorsolateral prefrontal cortex[PFC]and frontopolar PFC)in the gain condition and channels 20 and 21 in the loss condition.The oxygenated hemoglobin concentration of the differential waveform(Δ[oxy-Hb])of channel 12(corresponding to the frontopolar PFC)correlated positively with the Addiction Factor Scale score and negatively with the serum beta-endorphin concentration.
基金financially supported by the Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation(Nos.2025GXNSFAA069283 and 2023GXNSFAA026264)Guangxi Science and Technology Base and Talent Special Project(No.GuikeAD21220008)+3 种基金the National Natural Science Foundation of China(No.82060195)Guangxi Medical and Health Suitable Technology Development and Popularization Applications Project(No.S2023093)the Key Laboratory of Micro-Nanoscale Bioanalysis and Drug Screening,the Education Department of Guangxi Zhuang Autonomous Region(No.GXYWSX202404)the Major Talent Project of Guangxi Autonomous Region
文摘Maxillofacial trauma is an infection and oxidative stress-induced damage to maxillofacial area related cells.Increasing evidences have suggested that therapeutic strategies with controllable anti-infective and anti-inflammatory capabilities hold great potentials in the clinical treatment of maxillofacial trauma.Herein,we reported an infectious microenvironment responsive bimetallic sulfide(FeCuS_(x),FCS)combining with near infrared(NIR)irradiation for maxillofacial trauma therapy.In cellular levels,FCS exhibited the most efficient antioxidant and anti-inflammatory,cell migration,and angiogenesis behaviors through down-regulating the inflammatory factor(iNOS)expression level,up-regulating anti-inflammatory factors(Arg^(-1)and TGF-β)expression level,inducing macrophages M2 polarization(CD86down-regulation and CD206 up-regulation),and promoting tissue repair factors(CD31)expression level.Besides,it presented the excellent antibacterial ability of Escherichia coli(99.74%)and MRSA(99.78%)for FCS+NIR.Significantly,it also confirmed that FCS+NIR presented the excellent functions of inhibiting wound infections,decreasing wound inflammation,as well as promoting trauma tissue repairing.Altogether,it had developed the strategy of FCS+NIR for the synergistic enhancement of infectious maxillofacial trauma healing,could also serve as a promising therapeutic strategy for the treatment of infectious diseases.
