Based on the information system characteristics of mine, proposed network architecture design of the mine property. And in this framework based on the design of three-dimensional virtual mine described the application...Based on the information system characteristics of mine, proposed network architecture design of the mine property. And in this framework based on the design of three-dimensional virtual mine described the application of intelligent management platform. Three-dimensional virtual underground mine that shows the situation, the core application is through remote monitoring system of information exchange between devices （material object communication）. Internet of things in the framework of mining three-dimensional virtual reconstruction of mine. On coal mine safety in the production process of human, machine and environment, control elements and their harmony and unity. 3D virtual mine management platform integrates personnel positioning, dust control, gas monitoring, roof pressure monitoring, fan-line monitoring and other subsystems. Platform through the underground mine sensing equipment to conduct various types of monitoring data integration, through the transport layer device to transmit the information to the application layer intelligence processing software platform, the system automatically handles the operational status of each subsystem and the need for safe production under the proper introduction of human factors deal with special event. 3D virtual mine management platform to mining, excavation, transport, ventilation and other safety information quickly and accurately transmitted to the ground operation control center. Underground for the first time on the linkage between systems in case of emergencies, to provide safety for management decision support.展开更多
Computational approaches,encompassing both physics-based and machine learning(ML)methodologies,have gained substantial traction in drug repurposing efforts targeting specific therapeutic entities.The human dopamine(DA...Computational approaches,encompassing both physics-based and machine learning(ML)methodologies,have gained substantial traction in drug repurposing efforts targeting specific therapeutic entities.The human dopamine(DA)transporter(hDAT)is the primary therapeutic target of numerous psychiatric medications.However,traditional hDAT-targeting drugs,which interact with the primary binding site,encounter significant limitations,including addictive potential and stimulant effects.In this study,we propose an integrated workflow combining virtual screening based on weighted holistic atom localization and entity shape(WHALES)descriptors with in vitro experimental validation to repurpose novel hDAT-targeting drugs.Initially,WHALES descriptors facilitated a similarity search,employing four benztropine-like atypical inhibitors known to bind hDAT's allosteric site as templates.Consequently,from a compound library of 4,921 marketed and clinically tested drugs,we identified 27 candidate atypical inhibitors.Subsequently,ADMETlab was employed to predict the pharmacokinetic and toxicological properties of these candidates,while induced-fit docking(IFD)was performed to estimate their binding affinities.Six compounds were selected for in vitro assessments of neurotransmitter reuptake inhibitory activities.Among these,three exhibited significant inhibitory potency,with half maximal inhibitory concentration(IC_(50))values of 0.753μM,0.542μM,and 1.210μM,respectively.Finally,molecular dynamics(MD)simulations and end-point binding free energy analyses were conducted to elucidate and confirm the inhibitory mechanisms of the repurposed drugs against hDAT in its inward-open conformation.In conclusion,our study not only identifies promising active compounds as potential atypical inhibitors for novel therapeutic drug development targeting hDAT but also validates the effectiveness of our integrated computational and experimental workflow for drug repurposing.展开更多
With the increasing integration of renewable energy,microgrids are increasingly facing stability challenges,primarily due to the lack of inherent inertia in inverter-dominated systems,which is traditionally provided b...With the increasing integration of renewable energy,microgrids are increasingly facing stability challenges,primarily due to the lack of inherent inertia in inverter-dominated systems,which is traditionally provided by synchronous generators.To address this critical issue,Virtual Synchronous Generator(VSG)technology has emerged as a highly promising solution by emulating the inertia and damping characteristics of conventional synchronous generators.To enhance the operational efficiency of virtual synchronous generators(VSGs),this study employs smallsignal modeling analysis,root locus methods,and synchronous generator power-angle characteristic analysis to comprehensively evaluate how virtual inertia and damping coefficients affect frequency stability and power output during transient processes.Based on these analyses,an adaptive control strategy is proposed:increasing the virtual inertia when the rotor angular velocity undergoes rapid changes,while strengthening the damping coefficient when the speed deviation exceeds a certain threshold to suppress angular velocity oscillations.To validate the effectiveness of the proposed method,a grid-connected VSG simulation platform was developed inMATLAB/Simulink.Comparative simulations demonstrate that the proposed adaptive control strategy outperforms conventional VSGmethods by significantly reducing grid frequency deviations and shortening active power response time during active power command changes and load disturbances.This approach enhances microgrid stability and dynamic performance,confirming its viability for renewable-dominant power systems.Future work should focus on experimental validation and real-world parameter optimization,while further exploring the strategy’s effectiveness in improvingVSG low-voltage ride-through(LVRT)capability and power-sharing applications in multi-parallel configurations.展开更多
Virtual power plant(VPP)integrates a variety of distributed renewable energy and energy storage to participate in electricity market transactions,promote the consumption of renewable energy,and improve economic effici...Virtual power plant(VPP)integrates a variety of distributed renewable energy and energy storage to participate in electricity market transactions,promote the consumption of renewable energy,and improve economic efficiency.In this paper,aiming at the uncertainty of distributed wind power and photovoltaic output,considering the coupling relationship between power,carbon trading,and green cardmarket,the optimal operationmodel and bidding scheme of VPP in spot market,carbon trading market,and green card market are established.On this basis,through the Shapley value and independent risk contribution theory in cooperative game theory,the quantitative analysis of the total income and risk contribution of various distributed resources in the virtual power plant is realized.Moreover,the scheduling strategies of virtual power plants under different risk preferences are systematically compared,and the feasibility and accuracy of the combination of Shapley value and independent risk contribution theory in ensuring fair income distribution and reasonable risk assessment are emphasized.A comprehensive solution for virtual power plants in the multi-market environment is constructed,which integrates operation strategy,income distribution mechanism,and risk control system into a unified analysis framework.Through the simulation of multi-scenario examples,the CPLEXsolver inMATLAB software is used to optimize themodel.The proposed joint optimization scheme can increase the profit of VPP participating in carbon trading and green certificate market by 29%.The total revenue of distributed resources managed by VPP is 9%higher than that of individual participation.展开更多
Conventional surgical teaching techniques face several challenges,highlighting a necessity for ongoing innovation in ophthalmology education to align with the evolving demands of clinical practice.The recent rapid adv...Conventional surgical teaching techniques face several challenges,highlighting a necessity for ongoing innovation in ophthalmology education to align with the evolving demands of clinical practice.The recent rapid advancement of computer technology has enabled the integration of virtual reality(VR)into medical training,thereby revolutionizing ophthalmic surgical education through VRbased educational methods.VR technology offers a safe,risk-free environment for trainees to practice repeatedly,enhancing surgical skills and accelerating the learning curve without compromising patient safety.This research outlines the application of VR technology in ophthalmic surgical skills training,particularly in cataract and vitreoretinal surgery.Including assessing the effectiveness of intraocular surgery training systems,evaluating skills transfer to the operating room,comparing it with wet lab cataract surgery training,and enhancing non-dominant hand training for cataract surgery,among other aspects.Additionally,this paper will identify the limitations of VR technology in ocular surgical skills training,offer improvement strategies,and detail the advantages and prospects,with the objective of guiding subsequent researchers.展开更多
Ensuring reliable power supply in urban distribution networks is a complex and critical task.To address the increased demand during extreme scenarios,this paper proposes an optimal dispatch strategy that considers the...Ensuring reliable power supply in urban distribution networks is a complex and critical task.To address the increased demand during extreme scenarios,this paper proposes an optimal dispatch strategy that considers the coordination with virtual power plants(VPPs).The proposed strategy improves systemflexibility and responsiveness by optimizing the power adjustment of flexible resources.In the proposed strategy,theGaussian Process Regression(GPR)is firstly employed to determine the adjustable range of aggregated power within the VPP,facilitating an assessment of its potential contribution to power supply support.Then,an optimal dispatch model based on a leader-follower game is developed to maximize the benefits of the VPP and flexible resources while guaranteeing the power balance at the same time.To solve the proposed optimal dispatch model efficiently,the constraints of the problem are reformulated and resolved using the Karush-Kuhn-Tucker(KKT)optimality conditions and linear programming duality theorem.The effectiveness of the strategy is illustrated through a detailed case study.展开更多
Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the u...Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.展开更多
Distributed virtual coal-mine geography environment（CM-DVGE） researches the virtual reality simulation of coal-mine environment in cyberspace and the performance of coal production process. The goal is to deal with ...Distributed virtual coal-mine geography environment（CM-DVGE） researches the virtual reality simulation of coal-mine environment in cyberspace and the performance of coal production process. The goal is to deal with the practical safety problems of observation, analysis, design and training during the underground coal production process. This paper first probed into the evolution of CM-DVGE from a historical point of view, then respectively analyzed the characteristics of its physical progressive levels according to the cognitivd law and its logical structure of data on the basis of data flow, and concluded by putting forward the prospect of the application of CM-DVGE, thus enriched and developed the method of synthetic study of coal mine.展开更多
The management of patients with concomitant chronic pain (CP) and Major Depressive Disorder (MDD) remains challenging for clinicians. Current chronic pharmacologic management is often unsuccessful, or has intolerable ...The management of patients with concomitant chronic pain (CP) and Major Depressive Disorder (MDD) remains challenging for clinicians. Current chronic pharmacologic management is often unsuccessful, or has intolerable side effects to the patients. While not restricted to patients with chronic pain, these patients are often diagnosed with depression, presenting with symptoms such as poor mood, anhedonia, and altered cognitive processes. It is estimated that a substantial proportion of treated patients do not derive a substantive benefit from traditional pharmacological treatments for depression. The present study involved a retrospective review of cases, exploring the patient-reported satisfaction with and tolerability of a novel use of virtual reality (VR), coined KVR, as an adjunct to intravenous ketamine infusion therapies. Specifically, the ketamine-virtual reality protocol was employed as a potential adjunctive intervention for patients suffering from chronic pain and depression. Visual Analog Scores (VAS) associated with pain were significantly lower on the third than on the first assessment day. Montgomery-?sberg Depression Rating Scale (MADRS) scores improved following infusion and across days (i.e., sessions). Lastly, 2/3 of patients preferred the use of VR with their ketamine infusion. The results are considered in terms of implementing prospective studies to examine whether the combination therapies have a synergistic benefit and the nature and magnitude of clinically meaningful treatment effects, if any.展开更多
Objectives:To explore the efficacy and safety of virtual reality(VR)in relieving negative emotions in patients with breast cancer with different personalities.Methods:A randomized controlled trial was conducted.Betwee...Objectives:To explore the efficacy and safety of virtual reality(VR)in relieving negative emotions in patients with breast cancer with different personalities.Methods:A randomized controlled trial was conducted.Between April 2023 and October 2023,we enrolled patients with breast cancer treated in the Department of Breast Cancer and Oncology at Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangdong Province.The patients were randomly divided into an intervention group(n=118)and a control group(n=119)using block randomization.The intervention group received the VR intervention 3-5 times over 5±2 weeks using natural landscapes with music or relaxation guidance,and the duration of each VR intervention was 15±3 min.The control group received routine nursing care,including disease education and psychological counseling.Patients were assessed using the Type D Scale,Positive and Negative Affect Scale,and Distress Thermometer,and adverse events during the intervention were recorded.Results:Overall,85 patients completed the study(44 in the intervention group and 41 in the control group).Patients with Type D personalities showed more negative emotions[25.0(21.5,27.5)vs.19.0(16.0,24.0),P=0.001]and distressed attitudes[4.0(2.0,5.0)vs.3.0(1.0,4.0),P=0.020]with fewer positive emotions(27.2±5.6 vs.31.0±5.9,P=0.014)than those with non-Type D personalities.Total population analysis revealed no significant differences between the groups.However,in the subgroup analysis,patients with Type D personalities in the intervention group showed greater relief from negative emotions than those in the control group[median difference,-5.0(-9.0,-2.5)vs.-2.0(-4.0,2.0),P=0.046].No significant differences were found between groups of patients with non-Type D personality traits.The proportion of adverse events was not significantly different between groups(P=0.110).Conclusions:Breast cancer patients with Type D personalities suffer more severe negative emotions and distress,and more attention should be paid to them.VR intervention significantly and safely reduced negative emotions in patients with Type D personalities.展开更多
As the penetration rate of distributed energy increases,the transient power angle stability problem of the virtual synchronous generator(VSG)has gradually become prominent.In view of the situation that the grid impeda...As the penetration rate of distributed energy increases,the transient power angle stability problem of the virtual synchronous generator(VSG)has gradually become prominent.In view of the situation that the grid impedance ratio(R/X)is high and affects the transient power angle stability of VSG,this paper proposes a VSG transient power angle stability control strategy based on the combination of frequency difference feedback and virtual impedance.To improve the transient power angle stability of the VSG,a virtual impedance is adopted in the voltage loop to adjust the impedance ratio R/X;and the PI control feedback of the VSG frequency difference is introduced in the reactive powervoltage link of theVSGto enhance the damping effect.Thesecond-orderVSGdynamic nonlinearmodel considering the reactive power-voltage loop is established and the influence of different proportional integral(PI)control parameters on the system balance stability is analyzed.Moreover,the impact of the impedance ratio R/X on the transient power angle stability is presented using the equal area criterion.In the simulations,during the voltage dips with the reduction of R/X from 1.6 to 0.8,Δδ_(1)is reduced from 0.194 rad to 0.072 rad,Δf_(1)is reduced from 0.170 to 0.093 Hz,which shows better transient power angle stability.Simulation results verify that compared with traditional VSG,the proposedmethod can effectively improve the transient power angle stability of the system.展开更多
Background: Dengue is a Neglected tropical disease (NTDs) with high incidence in Brazil. This disease is caused by Dengue virus and is transmitted by Aedes aegypti mosquito. The search for new approaches for controlli...Background: Dengue is a Neglected tropical disease (NTDs) with high incidence in Brazil. This disease is caused by Dengue virus and is transmitted by Aedes aegypti mosquito. The search for new approaches for controlling of this disease is the subject of numerous studies. The aaNAT is a key enzyme in the metabolism of A. aegypti and is crucial in the sclerotization process, as well as regulation of circadian rhythm and inactivation of neurotransmitters. Computational techniques applied to studies of biological systems become an effective weapon in the mapping and management of 3D data structures, giving direction and guidance of potential ligands that can form stable complexes with targets of interest, using a Molecular Docking approach. The present study was conducted by a virtual screening, followed by docking calculations, in order to find molecules that could inhibit aaNAT. In this study, we used available compounds in SAM database (Bioinformatics and Medicinal Chemistry Laboratory—Southwest Bahia State University, Jequié-Bahia, Brazil), PubChem and ZINC. Results: The result of dockings with selected ligands showed good energy affinities, presenting potential inhibitory interactions with the enzyme active site. Conclusions: The Coa-S-acetyl-tryptamine and 3-indoleacriloil-coenzyme-A showed the same binding energies -8.9 Kcal/Mol and were described as possible inhibitors of aaNAT.展开更多
The use of virtual reality to educate preoperative patients has a positive impact on nurses as well as patients undergoing treatment.It can help improve patient satisfaction and improve favorable outcomes by reducing ...The use of virtual reality to educate preoperative patients has a positive impact on nurses as well as patients undergoing treatment.It can help improve patient satisfaction and improve favorable outcomes by reducing patient anxiety and proving adequate knowledge about the procedure and possible outcomes to the patient.It also reduces burden on nursing staff and counsellors.Larger and more diverse cohort studies will help us understand the wider application of this tool on the patient population.It may be difficult to apply this tool on elderly patients with failing eyesight,multiple physical comorbidities.Also,there may be reduced acceptance of this modality by older nursing staff and practitioners who may prefer the traditional verbal version for counselling.We will benefit from a combined approach of using virtual reality apps with tradition one-on-one counselling to help alleviate patient concerns and improve patient and healthcare professional satisfaction.展开更多
This research pioneers the integration of geographic information systems(GIS)and 3D modeling within a virtual reality(VR)framework to assess the viability and planning of a 20 MW hybrid wind-solarphotovoltaic(PV)syste...This research pioneers the integration of geographic information systems(GIS)and 3D modeling within a virtual reality(VR)framework to assess the viability and planning of a 20 MW hybrid wind-solarphotovoltaic(PV)system connected to the local grid.The study focuses on Dakhla,Morocco,a region with vast untapped renewable energy potential.By leveraging GIS,we are innovatively analyzing geographical and environmental factors that influence optimal site selection and system design.The incorporation of VR technologies offers an unprecedented level of realism and immersion,allowing stakeholders to virtually experience the project's impact and design in a dynamic,interactive environment.This novel methodology includes extensive data collection,advanced modeling,and simulations,ensuring that the hybrid system is precisely tailored to the unique climatic and environmental conditions of Dakhla.Our analysis reveals that the region possesses a photovoltaic solar potential of approximately2400 k Wh/m^(2) per year,with an average annual wind power density of about 434 W/m^(2) at an 80-meter hub height.Productivity simulations indicate that the 20 MW hybrid system could generate approximately 60 GWh of energy per year and 1369 GWh over its 25-year lifespan.To validate these findings,we employed the System Advisor Model(SAM)software and the Global Solar Photovoltaic Atlas platform.This comprehensive and interdisciplinary approach not only provides a robust assessment of the system's feasibility but also offers valuable insights into its potential socio-economic and environmental impact.展开更多
Background Over the last few years,the rapid advancement of technology has led to the development of many approaches to digitalization.In this respect,metaverse provides 3D persistent virtual environments that can be ...Background Over the last few years,the rapid advancement of technology has led to the development of many approaches to digitalization.In this respect,metaverse provides 3D persistent virtual environments that can be used to access digital content,meet virtually,and perform several professional and leisure tasks.Among the numerous technologies supporting the metaverse,immersive Virtual Reality(VR)plays a primary role and offers highly interactive social experiences.Despite growing interest in this area,there are no clear design guidelines for creating environments tailored to the metaverse.Methods This study seeks to advance research in this area by moving from state-of-the-art studies on the design of immersive virtual environments in the context of metaverse and proposing how to integrate cutting-edge technologies within this context.Specifically,the best practices were identified by i)analyzing literature studies focused on human behavior in immersive virtual environments,ii)extracting common features of existing social VR platforms,and iii)conducting interviews with experts in a specific application domain.Specifically,this study considered the creation of a new virtual environment for MetaLibrary,a VR-based social platform aimed at integrating public libraries into metaverse.Several implementation challenges and additional requirements have been identified for the development of virtual environments(VEs).These elements were considered in the selection of specific cutting-edge technologies and their integration into the development process.A user study was also conducted to investigate some design aspects(namely lighting conditions and richness of the scene layout)for which deriving clear indications from the above analysis was not possible because different alternative configurations could be chosen.Results The work reported in this paper seeks to bridge the gap between existing VR platforms and related literature in the field,on the one hand,and requirements regarding immersive virtual environments for the metaverse,on the other hand,by reporting a set of best practices which were used to build a social virtual environment that meets users'expectations and needs.Conclusions Results suggest that carefully designed virtual environments can positively affect user experience and interaction within metaverse.The insights gained from this study offer valuable cues for developing immersive virtual environments for the metaverse to deliver more effective and engaging experiences.展开更多
To address the challenges of insufficient visualization in the industrial robot assembly operation system and the limitation of visualizing only geometric attributes of physical properties,a method is proposed for con...To address the challenges of insufficient visualization in the industrial robot assembly operation system and the limitation of visualizing only geometric attributes of physical properties,a method is proposed for constructing an industrial robot assembly system based on virtual reality technology.Focusing on the shaft hole assembly,the mechanical characteristics of the industrial robot shaft hole assembly process are analyzed and a dynamic model is established for shaft hole assembly operations.The key elements of virtual assembly operations for industrial robots are summarized and a five-dimensional model is proposed for industrial robot virtual operations.Utilizing the Unity3D engine based on the 5-D model for industrial robot virtual operations,an industrial robot shaft hole assembly system is developed.This system enables virtual assembly operations,displays physical attributes,and provides valuable references for the research of virtual systems.展开更多
The power-electronics-based DC microgrid system composed of new energy sources in railway field has low inertia,weak damping characteristics,and the voltage fluctuation microgrid systems caused by the power disturbanc...The power-electronics-based DC microgrid system composed of new energy sources in railway field has low inertia,weak damping characteristics,and the voltage fluctuation microgrid systems caused by the power disturbance of solar.In order to improve the inertia of the DC microgrid system,a virtual DC generator technology is adopted in the interface converter of photovoltaic(PV)power generation unit,so that it has the external characteristics of DC generator.However,the influence of PV maximum power point tracking(MPPT)is not considered in the traditional virtual DC generator control.Therefore,an improved control strategy for virtual DC generator is proposed,and its small signal model is established to analyze the influence of inertia and damping coefficient on stability.The results show that the proposed method effectively weakens the impact on DC bus voltage when the output of PV power unit changes suddenly,which improves the stability of the microgrid.Meanwhile,the correctness and feasibility of the method are verified.展开更多
The early involvement of test and evaluation can significantly reduce the cost of modifying issues and errors found in the later stages of aircraft development and design process.This paper presents a methodology for ...The early involvement of test and evaluation can significantly reduce the cost of modifying issues and errors found in the later stages of aircraft development and design process.This paper presents a methodology for aircraft mission effectiveness evaluation and design space exploration based on Virtual Operational Test(VOT),incorporating Virtual Open Scenario(VOS)and User in Scenarios(UIS)concepts.By employing modeling and simulation technologies in the early stages of aircraft development and design,a virtual environment can be constructed,allowing aircraft users to participate more closely and conveniently in the design process.Virtual tests conducted by users within the mission context provide data on mission effectiveness and critical user feedback.This paper outlines the main components of the virtual operational test process and related conceptual methods,and discusses an open support system framework that supports VOT.The effectiveness and adaptability of the method are demonstrated through two case studies:a beyond-visual-range air combat scenario and a helicopter ground attack scenario.These case studies demonstrate the evaluation of aircraft mission effectiveness and the sensitivity analysis and optimization of design and operational parameters based on VOT.展开更多
We uncover the virtual monopoles underlying the nontrivial phases of the one-dimensional nonlinear excitations of rogue waves by extending the Dirac magnetic monopole theory to a complex plane. We find that the densit...We uncover the virtual monopoles underlying the nontrivial phases of the one-dimensional nonlinear excitations of rogue waves by extending the Dirac magnetic monopole theory to a complex plane. We find that the density zeros of the nonlinear waves on the extended complex plane constitute the virtual monopole fields with a quantized flux of elementary π. We then explain the exotic properties of rogue waves by means of a virtual monopole collision mechanism and find that the maximum amplitude amplification ratio and multiple phase steps of the high-order rogue waves are closely related to the number of their contained monopoles. These results open a new avenue for studying topological properties of nonlinear waves and provide an alternative way to understand their dynamics.展开更多
文摘Based on the information system characteristics of mine, proposed network architecture design of the mine property. And in this framework based on the design of three-dimensional virtual mine described the application of intelligent management platform. Three-dimensional virtual underground mine that shows the situation, the core application is through remote monitoring system of information exchange between devices （material object communication）. Internet of things in the framework of mining three-dimensional virtual reconstruction of mine. On coal mine safety in the production process of human, machine and environment, control elements and their harmony and unity. 3D virtual mine management platform integrates personnel positioning, dust control, gas monitoring, roof pressure monitoring, fan-line monitoring and other subsystems. Platform through the underground mine sensing equipment to conduct various types of monitoring data integration, through the transport layer device to transmit the information to the application layer intelligence processing software platform, the system automatically handles the operational status of each subsystem and the need for safe production under the proper introduction of human factors deal with special event. 3D virtual mine management platform to mining, excavation, transport, ventilation and other safety information quickly and accurately transmitted to the ground operation control center. Underground for the first time on the linkage between systems in case of emergencies, to provide safety for management decision support.
基金supported by the Natural Science Foundation of China(Grant No.:21505009)the Natural Science Foundation of Chongqing,China(Grant No.:2023NSCQ-MSX0140)the Open Project of Central Nervous System Drug Key Laboratory of Sichuan Province,China(Grant No.:230012-01SZ).
文摘Computational approaches,encompassing both physics-based and machine learning(ML)methodologies,have gained substantial traction in drug repurposing efforts targeting specific therapeutic entities.The human dopamine(DA)transporter(hDAT)is the primary therapeutic target of numerous psychiatric medications.However,traditional hDAT-targeting drugs,which interact with the primary binding site,encounter significant limitations,including addictive potential and stimulant effects.In this study,we propose an integrated workflow combining virtual screening based on weighted holistic atom localization and entity shape(WHALES)descriptors with in vitro experimental validation to repurpose novel hDAT-targeting drugs.Initially,WHALES descriptors facilitated a similarity search,employing four benztropine-like atypical inhibitors known to bind hDAT's allosteric site as templates.Consequently,from a compound library of 4,921 marketed and clinically tested drugs,we identified 27 candidate atypical inhibitors.Subsequently,ADMETlab was employed to predict the pharmacokinetic and toxicological properties of these candidates,while induced-fit docking(IFD)was performed to estimate their binding affinities.Six compounds were selected for in vitro assessments of neurotransmitter reuptake inhibitory activities.Among these,three exhibited significant inhibitory potency,with half maximal inhibitory concentration(IC_(50))values of 0.753μM,0.542μM,and 1.210μM,respectively.Finally,molecular dynamics(MD)simulations and end-point binding free energy analyses were conducted to elucidate and confirm the inhibitory mechanisms of the repurposed drugs against hDAT in its inward-open conformation.In conclusion,our study not only identifies promising active compounds as potential atypical inhibitors for novel therapeutic drug development targeting hDAT but also validates the effectiveness of our integrated computational and experimental workflow for drug repurposing.
基金financially supported by the Talent Initiation Fund of Wuxi University(550220008).
文摘With the increasing integration of renewable energy,microgrids are increasingly facing stability challenges,primarily due to the lack of inherent inertia in inverter-dominated systems,which is traditionally provided by synchronous generators.To address this critical issue,Virtual Synchronous Generator(VSG)technology has emerged as a highly promising solution by emulating the inertia and damping characteristics of conventional synchronous generators.To enhance the operational efficiency of virtual synchronous generators(VSGs),this study employs smallsignal modeling analysis,root locus methods,and synchronous generator power-angle characteristic analysis to comprehensively evaluate how virtual inertia and damping coefficients affect frequency stability and power output during transient processes.Based on these analyses,an adaptive control strategy is proposed:increasing the virtual inertia when the rotor angular velocity undergoes rapid changes,while strengthening the damping coefficient when the speed deviation exceeds a certain threshold to suppress angular velocity oscillations.To validate the effectiveness of the proposed method,a grid-connected VSG simulation platform was developed inMATLAB/Simulink.Comparative simulations demonstrate that the proposed adaptive control strategy outperforms conventional VSGmethods by significantly reducing grid frequency deviations and shortening active power response time during active power command changes and load disturbances.This approach enhances microgrid stability and dynamic performance,confirming its viability for renewable-dominant power systems.Future work should focus on experimental validation and real-world parameter optimization,while further exploring the strategy’s effectiveness in improvingVSG low-voltage ride-through(LVRT)capability and power-sharing applications in multi-parallel configurations.
基金funded by the Department of Education of Liaoning Province and was supported by the Basic Scientific Research Project of the Department of Education of Liaoning Province(Grant No.LJ222411632051)and(Grant No.LJKQZ2021085)Natural Science Foundation Project of Liaoning Province(Grant No.2022-BS-222).
文摘Virtual power plant(VPP)integrates a variety of distributed renewable energy and energy storage to participate in electricity market transactions,promote the consumption of renewable energy,and improve economic efficiency.In this paper,aiming at the uncertainty of distributed wind power and photovoltaic output,considering the coupling relationship between power,carbon trading,and green cardmarket,the optimal operationmodel and bidding scheme of VPP in spot market,carbon trading market,and green card market are established.On this basis,through the Shapley value and independent risk contribution theory in cooperative game theory,the quantitative analysis of the total income and risk contribution of various distributed resources in the virtual power plant is realized.Moreover,the scheduling strategies of virtual power plants under different risk preferences are systematically compared,and the feasibility and accuracy of the combination of Shapley value and independent risk contribution theory in ensuring fair income distribution and reasonable risk assessment are emphasized.A comprehensive solution for virtual power plants in the multi-market environment is constructed,which integrates operation strategy,income distribution mechanism,and risk control system into a unified analysis framework.Through the simulation of multi-scenario examples,the CPLEXsolver inMATLAB software is used to optimize themodel.The proposed joint optimization scheme can increase the profit of VPP participating in carbon trading and green certificate market by 29%.The total revenue of distributed resources managed by VPP is 9%higher than that of individual participation.
基金Supported by the Key Special Project of“Cutting-Edge Biotechnology”in the National Key Research and Development Program of China(No.2024YFC3406200)Sanming Project of Medicine in Shenzhen(No.SZSM202411007)Shenzhen Science and Technology Program(No.JCYJ20240813152704006).
文摘Conventional surgical teaching techniques face several challenges,highlighting a necessity for ongoing innovation in ophthalmology education to align with the evolving demands of clinical practice.The recent rapid advancement of computer technology has enabled the integration of virtual reality(VR)into medical training,thereby revolutionizing ophthalmic surgical education through VRbased educational methods.VR technology offers a safe,risk-free environment for trainees to practice repeatedly,enhancing surgical skills and accelerating the learning curve without compromising patient safety.This research outlines the application of VR technology in ophthalmic surgical skills training,particularly in cataract and vitreoretinal surgery.Including assessing the effectiveness of intraocular surgery training systems,evaluating skills transfer to the operating room,comparing it with wet lab cataract surgery training,and enhancing non-dominant hand training for cataract surgery,among other aspects.Additionally,this paper will identify the limitations of VR technology in ocular surgical skills training,offer improvement strategies,and detail the advantages and prospects,with the objective of guiding subsequent researchers.
基金supported by the Science and Technology Project of Sichuan Electric Power Company“Power Supply Guarantee Strategy for Urban Distribution Networks Considering Coordination with Virtual Power Plant during Extreme Weather Event”(No.521920230003).
文摘Ensuring reliable power supply in urban distribution networks is a complex and critical task.To address the increased demand during extreme scenarios,this paper proposes an optimal dispatch strategy that considers the coordination with virtual power plants(VPPs).The proposed strategy improves systemflexibility and responsiveness by optimizing the power adjustment of flexible resources.In the proposed strategy,theGaussian Process Regression(GPR)is firstly employed to determine the adjustable range of aggregated power within the VPP,facilitating an assessment of its potential contribution to power supply support.Then,an optimal dispatch model based on a leader-follower game is developed to maximize the benefits of the VPP and flexible resources while guaranteeing the power balance at the same time.To solve the proposed optimal dispatch model efficiently,the constraints of the problem are reformulated and resolved using the Karush-Kuhn-Tucker(KKT)optimality conditions and linear programming duality theorem.The effectiveness of the strategy is illustrated through a detailed case study.
文摘Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.
文摘Distributed virtual coal-mine geography environment（CM-DVGE） researches the virtual reality simulation of coal-mine environment in cyberspace and the performance of coal production process. The goal is to deal with the practical safety problems of observation, analysis, design and training during the underground coal production process. This paper first probed into the evolution of CM-DVGE from a historical point of view, then respectively analyzed the characteristics of its physical progressive levels according to the cognitivd law and its logical structure of data on the basis of data flow, and concluded by putting forward the prospect of the application of CM-DVGE, thus enriched and developed the method of synthetic study of coal mine.
文摘The management of patients with concomitant chronic pain (CP) and Major Depressive Disorder (MDD) remains challenging for clinicians. Current chronic pharmacologic management is often unsuccessful, or has intolerable side effects to the patients. While not restricted to patients with chronic pain, these patients are often diagnosed with depression, presenting with symptoms such as poor mood, anhedonia, and altered cognitive processes. It is estimated that a substantial proportion of treated patients do not derive a substantive benefit from traditional pharmacological treatments for depression. The present study involved a retrospective review of cases, exploring the patient-reported satisfaction with and tolerability of a novel use of virtual reality (VR), coined KVR, as an adjunct to intravenous ketamine infusion therapies. Specifically, the ketamine-virtual reality protocol was employed as a potential adjunctive intervention for patients suffering from chronic pain and depression. Visual Analog Scores (VAS) associated with pain were significantly lower on the third than on the first assessment day. Montgomery-?sberg Depression Rating Scale (MADRS) scores improved following infusion and across days (i.e., sessions). Lastly, 2/3 of patients preferred the use of VR with their ketamine infusion. The results are considered in terms of implementing prospective studies to examine whether the combination therapies have a synergistic benefit and the nature and magnitude of clinically meaningful treatment effects, if any.
基金supported by a project of the National Natural Science Foundation of China:Research on the integration of artificial intelligence and virtual reality technology to promote psychological rehabilitation of breast cancer patients with different personalities(project approval no.82073408).
文摘Objectives:To explore the efficacy and safety of virtual reality(VR)in relieving negative emotions in patients with breast cancer with different personalities.Methods:A randomized controlled trial was conducted.Between April 2023 and October 2023,we enrolled patients with breast cancer treated in the Department of Breast Cancer and Oncology at Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangdong Province.The patients were randomly divided into an intervention group(n=118)and a control group(n=119)using block randomization.The intervention group received the VR intervention 3-5 times over 5±2 weeks using natural landscapes with music or relaxation guidance,and the duration of each VR intervention was 15±3 min.The control group received routine nursing care,including disease education and psychological counseling.Patients were assessed using the Type D Scale,Positive and Negative Affect Scale,and Distress Thermometer,and adverse events during the intervention were recorded.Results:Overall,85 patients completed the study(44 in the intervention group and 41 in the control group).Patients with Type D personalities showed more negative emotions[25.0(21.5,27.5)vs.19.0(16.0,24.0),P=0.001]and distressed attitudes[4.0(2.0,5.0)vs.3.0(1.0,4.0),P=0.020]with fewer positive emotions(27.2±5.6 vs.31.0±5.9,P=0.014)than those with non-Type D personalities.Total population analysis revealed no significant differences between the groups.However,in the subgroup analysis,patients with Type D personalities in the intervention group showed greater relief from negative emotions than those in the control group[median difference,-5.0(-9.0,-2.5)vs.-2.0(-4.0,2.0),P=0.046].No significant differences were found between groups of patients with non-Type D personality traits.The proportion of adverse events was not significantly different between groups(P=0.110).Conclusions:Breast cancer patients with Type D personalities suffer more severe negative emotions and distress,and more attention should be paid to them.VR intervention significantly and safely reduced negative emotions in patients with Type D personalities.
基金supported by theMajor Science and Technology Projects of China Southern Power Grid(Grant number CGYKJXM20210328).
文摘As the penetration rate of distributed energy increases,the transient power angle stability problem of the virtual synchronous generator(VSG)has gradually become prominent.In view of the situation that the grid impedance ratio(R/X)is high and affects the transient power angle stability of VSG,this paper proposes a VSG transient power angle stability control strategy based on the combination of frequency difference feedback and virtual impedance.To improve the transient power angle stability of the VSG,a virtual impedance is adopted in the voltage loop to adjust the impedance ratio R/X;and the PI control feedback of the VSG frequency difference is introduced in the reactive powervoltage link of theVSGto enhance the damping effect.Thesecond-orderVSGdynamic nonlinearmodel considering the reactive power-voltage loop is established and the influence of different proportional integral(PI)control parameters on the system balance stability is analyzed.Moreover,the impact of the impedance ratio R/X on the transient power angle stability is presented using the equal area criterion.In the simulations,during the voltage dips with the reduction of R/X from 1.6 to 0.8,Δδ_(1)is reduced from 0.194 rad to 0.072 rad,Δf_(1)is reduced from 0.170 to 0.093 Hz,which shows better transient power angle stability.Simulation results verify that compared with traditional VSG,the proposedmethod can effectively improve the transient power angle stability of the system.
文摘Background: Dengue is a Neglected tropical disease (NTDs) with high incidence in Brazil. This disease is caused by Dengue virus and is transmitted by Aedes aegypti mosquito. The search for new approaches for controlling of this disease is the subject of numerous studies. The aaNAT is a key enzyme in the metabolism of A. aegypti and is crucial in the sclerotization process, as well as regulation of circadian rhythm and inactivation of neurotransmitters. Computational techniques applied to studies of biological systems become an effective weapon in the mapping and management of 3D data structures, giving direction and guidance of potential ligands that can form stable complexes with targets of interest, using a Molecular Docking approach. The present study was conducted by a virtual screening, followed by docking calculations, in order to find molecules that could inhibit aaNAT. In this study, we used available compounds in SAM database (Bioinformatics and Medicinal Chemistry Laboratory—Southwest Bahia State University, Jequié-Bahia, Brazil), PubChem and ZINC. Results: The result of dockings with selected ligands showed good energy affinities, presenting potential inhibitory interactions with the enzyme active site. Conclusions: The Coa-S-acetyl-tryptamine and 3-indoleacriloil-coenzyme-A showed the same binding energies -8.9 Kcal/Mol and were described as possible inhibitors of aaNAT.
文摘The use of virtual reality to educate preoperative patients has a positive impact on nurses as well as patients undergoing treatment.It can help improve patient satisfaction and improve favorable outcomes by reducing patient anxiety and proving adequate knowledge about the procedure and possible outcomes to the patient.It also reduces burden on nursing staff and counsellors.Larger and more diverse cohort studies will help us understand the wider application of this tool on the patient population.It may be difficult to apply this tool on elderly patients with failing eyesight,multiple physical comorbidities.Also,there may be reduced acceptance of this modality by older nursing staff and practitioners who may prefer the traditional verbal version for counselling.We will benefit from a combined approach of using virtual reality apps with tradition one-on-one counselling to help alleviate patient concerns and improve patient and healthcare professional satisfaction.
文摘This research pioneers the integration of geographic information systems(GIS)and 3D modeling within a virtual reality(VR)framework to assess the viability and planning of a 20 MW hybrid wind-solarphotovoltaic(PV)system connected to the local grid.The study focuses on Dakhla,Morocco,a region with vast untapped renewable energy potential.By leveraging GIS,we are innovatively analyzing geographical and environmental factors that influence optimal site selection and system design.The incorporation of VR technologies offers an unprecedented level of realism and immersion,allowing stakeholders to virtually experience the project's impact and design in a dynamic,interactive environment.This novel methodology includes extensive data collection,advanced modeling,and simulations,ensuring that the hybrid system is precisely tailored to the unique climatic and environmental conditions of Dakhla.Our analysis reveals that the region possesses a photovoltaic solar potential of approximately2400 k Wh/m^(2) per year,with an average annual wind power density of about 434 W/m^(2) at an 80-meter hub height.Productivity simulations indicate that the 20 MW hybrid system could generate approximately 60 GWh of energy per year and 1369 GWh over its 25-year lifespan.To validate these findings,we employed the System Advisor Model(SAM)software and the Global Solar Photovoltaic Atlas platform.This comprehensive and interdisciplinary approach not only provides a robust assessment of the system's feasibility but also offers valuable insights into its potential socio-economic and environmental impact.
基金Supported by Fondazione TIM in the context of the “Facciamola Facile” initiativeby Programma Operativo Nazionale (PON)“Ricerca e Innovazione” 2014-2020-DM 1062/2021 funds
文摘Background Over the last few years,the rapid advancement of technology has led to the development of many approaches to digitalization.In this respect,metaverse provides 3D persistent virtual environments that can be used to access digital content,meet virtually,and perform several professional and leisure tasks.Among the numerous technologies supporting the metaverse,immersive Virtual Reality(VR)plays a primary role and offers highly interactive social experiences.Despite growing interest in this area,there are no clear design guidelines for creating environments tailored to the metaverse.Methods This study seeks to advance research in this area by moving from state-of-the-art studies on the design of immersive virtual environments in the context of metaverse and proposing how to integrate cutting-edge technologies within this context.Specifically,the best practices were identified by i)analyzing literature studies focused on human behavior in immersive virtual environments,ii)extracting common features of existing social VR platforms,and iii)conducting interviews with experts in a specific application domain.Specifically,this study considered the creation of a new virtual environment for MetaLibrary,a VR-based social platform aimed at integrating public libraries into metaverse.Several implementation challenges and additional requirements have been identified for the development of virtual environments(VEs).These elements were considered in the selection of specific cutting-edge technologies and their integration into the development process.A user study was also conducted to investigate some design aspects(namely lighting conditions and richness of the scene layout)for which deriving clear indications from the above analysis was not possible because different alternative configurations could be chosen.Results The work reported in this paper seeks to bridge the gap between existing VR platforms and related literature in the field,on the one hand,and requirements regarding immersive virtual environments for the metaverse,on the other hand,by reporting a set of best practices which were used to build a social virtual environment that meets users'expectations and needs.Conclusions Results suggest that carefully designed virtual environments can positively affect user experience and interaction within metaverse.The insights gained from this study offer valuable cues for developing immersive virtual environments for the metaverse to deliver more effective and engaging experiences.
基金Sponsored by the National Natural Science Foundation of China(Grant No.52005003)the Science and Technology Planning Project of Wuhu City(Grant No.2022jc41)。
文摘To address the challenges of insufficient visualization in the industrial robot assembly operation system and the limitation of visualizing only geometric attributes of physical properties,a method is proposed for constructing an industrial robot assembly system based on virtual reality technology.Focusing on the shaft hole assembly,the mechanical characteristics of the industrial robot shaft hole assembly process are analyzed and a dynamic model is established for shaft hole assembly operations.The key elements of virtual assembly operations for industrial robots are summarized and a five-dimensional model is proposed for industrial robot virtual operations.Utilizing the Unity3D engine based on the 5-D model for industrial robot virtual operations,an industrial robot shaft hole assembly system is developed.This system enables virtual assembly operations,displays physical attributes,and provides valuable references for the research of virtual systems.
基金supported by National Natural Science Foundation of China(No.52067013)Natural Science Foundation of Gansu Province(No.20JR5RA395)Tianyou Innovation Team of Lanzhou Jiaotong University(No.TY202010).
文摘The power-electronics-based DC microgrid system composed of new energy sources in railway field has low inertia,weak damping characteristics,and the voltage fluctuation microgrid systems caused by the power disturbance of solar.In order to improve the inertia of the DC microgrid system,a virtual DC generator technology is adopted in the interface converter of photovoltaic(PV)power generation unit,so that it has the external characteristics of DC generator.However,the influence of PV maximum power point tracking(MPPT)is not considered in the traditional virtual DC generator control.Therefore,an improved control strategy for virtual DC generator is proposed,and its small signal model is established to analyze the influence of inertia and damping coefficient on stability.The results show that the proposed method effectively weakens the impact on DC bus voltage when the output of PV power unit changes suddenly,which improves the stability of the microgrid.Meanwhile,the correctness and feasibility of the method are verified.
文摘The early involvement of test and evaluation can significantly reduce the cost of modifying issues and errors found in the later stages of aircraft development and design process.This paper presents a methodology for aircraft mission effectiveness evaluation and design space exploration based on Virtual Operational Test(VOT),incorporating Virtual Open Scenario(VOS)and User in Scenarios(UIS)concepts.By employing modeling and simulation technologies in the early stages of aircraft development and design,a virtual environment can be constructed,allowing aircraft users to participate more closely and conveniently in the design process.Virtual tests conducted by users within the mission context provide data on mission effectiveness and critical user feedback.This paper outlines the main components of the virtual operational test process and related conceptual methods,and discusses an open support system framework that supports VOT.The effectiveness and adaptability of the method are demonstrated through two case studies:a beyond-visual-range air combat scenario and a helicopter ground attack scenario.These case studies demonstrate the evaluation of aircraft mission effectiveness and the sensitivity analysis and optimization of design and operational parameters based on VOT.
基金supported by the National Natural Science Foundation of China (Grant Nos.12375005,12022513,and12235007)the National Safety Academic Fund(Grant No.U2330401)。
文摘We uncover the virtual monopoles underlying the nontrivial phases of the one-dimensional nonlinear excitations of rogue waves by extending the Dirac magnetic monopole theory to a complex plane. We find that the density zeros of the nonlinear waves on the extended complex plane constitute the virtual monopole fields with a quantized flux of elementary π. We then explain the exotic properties of rogue waves by means of a virtual monopole collision mechanism and find that the maximum amplitude amplification ratio and multiple phase steps of the high-order rogue waves are closely related to the number of their contained monopoles. These results open a new avenue for studying topological properties of nonlinear waves and provide an alternative way to understand their dynamics.
