Comprehensive Summary A general and efficient strategy for the synthesis ofγ-lactams has been reported.The hydroxylamines form Lossen rearrangement products of electron-deficient group migration with base and then un...Comprehensive Summary A general and efficient strategy for the synthesis ofγ-lactams has been reported.The hydroxylamines form Lossen rearrangement products of electron-deficient group migration with base and then undergo[3+2]cycloaddition reaction with vinyl cyclopropane,which could be performed with broad substrate scope,excellent functional group tolerance and high efficiency to produce the desired products.It also allowed further modification to other derivatives of theseγ-lactams.展开更多
基金the National Natural Science Foundation of China(21925108,21901203,21901204)for financial support.
文摘Comprehensive Summary A general and efficient strategy for the synthesis ofγ-lactams has been reported.The hydroxylamines form Lossen rearrangement products of electron-deficient group migration with base and then undergo[3+2]cycloaddition reaction with vinyl cyclopropane,which could be performed with broad substrate scope,excellent functional group tolerance and high efficiency to produce the desired products.It also allowed further modification to other derivatives of theseγ-lactams.
