Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography（OCTA） based on optical microangiography（OMAG） measurements of macular vessels in n...Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography（OCTA） based on optical microangiography（OMAG） measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA（Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.） scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network： vessel area density（VAD）, vessel skeleton density（VSD）, vessel diameter index（VDI）, vessel perimeter index（VPI）, vessel complexity index（VCI）, flux, and foveal avascular zone（FAZ）. Coefficient of variation（CV） and intraclass correlation coefficient（ICC） were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%（intravisit） and ≤ 4.6%（intervisit）] and interobserver reproducibility（ICCs ≥ 0.923） for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes.展开更多
Objective:To evaluate the structural changes of atherosclerotic plaque before and after acupuncture treatment by three-dimensional ultrasound of Vascular Plaque Quantification technology.Methods:Forty subjects were re...Objective:To evaluate the structural changes of atherosclerotic plaque before and after acupuncture treatment by three-dimensional ultrasound of Vascular Plaque Quantification technology.Methods:Forty subjects were recruited and randomly divided into acupuncture group and sham acupuncture group.All patients were treated twice a week for 3 months and were observed the changes of the bilateral carotid plaque volume(PV),gray scale value(GSM)and inner media thickness(IMT).Results:The acupuncture group’s PV decreased after 3 months,while the sham group’s increased slightly.The result were statistically significant(P≤0.05).After treatment,the acupuncture group’s left GSM was higher than before,while the sham group’s was slightly lower than before.The result were statistically significant(P≤0.05).Although the difference of the acupuncture group’s right GSM before and after treatment was not statistically significant,it also had a rising trend.Conclusion:Acupuncture can reduce the volume of carotid atherosclerotic plaque and stabilize the nature of the plaque.展开更多
基金sponsored by the National Natural Science Foundation of China[81570891 and 81272981]Beijing Natural Science Foundation[No.7151003]
文摘Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography（OCTA） based on optical microangiography（OMAG） measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA（Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.） scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network： vessel area density（VAD）, vessel skeleton density（VSD）, vessel diameter index（VDI）, vessel perimeter index（VPI）, vessel complexity index（VCI）, flux, and foveal avascular zone（FAZ）. Coefficient of variation（CV） and intraclass correlation coefficient（ICC） were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%（intravisit） and ≤ 4.6%（intervisit）] and interobserver reproducibility（ICCs ≥ 0.923） for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes.
基金Clinical Study on Quantitative Evaluation of Therapeutic Effect of Acupuncture and Moxibustion Treating Carotid Arteriosclerosis by Ultra-Speed Pulse Wave Imaging(No.20201137)of Acupuncture on Carotid Plaque in Patients with Phlegm-damp Constitutio(No.20191162)。
文摘Objective:To evaluate the structural changes of atherosclerotic plaque before and after acupuncture treatment by three-dimensional ultrasound of Vascular Plaque Quantification technology.Methods:Forty subjects were recruited and randomly divided into acupuncture group and sham acupuncture group.All patients were treated twice a week for 3 months and were observed the changes of the bilateral carotid plaque volume(PV),gray scale value(GSM)and inner media thickness(IMT).Results:The acupuncture group’s PV decreased after 3 months,while the sham group’s increased slightly.The result were statistically significant(P≤0.05).After treatment,the acupuncture group’s left GSM was higher than before,while the sham group’s was slightly lower than before.The result were statistically significant(P≤0.05).Although the difference of the acupuncture group’s right GSM before and after treatment was not statistically significant,it also had a rising trend.Conclusion:Acupuncture can reduce the volume of carotid atherosclerotic plaque and stabilize the nature of the plaque.
