BACKGROUND We have innovatively amalgamated membrane blood purification and centrifugal blood cell separation technologies to address the limitations of current artificial liver support(ALS)models,and develop a versat...BACKGROUND We have innovatively amalgamated membrane blood purification and centrifugal blood cell separation technologies to address the limitations of current artificial liver support(ALS)models,and develop a versatile plasma purification system(VPPS)through centrifugal plasma separation.AIM To investigate the influence of VPPS on long-term rehospitalization and mortality rates among patients with acute-on-chronic liver failure(ACLF).METHODS This real-world,prospective study recruited inpatients diagnosed with ACLF from the Second Xiangya Hospital of Central South University between October 2021 and March 2024.Patients were categorized into the VPPS and non-VPPS groups based on the distinct ALS models administered to them.Self-administered questionnaires,clinical records,and self-reported data served as the primary methods for data collection.The laboratory results were evaluated at six distinct time points.All patients were subjected to follow-up assessments for>12 months.Kaplan-Meier survival analyses and Cox proportional hazards models were used to evaluate the risks of hospitalization and mortality during the follow-up period.RESULTS A cohort of 502 patients diagnosed with ACLF was recruited,with 260 assigned to the VPPS group.On comparing baseline characteristics,the VPPS group exhibited a significantly shorter length of stay,higher incidence of spontaneous peritonitis and pulmonary aspergillosis compared to the non-VPPS group(P<0.05).Agehazard ratio(HR=1.142,95%CI:1.01-1.23,P=0.018),peritonitis(HR=2.825,95%CI:1.07-6.382,P=0.026),albumin(HR=0.67,95%CI:0.46-0.942,P=0.023),total bilirubin(HR=1.26,95%CI:1.01-3.25,P=0.021),international normalized ratio(HR=1.97,95%CI:1.21-2.908,P=0.014),and VPPS/non-VPPS(HR=3.24,95%CI:2.152-4.76,P<0.001)were identified as significant independent predictors of mortality in both univariate and multivariate analyses throughout the follow-up period.Kaplan-Meier survival analyses demonstrated significantly higher rehospitalization and mortality rates in the non-VPPS group compared to the VPPS group during follow-up of≥2 years(log-rank test,P<0.001).CONCLUSION These findings suggest that VPPS is safe and has a positive influence on prognostic outcomes in patients with ACLF.展开更多
With digital coding technology,reconfigurable intelligent surfaces(RISs)become powerful real-time sys-tems for manipulating electromagnetic(EM)waves.However,most automatic RIS designs involve exten-sive numerical simu...With digital coding technology,reconfigurable intelligent surfaces(RISs)become powerful real-time sys-tems for manipulating electromagnetic(EM)waves.However,most automatic RIS designs involve exten-sive numerical simulations of the unit,including the passive pattern and active devices,requiring high data acquisition and training costs.In addition,for passive patterns,the widely employed random pixe-lated method presents design efficiency and effectiveness challenges due to the massive pixel combina-tions and blocked excitation current flow in discrete patterns.To overcome these two critical problems,we propose a versatile RIS design paradigm with efficient topology representation and a separate design architecture.First,a non-uniform rational B-spline(NURBS)is introduced to represent continuous pat-terns and solve excitation current flow issues.This representation makes it possible to finely tune con-tinuous patterns with several control points,greatly reducing the pattern solution space by 20-fold and facilitating RIS optimization.Then,employing multiport network theory to separate the passive pat-tern and active device from the unit,the separate design architecture significantly reduces the dataset acquisition cost by 62.5%.Through multistep multiport calculation,the multistate EM responses of the RIS under different structural combinations can be quickly obtained with only one prediction of pattern response,thereby achieving dataset and model reuse for different RIS designs.With a hybrid continuous-discrete optimization algorithm,three examples—including two typical high-performance RISs and an ultra-wideband multilayer RIS—are provided to validate the superiority of our paradigm.Our work offers an efficient solution for RIS automatic design,and the resulting structure is expected to boost RIS appli-cations in the fields of wireless communication and sensing.展开更多
A quantum teleportation network involving multiple users is essential for future quantum internet.So far,controlled quantum teleportation has been demonstrated in a three-user network.However,versatile and controlled ...A quantum teleportation network involving multiple users is essential for future quantum internet.So far,controlled quantum teleportation has been demonstrated in a three-user network.However,versatile and controlled quantum teleportation network involving more users is in demand,which satisfies different combinations of users for practical requirements.Here we propose a highly versatile and controlled teleportation network that can switch among various combinations of different users.We use a single continuous-variable six-partite Greenberger-Horne-Zeilinger(GHZ)state to realize such a task by choosing the different measurement and feedback operations.The controlled teleportation network,which includes one sub-network,two sub-networks and three sub-networks,can be realized for different application of user combinations.Furthermore,the coherent feedback control(CFC)can manipulate and improve the teleportation performance.Our approach is flexible and scalable,and would provide a versatile platform for demonstrations of complex quantum communication and quantum computing protocols.展开更多
Diversity-oriented synthesis is a powerful and interesting synthetic tool for the rapid construction of structurally complex and privileged scaffolds from readily accessible starting materials.To date,diversity-orient...Diversity-oriented synthesis is a powerful and interesting synthetic tool for the rapid construction of structurally complex and privileged scaffolds from readily accessible starting materials.To date,diversity-oriented synthesis mostly relies on the employment of versatile reagents.Versatile reagents can be regulated as controllable and flexible building blocks for multipurpose utilizations.Over the past decade,a variety of multifunctional reagents have been developed.However,most versatile reagents usually need multi-step synthesis,thus restricting their wide application to a large extent.In terms of the practicalities and universalities,we prefer to pay more attention to the utilization of simple and practical versatile reagents with multiple reactivities,mainly including atropaldehyde acetals,aryl methyl ketones,vinylene carbonate,vinyl azides,aryldiazonium salts,rongalite,halodifluoromethyl compounds.Most importantly,these versatile reagents can also play different roles simultaneously in the same reaction,in which their different reactivities are converged into the final target products.Such strategy can not only offer more possibilities for the synthesis of several active pharmaceutical ingredients,but also minimize the occurrence of some side reactions by lessening the varieties of materials.Also,a perspective is given at the end of this review.展开更多
为了解决多功能视频编码(versatile video coding,VVC)标准下具有相同编码参数的视频双压缩检测方法准确率不高的问题,提出了一种基于编码单元(coding unit,CU)尺寸、划分模式和预测模式的检测方法。对待检测的视频进行多次编解码,分析...为了解决多功能视频编码(versatile video coding,VVC)标准下具有相同编码参数的视频双压缩检测方法准确率不高的问题,提出了一种基于编码单元(coding unit,CU)尺寸、划分模式和预测模式的检测方法。对待检测的视频进行多次编解码,分析并确定VVC流中与压缩编码次数密切相关的基础码流特征;以CU尺寸、划分模式和预测模式构建高级码流特征输入支持向量机完成视频的双压缩检测。实验结果表明,与对比文献的方法相比,所提方法的视频双压缩检测准确率有较大提升,平均准确率达到了95.82%。展开更多
The recombinant suicide plasmid pYYvpr contained a Kan resistant cassette and a 778bp internal piece of the vpr gene. It was transformed into the wild type E.coli strain, MC 1061,which possessed the full-length vpr ge...The recombinant suicide plasmid pYYvpr contained a Kan resistant cassette and a 778bp internal piece of the vpr gene. It was transformed into the wild type E.coli strain, MC 1061,which possessed the full-length vpr gene and did not contain the λ pir gene. The recombinant suicide plasmid could not replicate in MC 1061. Colonies grew on the plates of Kan were analysed by PCR and Southern blot with two different Dig-probes,vpr and Kan R probes. One colony was detected vpr and Kan R gene by PCR and Southern blot showed the mutant had the different vpr map with the wild type. The isogenic knockout mutant, named MC1061 Δvpr,was confirmed.The mutant supported lysogenic infection of VT2 recombinant phage, but did not support lytic infection. All results showed that the vpr gene should be related to the lytic infection of VT2 phage.展开更多
近年来,随着计算机视觉在智能监控、自动驾驶等领域的广泛应用,越来越多视频不仅用于人类观看,还可直接由机器视觉算法进行自动分析。如何高效地面向机器视觉存储和传输此类视频成为新的挑战。然而,现有的视频编码标准,如最新的多功能...近年来,随着计算机视觉在智能监控、自动驾驶等领域的广泛应用,越来越多视频不仅用于人类观看,还可直接由机器视觉算法进行自动分析。如何高效地面向机器视觉存储和传输此类视频成为新的挑战。然而,现有的视频编码标准,如最新的多功能视频编码(Versatile Video Coding,VVC/H.266),主要针对人眼视觉特性进行优化,未能充分考虑压缩对机器视觉任务的性能影响。为解决这一问题,本文以多目标跟踪作为典型的机器视觉视频处理任务,提出一种面向机器视觉的VVC帧内编码算法。首先,使用神经网络可解释性方法,梯度加权类激活映射(Gradient-weighted Class Activation Mapping,GradCAM++),对视频内容进行显著性分析,定位出机器视觉任务所关注的区域,并以显著图的形式表示。随后,为了突出视频画面中的关键边缘轮廓信息,本文引入边缘检测并将其结果与显著性分析结果进行融合,得到最终的机器视觉显著性图。最后,基于融合后的机器视觉显著性图改进VVC模式选择过程,优化VVC中的块划分和帧内预测的模式决策过程。通过引入机器视觉失真,代替原有的信号失真来调整率失真优化公式,使得编码器在压缩过程中尽可能保留对视觉任务更为相关的信息。实验结果表明,与VVC基准相比,所提出方法在保持相同机器视觉检测精度的同时,可节约12.7%的码率。展开更多
基金Supported by Natural Science Foundation of Hunan Province,China,No.2022JJ30842 and No.2024JJ6560Clinical Medical Research Center for Viral Hepatitis of Hunan Province,No.2023SK4009Beijing iGandan Foundation,No.RGGJJ-2021-017 and No.iGandanF-1082022-RGG023.
文摘BACKGROUND We have innovatively amalgamated membrane blood purification and centrifugal blood cell separation technologies to address the limitations of current artificial liver support(ALS)models,and develop a versatile plasma purification system(VPPS)through centrifugal plasma separation.AIM To investigate the influence of VPPS on long-term rehospitalization and mortality rates among patients with acute-on-chronic liver failure(ACLF).METHODS This real-world,prospective study recruited inpatients diagnosed with ACLF from the Second Xiangya Hospital of Central South University between October 2021 and March 2024.Patients were categorized into the VPPS and non-VPPS groups based on the distinct ALS models administered to them.Self-administered questionnaires,clinical records,and self-reported data served as the primary methods for data collection.The laboratory results were evaluated at six distinct time points.All patients were subjected to follow-up assessments for>12 months.Kaplan-Meier survival analyses and Cox proportional hazards models were used to evaluate the risks of hospitalization and mortality during the follow-up period.RESULTS A cohort of 502 patients diagnosed with ACLF was recruited,with 260 assigned to the VPPS group.On comparing baseline characteristics,the VPPS group exhibited a significantly shorter length of stay,higher incidence of spontaneous peritonitis and pulmonary aspergillosis compared to the non-VPPS group(P<0.05).Agehazard ratio(HR=1.142,95%CI:1.01-1.23,P=0.018),peritonitis(HR=2.825,95%CI:1.07-6.382,P=0.026),albumin(HR=0.67,95%CI:0.46-0.942,P=0.023),total bilirubin(HR=1.26,95%CI:1.01-3.25,P=0.021),international normalized ratio(HR=1.97,95%CI:1.21-2.908,P=0.014),and VPPS/non-VPPS(HR=3.24,95%CI:2.152-4.76,P<0.001)were identified as significant independent predictors of mortality in both univariate and multivariate analyses throughout the follow-up period.Kaplan-Meier survival analyses demonstrated significantly higher rehospitalization and mortality rates in the non-VPPS group compared to the VPPS group during follow-up of≥2 years(log-rank test,P<0.001).CONCLUSION These findings suggest that VPPS is safe and has a positive influence on prognostic outcomes in patients with ACLF.
基金supported by the National Key Research and Development Program of China(2023YFB3811502)the National Science Foundation of China(62225108)+5 种基金the Fundamental Research Funds for the Central Universities(2242022k60003)the National Natural Science Foundation of China(62288101 and 62201139)the Jiangsu Province Frontier Leading Technology Basic Research Project(BK20212002)the Jiangsu Provincial Scientific Research Center of Applied Mathematics(BK20233002)the Fundamental Research Funds for the Central Universities(2242024RCB0005 and 2242024K30009)the 111 Project(111-2-05).
文摘With digital coding technology,reconfigurable intelligent surfaces(RISs)become powerful real-time sys-tems for manipulating electromagnetic(EM)waves.However,most automatic RIS designs involve exten-sive numerical simulations of the unit,including the passive pattern and active devices,requiring high data acquisition and training costs.In addition,for passive patterns,the widely employed random pixe-lated method presents design efficiency and effectiveness challenges due to the massive pixel combina-tions and blocked excitation current flow in discrete patterns.To overcome these two critical problems,we propose a versatile RIS design paradigm with efficient topology representation and a separate design architecture.First,a non-uniform rational B-spline(NURBS)is introduced to represent continuous pat-terns and solve excitation current flow issues.This representation makes it possible to finely tune con-tinuous patterns with several control points,greatly reducing the pattern solution space by 20-fold and facilitating RIS optimization.Then,employing multiport network theory to separate the passive pat-tern and active device from the unit,the separate design architecture significantly reduces the dataset acquisition cost by 62.5%.Through multistep multiport calculation,the multistate EM responses of the RIS under different structural combinations can be quickly obtained with only one prediction of pattern response,thereby achieving dataset and model reuse for different RIS designs.With a hybrid continuous-discrete optimization algorithm,three examples—including two typical high-performance RISs and an ultra-wideband multilayer RIS—are provided to validate the superiority of our paradigm.Our work offers an efficient solution for RIS automatic design,and the resulting structure is expected to boost RIS appli-cations in the fields of wireless communication and sensing.
基金Project supported by the Natural Science Foundation of Shanxi Province of China (Grant No. 202203021221214)the National Natural Science Foundation of China (Grant Nos. 62122044, 62135008, 61925503, 11904218, 12004276, 12147215, and 11834010)+4 种基金the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province of China (Grant Nos. 2019L0092 and 2020L0029)the Key Project of the National Key Research and Development Program of China (Grant No. 2022YFA1404500)the Program for the Innovative Talents of Higher Education Institutions of Shanxi Province of Chinathe Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxithe Fund for Shanxi “1331 Project” Key Subjects Construction
文摘A quantum teleportation network involving multiple users is essential for future quantum internet.So far,controlled quantum teleportation has been demonstrated in a three-user network.However,versatile and controlled quantum teleportation network involving more users is in demand,which satisfies different combinations of users for practical requirements.Here we propose a highly versatile and controlled teleportation network that can switch among various combinations of different users.We use a single continuous-variable six-partite Greenberger-Horne-Zeilinger(GHZ)state to realize such a task by choosing the different measurement and feedback operations.The controlled teleportation network,which includes one sub-network,two sub-networks and three sub-networks,can be realized for different application of user combinations.Furthermore,the coherent feedback control(CFC)can manipulate and improve the teleportation performance.Our approach is flexible and scalable,and would provide a versatile platform for demonstrations of complex quantum communication and quantum computing protocols.
基金supported by the National Natural Science Foundation of China(No.22072049)National Key Research and Development Project(No.2022YFE0124100)+2 种基金Major Special Projects of Science and Technology of Ordos(No.2022EEDSKJZDZX003)Program for HUST Academic Frontier Youth Team(No.2019QYTD06)is also acknowledgedChen is also grateful for the financial support from China Scholarship Council(CSC).
文摘Diversity-oriented synthesis is a powerful and interesting synthetic tool for the rapid construction of structurally complex and privileged scaffolds from readily accessible starting materials.To date,diversity-oriented synthesis mostly relies on the employment of versatile reagents.Versatile reagents can be regulated as controllable and flexible building blocks for multipurpose utilizations.Over the past decade,a variety of multifunctional reagents have been developed.However,most versatile reagents usually need multi-step synthesis,thus restricting their wide application to a large extent.In terms of the practicalities and universalities,we prefer to pay more attention to the utilization of simple and practical versatile reagents with multiple reactivities,mainly including atropaldehyde acetals,aryl methyl ketones,vinylene carbonate,vinyl azides,aryldiazonium salts,rongalite,halodifluoromethyl compounds.Most importantly,these versatile reagents can also play different roles simultaneously in the same reaction,in which their different reactivities are converged into the final target products.Such strategy can not only offer more possibilities for the synthesis of several active pharmaceutical ingredients,but also minimize the occurrence of some side reactions by lessening the varieties of materials.Also,a perspective is given at the end of this review.
文摘现有的基于卷积神经网络(convolutional neural network,CNN)的环路滤波器倾向于将多个网络应用于不同的量化参数(quantization parameter,QP),消耗训练模型中的大量资源,并增加内存负担。针对这一问题,提出一种基于CNN的QP自适应环路滤波器。首先,设计一个轻量级分类网络,按照滤波难易程度将编码树单元(coding tree unit,CTU)划分为难、中、易3类;然后,构建3个融合了特征信息增强融合模块的基于CNN的滤波网络,以满足不同QP下的3类CTU滤波需求。将所提出的环路滤波器集成到多功能视频编码(versatile video coding,VVC)标准H.266/VVC的测试软件VTM 6.0中,替换原有的去块效应滤波器(deblocking filter,DBF)、样本自适应偏移(sample adaptive offset,SAO)滤波器和自适应环路滤波器。实验结果表明,该方法平均降低了3.14%的比特率差值(Bjøntegaard delta bit rate,BD-BR),与其他基于CNN的环路滤波器相比,显著提高了压缩效率,并减少了压缩伪影。
文摘为了解决多功能视频编码(versatile video coding,VVC)标准下具有相同编码参数的视频双压缩检测方法准确率不高的问题,提出了一种基于编码单元(coding unit,CU)尺寸、划分模式和预测模式的检测方法。对待检测的视频进行多次编解码,分析并确定VVC流中与压缩编码次数密切相关的基础码流特征;以CU尺寸、划分模式和预测模式构建高级码流特征输入支持向量机完成视频的双压缩检测。实验结果表明,与对比文献的方法相比,所提方法的视频双压缩检测准确率有较大提升,平均准确率达到了95.82%。
文摘The recombinant suicide plasmid pYYvpr contained a Kan resistant cassette and a 778bp internal piece of the vpr gene. It was transformed into the wild type E.coli strain, MC 1061,which possessed the full-length vpr gene and did not contain the λ pir gene. The recombinant suicide plasmid could not replicate in MC 1061. Colonies grew on the plates of Kan were analysed by PCR and Southern blot with two different Dig-probes,vpr and Kan R probes. One colony was detected vpr and Kan R gene by PCR and Southern blot showed the mutant had the different vpr map with the wild type. The isogenic knockout mutant, named MC1061 Δvpr,was confirmed.The mutant supported lysogenic infection of VT2 recombinant phage, but did not support lytic infection. All results showed that the vpr gene should be related to the lytic infection of VT2 phage.
文摘近年来,随着计算机视觉在智能监控、自动驾驶等领域的广泛应用,越来越多视频不仅用于人类观看,还可直接由机器视觉算法进行自动分析。如何高效地面向机器视觉存储和传输此类视频成为新的挑战。然而,现有的视频编码标准,如最新的多功能视频编码(Versatile Video Coding,VVC/H.266),主要针对人眼视觉特性进行优化,未能充分考虑压缩对机器视觉任务的性能影响。为解决这一问题,本文以多目标跟踪作为典型的机器视觉视频处理任务,提出一种面向机器视觉的VVC帧内编码算法。首先,使用神经网络可解释性方法,梯度加权类激活映射(Gradient-weighted Class Activation Mapping,GradCAM++),对视频内容进行显著性分析,定位出机器视觉任务所关注的区域,并以显著图的形式表示。随后,为了突出视频画面中的关键边缘轮廓信息,本文引入边缘检测并将其结果与显著性分析结果进行融合,得到最终的机器视觉显著性图。最后,基于融合后的机器视觉显著性图改进VVC模式选择过程,优化VVC中的块划分和帧内预测的模式决策过程。通过引入机器视觉失真,代替原有的信号失真来调整率失真优化公式,使得编码器在压缩过程中尽可能保留对视觉任务更为相关的信息。实验结果表明,与VVC基准相比,所提出方法在保持相同机器视觉检测精度的同时,可节约12.7%的码率。
