The widespread production and use of plastic products have highlighted the ecological risks of microplastics(MPs).MPs,mainly as microfibers(MFs),can carry various pollutants,and their properties may change over time,p...The widespread production and use of plastic products have highlighted the ecological risks of microplastics(MPs).MPs,mainly as microfibers(MFs),can carry various pollutants,and their properties may change over time,potentially affecting their interactions with pollutants.This study aims to compare the combined toxicity effects of virgin and aged MFs with the common heavy metal copper(Cu).Gibel carp Carassius auratus gibelio were exposed to 1 mg/L of virgin and aged polyacrylonitrile MFs(PanMfs)separately and in combination with Cu(0.5-mg/L copper sulfate)for 21 d.Results show that both aged and virgin PanMfs significantly reduced Cu accumulation in gibel carp,with no notable difference.Cu adversely affected the carp's intestine and liver,while PanMfs alone had minimal histological impact but notably mitigated intestinal damage caused by Cu.Enzyme activity and gene expression analysis indicated that both PanMfs and Cu exposure,alone or combined,compromised gibel carp's antioxidant capacity,digestive and liver functions,induced inflammation,and affected liver metabolism and intestinal immune response.Integrated biomarker response analysis of enzyme activity and gene expression showed that combined Cu and PanMfs exposure had a stronger impact on gibel carp than individual exposure.However,whether exposed individually or in combination,aged PanMfs had a slightly greater impact than virgin PanMfs.This study showed that PanMfs alone exhibit minimal toxic effects on gibel carp but significantly modify Cu toxicity,with negligible differences between aged and virgin PanMfs except for slight disparities in enzyme activity and gene expression.展开更多
Bionanocomposite film is produced from renewable and biodegradable natural resources.Although elephant foot yam(EFY)starch(Amorphophallus paeoniifolius)is a promising polymer for bionanocomposite film,the native hydro...Bionanocomposite film is produced from renewable and biodegradable natural resources.Although elephant foot yam(EFY)starch(Amorphophallus paeoniifolius)is a promising polymer for bionanocomposite film,the native hydrophilic properties influence the overall performance characteristics.Incorporating virgin coconut oil(VCO)and monoglyceride as hydrophobic components can improve mechanical properties and reduce permeability while increasing the hydrophobicity of the composite.Therefore,this study aimed to determine the effect of adding VCO and monoglyceride on EFY starch-nanocrystalline film at 3 and 5 wt%concentrations.Experimental tests were conducted to evaluate the physical and mechanical properties,water vapor transmission rate(WVTR),morphology,functional groups,biodegradability,and hydrophobicity.The results showed that the addition of 5 wt%monoglyceride produced optimum outcomes by reducing the WVTR to 3.99 g.m^(−2).h^(−1),increasing the thickness to 0.134 mm and decreasing the solubility to 36.04%.The Universal Testing Machine(UTM)tests showed an elongation of 74.59%,showing excellent elasticity.The Scanning Electron Microscope(SEM)test showed the bonds formed with starch granules,leading to a flatter surface.The Fourier Transform Infrared Spectroscopy(FTIR)test also showed an increase in the wavelength of the C=O groups and a decrease in the O-H groups.The contact angle test processed using image-J showed high hydrophobicity,consequently reducing the biodegradability of bionanocomposite film by the Aspergillus niger fungal degradation test.In conclusion,this study successfully developed bionanocomposite film with enhanced hydrophobicity,elasticity,and barrier properties,highly suitable for protecting food from humid air.The composite holds great potential for further development as an environmentally friendly packaging solution.展开更多
Metabolic dysfunction-associated steatotic liver disease is a multifaceted disease associated with obesity,insulin resistance(IR),type 2 diabetes mellitus-in a word,metabolic syndrome-which has been extensively studie...Metabolic dysfunction-associated steatotic liver disease is a multifaceted disease associated with obesity,insulin resistance(IR),type 2 diabetes mellitus-in a word,metabolic syndrome-which has been extensively studied because it is related to an alteration of the normal metabolism of glucose and lipids,ultimately leading to triglyceride accumulation within hepatocytes.This lipid overload triggers an inflammatory status,also influenced by gut-liver axis dysfunction,with gut dysbiosis,which alters intestinal permeability,causing inflammation and IR in a vicious circle.Several approaches have been attempted to treat this condition and stop its poss-ible evolution towards increasingly serious stages,but the first step is always lifestyle modification.The Mediterranean diet seems to be the most reliable for affecting liver steatosis,probably thanks to extra virgin olive oil,a healthy food with a high content of monounsaturated fatty acids and variable concentrations of phenols(oleocanthal)and phenolic alcohols,such as hydroxytyrosol and tyrosol.This review investigates the mechanisms underlying the bidirectional and synergistic relationships among metabolic dysfunction-associated steatotic liver disease,IR,and the gut-liver axis,specifically focusing on the role of extra virgin olive oil as one of the main antioxidant components of the Mediterranean diet.展开更多
Current mix design practices typically assume total blending and use the white curve of reclaimed asphalt pavement(RAP)to determine the gradation and optimum asphalt content(OAC)of recycled hot mix asphalt(HMA),often ...Current mix design practices typically assume total blending and use the white curve of reclaimed asphalt pavement(RAP)to determine the gradation and optimum asphalt content(OAC)of recycled hot mix asphalt(HMA),often overlooking the effects of RAP agglomeration and partial blending.This oversight can result in unsatisfactory performance,particularly when higher RAP content is used.Therefore,this paper reviews and discusses strategies for adjusting the mix design of recycled HMA to enhance its in-service performance.The discussion begins with RAP particle agglomeration,a significant phenomenon that significantly impacts the aggregate gradation of recycled HMA.Subsequently,detection methods to clarify the blending between virgin and RAP binders are described.Partial blending between RAP and virgin binders is common,and various indexes have been proposed to quantify the blending degree.Finally,the adjusted mix design method of recycled HMA is presented,emphasizing gradation optimization and corrected OAC.Gradation optimization should account for RAP agglomeration,while the corrected OAC should consider particle blending.Recycled HMA using the adjusted mix design exhibits improved crack resistance and fatigue life without substantially impairing rutting performance.This review aims to help both academics and highway agencies maximize the utilization of RAP materials within sustainable pavement frameworks.展开更多
采用ADCh ips公司的32位多媒体芯片V irg ine G 2与具有I2C总线接口的M 62334 DAC的连接,实现了轿车视音汉字显示操作控制系统的AD键方式键盘控制和自定义数字键盘控制;文章介绍了V irg ine G 2与I2C总线控制的自定义接口与通信协议,论...采用ADCh ips公司的32位多媒体芯片V irg ine G 2与具有I2C总线接口的M 62334 DAC的连接,实现了轿车视音汉字显示操作控制系统的AD键方式键盘控制和自定义数字键盘控制;文章介绍了V irg ine G 2与I2C总线控制的自定义接口与通信协议,论述了系统功能特点,给出了硬件电路原理图和软件设计框图;用该电路对西门子CD 723汽车音响控制器、车载电视及DVD等设备进行控制,功能强,效果好。展开更多
Background: Hysterosalpingogram (HSG) and Laparoscopy and dye tests for tubal assessment for a virgin who places high premium on her virginity could be challenging. Routine HSG may result in loss or damage to the hyme...Background: Hysterosalpingogram (HSG) and Laparoscopy and dye tests for tubal assessment for a virgin who places high premium on her virginity could be challenging. Routine HSG may result in loss or damage to the hymen and loss of virginity. Aim: The aim of the procedure of retrograde dye test was explored to see the possibility of assessing tubal patency during laparotomy. Case Presentation: At laparotomy and after myomectomy in a 32 year old virgin, a moderate sized Wilkinson’s cannula was gently inserted at the fimbrial end of the both tubes and 50mls of dilute Methylene-Blue solution was injected in each tube at a time to see whether the dye will appear at the vagina introitus. There was no resistance to flow of the dye in both tubes. Inspection of the vaginal introitus revealed a gush of dye flowing through it as the dye was introduced through each tube confirming the patency of both tubes. Conclusion: Retrograde dye test at the time of abdominal procedures like myomectomy, pelvic adhesiolysis and excision of endometriotic cyst can be cost effective. This procedure is also useful in assessing tubal patency for women who undergo laparotomy and also wish to preserve their virginity.展开更多
Thomas Middleton and William Rowley’s The Changeling enacts an astonishment on the stage to the audience about the protagonist Beatrice-Joanna’s down fall-the noble lady being straightly encroached by her desire and...Thomas Middleton and William Rowley’s The Changeling enacts an astonishment on the stage to the audience about the protagonist Beatrice-Joanna’s down fall-the noble lady being straightly encroached by her desire and being manipulated by the obscene servant De Flores, who, by means of rape, controls her body and finally destroys her. My article attempts to explore male’s expectations and their power over female’s sexuality with Jacques Lacan’s psychoanalytical approach. Moreover, it will elaborate that Beatrice-Joanna’s tragic outcome is not only contributed by her murder and moral degradations, but also, before her transgression being committed, her body has already been regulated by the patriarchal power in the Renaissance society-either she is valuable in the marriage market with her chastity or she is condemned by losing it. Also, the science of medicine employed to test virginity represents the male’s methodological hegemony and anxiety in facing the unknown of a female’s chastity. For the fantasy always regulating the male’s power structure over female’s body, the real manipulation over female sexuality is doomed to be an illusion.展开更多
Data centers are recognized as one of the most important aspects of the fourth industrial revolution since conventional data centers are inefficient and have dependency on high energy consumption,in which the cooling ...Data centers are recognized as one of the most important aspects of the fourth industrial revolution since conventional data centers are inefficient and have dependency on high energy consumption,in which the cooling is responsible for 40%of the usage.Therefore,this research proposes the immersion cooling method to solving the high energy consumption of data centers by cooling its component using two types of dielectric fluids.Four stages of experimentalmethods are used,such as fluid types,cooling effectiveness,optimization,and durability.Furthermore,benchmark software is used to measure the CPU maximum work with the temperature data performed for 24 h.The results of this study show that the immersion cooling reduces 13℃ lower temperature than the conventional cooling method which means it saves more energy consumption in the data center.The most optimum variable used to decrease the temperature is 1.5 lpm of flow rate and 800 rpm of fan rotation.Furthermore,the cooling performance of the dielectric fluids shows that the mineral oil(MO)is better than the virgin coconut oil(VCO).In durability experiment,there are no components damage after five months immersed in the fluid.展开更多
A record number of non-astronauts flew into space in 2021,including a 90-year-old actor,a physician’s assistant,a football player turned TV host,a Dutch teenager,and four billionaires.The companies that sent most of ...A record number of non-astronauts flew into space in 2021,including a 90-year-old actor,a physician’s assistant,a football player turned TV host,a Dutch teenager,and four billionaires.The companies that sent most of these civilians aloft-Virgin Galactic,Blue Origin,and SpaceX-hope the flights will inaugurate a boom in space tourism.Blue Origin,started by Amazon founder Jeff Bezos,claims it has sold nearly 100 million USD of tickets for upcoming trips[1],while 700 people have paid up to 450000USD apiece for places on future flights by Virgin Galactic,launched by British billionaire Richard Branson[2].展开更多
Oxidative stress has been discovered to be involved in the progression of diabetes mellitus. The antioxidant properties of virgin coconut oil (VCO) among other functions might have a beneficial effect in ameliorating ...Oxidative stress has been discovered to be involved in the progression of diabetes mellitus. The antioxidant properties of virgin coconut oil (VCO) among other functions might have a beneficial effect in ameliorating the disease. This study was aimed to determine the glycemic and antioxidant effects of VCO in alloxan induced diabetic rats. 24 male Sprague-Dawley rats were divided into 4 groups as follows: control (C), diabetes untreated (DUT), diabetes treated with 7.5 ml/kg VCO (DT7.5) and diabetes treated with 10 ml/kg VCO (DT10). Alloxan (100 mg/kg b.w I.P) was used to induce diabetes and VCO was administered orally once daily for 4 weeks. Fasting blood glucose level was measured on Day 0 (72 hours post alloxan injection) and after 4 weeks. Glucose tolerance test was conducted on the 4th week as well as the determination of serum insulin and liver antioxidant parameters using standard biochemical methods. Values are means ± S.E.M., compared by ANOVA and Tukey’s post hoc test. The results show that VCO significantly reduced the fasting blood glucose level in DT7.5 rats (132.4 ± 6.911) and DT10 rats (131.6 ± 12.2) are compared with DUT rats (320.4 ± 22.99) and improved the oral glucose tolerance. Serum insulin was increased in DT10 rats. GSH activities significantly increased p 10 rats (0.39 ± 0.022) when compared to DUT rats (0.032 ± 0.004). CAT activities also significantly increased p 7.5 (17.63 ± 0.61) and DT10 rats (30.88 ± 0.97) when compared to DUT rats (10.98 ± 0.6). SOD activities significantly increased p 0.05 in DT7.5 (2.634 ± 0.04) and DT10 rats (2.258 ± 0.32) when compared to DUT rats (1.366 ± 0.05) while MDA significantly reduced p 7.5 (49.16 ± 0.51) and DT10 (33.64 ± 0.42) rats when compared to DUT rats (99.93 ± 4.79). This study revealed that VCO has a hypoglycemic action, enhances insulin secretion and also ameliorates oxidative stress induced in type I (alloxan-induced diabetic) male rats.展开更多
The Mediterranean diet has long been recognized as one of the most effective ways to prevent and improve cardiovascular disease.Extra virgin olive oil(EVOO)is the typical sources of fat in the Mediterranean diet which...The Mediterranean diet has long been recognized as one of the most effective ways to prevent and improve cardiovascular disease.Extra virgin olive oil(EVOO)is the typical sources of fat in the Mediterranean diet which have been shown to have noteworthy nutritional value and positive impact on human health.It is worth noting that EVOO owes its superior nutritional value to its bioactive composition.The main component of EVOO is monounsaturated fatty acids(MUFAs)in the form of oleic acid.Oleic acid accounts for up to 70%-80%of EVOO.Secondly,EVOO contains approximately more than 30 phenolic compounds,of which HT is essential for the protection against cardiovascular diseases.In this review,we focused on the potential mechanisms of oleic acid and polyphenols combat cardiovascular diseases risk in terms of oxidative stress,inflammation,blood pressure,endothelial function and cholesterol.This review might provide a reference for the studies on cardiovascular protective effects of EVOO.展开更多
In some worldwide hard coal basins recovery of methane from virgin coal beds is difficult. In general,mentioned difficulties are related to geo-mechanical, petrographical and physical-chemical properties of coals in q...In some worldwide hard coal basins recovery of methane from virgin coal beds is difficult. In general,mentioned difficulties are related to geo-mechanical, petrographical and physical-chemical properties of coals in question, occurring for example in the Bowen Basin(Australia) or the Upper Silesian Coal Basin(Poland). Among numerous properties and parameters, the following are very essential: susceptibility of coal beds to deformation connected with coal stress state change and contemporary shrinkage of the coal matrix during methane desorption. Those adverse geo-mechanical and physical-chemical effects are accompanied by essential change of the porous coal structure, which under these disadvantageous conditions is very complex. This study aims to show difficulties, which occur in phase of recognition of the methane-reach coal deposit. Volume absorbed methane(not surface adsorbed) in sub-micropores having minimal size comparable with gas molecule diameter must possess energy allowing separation of the nodes and methane release to micropores.展开更多
Virgin Coconut Meal (VCM) was used for the development of instant wheat sooji (semolina) halwa mix with better nutritional attributes. Central composite rotatable design (CCRD) with 2 independent variables (sugar and ...Virgin Coconut Meal (VCM) was used for the development of instant wheat sooji (semolina) halwa mix with better nutritional attributes. Central composite rotatable design (CCRD) with 2 independent variables (sugar and VCM) and 4 responses (lightness, redness, taste and overall acceptability) was used for the optimisation. VCM incorporated instant halwa mix prepared using optimised levels of ingredients contained moisture 0.95%;fat 26.2%;protein 7.65%;total ash 0.86%;fibre 1.02% and received overall acceptability score of 8.5 on a 9 point hedonic scale providing 523.86 K·cal/ 100g. The changes in quality of stored VCM incorporated instant halwa mix packed in polypropylene (PP, 75 μ) and laminates of metallised polyester (MP, 90 μ) were monitored in order to assess the shelf-life. Instant halwa mix remained stable and acceptable for one year in both the packaging materials under ambient temperature conditions (15℃ - 34℃). However, the rate of lipid peroxidation was found to be slightly higher in PP packed samples as compared to MP packed ones. Fatty acid composition of VCM incorporated instant halwa mix remained practically unchanged during storage. Oleic acid was the major fatty acid present in fat extracted from halwa mix followed by palmitic and lauric acids.展开更多
Sensory evaluation of olive oil, meaning the official organoleptic assessment of olive oil respectively the ＂Panel Test＂ （PT）, is based on the standards of the International Olive Council （IOC）, as well as on th...Sensory evaluation of olive oil, meaning the official organoleptic assessment of olive oil respectively the ＂Panel Test＂ （PT）, is based on the standards of the International Olive Council （IOC）, as well as on the Regulation （EC） 640/2008 of the European Commission. These regulations lead to the classification of olive oil as ＂extra virgin＂ （EVOO）, ＂virgin＂ （VOO） or ＂lampant＂, which however is not sufficient to clearly discriminate between different quality levels within the grade EVOO. The objective of the study at hand was to develop and validate an objective sensory evaluation method for the quality certification of olive oil within the grade EVOO. A new rating system, including a detailed description and evaluation of the complexity and persistence of flavour, was established. First, a comparison between different profile sheets from various olive oil competitions （Ercole Olivario, Premio Biol, Leone D＇Oro Mario Solinas Award, among others） and the official profile sheet from the IOC/EC for the panel test （PT） took place. In consecutive steps the basic test procedure from the panel test （PT） then was extended with additional sensory descriptors. Two trained olive oil panels （the German Olive Oil Panel （DOP） and the Swiss Olive Oil Panel （SOP）） were further educated to profile various green and ripe aroma components and to evaluate the complexity of the perceived aroma components and their persistency （descriptor： ＂harmony/persistency＂）. This extended methodology was cross-validated over a time period of 3 years between the two panels （DOP/SOP）.展开更多
The adulteration concentration of palm kernel oil(PKO)in virgin coconut oil(VCO)was quantified using near-infrared(NIR)hyperspectral imaging.Nowadays,some VCO is adulterated with lower-priced PKO to reduce production ...The adulteration concentration of palm kernel oil(PKO)in virgin coconut oil(VCO)was quantified using near-infrared(NIR)hyperspectral imaging.Nowadays,some VCO is adulterated with lower-priced PKO to reduce production costs,which diminishes the quality of the VCO.This study used NIR hyperspectral imaging in the wavelength region 900-1,650 nm to create a quantitative model for the detection of PKO contaminants(0-100%)in VCO and to develop predictive mapping.The prediction equation for the adulteration of VCO with PKO was constructed using the partial least squares regression method.The best predictive model was pre-processed using the standard normal variate method,and the coefficient of determination of prediction was 0.991,the root mean square error of prediction was 2.93%,and the residual prediction deviation was 10.37.The results showed that this model could be applied for quantifying the adulteration concentration of PKO in VCO.The prediction adulteration concentration mapping of VCO with PKO was created from a calibration model that showed the color level according to the adulteration concentration in the range of 0-100%.NIR hyperspectral imaging could be clearly used to quantify the adulteration of VCO with a color level map that provides a quick,accurate,and non-destructive detection method.展开更多
Virgin coconut meal (VCM) was used for the development of ready-to-eat Indian traditional sweet meat commonly known as “ladoo” both with and without sorbic acid (0.3%). The different ingredients were optimized follo...Virgin coconut meal (VCM) was used for the development of ready-to-eat Indian traditional sweet meat commonly known as “ladoo” both with and without sorbic acid (0.3%). The different ingredients were optimized following re-sponse surface methodology with three independent variables i.e. sugar, water and VCM and sensory attributes as responses. The changes in the quality of VCM ladoo packed in polypropylene (PP, 75 μ) and laminates of metalized polyester (MP, 75 μ) were monitored during storage to establish the shelf life under ambient temperature conditions (15?C - 34?C). Samples without added potassium sorbate spoiled within three weeks of storage due to mold growth and fermented odour. VCM ladoo containing sorbic acid did not support any microbial growth during storage up to 4 months, however, during storage samples packed in PP lost moisture and became hard and brittle, while those packed in MP remained soft. Peroxide and thiobarbituric acid values were higher in PP packed samples as compared to those packed in MP. Sorbic acid degraded during storage of ladoo and the rate of degradation was higher in PP packed ladoos than that in MP packed ones.展开更多
Biscuits were prepared by incorporating virgin coconut meal (VCM) into refined wheat flour (maida) at 5-25% level and evaluated for physical, chemical, nutritional, textural and sensory attributes. All the prepared bi...Biscuits were prepared by incorporating virgin coconut meal (VCM) into refined wheat flour (maida) at 5-25% level and evaluated for physical, chemical, nutritional, textural and sensory attributes. All the prepared biscuits had high protein and fiber contents as compared to control (100% refined wheat flour based product). With the incorporation of VCM, hardness and toughness of dough increased while there was a decrease in stickiness and adhesiveness values. Incorporation of VCM had a significant effect on color values of biscuits as the concentration of VCM was increased. The values of L* decreased while those for a* and b* increased. Sensory analysis revealed that 15% VCM biscuits were the most acceptable. The Differential scanning calorimetry (DSC) analysis revealed that the onset (To) decreased while end set (Tc) and enthalpy of gelatinization (ΔH) increased with the increase level of VCM.展开更多
基金Supported by the High-level Talent Program of Yangzhou University to Yingying ZHANG。
文摘The widespread production and use of plastic products have highlighted the ecological risks of microplastics(MPs).MPs,mainly as microfibers(MFs),can carry various pollutants,and their properties may change over time,potentially affecting their interactions with pollutants.This study aims to compare the combined toxicity effects of virgin and aged MFs with the common heavy metal copper(Cu).Gibel carp Carassius auratus gibelio were exposed to 1 mg/L of virgin and aged polyacrylonitrile MFs(PanMfs)separately and in combination with Cu(0.5-mg/L copper sulfate)for 21 d.Results show that both aged and virgin PanMfs significantly reduced Cu accumulation in gibel carp,with no notable difference.Cu adversely affected the carp's intestine and liver,while PanMfs alone had minimal histological impact but notably mitigated intestinal damage caused by Cu.Enzyme activity and gene expression analysis indicated that both PanMfs and Cu exposure,alone or combined,compromised gibel carp's antioxidant capacity,digestive and liver functions,induced inflammation,and affected liver metabolism and intestinal immune response.Integrated biomarker response analysis of enzyme activity and gene expression showed that combined Cu and PanMfs exposure had a stronger impact on gibel carp than individual exposure.However,whether exposed individually or in combination,aged PanMfs had a slightly greater impact than virgin PanMfs.This study showed that PanMfs alone exhibit minimal toxic effects on gibel carp but significantly modify Cu toxicity,with negligible differences between aged and virgin PanMfs except for slight disparities in enzyme activity and gene expression.
基金funded by an Internal Research Grant of Universitas Padjadjaran,Bandung,Indonesia.
文摘Bionanocomposite film is produced from renewable and biodegradable natural resources.Although elephant foot yam(EFY)starch(Amorphophallus paeoniifolius)is a promising polymer for bionanocomposite film,the native hydrophilic properties influence the overall performance characteristics.Incorporating virgin coconut oil(VCO)and monoglyceride as hydrophobic components can improve mechanical properties and reduce permeability while increasing the hydrophobicity of the composite.Therefore,this study aimed to determine the effect of adding VCO and monoglyceride on EFY starch-nanocrystalline film at 3 and 5 wt%concentrations.Experimental tests were conducted to evaluate the physical and mechanical properties,water vapor transmission rate(WVTR),morphology,functional groups,biodegradability,and hydrophobicity.The results showed that the addition of 5 wt%monoglyceride produced optimum outcomes by reducing the WVTR to 3.99 g.m^(−2).h^(−1),increasing the thickness to 0.134 mm and decreasing the solubility to 36.04%.The Universal Testing Machine(UTM)tests showed an elongation of 74.59%,showing excellent elasticity.The Scanning Electron Microscope(SEM)test showed the bonds formed with starch granules,leading to a flatter surface.The Fourier Transform Infrared Spectroscopy(FTIR)test also showed an increase in the wavelength of the C=O groups and a decrease in the O-H groups.The contact angle test processed using image-J showed high hydrophobicity,consequently reducing the biodegradability of bionanocomposite film by the Aspergillus niger fungal degradation test.In conclusion,this study successfully developed bionanocomposite film with enhanced hydrophobicity,elasticity,and barrier properties,highly suitable for protecting food from humid air.The composite holds great potential for further development as an environmentally friendly packaging solution.
文摘Metabolic dysfunction-associated steatotic liver disease is a multifaceted disease associated with obesity,insulin resistance(IR),type 2 diabetes mellitus-in a word,metabolic syndrome-which has been extensively studied because it is related to an alteration of the normal metabolism of glucose and lipids,ultimately leading to triglyceride accumulation within hepatocytes.This lipid overload triggers an inflammatory status,also influenced by gut-liver axis dysfunction,with gut dysbiosis,which alters intestinal permeability,causing inflammation and IR in a vicious circle.Several approaches have been attempted to treat this condition and stop its poss-ible evolution towards increasingly serious stages,but the first step is always lifestyle modification.The Mediterranean diet seems to be the most reliable for affecting liver steatosis,probably thanks to extra virgin olive oil,a healthy food with a high content of monounsaturated fatty acids and variable concentrations of phenols(oleocanthal)and phenolic alcohols,such as hydroxytyrosol and tyrosol.This review investigates the mechanisms underlying the bidirectional and synergistic relationships among metabolic dysfunction-associated steatotic liver disease,IR,and the gut-liver axis,specifically focusing on the role of extra virgin olive oil as one of the main antioxidant components of the Mediterranean diet.
基金sponsored by the National Natural Science Foundation of China(52178420,52408476)Special subsidy from Heilongjiang Provincial People's Government(HITTY-20190028)+1 种基金Postdoctoral Fellowship Program of CPSF(GZC20242207)the Fundamental Research Funds for the Central Universities(HIT.DZJJ.2023086).
文摘Current mix design practices typically assume total blending and use the white curve of reclaimed asphalt pavement(RAP)to determine the gradation and optimum asphalt content(OAC)of recycled hot mix asphalt(HMA),often overlooking the effects of RAP agglomeration and partial blending.This oversight can result in unsatisfactory performance,particularly when higher RAP content is used.Therefore,this paper reviews and discusses strategies for adjusting the mix design of recycled HMA to enhance its in-service performance.The discussion begins with RAP particle agglomeration,a significant phenomenon that significantly impacts the aggregate gradation of recycled HMA.Subsequently,detection methods to clarify the blending between virgin and RAP binders are described.Partial blending between RAP and virgin binders is common,and various indexes have been proposed to quantify the blending degree.Finally,the adjusted mix design method of recycled HMA is presented,emphasizing gradation optimization and corrected OAC.Gradation optimization should account for RAP agglomeration,while the corrected OAC should consider particle blending.Recycled HMA using the adjusted mix design exhibits improved crack resistance and fatigue life without substantially impairing rutting performance.This review aims to help both academics and highway agencies maximize the utilization of RAP materials within sustainable pavement frameworks.
文摘采用ADCh ips公司的32位多媒体芯片V irg ine G 2与具有I2C总线接口的M 62334 DAC的连接,实现了轿车视音汉字显示操作控制系统的AD键方式键盘控制和自定义数字键盘控制;文章介绍了V irg ine G 2与I2C总线控制的自定义接口与通信协议,论述了系统功能特点,给出了硬件电路原理图和软件设计框图;用该电路对西门子CD 723汽车音响控制器、车载电视及DVD等设备进行控制,功能强,效果好。
文摘Background: Hysterosalpingogram (HSG) and Laparoscopy and dye tests for tubal assessment for a virgin who places high premium on her virginity could be challenging. Routine HSG may result in loss or damage to the hymen and loss of virginity. Aim: The aim of the procedure of retrograde dye test was explored to see the possibility of assessing tubal patency during laparotomy. Case Presentation: At laparotomy and after myomectomy in a 32 year old virgin, a moderate sized Wilkinson’s cannula was gently inserted at the fimbrial end of the both tubes and 50mls of dilute Methylene-Blue solution was injected in each tube at a time to see whether the dye will appear at the vagina introitus. There was no resistance to flow of the dye in both tubes. Inspection of the vaginal introitus revealed a gush of dye flowing through it as the dye was introduced through each tube confirming the patency of both tubes. Conclusion: Retrograde dye test at the time of abdominal procedures like myomectomy, pelvic adhesiolysis and excision of endometriotic cyst can be cost effective. This procedure is also useful in assessing tubal patency for women who undergo laparotomy and also wish to preserve their virginity.
文摘Thomas Middleton and William Rowley’s The Changeling enacts an astonishment on the stage to the audience about the protagonist Beatrice-Joanna’s down fall-the noble lady being straightly encroached by her desire and being manipulated by the obscene servant De Flores, who, by means of rape, controls her body and finally destroys her. My article attempts to explore male’s expectations and their power over female’s sexuality with Jacques Lacan’s psychoanalytical approach. Moreover, it will elaborate that Beatrice-Joanna’s tragic outcome is not only contributed by her murder and moral degradations, but also, before her transgression being committed, her body has already been regulated by the patriarchal power in the Renaissance society-either she is valuable in the marriage market with her chastity or she is condemned by losing it. Also, the science of medicine employed to test virginity represents the male’s methodological hegemony and anxiety in facing the unknown of a female’s chastity. For the fantasy always regulating the male’s power structure over female’s body, the real manipulation over female sexuality is doomed to be an illusion.
基金This work is financially supported by the Ministry of Research and Technology of Indonesia(BRIN)in the project called“Penggunaan Immersion Cooling untukMeningkatkan Efisiensi Energi Data Center”.
文摘Data centers are recognized as one of the most important aspects of the fourth industrial revolution since conventional data centers are inefficient and have dependency on high energy consumption,in which the cooling is responsible for 40%of the usage.Therefore,this research proposes the immersion cooling method to solving the high energy consumption of data centers by cooling its component using two types of dielectric fluids.Four stages of experimentalmethods are used,such as fluid types,cooling effectiveness,optimization,and durability.Furthermore,benchmark software is used to measure the CPU maximum work with the temperature data performed for 24 h.The results of this study show that the immersion cooling reduces 13℃ lower temperature than the conventional cooling method which means it saves more energy consumption in the data center.The most optimum variable used to decrease the temperature is 1.5 lpm of flow rate and 800 rpm of fan rotation.Furthermore,the cooling performance of the dielectric fluids shows that the mineral oil(MO)is better than the virgin coconut oil(VCO).In durability experiment,there are no components damage after five months immersed in the fluid.
文摘A record number of non-astronauts flew into space in 2021,including a 90-year-old actor,a physician’s assistant,a football player turned TV host,a Dutch teenager,and four billionaires.The companies that sent most of these civilians aloft-Virgin Galactic,Blue Origin,and SpaceX-hope the flights will inaugurate a boom in space tourism.Blue Origin,started by Amazon founder Jeff Bezos,claims it has sold nearly 100 million USD of tickets for upcoming trips[1],while 700 people have paid up to 450000USD apiece for places on future flights by Virgin Galactic,launched by British billionaire Richard Branson[2].
文摘Oxidative stress has been discovered to be involved in the progression of diabetes mellitus. The antioxidant properties of virgin coconut oil (VCO) among other functions might have a beneficial effect in ameliorating the disease. This study was aimed to determine the glycemic and antioxidant effects of VCO in alloxan induced diabetic rats. 24 male Sprague-Dawley rats were divided into 4 groups as follows: control (C), diabetes untreated (DUT), diabetes treated with 7.5 ml/kg VCO (DT7.5) and diabetes treated with 10 ml/kg VCO (DT10). Alloxan (100 mg/kg b.w I.P) was used to induce diabetes and VCO was administered orally once daily for 4 weeks. Fasting blood glucose level was measured on Day 0 (72 hours post alloxan injection) and after 4 weeks. Glucose tolerance test was conducted on the 4th week as well as the determination of serum insulin and liver antioxidant parameters using standard biochemical methods. Values are means ± S.E.M., compared by ANOVA and Tukey’s post hoc test. The results show that VCO significantly reduced the fasting blood glucose level in DT7.5 rats (132.4 ± 6.911) and DT10 rats (131.6 ± 12.2) are compared with DUT rats (320.4 ± 22.99) and improved the oral glucose tolerance. Serum insulin was increased in DT10 rats. GSH activities significantly increased p 10 rats (0.39 ± 0.022) when compared to DUT rats (0.032 ± 0.004). CAT activities also significantly increased p 7.5 (17.63 ± 0.61) and DT10 rats (30.88 ± 0.97) when compared to DUT rats (10.98 ± 0.6). SOD activities significantly increased p 0.05 in DT7.5 (2.634 ± 0.04) and DT10 rats (2.258 ± 0.32) when compared to DUT rats (1.366 ± 0.05) while MDA significantly reduced p 7.5 (49.16 ± 0.51) and DT10 (33.64 ± 0.42) rats when compared to DUT rats (99.93 ± 4.79). This study revealed that VCO has a hypoglycemic action, enhances insulin secretion and also ameliorates oxidative stress induced in type I (alloxan-induced diabetic) male rats.
基金supported by the CACMS Innovation Fund(CI2021A00914)the Beijing Novaprogram(Z211100002121062)+1 种基金the Opening Project of the Key Laboratory of Integrative Chinese and Western Medicine for the Diagnosis and Treatment of Circulatory Diseases of Zhejiang Province(2C32001)the National Natural Science Foundation of China(82004193)。
文摘The Mediterranean diet has long been recognized as one of the most effective ways to prevent and improve cardiovascular disease.Extra virgin olive oil(EVOO)is the typical sources of fat in the Mediterranean diet which have been shown to have noteworthy nutritional value and positive impact on human health.It is worth noting that EVOO owes its superior nutritional value to its bioactive composition.The main component of EVOO is monounsaturated fatty acids(MUFAs)in the form of oleic acid.Oleic acid accounts for up to 70%-80%of EVOO.Secondly,EVOO contains approximately more than 30 phenolic compounds,of which HT is essential for the protection against cardiovascular diseases.In this review,we focused on the potential mechanisms of oleic acid and polyphenols combat cardiovascular diseases risk in terms of oxidative stress,inflammation,blood pressure,endothelial function and cholesterol.This review might provide a reference for the studies on cardiovascular protective effects of EVOO.
基金sponsored by statutory research University of Science and Technology AGH,Cracow,Poland(No.11 100 281)
文摘In some worldwide hard coal basins recovery of methane from virgin coal beds is difficult. In general,mentioned difficulties are related to geo-mechanical, petrographical and physical-chemical properties of coals in question, occurring for example in the Bowen Basin(Australia) or the Upper Silesian Coal Basin(Poland). Among numerous properties and parameters, the following are very essential: susceptibility of coal beds to deformation connected with coal stress state change and contemporary shrinkage of the coal matrix during methane desorption. Those adverse geo-mechanical and physical-chemical effects are accompanied by essential change of the porous coal structure, which under these disadvantageous conditions is very complex. This study aims to show difficulties, which occur in phase of recognition of the methane-reach coal deposit. Volume absorbed methane(not surface adsorbed) in sub-micropores having minimal size comparable with gas molecule diameter must possess energy allowing separation of the nodes and methane release to micropores.
文摘Virgin Coconut Meal (VCM) was used for the development of instant wheat sooji (semolina) halwa mix with better nutritional attributes. Central composite rotatable design (CCRD) with 2 independent variables (sugar and VCM) and 4 responses (lightness, redness, taste and overall acceptability) was used for the optimisation. VCM incorporated instant halwa mix prepared using optimised levels of ingredients contained moisture 0.95%;fat 26.2%;protein 7.65%;total ash 0.86%;fibre 1.02% and received overall acceptability score of 8.5 on a 9 point hedonic scale providing 523.86 K·cal/ 100g. The changes in quality of stored VCM incorporated instant halwa mix packed in polypropylene (PP, 75 μ) and laminates of metallised polyester (MP, 90 μ) were monitored in order to assess the shelf-life. Instant halwa mix remained stable and acceptable for one year in both the packaging materials under ambient temperature conditions (15℃ - 34℃). However, the rate of lipid peroxidation was found to be slightly higher in PP packed samples as compared to MP packed ones. Fatty acid composition of VCM incorporated instant halwa mix remained practically unchanged during storage. Oleic acid was the major fatty acid present in fat extracted from halwa mix followed by palmitic and lauric acids.
文摘Sensory evaluation of olive oil, meaning the official organoleptic assessment of olive oil respectively the ＂Panel Test＂ （PT）, is based on the standards of the International Olive Council （IOC）, as well as on the Regulation （EC） 640/2008 of the European Commission. These regulations lead to the classification of olive oil as ＂extra virgin＂ （EVOO）, ＂virgin＂ （VOO） or ＂lampant＂, which however is not sufficient to clearly discriminate between different quality levels within the grade EVOO. The objective of the study at hand was to develop and validate an objective sensory evaluation method for the quality certification of olive oil within the grade EVOO. A new rating system, including a detailed description and evaluation of the complexity and persistence of flavour, was established. First, a comparison between different profile sheets from various olive oil competitions （Ercole Olivario, Premio Biol, Leone D＇Oro Mario Solinas Award, among others） and the official profile sheet from the IOC/EC for the panel test （PT） took place. In consecutive steps the basic test procedure from the panel test （PT） then was extended with additional sensory descriptors. Two trained olive oil panels （the German Olive Oil Panel （DOP） and the Swiss Olive Oil Panel （SOP）） were further educated to profile various green and ripe aroma components and to evaluate the complexity of the perceived aroma components and their persistency （descriptor： ＂harmony/persistency＂）. This extended methodology was cross-validated over a time period of 3 years between the two panels （DOP/SOP）.
基金supported by the Thailand Research Fund through the Royal Golden Jubilee Ph.D.Program(PHD/0225/2561)the Faculty of Engineering,Kamphaeng Saen Campus,Kasetsart University,Thailand。
文摘The adulteration concentration of palm kernel oil(PKO)in virgin coconut oil(VCO)was quantified using near-infrared(NIR)hyperspectral imaging.Nowadays,some VCO is adulterated with lower-priced PKO to reduce production costs,which diminishes the quality of the VCO.This study used NIR hyperspectral imaging in the wavelength region 900-1,650 nm to create a quantitative model for the detection of PKO contaminants(0-100%)in VCO and to develop predictive mapping.The prediction equation for the adulteration of VCO with PKO was constructed using the partial least squares regression method.The best predictive model was pre-processed using the standard normal variate method,and the coefficient of determination of prediction was 0.991,the root mean square error of prediction was 2.93%,and the residual prediction deviation was 10.37.The results showed that this model could be applied for quantifying the adulteration concentration of PKO in VCO.The prediction adulteration concentration mapping of VCO with PKO was created from a calibration model that showed the color level according to the adulteration concentration in the range of 0-100%.NIR hyperspectral imaging could be clearly used to quantify the adulteration of VCO with a color level map that provides a quick,accurate,and non-destructive detection method.
文摘Virgin coconut meal (VCM) was used for the development of ready-to-eat Indian traditional sweet meat commonly known as “ladoo” both with and without sorbic acid (0.3%). The different ingredients were optimized following re-sponse surface methodology with three independent variables i.e. sugar, water and VCM and sensory attributes as responses. The changes in the quality of VCM ladoo packed in polypropylene (PP, 75 μ) and laminates of metalized polyester (MP, 75 μ) were monitored during storage to establish the shelf life under ambient temperature conditions (15?C - 34?C). Samples without added potassium sorbate spoiled within three weeks of storage due to mold growth and fermented odour. VCM ladoo containing sorbic acid did not support any microbial growth during storage up to 4 months, however, during storage samples packed in PP lost moisture and became hard and brittle, while those packed in MP remained soft. Peroxide and thiobarbituric acid values were higher in PP packed samples as compared to those packed in MP. Sorbic acid degraded during storage of ladoo and the rate of degradation was higher in PP packed ladoos than that in MP packed ones.
文摘Biscuits were prepared by incorporating virgin coconut meal (VCM) into refined wheat flour (maida) at 5-25% level and evaluated for physical, chemical, nutritional, textural and sensory attributes. All the prepared biscuits had high protein and fiber contents as compared to control (100% refined wheat flour based product). With the incorporation of VCM, hardness and toughness of dough increased while there was a decrease in stickiness and adhesiveness values. Incorporation of VCM had a significant effect on color values of biscuits as the concentration of VCM was increased. The values of L* decreased while those for a* and b* increased. Sensory analysis revealed that 15% VCM biscuits were the most acceptable. The Differential scanning calorimetry (DSC) analysis revealed that the onset (To) decreased while end set (Tc) and enthalpy of gelatinization (ΔH) increased with the increase level of VCM.
