Malassezia furfur is a lipophilic and dermatological pathogenic yeast,which normally exists on human skin,and causes tinea versicolor,seborrhoeic dermatitis,and atopic dermatitis,especially on human scalp.The multi-he...Malassezia furfur is a lipophilic and dermatological pathogenic yeast,which normally exists on human skin,and causes tinea versicolor,seborrhoeic dermatitis,and atopic dermatitis,especially on human scalp.The multi-herb extraction VGP which consists of Vitex trifolia fruit,Gentiana scabra,and Polygonum multiflorum root extract was used to study its effect of anti-inflammation,controlling sebum and dandruff on scalp care.Results showed that on the model of NHEK and THP1 cell inflammation induced by Malassezia furfur,VGP can inhibit the expression of interleukin 6(IL-6),prostaglandin E2(PGE-2),monocyte chemoattractant protein 1(MCP-1)and interleukin 1β(IL-1β)in a dose-dependent manner under 0.01%to 0.125%concentration.On the inflammatory model of 3D reconstructed skin induced by H2O2,VGP significantly improved the cell viability and skin structure,and reduced the production of interleukin 8(IL-8),PGE-2,and leukotriene B4(LTB4).During 4 week’s treatment with test shampoo contained 0.5%VGP thrice a week on 16 subjects met with different symptom,VGP reduced the sebum content and TEWL,improved the redness,itching and dandruff on human scalp skin.Therefore,as a natural active ingredient VGP can play a role in scalp care and skin care by targeting inflammation.展开更多
An investigation of the rock magnetic properties using stepwise isothermal remanence (IRM) acquisition, thermomagnetic analysis and temperature-dependent susceptibility history, identifies magnetite as the carrier of ...An investigation of the rock magnetic properties using stepwise isothermal remanence (IRM) acquisition, thermomagnetic analysis and temperature-dependent susceptibility history, identifies magnetite as the carrier of the main fraction of the remanence, associated with maghemite and hematite in Malan loess (L1), Holocene soil (S0) and last-glacial paleosol (S1). The presence of short-lived direction fluctuations indicates that no significant smoothing occurs in L1 when its remanence is locked, and thus L1 is capable of recording the geomagnetic secular variation (PSV), while the PSV has been severely smoothed or wiped out by pedogenic processes during S1 formation. It has been suggested that the Mono Lake and Laschamp excursions are two independent geomagnetic events based on this study.展开更多
A detailed record of the Matuyama-Brunhes (M-B) transition has been obtained from the loess unit 8 (L8) at Duanjiapo (34.2° N, 109.2° E), Shannxi Province of China. An investigation of the rock magnetic prop...A detailed record of the Matuyama-Brunhes (M-B) transition has been obtained from the loess unit 8 (L8) at Duanjiapo (34.2° N, 109.2° E), Shannxi Province of China. An investigation of the rock magnetic properties using hysteresis loops, thermomagnetic analyses identifies pseudo-single domain magnetite as the main carrier of the rema-nence, with a small contribution from maghemite and hema-tite. The paleo-direction records obtained reveal: ( i ) The M-B transition was recorded in the middle and lower part of L8, and comprises of five fast reversals. (ii) The duration of the M-B polarity transition related to the directional change is about 4800 a. (iii) The virtual geomagnetic pole (VGP) path during the transition is confined over Africa, peaked 90° away from the sampling site, in contrast with the results obtained from the Weinan loess section. The different VGPs are probably attributed to the pedogenesis.展开更多
The global spread of hypervirulent Klebsiella pneumoniae(hvKp)poses a serious public health threat.In this study,we conducted genomic epidemiology analysis on 2097 global hvKp isolates,including our 900 isolates seque...The global spread of hypervirulent Klebsiella pneumoniae(hvKp)poses a serious public health threat.In this study,we conducted genomic epidemiology analysis on 2097 global hvKp isolates,including our 900 isolates sequenced through the Illumina platform(177 of them fully sequenced through PacBio platform),representing the most comprehensive genomic analysis of hvKp to date.Our results identified six dominant clonal groups(CGs),particularly including CG23 and CG258,and 17 major virulence determinant combinations(VDCs)comprising 10 virulence gene profiles(VGPs),four types of virulence plasmids,four ICEKp variants,Tn7399,and all_island.Each CG harbored distinct advantageous VDCs,indicating strong genomic correlation and co-evolution.Additionally,the phylogeny and evolutionary history of CG23 and CG258 were characterized in depth.Notably,41.58%of the 2097 isolates were multidrug-resistant and 33.29%were carbapenem-resistant,indicating serious antimicrobial resistance.Overall,our study provides a global genomic landscape of hvKp,emphasizing the genetic basis for their global dissemination and the need for precise prevention and control.展开更多
文摘Malassezia furfur is a lipophilic and dermatological pathogenic yeast,which normally exists on human skin,and causes tinea versicolor,seborrhoeic dermatitis,and atopic dermatitis,especially on human scalp.The multi-herb extraction VGP which consists of Vitex trifolia fruit,Gentiana scabra,and Polygonum multiflorum root extract was used to study its effect of anti-inflammation,controlling sebum and dandruff on scalp care.Results showed that on the model of NHEK and THP1 cell inflammation induced by Malassezia furfur,VGP can inhibit the expression of interleukin 6(IL-6),prostaglandin E2(PGE-2),monocyte chemoattractant protein 1(MCP-1)and interleukin 1β(IL-1β)in a dose-dependent manner under 0.01%to 0.125%concentration.On the inflammatory model of 3D reconstructed skin induced by H2O2,VGP significantly improved the cell viability and skin structure,and reduced the production of interleukin 8(IL-8),PGE-2,and leukotriene B4(LTB4).During 4 week’s treatment with test shampoo contained 0.5%VGP thrice a week on 16 subjects met with different symptom,VGP reduced the sebum content and TEWL,improved the redness,itching and dandruff on human scalp skin.Therefore,as a natural active ingredient VGP can play a role in scalp care and skin care by targeting inflammation.
文摘An investigation of the rock magnetic properties using stepwise isothermal remanence (IRM) acquisition, thermomagnetic analysis and temperature-dependent susceptibility history, identifies magnetite as the carrier of the main fraction of the remanence, associated with maghemite and hematite in Malan loess (L1), Holocene soil (S0) and last-glacial paleosol (S1). The presence of short-lived direction fluctuations indicates that no significant smoothing occurs in L1 when its remanence is locked, and thus L1 is capable of recording the geomagnetic secular variation (PSV), while the PSV has been severely smoothed or wiped out by pedogenic processes during S1 formation. It has been suggested that the Mono Lake and Laschamp excursions are two independent geomagnetic events based on this study.
基金This work was supported by the National Natural Science Foundation of China (Grant No. 49425405).
文摘A detailed record of the Matuyama-Brunhes (M-B) transition has been obtained from the loess unit 8 (L8) at Duanjiapo (34.2° N, 109.2° E), Shannxi Province of China. An investigation of the rock magnetic properties using hysteresis loops, thermomagnetic analyses identifies pseudo-single domain magnetite as the main carrier of the rema-nence, with a small contribution from maghemite and hema-tite. The paleo-direction records obtained reveal: ( i ) The M-B transition was recorded in the middle and lower part of L8, and comprises of five fast reversals. (ii) The duration of the M-B polarity transition related to the directional change is about 4800 a. (iii) The virtual geomagnetic pole (VGP) path during the transition is confined over Africa, peaked 90° away from the sampling site, in contrast with the results obtained from the Weinan loess section. The different VGPs are probably attributed to the pedogenesis.
基金supported by the National Key R&D Program of China(2023YFC2605600 and 2023YFC2604400).
文摘The global spread of hypervirulent Klebsiella pneumoniae(hvKp)poses a serious public health threat.In this study,we conducted genomic epidemiology analysis on 2097 global hvKp isolates,including our 900 isolates sequenced through the Illumina platform(177 of them fully sequenced through PacBio platform),representing the most comprehensive genomic analysis of hvKp to date.Our results identified six dominant clonal groups(CGs),particularly including CG23 and CG258,and 17 major virulence determinant combinations(VDCs)comprising 10 virulence gene profiles(VGPs),four types of virulence plasmids,four ICEKp variants,Tn7399,and all_island.Each CG harbored distinct advantageous VDCs,indicating strong genomic correlation and co-evolution.Additionally,the phylogeny and evolutionary history of CG23 and CG258 were characterized in depth.Notably,41.58%of the 2097 isolates were multidrug-resistant and 33.29%were carbapenem-resistant,indicating serious antimicrobial resistance.Overall,our study provides a global genomic landscape of hvKp,emphasizing the genetic basis for their global dissemination and the need for precise prevention and control.
