Astrocyte plays a pivotal role in synaptic transmission with neuron.It maintains the ionic concentration in synapse to regulate signals from one cell to another.Calcium known as second messenger plays an important rol...Astrocyte plays a pivotal role in synaptic transmission with neuron.It maintains the ionic concentration in synapse to regulate signals from one cell to another.Calcium known as second messenger plays an important role in signal transduction.There are so many physiological processes that affect the cytosolic calcium concentration[Ca2+]i like calcium buffering,flow of calcium ion through channels,etc.The modeling of calcium signaling in astrocytes has become more sophisticated.The modeling effort has provided insight to understand the cell contraction.Main objective of this work is to study the effect of voltage-gated calcium channel on calcium profile under excess buffer approximation in the form of diffusion equation.A mathematical model is developed in the form of diffusion equation for the calcium profile.The model incorporates the important physiological parameter like diffusion coefficient association rate constant,etc.Appropriate boundary conditions have been framed.Finite element method is employed to solve the problem.A MATLAB program has been developed for the entire problem and simulated to compute the numerical results.展开更多
文摘Astrocyte plays a pivotal role in synaptic transmission with neuron.It maintains the ionic concentration in synapse to regulate signals from one cell to another.Calcium known as second messenger plays an important role in signal transduction.There are so many physiological processes that affect the cytosolic calcium concentration[Ca2+]i like calcium buffering,flow of calcium ion through channels,etc.The modeling of calcium signaling in astrocytes has become more sophisticated.The modeling effort has provided insight to understand the cell contraction.Main objective of this work is to study the effect of voltage-gated calcium channel on calcium profile under excess buffer approximation in the form of diffusion equation.A mathematical model is developed in the form of diffusion equation for the calcium profile.The model incorporates the important physiological parameter like diffusion coefficient association rate constant,etc.Appropriate boundary conditions have been framed.Finite element method is employed to solve the problem.A MATLAB program has been developed for the entire problem and simulated to compute the numerical results.
