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Efficacy of electroconvulsive therapy in treating auditory verbal hallucinations in a deaf patient with schizophrenia:A case report
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作者 Juan Wang Juan Li +2 位作者 Yan-Ge Wei Xin-Xin Lu Zhao-Hui Zhang 《World Journal of Psychiatry》 2025年第6期278-284,共7页
BACKGROUND Auditory verbal hallucinations(AVHs)are believed to be characteristic symptoms of schizophrenia.The prevalence of AVHs in deaf patients with schizophrenia is comparable to that in patients with schizophreni... BACKGROUND Auditory verbal hallucinations(AVHs)are believed to be characteristic symptoms of schizophrenia.The prevalence of AVHs in deaf patients with schizophrenia is comparable to that in patients with schizophrenia who have normal hearing ability.AVHs in deaf patients with schizophrenia require treatment.CASE SUMMARY A 22-year-old deaf woman with schizophrenia had experienced AVHs for 3 months.Her psychotic symptoms were not alleviated by antipsychotic medication alone.Modified electroconvulsive therapy in combination with antipsychotic drugs effectively alleviated her AVHs and disorganized behavior.During outpatient follow-up for 6 months,her condition have remained stable,and she has been able to take care of herself.CONCLUSION Treatment with modified electroconvulsive therapy was found to be safe and might be indicated for deaf patients whose symptoms are not well managed with antipsychotic medication alone.Deaf people might be unable to communicate through spoken language;therefore,to make proper diagnoses and provide appropriate treatment for these patients,psychiatrists must have patience and seek to understand patients’mental state. 展开更多
关键词 DEAFNESS Auditory verbal hallucinations SCHIZOPHRENIA Antipsychotic drugs Modified electroconvulsive therapy Case report
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Cerebral hemodynamic characteristics of patients with auditory verbal hallucinations and the construction of nomogram models
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作者 Zi-Yao Cai Ce Chen +4 位作者 Zi-Ye Huang Xin-Wu Ye Xiao-Zhuang Jin Hao-Ran Chen Jian-Min Sha 《World Journal of Psychiatry》 2025年第6期234-247,共14页
BACKGROUND The characteristics of cerebral hemodynamic indexes of patients with different types of auditory verbal hallucinations(AVHs)was not clear.AIM To explore the characteristics of cerebral hemodynamic indexes o... BACKGROUND The characteristics of cerebral hemodynamic indexes of patients with different types of auditory verbal hallucinations(AVHs)was not clear.AIM To explore the characteristics of cerebral hemodynamic indexes of patients with different types of AVHs and construct the risk nomogram prediction model of patients with different types of AVHs.METHODS Patients with different types of verbal hallucinations who visited Wenzhou Seventh People’s Hospital were retrospectively selected from March 2021 to March 2023,and these patients were classified into 117 cases of schizophrenia(SCZ)with AVHs,108 cases of post-traumatic stress disorder(PTSD)with AVHs,and 105 cases of recurrent depressive disorder with AVHs according to type.Transcranial doppler was performed to measure the hemodynamic parameters of the anterior cerebral artery(ACA),middle cerebral artery(MCA),posterior cerebral artery(PCA),basilar artery(BA)and vertebral artery(VA).Logistic regression modelling was used to explore the factors affecting patients with different types of AVHs and odds ratio,95%confidence interval(CI).A clinical prediction model was constructed,and the efficacy of the clinical prediction model was evaluated by using receiver operating characteristic,Hosmer-Lemeshow Goodness-of-Fit test,calibration curves and decision curve analysis.RESULTS The differences between the three groups of patients in mean velocity(Vm)-MCA,end-diastolic velocity(Vd)-MCA,Vm-ACA,pulsatility index(PI)-ACA,Vm-PCA,peak systolic velocity(Vs)-PCA,Vd-PCA,Vm-BA,Vs-BA,Vd-BA,PI-BA,resistance index(RI)-BA,Vm-VA,Vs-VA,Vd-VA,PI-VA,and RI-VA indexes were statistically significant.Rising Vm-ACA is an independent risk factor for SCZ with AVHs,and falling Vm-VA,Vd-MCA,and Vd-VA are independent risk factors for SCZ with AVHs.Rising Vm-ACA,Vm-PCA,Vs-PCA,Vd-PCA,Vm-BA,and Vs-BA are independent risk factors for PTSD with AVHs,and Vm-MCA,Vs-MCA,Vd-MCA,PI-PCA,and RIBA are independent protective factors for PTSD with AVHs.Elevated Vm-MCA,Vd-MCA,RI-BA,Vm-VA,and Vd-VA were independent risk factors,and elevated Vm-ACA,Vs-ACA,Vm-PCA,Vs-PCA,and Vd-PCA were independent protective factors.The areas under the curve of the three models were 0.82(95%CI:0.76-0.87),0.88(95%CI:0.83-0.92),and 0.81(95%CI:0.77-0.86),respectively;the Hosmer-Lemeshow Goodness-of-Fit test of the calibration curves of the three models suggests that P>0.05.CONCLUSION Monitoring the cerebral hemodynamic indexes of patients with AVHs is of practical significance in determining the type of mental disorder,which helps clinicians identify the type of AVHs and adopt more efficient treatment strategies to help patients recover. 展开更多
关键词 Auditory verbal hallucinations SCHIZOPHRENIA Posttraumatic stress disorder Recurrent depressive disorder Nomogram model
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Strategies for Fostering Interaction in Online Classrooms:A Conversation Analysis of Teacher-Student Verbal Interaction in Random Questioning in Pandemic-Initiated Online Teaching
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作者 Ping Zhang 《Journal of Contemporary Educational Research》 2024年第2期98-111,共14页
This paper aims to explore how a veteran teacher organizes online teaching initiated by the pandemic and how she deals with the problems in online teacher-student verbal interaction.By analyzing a corpus of 20 audio-r... This paper aims to explore how a veteran teacher organizes online teaching initiated by the pandemic and how she deals with the problems in online teacher-student verbal interaction.By analyzing a corpus of 20 audio-recorded online lessons between a math teacher and her students during the COVID-19 pandemic from April 11 to May 10,2022,four interactional segments are selected as the focus of the study.The results of the conversation analysis of the segments showed that students’modesty,lack of confidence,lack of ability,and network delay are the main factors affecting online teacher-student interaction.By encouraging students to answer questions,enlightening students to give answers,enriching students’answers,and entertaining the teaching atmosphere(“4Es”strategies),the teacher solved the problems successfully.The findings from this study can provide pedagogical experience and implications for practical teaching. 展开更多
关键词 Online teaching Teacher-student verbal interaction Conversation analysis “4Es”strategies
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Application of Nonverbal Language in Foreign Language Teaching and Testing
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作者 漆舒琴 龙玉梅 《海外英语》 2017年第20期234-235,共2页
Communication is a combination of both verbal language and nonverbal language. Verbal language varies in different cultures, so does nonverbal language. Nowadays more and more teachers have realized the necessity for ... Communication is a combination of both verbal language and nonverbal language. Verbal language varies in different cultures, so does nonverbal language. Nowadays more and more teachers have realized the necessity for students to speak the foreign language in class. However, there are still some problems in teaching, studying and testing foreign language, which will be dealt with in this paper. Some teachers speak foreign language with Chinese body language. Thus students, while talking in class,also use Chinese body language to indicate their thoughts. How can't misunderstanding occur when they communicate with native speakers of foreign language? So body language should be set as one of the contents of foreign language teaching. Therefore,body language and courtesies should play an important role in tests. 展开更多
关键词 body language courtesy verbal language nonverbal language CULTURE
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The Role of Non-verbal Behavior of Teachers in Providing Students Corrective Feedback and Their Consequences 被引量:3
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作者 Emre Guvendir 《Sino-US English Teaching》 2011年第9期577-591,共15页
Considering the primary focus of corrective feedback literature on verbal-correction provided by teachers and lack of attention to the role of other forms of corrective feedback in FL (foreign language) classroom in... Considering the primary focus of corrective feedback literature on verbal-correction provided by teachers and lack of attention to the role of other forms of corrective feedback in FL (foreign language) classroom interaction, this paper demonstrates how essential teachers' non-verbal communication and stance display are in making students' errors noticeable for them by providing samples from videotaped data. The findings in this study provide insights into the use of non-verbal behavior in providing students with corrective feedback. This study shows that research dealing only with verbal corrections provided by FL teachers cannot fully define the classroom interaction in terms of teachers' use of error correction techniques and student notification and uptake. 展开更多
关键词 corrective feedback verbal communication non-verbal communication student noticing
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Nonverbal and Intercultural Communication
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作者 龚春燕 《海外英语》 2010年第4X期150-151,共2页
Nonverbal communication is typically suggested to convey representational messages,and also particular signals are associated with specific signaler emotions and intentions.This essay will firstly address vocalization... Nonverbal communication is typically suggested to convey representational messages,and also particular signals are associated with specific signaler emotions and intentions.This essay will firstly address vocalization,which consist verbal and non-verbal signals.Also,other forms of physical behaviors used by humans to communicating meaning,such as gaze will be discussed.Finally,the association between culture and the encoding and decoding of different means of physical nonverbal communication will be presented. 展开更多
关键词 NONverbal COMMUNICATION CULTURE verbal
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Exploring the Relationship between Learning Styles and Proficiency in Verbal Communication
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作者 李培隆 赵足娥 《中国校外教育(上旬)》 2008年第S1期1378-1378,1416,共2页
In the light of need to use learning styles to enhance verbal proficiency,this paper will explore the interconnectedness of learning styles and proficiency in verbal communication.It will first introduce the backgroun... In the light of need to use learning styles to enhance verbal proficiency,this paper will explore the interconnectedness of learning styles and proficiency in verbal communication.It will first introduce the background of the study.This will be followed by an overview of the research on related literature and studies in the field.Lastly the paper concludes that foreign language teachers should give attention to the styles for languages learning and verbal proficiency since they are closely correlated. 展开更多
关键词 Learning STYLES PROFICIENCY verbal Communication E
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An Analysis of the Verbal Humor in the Movies If You Are The One Ⅰ&Ⅱ from the Perspective of Pragmatics
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作者 黄瑞 《海外英语》 2011年第5X期281-283,共3页
This study analyzes the the verbal humor in the movie series If You Are The One from the perspective of some pragmatic theories.The findings of the study provide explanations towards generative mechanism of humor,such... This study analyzes the the verbal humor in the movie series If You Are The One from the perspective of some pragmatic theories.The findings of the study provide explanations towards generative mechanism of humor,such as the violation of Cooperative Principle,avoiding face-threatening acts,and particularly,creatively reveal that special use of Politeness Principle can produce a humourous effect,too. 展开更多
关键词 verbal humor VIOLATION OVERUSE PRAGMATICS cooperative PRINCIPLE POLITENESS PRINCIPLE
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Cultural Context and Appreciation to Obama's Verbal Humor
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作者 岑俊毫 《海外英语》 2011年第11X期370-372,共3页
This paper aims to explain the restraint exerted by the deep structure of culture,such as history,religion,social convention and family,in understanding and appreciating foreign verbal humor,especially foreign statesm... This paper aims to explain the restraint exerted by the deep structure of culture,such as history,religion,social convention and family,in understanding and appreciating foreign verbal humor,especially foreign statesman's verbal humor;whereby the significance of the deep structure of culture is revealed.In this paper,Herbert Paul Grice's Conversational Implicature Theory,i.e.the violation of cooperative principle,is taken as the theoretic base;the deep structure of culture is the analytical background and some of Obama's remarks and speeches given informal occasions are taken as analyzed examples,from which the essential role of the deep structure of culture is emphasized and focused in cross-cultural communication. 展开更多
关键词 history RELIGION social CONVENTION Obama’s verbal HUMOR
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Semantic Perspective:Verbal Humor in Chinese Cross Talk
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作者 熊绍丽 《海外英语》 2014年第10X期260-261,共2页
This paper aims to study the verbal humor in Guo Degang's cross talk from semantic perspective.The focus is to illustrate the generating process and the mechanism of verbal humor.Three aspects of semantics which p... This paper aims to study the verbal humor in Guo Degang's cross talk from semantic perspective.The focus is to illustrate the generating process and the mechanism of verbal humor.Three aspects of semantics which produce humorous effect,morpheme absorption,ambiguity,and script opposition will be discussed.Finally,it is found out that script opposition can take place of morpheme absorption,ambiguity to explain how humor is caused fundamentally. 展开更多
关键词 verbal HUMOR SEMANTICS MORPHEME ABSORPTION ambigui
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Multimodal Discourse Analysis of College English Teacher 's Nonverbal Behaviors
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作者 王倩 《海外英语》 2015年第14期219-220,共2页
This paper analyzes College English teacher's non-verbal behaviors in multimedia classroom from the perspective ofMultimodal Discourse Analysis, aiming to explore how the non-verbal behaviors in classroom teaching... This paper analyzes College English teacher's non-verbal behaviors in multimedia classroom from the perspective ofMultimodal Discourse Analysis, aiming to explore how the non-verbal behaviors in classroom teaching can be applied in meaning-making process to facilitate teacher-students interaction and realize three metafunctions of language in class. 展开更多
关键词 teachers’ NON-verbal BEHAVIORS MULTIMODAL discours
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Cultivation of College Students' Ability in Cross-cultural Non-verbal Communication
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作者 张琳琳 《海外英语》 2015年第17期247-248,共2页
For a long time,students' non-verbal communicative competence is neglected by themselves as well as the teachers.Inthis paper a research is done to analyze the causes of students' non-verbal communicative fail... For a long time,students' non-verbal communicative competence is neglected by themselves as well as the teachers.Inthis paper a research is done to analyze the causes of students' non-verbal communicative failure.And some suggestions are givento cultivate students' ability in cross-cultural non-verbal Communication The students' enhanced communicative competencewill help them avoid non-verbal communicative failure and communicate effectively and appropriately in cross-cultural communi-cation. 展开更多
关键词 NON-verbal Communication CULTURE DIFFERENCE COMMUN
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Studies on the Avoidance of Cultural Conflicts from the Aspect of Relationship between Non-verbal Communication and Culture
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作者 于雪丽 《神州》 2014年第11期32-32,共1页
Nowadays,communication with foreign people isbecoming closer.While,misunderstandings occur frequently inthis process.The main purpose of this essay is to offer some pro-posals on the problem of misunderstandings and c... Nowadays,communication with foreign people isbecoming closer.While,misunderstandings occur frequently inthis process.The main purpose of this essay is to offer some pro-posals on the problem of misunderstandings and conflicts in inter-cultural communication from the aspect of relationship betweenculture and non-verbal communication. 展开更多
关键词 non-verbal communication CULTURE avoid-ance culture conflicts intercultural communication
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The Application of Non-verbal Communication Strategies in International Business Negotiations
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作者 张晓瑜 潘可欣 《海外英语》 2018年第2期238-239,共2页
As the economic globalization deepens, trades among nations are steadily increasing. Therefore, the international business negotiations become more and more significant. In the process of negotiations, the application... As the economic globalization deepens, trades among nations are steadily increasing. Therefore, the international business negotiations become more and more significant. In the process of negotiations, the application of appropriate strategies is necessary for negotiators to reach an agreement smoothly. However, the non-verbal communication plays an important role to some extent in real international business negotiations. This article tends to explore the application of non-verbal strategies in the international business negotiations. 展开更多
关键词 non-verbal communication international business negotiations STRATEGIES
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Clustering and switching during a semantic verbal fluency test contribute to differential diagnosis of cognitive impairment 被引量:12
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作者 Qianhua Zhao Qihao Guo Zhen Hong 《Neuroscience Bulletin》 SCIE CAS CSCD 2013年第1期75-82,共8页
The verbal fluency test (VFT) can be dissociated into "clustering" (generating words within subcategories) and "switching" (shifting between clusters), which may be valuable in differential diagnosis. In the... The verbal fluency test (VFT) can be dissociated into "clustering" (generating words within subcategories) and "switching" (shifting between clusters), which may be valuable in differential diagnosis. In the current study, we investigated the validity of VFT in the differential diagnosis of Alzheimer's disease (AD, n = 65), vascular dementia (VaD, n = 65), mild cognitive impairment (MCI, n = 92), and vascular cognitive impairment without dementia (VCIND, n = 76) relative to cognitively normal senior controls (NC, n = 374). We found that in the NC group, the total correct score was significantly correlated with age and education; males generated more subcategories; cluster size increased with education, and subcategory and switching decreased with age. A significantly progressive advantage was observed in VFT scores in the sequence NC 〉 MCI/VCIND 〉 AD/VaD, and this significantly discriminated dementia patients from the other groups. AD patients performed better in all four VFT scores than VaD patients. Subcategory and switching scores significantly distinguished AD from VaD patients (AD 〉 VaD; mean difference, 0.50 for subcategory, P 〈0.05; 0.71 for switching, P 〈0.05). MCI patients scored higher than VCIND patients, but the difference did not reach statistical significance. These results suggest that semantic VFT is useful for the detection of MCI and VCIND, and in the differential diagnosis of cognitive impairment. 展开更多
关键词 Alzheimer’s disease DEMENTIA verbal fluency mild cognitive impairment
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Transcranial direct current stimulation for auditory verbal hallucinations:a systematic review of clinical trials 被引量:7
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作者 Samaneh Rashidi Myles Jones +3 位作者 Eric Murillo-Rodriguez Sergio Machado Youguo Hao Ali Yadollahpour 《Neural Regeneration Research》 SCIE CAS CSCD 2021年第4期666-671,共6页
Transcranial direct current stimulation(tDCS)has been reportedly beneficial for different neurodegenerative disorders.tDCS has been reported as a potential adjunctive or alternative treatment for auditory verbal hallu... Transcranial direct current stimulation(tDCS)has been reportedly beneficial for different neurodegenerative disorders.tDCS has been reported as a potential adjunctive or alternative treatment for auditory verbal hallucination(AVH).This study aims to review the effects of tDCS on AVH in patients with schizophrenia through combining the evidence from randomized clinical trials(RCTs).The databases of PsycINFO(2000–2019),PubMed(2000–2019),EMBASE(2000–2019),CINAHL(2000–2019),Web of Science(2000–2019),and Scopus(2000–2019)were systematically searched.The clinical trials with RCT design were selected for final analysis.A total of nine RCTs were eligible and included in the review.Nine RCTs were included in the final analysis.Among them,six RCTs reported a significant reduction of AVH after repeated sessions of tDCS,whereas three RCTs did not show any advantage of active tDCS over sham tDCS.The current studies showed an overall decrease of approximately 28%of AVH after active tDCS and 10%after sham tDCS.The tDCS protocols targeting the sensorimotor frontal-parietal network showed greater treatment effects compared with the protocols targeting other regions.In this regard,cathodal tDCS over the left temporoparietal area showed inhibitory effects on AVHs.The most effective tDCS protocol on AVHs was twice-daily sessions(2 mA,20-minute duration)over 5 consecutive days(10 sessions)with the anode over the left dorsolateral prefrontal cortex and the cathode over the left temporal area.Some patient-specific and diseasespecific factors such as young age,nonsmoking status,and higher frequencies of AVHs seemed to be the predictors of treatment response.Taken together,the results of tDCS as an alternative treatment option for AVH show controversy among current literatures,since not all studies were positive.However,the studies targeting the same site of the brain showed that the tDCS could be a promising treatment option to reduce AVH.Further RCTs,with larger sample sizes,should be conducted to reach a conclusion on the efficacy of tDCS for AVH and to develop an effective therapeutic protocol for clinical setting. 展开更多
关键词 auditory verbal hallucinations dorsolateral prefrontal cortex effective protocol randomized clinical trial schizophrenia temporoparietal area transcranial direct current stimulation treatment efficacy
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Abnormal Local Activity and Functional Dysconnectivity in Patients with Schizophrenia Having Auditory Verbal Hallucinations 被引量:4
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作者 Cheng CHEN Gao-hua WANG +3 位作者 Shi-hao WU Ji-lin ZOU Yuan ZHOU Hui-ling WANG 《Current Medical Science》 SCIE CAS 2020年第5期979-984,共6页
Auditory verbal hallucination(AVH)is emphasized as a pathological hallmark of schizophrenia.Neuroimaging studies provide evidence linking AVH to overlapping functional abnormalities in distributed networks.However,no ... Auditory verbal hallucination(AVH)is emphasized as a pathological hallmark of schizophrenia.Neuroimaging studies provide evidence linking AVH to overlapping functional abnormalities in distributed networks.However,no clear conclusion has still been reached.This study aimed to further explore the brain activity of patients with schizophrenia having AVH from both local activity(LA)and functional connectivity(FC)insights,while excluding confounding factors from other positive symptoms.A total of 42 patients with AVH(AVH patients group,APG),26 without AVH(non-AVH patients group,NPG),and 82 normal controls(NC)underwent resting-state functional magnetic resonance imaging(fMRI).LA measures,including regional homogeneity(ReHo)and fractional amplitude of low-frequency fluctuations(fALFF),and FC measures were evaluated to understand the neuroimaging mechanism of AVH.APG showed increased ReHo and fALFF in the bilateral putamen(Put)compared with NPG and NC.FC analysis(using bilateral putamen as seeds)revealed that all patients showed abnormal FC of multiple resting state network regions,including the anterior and post cingulate cortex,middle frontal gyrus,inferior parietal gyrus,and left angular gyrus.Interestingly,APG showed significantly decreased FC of insula extending to the superior temporal gyrus and inferior frontal gyrus compared with NPG and NC.The present findings suggested a significant correlation of abnormal LA and dysfunctional putamen-auditory cortical connectivity with the neuropathological mechanism of AVH,providing evidence for the functional disconnection hypothesis of schizophrenia. 展开更多
关键词 auditory verbal hallucination functional connectivity local activity resting-state functional magnetic resonance imaging SCHIZOPHRENIA
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Atrophy of the left dorsolateral prefrontal cortex is associated with poor performance in verbal fluency in elderly poststroke women 被引量:2
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作者 Yang-Kun Chen Wei-Min Xiao +6 位作者 Defeng Wang Lin Shi Winnie CW Chu Vincent CT Mok Ka Sing Wong Gabor S Ungvari Wai Kwong Tang 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第4期346-356,共11页
This study aimed to investigate the association between atrophy in the prefrontal cortex with executive function and verbal fluency in elderly male and female patients poststroke. Thirty elderly female patients with n... This study aimed to investigate the association between atrophy in the prefrontal cortex with executive function and verbal fluency in elderly male and female patients poststroke. Thirty elderly female patients with non-aphasic ischemic stroke aged -〉 60 years and 30 age-matched non-aphasic male patients with ischemic stroke were recruited. Automatic magnetic resonance imaging segmentation was used to assess the volume of the whole prefrontal cortex, along with its subdivisions: anterior cingulate cortex, orbitofrontal cortex and dorsolateral prefrontal cortex. The Semantic Verbal Fluency Test was administered at 3 and 15 months poststroke. At 3 months poststroke, left dorsolateral prefrontal cortex volume was significantly correlated with Verbal Fluency Test score in female patients only (partial coefficient = 0.453, P = 0.045), after controlling for age, education, diabetes, neurological deficit, white matter lesions volume, as well as the location and volume of infarcts. At 15 months poststroke, there remained a significant association between the left dorsolateral prefrontal cortex volume and Verbal Fluency Test (partial coefficient = 0.661, P = 0.001) and between the left prefrontal cortex volume and Verbal Fluency Test (partial coefficient = 0.573, P = 0.004) in female patients after the same adjustments. These findings indicate that atrophy of the left dorsolateral prefrontal cortex contributes to the impairment of verbal fluency in elderly female patients with stroke. Sex differences may be present in the neuropsychological mechanisms of verbal fluency impairment in patients with stroke. 展开更多
关键词 neural regeneration NEUROIMAGING brain atrophy verbal fluency executive function stroke sex differences prefrontal cortex dorsolateral prefrontal cortex magnetic resonance imaging grants-supported paper photographs-containing paper NEUROREGENERATION
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Abnormal Effective Connectivity in the Brain is Involved in Auditory Verbal Hallucinations in Schizophrenia 被引量:10
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作者 Baojuan Li Long-Biao Cui +8 位作者 Yi-Bin Xi Karl J.Friston Fan Guo Hua-Ning Wang Lin-Chuan Zhang Yuan-Han Bai Qing-Rong Tan Hong Yin Hongbing Lu 《Neuroscience Bulletin》 SCIE CAS CSCD 2017年第3期281-291,共11页
Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations(AVHs) in schizophrenia(SZ) remains unclear. In this study, we used stocha... Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations(AVHs) in schizophrenia(SZ) remains unclear. In this study, we used stochastic dynamic causal modeling(s DCM) to quantify connections among the left dorsolateral prefrontal cortex(inner speech monitoring), auditory cortex(auditory processing), hippocampus(memory retrieval), thalamus(information filtering), and Broca's area(language production) in 17 first-episode drug-na?¨ve SZ patients with AVHs, 15 without AVHs, and 19 healthy controls using resting-state functional magnetic resonance imaging.Finally, we performed receiver operating characteristic(ROC) analysis and correlation analysis between image measures and symptoms. s DCM revealed an increasedsensitivity of auditory cortex to its thalamic afferents and a decrease in hippocampal sensitivity to auditory inputs in SZ patients with AVHs. The area under the ROC curve showed the diagnostic value of these two connections to distinguish SZ patients with AVHs from those without AVHs. Furthermore, we found a positive correlation between the strength of the connectivity from Broca's area to the auditory cortex and the severity of AVHs. These findings demonstrate, for the first time, augmented AVHspecific excitatory afferents from the thalamus to the auditory cortex in SZ patients, resulting in auditory perception without external auditory stimuli. Our results provide insights into the neural mechanisms underlying AVHs in SZ. This thalamic-auditory cortical-hippocampal dysconnectivity may also serve as a diagnostic biomarker of AVHs in SZ and a therapeutic target based on direct in vivo evidence. 展开更多
关键词 Effective connectivity Stochastic dynamic causal modeling Auditory verbal hallucinations Schizophrenia
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Reduced temporal activation during a verbal fluency test in clinical high risk of psychosis: a functional near-infrared spectroscopy-based study 被引量:3
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作者 Yanyan Wei Xiaochen Tang +6 位作者 Tingyu Zhang Wenjun Su Lihua Xu Huiru Cui Zhenying Qian Tianhong Zhang Jijun Wang 《General Psychiatry》 CAS CSCD 2022年第2期101-108,共8页
Background Clinical high risk(CHR)of psychosis is a state in which positive symptoms cause the subjects distress but do not approach a severity level that fulfils the criteria for a psychotic episode.CHR exhibits cogn... Background Clinical high risk(CHR)of psychosis is a state in which positive symptoms cause the subjects distress but do not approach a severity level that fulfils the criteria for a psychotic episode.CHR exhibits cognitive deficits;however,the underlying neurobiological mechanisms remain unclear.This study aimed to investigate whether brain activation measured by the levels of oxygenated hemoglobin(oxy-Hb)in CHR subjects could be correlated with cognitive deficits.Methods Fifty-eight CHR individuals who fulfilled the criteria for attenuated positive syndrome as specified in the Structured Interview for Prodromal Syndrome(SIPS)and the Scale of Prodromal Syndrome(SOPS)and 58 age-and sex-matched healthy participants were included in the study.All subjects completed the Measurement and Treatment Research to Improve Cognition in Schizophrenia(MATRICS)Consensus Cognitive Battery(MCCB)that includes tests measuring attention,verbal memory,verbal fluency,executive function,and general intelligence.Functional near-infrared spectroscopy(fNIRS)was used to measure the level of oxy-Hb in the dorsolateral prefrontal and frontotemporal cortices.Results We observed significantly decreased oxy-Hb levels in channel 32(located in the right superior temporal gyrus,rSTG)within the CHR individuals compared with that in the healthy controls(HCs)(t=−3.44,Bonferroni-corrected p=0.002),indicating lower brain activity.A significant positive correlation was observed between task-relatedβvalues and working memory in the CHR group(r=0.35,p=0.008).Conclusions The brain activation of rSTG is abnormal among subjects at clinicial high risk for psychosis.This abnormality is probably associated with the neural mechanisms of deficits in the working memory during the early stage of psychosis. 展开更多
关键词 DISTRESS ACTIVATION verbal
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