Introduction: There is a lack of the awareness in the fruit and vegetable (F & V) recommendation among Saudi society. Although the known facts of the benefits of F & V on health, information on Saudi society f...Introduction: There is a lack of the awareness in the fruit and vegetable (F & V) recommendation among Saudi society. Although the known facts of the benefits of F & V on health, information on Saudi society following the advised recommendation whether by WHO or local are still unknown. Aim: This cross-sectional study aims to examine the perception of F & V intake among students at Umm Al-Qura University and to assess if they follow these recommendations of F & V locally and internationally. Method: Students from Umm Al-Qura University participated in this study (n = 98, age between 18 - 55). All data were collected using short online survey via Online survey—Survey Monkey in 2019. Result: 55% students were not aware of these recommendations whereas 45% were aware of WHO recommendation. The majority of students 53% have less than two portions a day of F & V. Only 14% have between two to four portions a day. 32% do not eat any portion of F & V daily. 59%, 14%, 5% of students believe that they should have five, seven, more than seven portions a day for being healthy respectively. Maintaining health, reducing the risk for chronic disease and providing essential vitamins and minerals to the body were all reasons why students believe that they should have F & V everyday by 71%. Busy lifestyle, F & V cost, lack of the awareness about the health benefits, dislike of the taste, some F & V spoiled easily were all factors affecting eating F & V daily. Conclusion: University students need educational and nutritional campaigns to spread the awareness about the health benefits of F & V. Most importantly the ministry of health should support those campaigns to increase students’ awareness and build a healthy society with a good habit.展开更多
The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A549 and its possible mechanism on the VEGFNEGFR signal pathway were investigated. The exploration of the interactio...The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A549 and its possible mechanism on the VEGFNEGFR signal pathway were investigated. The exploration of the interaction between tanshinone IIA and its target proteins provides a feasible platform for studying the anticancer mechanism of active components of herbs. The CCK-8 assay was used to evaluate the proliferative activity of A549 cells treated with tanshinone IIA (2.5-80 mu mol/E) for 24, 48 and 72 h, respectively. Flow cytometry was used for the detection of cell apoptosis and cell cycle perturbation. VEGF and VEGFR2 expression were studied by Western blotting. The binding mode of tanshinone IIA within the crystal stmcture of the VEGFR2 protein was evaluated with molecular docking analysis by use of the CDOCKER algorithm in Discovery Studio 2.1. The CCK-8 results showed that tanshinone IIA can significantly inhibit A549 cell proliferation in a dose- and time-dependent manner. Flow cytometry results showed that the apoptosis rate of tested group was higher than the vehicle control, and tanshinone IIA-treated cells accumulated at the S phase, which was higher than the vehicle control. Furthermore, the expression of VEGF and VEGFR2 was decreased in Western blot Finally, molecular docking analysis revealed that tanshinone IIA could be stably docked into the kinase domain of VEGFR2 protein with its unique modes to form H-bonds with Cys917 and pi-pi stacking interactions with Va1848. In conclusion, tanshinone IIA may suppress A549 proliferation, induce apoptosis and cell cycle arrest at the S phase. This drug may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.展开更多
Two things come to mind when we,salivating,recall Veg Tables.First,roses,because the vegetarian cafe serves pink glasses of rose-and-beet-infused water on the fourth floor of florist-meets-clothing-boutique Goelia 225...Two things come to mind when we,salivating,recall Veg Tables.First,roses,because the vegetarian cafe serves pink glasses of rose-and-beet-infused water on the fourth floor of florist-meets-clothing-boutique Goelia 225.Second,photography,since the historic qilou was once a happening portrait studio on Beijing Lu(and because we made a lot of Instagram art during our first trip).展开更多
文摘Introduction: There is a lack of the awareness in the fruit and vegetable (F & V) recommendation among Saudi society. Although the known facts of the benefits of F & V on health, information on Saudi society following the advised recommendation whether by WHO or local are still unknown. Aim: This cross-sectional study aims to examine the perception of F & V intake among students at Umm Al-Qura University and to assess if they follow these recommendations of F & V locally and internationally. Method: Students from Umm Al-Qura University participated in this study (n = 98, age between 18 - 55). All data were collected using short online survey via Online survey—Survey Monkey in 2019. Result: 55% students were not aware of these recommendations whereas 45% were aware of WHO recommendation. The majority of students 53% have less than two portions a day of F & V. Only 14% have between two to four portions a day. 32% do not eat any portion of F & V daily. 59%, 14%, 5% of students believe that they should have five, seven, more than seven portions a day for being healthy respectively. Maintaining health, reducing the risk for chronic disease and providing essential vitamins and minerals to the body were all reasons why students believe that they should have F & V everyday by 71%. Busy lifestyle, F & V cost, lack of the awareness about the health benefits, dislike of the taste, some F & V spoiled easily were all factors affecting eating F & V daily. Conclusion: University students need educational and nutritional campaigns to spread the awareness about the health benefits of F & V. Most importantly the ministry of health should support those campaigns to increase students’ awareness and build a healthy society with a good habit.
基金supported by the National Natural Science Foundation of China(No.81274135)
文摘The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A549 and its possible mechanism on the VEGFNEGFR signal pathway were investigated. The exploration of the interaction between tanshinone IIA and its target proteins provides a feasible platform for studying the anticancer mechanism of active components of herbs. The CCK-8 assay was used to evaluate the proliferative activity of A549 cells treated with tanshinone IIA (2.5-80 mu mol/E) for 24, 48 and 72 h, respectively. Flow cytometry was used for the detection of cell apoptosis and cell cycle perturbation. VEGF and VEGFR2 expression were studied by Western blotting. The binding mode of tanshinone IIA within the crystal stmcture of the VEGFR2 protein was evaluated with molecular docking analysis by use of the CDOCKER algorithm in Discovery Studio 2.1. The CCK-8 results showed that tanshinone IIA can significantly inhibit A549 cell proliferation in a dose- and time-dependent manner. Flow cytometry results showed that the apoptosis rate of tested group was higher than the vehicle control, and tanshinone IIA-treated cells accumulated at the S phase, which was higher than the vehicle control. Furthermore, the expression of VEGF and VEGFR2 was decreased in Western blot Finally, molecular docking analysis revealed that tanshinone IIA could be stably docked into the kinase domain of VEGFR2 protein with its unique modes to form H-bonds with Cys917 and pi-pi stacking interactions with Va1848. In conclusion, tanshinone IIA may suppress A549 proliferation, induce apoptosis and cell cycle arrest at the S phase. This drug may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
文摘Two things come to mind when we,salivating,recall Veg Tables.First,roses,because the vegetarian cafe serves pink glasses of rose-and-beet-infused water on the fourth floor of florist-meets-clothing-boutique Goelia 225.Second,photography,since the historic qilou was once a happening portrait studio on Beijing Lu(and because we made a lot of Instagram art during our first trip).
