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A new multi-DOF envelope forming process for fabricating spiral bevel gears with back taper tooth 被引量:1
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作者 Xinghui HAN Yanhui WANG +3 位作者 Lin HUA Wuhao ZHUANG Fangyan ZHENG Wei FENG 《Chinese Journal of Aeronautics》 2025年第1期568-585,共18页
Spiral bevel gears are critical transmission components,and are widely used in the aerospace field.This paper proposes a new multi-DOF envelope forming process for fabricating spiral bevel gears.Firstly,the multi-DOF ... Spiral bevel gears are critical transmission components,and are widely used in the aerospace field.This paper proposes a new multi-DOF envelope forming process for fabricating spiral bevel gears.Firstly,the multi-DOF envelope forming principle of spiral bevel gears is proposed.Secondly,the design methods for the envelope tool geometry and movement are proposed based on the envelope geometry and movement relationships.Thirdly,the metal flow and tooth filling laws are revealed through 3D FE simulation of the multi-DOF envelope forming process of a typical spiral bevel gear.Fourthly,a new method for separating the envelope tool and the formed spiral bevel gear with back taper tooth is proposed to avoid their interference.Finally,experiments on multi-DOF envelope forming of this typical spiral bevel gear are conducted using new heavy load multi-DOF envelope forming equipment.The simulation and experimental results show the feasibility of the proposed multi-DOF envelope forming process for fabricating spiral bevel gears with back taper tooth and the corresponding process design methods. 展开更多
关键词 Multi-DOF envelope forming Spiral bevel gear Back taper tooth Metal flow Process design
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JCMT observations of CO, SO_(2), and a U-line in circumstellar envelopes of four O-rich AGB stars
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作者 Yanan Feng Xiaohu Li +4 位作者 Sheng-Li Qin Tom J.Millar Ryszard Szczerba Zhenzhen Miao Juan Tuo 《Chinese Physics B》 2025年第6期693-699,共7页
The circumstellar envelopes(CSE) of asymptotic giant branch(AGB) stars are abundant in molecular emissions, offering valuable insights into the physical and chemical conditions of these evolving stars. In this paper, ... The circumstellar envelopes(CSE) of asymptotic giant branch(AGB) stars are abundant in molecular emissions, offering valuable insights into the physical and chemical conditions of these evolving stars. In this paper, we report observations of two molecules(CO and SO_(2)) toward four O-rich AGB stars using the James Clerk Maxwell Telescope(JCMT). We detected an unusual SO_(2) spectral feature comprising both broad and narrow components in IK Tau and AP Lyn. The broad line profiles may originate from thermal molecular emission, while the narrow profiles could come from other species(or masers) or astrophysical phenomena occurring within the CSEs of the AGB stars, such as episodic mass loss, bipolar outflows, or emissions associated with the complex physical processes near the central star. The narrow lines of SO_(2) may also arise from vibrationally excited emissions. Additionally, we observed the same U-line in both TX Cam and IK Tau, which may originate from the molecule N^(17)O. We analyzed the identified molecular lines using rotational diagrams to determine their excitation temperatures, column densities, and fractional abundances. This information aids in the constructing of reliable astrochemical models for a more detailed examination of the target stars. The narrow component of the SO_(2) line suggests unusual astrophysical phenomena, making IK Tau and AP Lyn particularly intriguing for further investigation to fully understand the physical processes at play in these sources. 展开更多
关键词 asymptotic giant branch circumstellar envelopes SO_(2)
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Flight envelope constrained UAV shipboard landing control within an identified quiescent period
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作者 Cheng ZHANG Tao SONG +1 位作者 Hong TAO Tao JIANG 《Chinese Journal of Aeronautics》 2025年第8期498-511,共14页
UAV shipboard landing poses significant challenges in terms of safety and efficiency,due to the oscillatory ship motion caused by wave interactions and wind gusts,especially in rough sea states.To solve this issue,a f... UAV shipboard landing poses significant challenges in terms of safety and efficiency,due to the oscillatory ship motion caused by wave interactions and wind gusts,especially in rough sea states.To solve this issue,a flight envelope constrained fixed-time control strategy is proposed to achieve a reliable UAV landing on a maneuvering ship.Firstly,a sliding data window autoregressive model is designed to predict the ship's roll and pitch motions,which are accordingly utilized to identify an appropriate quiescent period for safe landing.Subsequently,a barrier-function-based nonsingular terminal sliding mode controller is developed to eliminate the tracking errors within the identified quiescent period,while ensuring the errors remain bounded to satisfy flight envelope constraints.In particular,lumped disturbance components are estimated by integrating a fixed-time disturbance observer and compensated in the controller.The key advantage of the proposed approach is that it well balances the control requirements between precise landing position and safe landing attitude,guaranteeing both steady-state performance and transient behavior of the tracking error.Finally,comparative Gazebo simulations in different sea state scenarios are conducted to verify the satisfactory control performance. 展开更多
关键词 Unmanned aerial vehicle Shipboard landing Ship motion prediction Flight envelope Sliding mode control
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Adjusting Accuracy of Digital Image Correlation Through Variable Subsets and Application in Airship Envelope
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作者 ZHU Fangtao VWANG Quanbao +1 位作者 XIE Weicheng DUAN Dengping 《Journal of Shanghai Jiaotong university(Science)》 2025年第2期239-251,共13页
The stratospheric airship is affected by harsh conditions in the stratosphere environment.To ensure the safety of the airship,it is necessary to detect the material state of the airship envelope.Since digital image co... The stratospheric airship is affected by harsh conditions in the stratosphere environment.To ensure the safety of the airship,it is necessary to detect the material state of the airship envelope.Since digital image correlation possesses non-contact strain measurement ability,this paper explores the infuence of different shapes of the subset on measurement accuracy.Through the results,it is found that increasing the aspect ratio of subsets can improve the strain accuracy measured in the c-direction,and reducing the aspect ratio can improve the strain accuracy measured in the y-direction.This trend becomes more obvious as the strain increases.Based on this discovery,a subset adaptive algorithm is proposed.The feasibility of the algorithm is verified by experiments,and the precision of strain measurement can be effectively improved by adjusting the threshold value.Therefore,the algorithm can be utilized to increase the measurement accuracy in the larger strain direction without changing the size of the subset. 展开更多
关键词 shape of subset digital image correlation strain of airship envelope self-adaptive selection
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Comparative Studies on the Fine Structure and Elemental Composition of Envelopes of Trachelomonas and Strombomonas (Euglenophyta) 被引量:1
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作者 王全喜 刘洪家 +3 位作者 于晶 孙世琴 张大维 包文美 《Acta Botanica Sinica》 CSCD 2003年第5期601-607,共7页
Fine structure and elemental composition of envelopes of 10 taxa of Trachelomonas and Strombomonas from natural freshwater bodies in China were studied and phylogeny of both genera were discussed. The results indicate... Fine structure and elemental composition of envelopes of 10 taxa of Trachelomonas and Strombomonas from natural freshwater bodies in China were studied and phylogeny of both genera were discussed. The results indicate that iron (Fe) and silicon (Si) are the primary mineral elements of the envelopes. Composition of mineral elements was uncorrelated with envelope color, however, it was highly correlated with the microarchitecture of the envelopes. Content of Si was higher than that of Fe in all species of Strombomonas and some species of Trachelomonas with rough surface. In most species of Trachelomonas, especially those with dense and smoothy surface, content of Fe was higher than that of Si. Based on the above results, we propose to assign those species of Strombomonas into Trachelomonas and consider them as a group of the latter. These species were the most primitive among the group with envelopes in Euglenaceae. 展开更多
关键词 Trachelomonas Strombomonas envelope elemental composition fine structure
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Elastic envelope inversion using multicomponent seismic data with filtered-out low frequencies 被引量:2
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作者 黄超 董良国 迟本鑫 《Applied Geophysics》 SCIE CSCD 2015年第3期362-377,467,共17页
The absence of low-frequency information in seismic data is one of the most difficult problems in elastic full waveform inversion. Without low-frequency data, it is difficult to recover the long-wavelength components ... The absence of low-frequency information in seismic data is one of the most difficult problems in elastic full waveform inversion. Without low-frequency data, it is difficult to recover the long-wavelength components of subsurface models and the inversion converges to local minima. To solve this problem, the elastic envelope inversion method is introduced. Based on the elastic envelope operator that is capable of retrieving low- frequency signals hidden in multicomponent data, the proposed method uses the envelope of multicomponent seismic signals to construct a misfit function and then recover the long- wavelength components of the subsurface model. Numerical tests verify that the elastic envelope method reduces the inversion nonlinearity and provides better starting models for the subsequent conventional elastic full waveform inversion and elastic depth migration, even when low frequencies are missing in multicomponent data and the starting model is far from the true model. Numerical tests also suggest that the proposed method is more effective in reconstructing the long-wavelength components of the S-wave velocity model. The inversion of synthetic data based on the Marmousi-2 model shows that the resolution of conventional elastic full waveform inversion improves after using the starting model obtained using the elastic envelope method. Finally, the limitations of the elastic envelope inversion method are discussed. 展开更多
关键词 elastic wave multicomponent data elastic envelope full waveform inversion
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Injective Envelopes of a Hilbert C~*Module
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作者 许天周 蔡涛 李炳照 《Journal of Beijing Institute of Technology》 EI CAS 2001年第2期119-124,共6页
As in homology, the notion of injectivity is introduced in the category whose objects are Hilbert C * module over a C * algebra and whose morphism are bounded module operators. The definition of injective envelope... As in homology, the notion of injectivity is introduced in the category whose objects are Hilbert C * module over a C * algebra and whose morphism are bounded module operators. The definition of injective envelopes of an extension of a Hilbert C * modules over a C * algebra is introduced, and is characterized in terms of the injectivity and essence. It is shown that every Hilbert C * module has a unique (up to H isometrics) injective envelope if it exists. It is also shown that an extension of a Hilbert C * module is an injective envelope if and only if it is an injective and essential extension. Moreover, every Hilbert C * module over a W * algebra has a unique (up to H isometrics) injective envelope and the injective envelope of a Hilbert C * module H is maximal essential extension of H . 展开更多
关键词 C * algebra Hilbert C * module injective envelope
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INVESTIGATION OF AIR FLOW ON FLIGHT DECK AND SHIPBOARD OPERATION ENVELOPE 被引量:1
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作者 孙文胜 高正 辛宏 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 1995年第1期45-51,共7页
The Shipboard Operation Envelope(SOE) is the safe boundary of the helicopter/ship dynamic interface. The night deck on a ship is usually behind the hangar, where the airflow is turbulent due to the influence of the up... The Shipboard Operation Envelope(SOE) is the safe boundary of the helicopter/ship dynamic interface. The night deck on a ship is usually behind the hangar, where the airflow is turbulent due to the influence of the upper structure, wind and ship speed. The turbulent airnow is the major adverse factor for the safety of shipboard operations. In this paper, the night deck abbot is analysed as the superposition of two penyndicular 2-D airflows.N-S equations are used to calculate the velocity field and the range of turbulent airflow using finite element method. The result is correspondent well with test. Incorporating the influence of the airflow and giving some restrictions on the movements of the ship and on the control margin of the helicopter, the operation envelopes are calculated. The operation envelopes include three types for hovering over the deck, taking-off from and landing on ship, and landing with a landing-aid system. These results are helpful to the pilot training and night safety. 展开更多
关键词 HELICOPTER now field finite element operation envelope RESTRICTION
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Implementation of Envelope Analysis on a Wireless Condition Monitoring System for Bearing Fault Diagnosis 被引量:30
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作者 Guo-Jin Feng James Gu +3 位作者 Dong Zhen Mustafa Aliwan Feng-Shou Gu Andrew D.Ball 《International Journal of Automation and computing》 EI CSCD 2015年第1期14-24,共11页
Envelope analysis is an effective method for characterizing impulsive vibrations in wired condition monitoring(CM)systems. This paper depicts the implementation of envelope analysis on a wireless sensor node for obtai... Envelope analysis is an effective method for characterizing impulsive vibrations in wired condition monitoring(CM)systems. This paper depicts the implementation of envelope analysis on a wireless sensor node for obtaining a more convenient and reliable CM system. To maintain CM performances under the constraints of resources available in the cost effective Zigbee based wireless sensor network(WSN), a low cost cortex-M4 F microcontroller is employed as the core processor to implement the envelope analysis algorithm on the sensor node. The on-chip 12 bit analog-to-digital converter(ADC) working at 10 k Hz sampling rate is adopted to acquire vibration signals measured by a wide frequency band piezoelectric accelerometer. The data processing flow inside the processor is optimized to satisfy the large memory usage in implementing fast Fourier transform(FFT) and Hilbert transform(HT). Thus, the envelope spectrum can be computed from a data frame of 2048 points to achieve a frequency resolution acceptable for identifying the characteristic frequencies of different bearing faults. Experimental evaluation results show that the embedded envelope analysis algorithm can successfully diagnose the simulated bearing faults and the data transmission throughput can be reduced by at least 95% per frame compared with that of the raw data, allowing a large number of sensor nodes to be deployed in the network for real time monitoring. 展开更多
关键词 Wireless sensor network(WSN) envelope analysis fault diagnosis local processing Hilbert transformation
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Rolling Bearing Feature Frequency Extraction using Extreme Average Envelope Decomposition 被引量:4
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作者 SHI Kunju LIU Shulin +1 位作者 JIANG Chao ZHANG Hongli 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2016年第5期1029-1036,共8页
The vibration signal contains a wealth of sensitive information which reflects the running status of the equipment. It is one of the most important steps for precise diagnosis to decompose the signal and extracts the ... The vibration signal contains a wealth of sensitive information which reflects the running status of the equipment. It is one of the most important steps for precise diagnosis to decompose the signal and extracts the effective information properly. The traditional classical adaptive signal decomposition method, such as EMD, exists the problems of mode mixing, low decomposition accuracy etc. Aiming at those problems, EAED(extreme average envelope decomposition) method is presented based on EMD. EAED method has three advantages. Firstly, it is completed through midpoint envelopment method rather than using maximum and minimum envelopment respectively as used in EMD. Therefore, the average variability of the signal can be described accurately. Secondly, in order to reduce the envelope errors during the signal decomposition, replacing two envelopes with one envelope strategy is presented. Thirdly, the similar triangle principle is utilized to calculate the time of extreme average points accurately. Thus, the influence of sampling frequency on the calculation results can be significantly reduced. Experimental results show that EAED could separate out single frequency components from a complex signal gradually. EAED could not only isolate three kinds of typical bearing fault characteristic of vibration frequency components but also has fewer decomposition layers. EAED replaces quadratic enveloping to an envelope which ensuring to isolate the fault characteristic frequency under the condition of less decomposition layers. Therefore, the precision of signal decomposition is improved. 展开更多
关键词 adaptive signal decomposition extreme average envelope decomposition EMD fault diagnosis
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Recent advances in the study of active endogenous retrovirus envelope glycoproteins in the mammalian placenta 被引量:2
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作者 Yufei Zhang Jing Shi Shuying Liu 《Virologica Sinica》 SCIE CAS CSCD 2015年第4期239-248,共10页
Endogenous retroviruses(ERVs) are a component of the vertebrate genome and originate from exogenous infections of retroviruses in the germline of the host. ERVs have coevolved with their hosts over millions of years. ... Endogenous retroviruses(ERVs) are a component of the vertebrate genome and originate from exogenous infections of retroviruses in the germline of the host. ERVs have coevolved with their hosts over millions of years. Envelope glycoproteins of endogenous retroviruses are often expressed in the mammalian placenta, and their potential function has aroused considerable research interest, including the manipulation of maternal physiology to benefit the fetus. In most mammalian species, trophoblast fusion in the placenta is an important event, involving the formation of a multinucleated syncytiotrophoblast layer to fulfill essential fetomaternal exchange functions. The key function in this process derives from the envelope genes of endogenous retroviruses, namely syncytins, which show fusogenic properties and placenta-specific expression. This review discusses the important role of the recognized endogenous retrovirus envelope glycoproteins in the mammalian placenta. 展开更多
关键词 envelope GLYCOPROTEIN ENDOGENOUS RETROVIRUS placen
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Design of a memory polynomial predistorter for wideband envelope tracking amplifiers 被引量:5
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作者 Jing Zhang Songbai He Lu Gan 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2011年第2期193-199,共7页
Efficiency and linearity of the microwave power amplifier are critical elements for mobile communication systems. A memory polynomial baseband predistorter based on an indirect learning architecture is presented for i... Efficiency and linearity of the microwave power amplifier are critical elements for mobile communication systems. A memory polynomial baseband predistorter based on an indirect learning architecture is presented for improving the linearity of an envelope tracing (ET) amplifier with application to a wireless transmitter. To deal with large peak-to-average ratio (PAR) problem, a clipping procedure for the input signal is employed. Then the system performance is verified by simulation results. For a single carrier wideband code division multiple access (WCDMA) signal of 16-quadrature amplitude modulation (16-QAM), about 2% improvement of the error vector magnitude (EVM) is achieved at an average output power of 45.5 dBm and gain of 10.6 dB, with adjacent channel leakage ratio (ACLR) of -64.55 dBc at offset frequency of 5 MHz. Moreover, a three-carrier WCDMA signal and a third-generation (3G) long term evolution (LTE) signal are used as test signals to demonstrate the performance of the proposed linearization scheme under different bandwidth signals. 展开更多
关键词 envelope tracking memory polynomial predistorter indirect learning architecture power amplifier memory effects.
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Envelope函数与Chebyshev滤波的滚动轴承故障诊断
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作者 尹学慧 黄晋英 +2 位作者 张占一 侯尧花 郝高岩 《组合机床与自动化加工技术》 北大核心 2019年第4期116-119,128,共5页
为了更有效的提取变工况下滚动轴承的故障特征,抑制振动信号中由转速或载荷波动引起的趋势项。文章针对变工况条件下的滚动轴承故障诊断,提出了一种基于Envelope函数与包络阶次谱的变工况下滚动轴承故障诊断。在传统的故障诊断方法中,... 为了更有效的提取变工况下滚动轴承的故障特征,抑制振动信号中由转速或载荷波动引起的趋势项。文章针对变工况条件下的滚动轴承故障诊断,提出了一种基于Envelope函数与包络阶次谱的变工况下滚动轴承故障诊断。在传统的故障诊断方法中,求某一信号包络时用的最多的是希尔伯特变换,但并不是希尔伯特变换适用于所有信号包络的情况。文章运用契比雪夫滤波方法提高信号中的信噪比,为避免转速升降、波动或载荷变化引起的趋势项对测试信号的影响,用Envelope函数计算信号包络。通过仿真数据和实验数据分析表明基于Envelope函数的包络能更有效的计算出变工况下调幅信号中的调制阶次,用切比雪夫波滤波可以使得变工况下信号中故障特征阶次更加明显,更有利于故障识别,为变工况下的机械故障诊断提供参考。 展开更多
关键词 envelope函数 故障诊断 包络阶次谱 切比雪夫
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Nuclear Envelope Protein MAN1 Regulates the Drosophila Circadian Clock via Period 被引量:2
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作者 Bei Bu Weiwei He +1 位作者 Li Song Luoying Zhang 《Neuroscience Bulletin》 SCIE CAS CSCD 2019年第6期969-978,共10页
Almost all organisms exhibit ~24-h rhythms, or circadian rhythms, in a plentitude of biological processes.These rhythms are driven by endogenous molecular clocks consisting of a series of transcriptional and translati... Almost all organisms exhibit ~24-h rhythms, or circadian rhythms, in a plentitude of biological processes.These rhythms are driven by endogenous molecular clocks consisting of a series of transcriptional and translational feedback loops. Previously, we have shown that the inner nuclear membrane protein MAN1 regulates this clock and thus the locomotor rhythm in flies, but the mechanism remains unclear. Here, we further confirmed the previous findings and found that knocking down MAN1 in the pacemaker neurons of adult flies is sufficient to lengthen the period of the locomotor rhythm. Molecular analysis revealed that knocking down MAN1 led to reduced m RNA and protein levels of the core clock gene period(per),likely by reducing its transcription. Over-expressing per rescued the long period phenotype caused by MAN1 deficiency whereas per mutation had an epistatic effect on MAN1, indicating that MAN1 sets the pace of the clock by targeting per. 展开更多
关键词 Circadian clock DROSOPHILA Nuclear envelope MAN1 PERIOD
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Virus entry mediated by hepatitis B virus envelope proteins 被引量:2
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作者 John M Taylor 《World Journal of Gastroenterology》 SCIE CAS 2013年第40期6730-6734,共5页
Hepatitis B virus(HBV),a major cause of human liver disease worldwide,encodes three envelope proteins needed for the attachment and entry of the virus into susceptible host cells.A second virus,hepatitis delta virus,w... Hepatitis B virus(HBV),a major cause of human liver disease worldwide,encodes three envelope proteins needed for the attachment and entry of the virus into susceptible host cells.A second virus,hepatitis delta virus,which is known to enhance liver disease in HBV infected patients,diverts the same HBV envelope proteins to achieve its own assembly and infection.In the lab,lentiviral vectors based on human immunodeficiency virus type 1 can be assembled using the HBV envelope proteins,and will similarly infect susceptible cells.This article provides a partial review and some personal reflections of how these three viruses infect and of how recipient cells become susceptible,along with some consideration of questions that remain to be answered. 展开更多
关键词 HEPATITIS B VIRUS HEPATITIS delta VIRUS Receptor envelope PROTEINS ENTRY
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Equatorial Envelope Rossby Solitions in a Shear Flow 被引量:2
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作者 赵强 付遵涛 刘式适 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2001年第3期418-428,共11页
A simple shallow-water model on an equatorial β-plane is employed to investigate the nonlinear equatorial Rossby solitons in a mean zonal flow with meridional shear by the asymptotic method of multiple scales. The cu... A simple shallow-water model on an equatorial β-plane is employed to investigate the nonlinear equatorial Rossby solitons in a mean zonal flow with meridional shear by the asymptotic method of multiple scales. The cubic nonlinear Schr?dinger (NLS, for short) equation, satisfied for large amplitude equatorial envelope Rossby solitons in shear basic flow, is derived. The effects of basic flow shear on the nonlinear equatorial Rossby solitons are also analyzed. Key words Envelope solitons - NLS This work was supported by the Foundation for University Key Teacher by the Ministry of Education. 展开更多
关键词 envelope solitons NLS
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Constant envelope FrFT OFDM: spectral and energy efficiency analysis 被引量:3
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作者 DIDA Mussa Ally HUAN Hao +2 位作者 TAO Ran WANG Teng URYNBASSAROVA Didar 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2019年第3期467-473,共7页
Constant envelope with a fractional Fourier transformorthogonal frequency division multiplexing(CE-FrFT-OFDM)is a special case of a constant envelope OFDM(CE-OFDM),both being energy efficient wireless communication te... Constant envelope with a fractional Fourier transformorthogonal frequency division multiplexing(CE-FrFT-OFDM)is a special case of a constant envelope OFDM(CE-OFDM),both being energy efficient wireless communication techniques with a 0 dB peak to average power ratio(PAPR).However,with the proper selection of fractional order,the first technique has a high bit error rate(BER)performance in the frequency-time selective channels.This paper performs further analysis of CE-FrFT-OFDM by examining its spectral efficiency(SE)and energy efficiency(EE)and compare to the famous OFDM and FrFT-OFDM techniques.Analytical and comprehensive simulations conducted show that,the CE-FrFT-OFDM has five times the EE of OFDM and FrFT-OFDM systems with a slightly less SE.Increasing CE-FrFT-OFDM’s transmission power by increasing its amplitude to 1.7 increases its SE to match that of the OFDM and FrFT-OFDM systems while slightly reducing its EE by 20%to be four times that of OFDM and FrFTOFDM systems.OFDM and FrFT-OFDM’s amplitude fluctuations cause rapid changing output back-off(OBO)power requirements and further reduce power amplifier(PA)efficiency while CE-FrFTOFDM stable operational linear range makes it a better candidate and outperforms the other techniques when their OBO exceeds 1.7.Higher EE and low BER in time-frequency selective channel are attracting features for CE-FrFT-OFDM deployment in mobile devices. 展开更多
关键词 FRACTIONAL FOURIER transform (FrFT) constant envelope SPECTRAL EFFICIENCY (SE) energy EFFICIENCY (EE) high power amplifier
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Development of Neutralizing Antibodies against Zika Virus Based on Its Envelope Protein Structure 被引量:2
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作者 Chunpeng Yang Rui Gong Natalia de Val 《Virologica Sinica》 SCIE CAS CSCD 2019年第2期168-174,共7页
As we know more about Zika virus(ZIKV), as well as its linkage to birth defects(microcephaly) and autoimmune neurological syndromes, we realize the importance of developing an efficient vaccine against it. Zika virus ... As we know more about Zika virus(ZIKV), as well as its linkage to birth defects(microcephaly) and autoimmune neurological syndromes, we realize the importance of developing an efficient vaccine against it. Zika virus disease has affected many countries and is becoming a major public health concern. To deal with the infection of ZIKV, plenty of experiments have been done on selection of neutralizing antibodies that can target the envelope(E) protein on the surface of the virion. However, the existence of antibody-dependent enhancement(ADE) effect might limit the use of them as therapeutic candidates. In this review, we classify the neutralizing antibodies against ZIKV based on the epitopes and summarize the resolved structural information on antibody/antigen complex from X-ray crystallography and cryo-electron microscopy(cryo-EM), which might be useful for further development of potent neutralizing antibodies and vaccines toward clinical use. 展开更多
关键词 Zika VIRUS (ZIKV envelope protein NEUTRALIZING ANTIBODY X-ray CRYSTALLOGRAPHY Cryo-electron microscopy (cryo-EM)
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Pepper mild mottle virus coat protein interacts with pepper chloroplast outer envelope membrane protein OMP24 to inhibit antiviral immunity in plants 被引量:5
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作者 Kelei Han Hongying Zheng +11 位作者 Dankan Yan Huijie Zhou Zhaoxing Jia Yushan Zhai Jian Wu Yuwen Lu Guanwei Wu Shaofei Rao Jianping Chen Jiejun Peng Rende Qi Fei Yan 《Horticulture Research》 SCIE CSCD 2023年第5期16-28,共13页
Pepper mild mottle virus(PMMoV)is a devastating viral pathogen of pepper(Capsicum annuum)but it is unclear whether and how peppers protect against PMMoV infection.The expression of the chloroplast outer membrane prote... Pepper mild mottle virus(PMMoV)is a devastating viral pathogen of pepper(Capsicum annuum)but it is unclear whether and how peppers protect against PMMoV infection.The expression of the chloroplast outer membrane protein 24(OMP24)of C.annuum was upregulated under PMMoV infection and it interacted with PMMoV coat protein(CP).Silencing of OMP24 in either C.annuum or Nicotiana benthamiana facilitated PMMoV infection,whereas overexpression of N.benthamiana OMP24 in transgenic plants inhibited PMMoV infection.Both C.annuum OMP24(CaOMP24)and N.benthamiana OMP24(NbOMP24)localized to the chloroplast and have a moderately hydrophobic transmembrane domain that is necessary for their localization.Overexpression of CaOMP24 induced stromules,perinuclear chloroplast clustering,and accumulation of reactive oxygen species(ROS),the typical defense responses of chloroplasts transferring the retrograde signaling to the nucleus to regulate resistance genes.The expression of PR1 and PR2 was also upregulated significantly in plants overexpressing OMP24.Self-interaction of OMP24 was demonstrated and was required for OMP24-mediated plant defense.Interaction with PMMoV CP interfered with the self-interaction of OMP24 and impaired OMP24-induced stromules,perinuclear chloroplast clustering and ROS accumulation.The results demonstrate the defense function of OMP24 in pepper during viral infection and suggest a possible mechanism by which PMMoV CP modulates the plant defense to facilitate viral infection. 展开更多
关键词 outer IMMUNITY envelope
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THE NOVEL ANNULAR ENVELOPE CYLINDRICAL WORM AND FUZZY OPTIMAL DESIGN OF ITS DRIVE
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作者 李秀梅 李贵涛 +2 位作者 程福安 张鹏程 王树人 《Transactions of Tianjin University》 EI CAS 1997年第1期35-39,共5页
The cylindrical worm processed by annular grinding wheel envelope in two degree of freedom motion state is a novel worm. This paper explains the shaping principle of such a worm. To improve meshing quality and the p... The cylindrical worm processed by annular grinding wheel envelope in two degree of freedom motion state is a novel worm. This paper explains the shaping principle of such a worm. To improve meshing quality and the properties of contact and lubrication, the multi objective optimization has been conducted for the first time to the parameters of such a worm pair by the fuzzy optimal method. The results show that, the shape of the contact line is visibly more sloped than before being optimized, lubrication angle is apparently bigger, and the distribution of contact lines is much improved. 展开更多
关键词 two degree of freedom motion annular grinding wheel envelope multi objective fuzzy optimization
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