BACKGROUND Helicobacter pylori(H.pylori)infection rates have been changing with different populations and geographic areas.Currently,there is still a lack of comprehensive survey data on the H.pylori infection rate an...BACKGROUND Helicobacter pylori(H.pylori)infection rates have been changing with different populations and geographic areas.Currently,there is still a lack of comprehensive survey data on the H.pylori infection rate and its risk factors in the natural population of Xinjiang Uygur Autonomous Region.AIM To understand the H.pylori infection and risk factors in Xinjiang Uygur Autonomous Region for the prevention and control strategies.METHODS This study comprehensively collected the survey data on H.pylori infection in 15 regions of Xinjiang Uygur Autonomous Region by using the method of stratified random cluster sampling.A total of 4361 individuals from the general population were selected as research subjects,and questionnaire surveys and blood tests for H.pylori antibodies were conducted.RESULTS The overall H.pylori infection rate in Xinjiang Uygur Autonomous Region was 70.79%(3087/4361).The H.pylori infection rate showed a trend of first increasing and then decreasing with the increase of age,and the difference was statistically significant(P<0.05).The analysis of the H.pylori infection rates among different ethnic groups showed that the infection rates of ethnic minorities such as Uyghur,Kirgiz,and Tajik were significantly higher than those of Han and Hui ethnic groups,and the difference was statistically significant(P<0.01).Multivariate analysis showed that altitude,regular consumption of beef,mutton,dried nuts,barbecue foods,and drinking river water were positively correlated with the H.pylori infection rate.CONCLUSION This study indicates that the overall H.pylori infection rate in Xinjiang Uygur Autonomous Region is relatively high,with obvious regional and ethnic differences,which are closely related to the sanitation conditions and eating habits.展开更多
We sought to investigate the correlation between the -455G/A and -148C/T polymorphisms of the β-fibrinogen gene and plasma fibrinogen levels in patients with cerebral infarction and in healthy subjects among the Xinj...We sought to investigate the correlation between the -455G/A and -148C/T polymorphisms of the β-fibrinogen gene and plasma fibrinogen levels in patients with cerebral infarction and in healthy subjects among the Xinjiang Uygur and Han Chinese populations, by using polymerase chain reaction-restriction enzyme digestion analysis. Results showed that there were no statistically significant differences in the distributions of the -455G/A genotype and allele frequency between the Uygurs and the Han. Plasma fibrinogen levels in cerebral infarction patients among the Uygurs and the Han were higher than those among healthy subjects. In particular, the frequencies of the -455G/A AA and -148C/T TT genotypes were significantly higher than in healthy subjects. Individuals carrying the A or T allele had a higher incidence of cerebral infarction compared with those carrying the G or C allele. Our experimental findings indicate that the -148C/T and -455G/A polymorphisms are associated with cerebral infarction in Xinjiang Uygur and Han Chinese subjects. The susceptibility- conferring alleles are -148T and -455A, and the susceptibility-conferring genotype is -455G/A ＋ AA.展开更多
The Getah virus(GETV),a mosquito-borne RNA virus,is widely distributed in Oceania and Asia.GETV is not the only pathogenic to horses,pigs,cattle,foxes and boars,but it can also cause fever in humans.Since its first re...The Getah virus(GETV),a mosquito-borne RNA virus,is widely distributed in Oceania and Asia.GETV is not the only pathogenic to horses,pigs,cattle,foxes and boars,but it can also cause fever in humans.Since its first reported case in Chinese mainland in 2017,the number of GETV-affected provinces has increased to seventeen till now.Therefore,we performed an epidemiologic investigation of GETV in the Xinjiang region,located in northwestern China,during the period of 2017-2020.ELISA was used to analyze 3299 serum samples collected from thoroughbred horse,local horse,sheep,goat,cattle,and pigs,with thoroughbred horse(74.8%),local horse(67.3%),goat(11.7%),sheep(10.0%),cattle(25.1%)and pigs(51.1%)being positive for anti-GETV antibodies.Interestingly,the neutralizing antibody titer in horses was much higher than in other species.Four samples from horses and pigs were positive for GETV according to RT-PCR.Furthermore,from the serum of a local horse,we isolated GETV which was designated as strain XJ-2019-07,and determined its complete genome sequence.From the phylogenetic relationships,it belongs to the Group III lineage.This is the first evidence of GETV associated to domestic animals in Xinjiang.Overall,GETV is prevalent in Xinjiang and probably has been for several years.Since no vaccine against GETV is available in China,detection and monitoring strategies should be improved in horses and pigs,especially imported and farmed,in order to prevent economic losses.展开更多
Kaposi's sarcoma-associated herpesvirus(KSHV) is the infectious etiologic agent associated with Kaposi's sarcoma(KS), primary effusion lymphoma, and multicentric Castleman disease. It has been shown that high ...Kaposi's sarcoma-associated herpesvirus(KSHV) is the infectious etiologic agent associated with Kaposi's sarcoma(KS), primary effusion lymphoma, and multicentric Castleman disease. It has been shown that high KSHV prevalence and high incidence of both classic KS and AIDSassociated KS are found mostly among people of Uygur ethnicity in Xinjiang, while people of Han ethnicity in Xinjiang have a higher KSHV seroprevalence than those of other Han populations in China's Mainland. However, it is still unclear why there is such geographical and population variation in KSHV distribution in China. In this work, we focused on the populations in the Kashgar region and Urumqi area, where a total of 1294 research subjects were randomly selected to investigate the potential correlation between KSHV prevalence and different ethnicities in endemic areas of Xinjiang, and to determine risk factors that may affect KSHV infection rates or KS incidence. We identified a high seroprevalence of KSHV and high peripheral blood DNA infection in the general Uygur and Han populations in both Urumqi and Kashgar regions of Xinjiang, and determined that advancing age, low education level, and stationary population status affect KSHV infection rates. Further, KSHV-positive Uygur participants were shown to have higher prevalence of neutralizing antibodies and neutralizing antibody titers than KSHV-positive Han participants.展开更多
It is not clear how HPV infection is prevalent among Uygur women in Xinjiang Uygur Autonomous Region, China and whether the distribution of HPV infection is related with cervical intraepithelial neoplasia （CIN） inci...It is not clear how HPV infection is prevalent among Uygur women in Xinjiang Uygur Autonomous Region, China and whether the distribution of HPV infection is related with cervical intraepithelial neoplasia （CIN） incidence among them. A study including 883 Uygur women were conducted from 2006 to 2007 in Hetian Prefecture, Xinjiang Uygur Autonomous Region, China.展开更多
This study aimed to test the effects of five single nucleotide polymorphisms within SLC2A9 on uric acid level in a special ethnic population,the Uygurs in Xinjiang,China.According to our inclusion and exclusion criter...This study aimed to test the effects of five single nucleotide polymorphisms within SLC2A9 on uric acid level in a special ethnic population,the Uygurs in Xinjiang,China.According to our inclusion and exclusion criteria,Uygur adults from Xinjiang constituted the study population.There were 1053 Uygur adults with hyperuricemia and 1373 normal Uygur adults who served as controls.Five single nucleotide polymorphisms within SLC2A9(rs938557,rs7679916,rs7349721,rsl3101785,and rs 13137343)were selected with the HapMap dataset and TaqMan assays.We found that,in normouricemia group,rs938557 was significantly correlated with uric acid(β=11.39±3.74,P=0.0024)adjusting for age,gender and BMI;rs7679916 and rsl3137343 were marginally associated with uric acid concentration(β=5.77±3.O9,P=0.0626;p=-5.99±3.08,P=0.0520).In the hyperuricemia group,no SNP was found to possibly influence uric acid concentration.None of these SNPs showed significant association with hyperuricemia after controlling for age,gender and BMI.There were significant or marginal correlations between certain single nucleotide polymorphisms in the SLC2A9 region and uric acid concentration in Uygur normouricemia samples.In turn,some of these single nucleotide polymorphisms in SLC2A9 may increase the risk of hyperuricemia.展开更多
BACKGROUND：Matrix metalloproteinase-9 （MMP-9） plays a pivotal role in early atherosclerosis, vascular remodeling and development of atherosclerotic lesion. The potentially functional MMP-9 gene polymorphism may con...BACKGROUND：Matrix metalloproteinase-9 （MMP-9） plays a pivotal role in early atherosclerosis, vascular remodeling and development of atherosclerotic lesion. The potentially functional MMP-9 gene polymorphism may contribute to the susceptibility of acute coronary syndrome （ACS）. This study aimed to investigate the association between two single nucleotide polymorphisms （-1562C〉T, R279Q） of the MMP-9 gene in patients with ACS in the Uygur population of China. METHODS：This case-control study was composed of 361 ACS patients and 432 control subjects, who had undergone coronary angiography. Among the ACS patients, 162 （44.9%） had single-vessel disease, 145 （40.2%） had two-vessel disease, and 54 （14.9%） had three-vessel disease. The genotypes of the two selected SNPs were determined by the method of polymerase chain reaction and restriction fragment length polymorphism （RFLP-PCR）. The relationship between the polymorphism of the MMP-9 gene and the severity of coronary arterial stenosis was analyzed.RESULTS： Analysis of the two SNPs showed that the frequency of CT and TT genotypes in patients with ACS was significantly higher than that in the control group （ACS vs. controls; CT＋TT： 25.5% vs. 15.8%, P=0.001）. And the -1562 gene allele （C/T） was significantly associated with acute coronary syndrome （ACS vs. controls; C allele： 85.7% vs. 91.5%, T allele： 14.3% vs. 8.5%, P〈0.001）. But the frequencies of CT＋TT and CC genotypes were not statistically different among ACS patients with one, two and three or more significantly diseased vessels （P=0.55）. The R279Q polymorphism site with regard to the association with ACS was not significant （P〉0.05）. The presence of CT or TT genotypes, assuming codominant effect of the T allele, was independently associated with increased risk of coronary artery disease when adjustment was made for age, body mass index, smoking, hypertension and diabetes mellitus [odds ratio=1.737 （95% confidence interval, 1.337-2.257）, P=0.018]. CONCLUSIONS： MMP-9-1562C〉T polymorphism is associated with the susceptibility to ACS in the Uygur population of China. However, this mutation apparently is not related to the severity of coronary arterial stenosis. Another SNP （R279Q） polymorphism of MMP-9 is not significantly associated with the risk of ACS.展开更多
Spatial interpolation methods are frequently used to estimate values of meteorological data in locations where they are not measured. However, very little research has been investigated the relative performance of dif...Spatial interpolation methods are frequently used to estimate values of meteorological data in locations where they are not measured. However, very little research has been investigated the relative performance of different interpolation methods in meteorological data of Xinjiang Uygur Autonomous Region (Xinjiang). Actually, it has importantly practical significance to as far as possibly improve the accuracy of interpolation results for meteorological data, especially in mountainous Xinjiang. There- fore, this paper focuses on the performance of different spatial interpolation methods for monthly temperature data in Xinjiang. The daily observed data of temperature are collected from 38 meteorological stations for the period 1960- 2004. Inverse distance weighting (IDW), ordinary kriging (OK), temperature lapse rate method (TLR) and multiple linear regressions (MLR) are selected as interpolated methods. Two rasterized methods, multiple regression plus space residual error and directly interpolated observed temperature (DIOT) data, are used to analyze and compare the performance of these interpolation methods respectively. Moreover, cross-validation is used to evaluate the performance of different spatial interpolation methods. The results are as follows: 1) The method of DIOT is unsuitable for the study area in this paper. 2) It is important to process the observed data by local regression model before the spatial interpolation. 3) The MLR-IDW is the optimum spatial interpolation method for the monthly mean temperature based on cross-validation. For the authors, the reliability of results and the influence of measurement accuracy, density, distribution and spatial variability on the accuracy of the interpolation methods will be tested and analyzed in the future.展开更多
AIM:To investigate the incidence of gastroesophageal reflux disease(GERD) and its related risk factors in Uygur and Han Chinese adult in Urumqi,China.METHODS:A population-based cross-sectional survey was undertaken in...AIM:To investigate the incidence of gastroesophageal reflux disease(GERD) and its related risk factors in Uygur and Han Chinese adult in Urumqi,China.METHODS:A population-based cross-sectional survey was undertaken in a total of 972 Uygur(684 male and 288 female) aged from 24 to 61 and 1023 Han Chinese(752 male and 271 female) aged from 23 to 63 years.All participants were recruited from the residents who visited hospital for health examination from November 2011 to May 2012.Each participant signed an informed consent and completed a GERD questionnaire(GerdQ) and a lifestyle-food frequency questionnaire survey.Participants whose Gerd Q score was ≥ 8 and met one of the following requirements would be enrolled into this research:(1) being diagnosed with erosive esophagitis(EE) or Barrett's esophagus(BE) by endoscopy;(2) negative manifestation under endoscopy(non-erosive reflux disease,NERD) with abnormal acid reflux revealed by 24-h esophageal pH monitoring;and(3) suffering from typical heartburn and regurgitation with positive result of proton pump inhibitor test.RESULTS:According to Gerd Q scoring criteria,340 cases of Uygur and 286 cases of Han Chinese were defined as GERD.GERD incidence in Uygur was significantly higher than in Han Chinese(35% vs 28%,χ2 = 11.09,P < 0.005),Gerd Q score in Uygur was higher than in Han Chinese(7.85 ± 3.1 vs 7.15 ± 2.9,P < 0.005),and Gerd Q total score in Uygur male was higher than in female(8.15 ± 2.8 vs 6.85 ± 2.5,P < 0.005).According to normalized methods,304(31%) cases of Uygur were diagnosed with GERD,including 89 cases of EE,185 cases of NERD and 30 cases of BE;256(25%) cases of Han Chinese were diagnosed with GERD,including 90 cases of EE,140 cases of NERD and 26 cases of BE.GERD incidence in Uygur was significantly higher than in Han Chinese(31% vs 25%,χ2 = 9.34,P < 0.005) while the incidences were higher in males of both groups than in females(26% vs 5% in Uygur,χ2 = 35.95,P < 0.005,and 19.8% vs 5.2% in Han,χ2 = 5.48,P < 0.025).GERD incidence in Uygur male was higher than in Han Chinese male(26% vs 19.8%,χ2 = 16.51,P < 0.005),and incidence of NERD in Uygur was higher than in Han Chinese(χ2 = 10.06,P < 0.005).Occupation(r = 0.623),gender(r = 0.839),smoking(r = 0.322),strong tea(r = 0.658),alcohol drinking(r = 0.696),meat-based diet(mainly meat)(r = 0.676) and body mass index(BMI)(r = 0.567) were linearly correlated with GERD in Uygur(r = 0.833,P = 0.000);while gender(r = 0.957),age(r = 0.016),occupation(r = 0.482),strong tea(r = 1.124),alcohol drinking(r = 0.558),meat diet(r = 0.591) and BMI(r = 0.246) were linearly correlated with GERD in Han Chinese(r = 0.786,P = 0.01).There was no significant difference between Gerd Q scoring and three normalized methods for the diagnosis of GERD.CONCLUSION:GERD is highly prevalent in adult in Urumqi,especially in Uygur.Male,civil servant,smoking,strong tea,alcohol drinking,meat diet and BMI are risk factors correlated to GERD.展开更多
Evaluating the prevalence of kidney damage according to population-based studies in different communities has been limited in developing countries.We conducted a population-based screening study in Uygur people of Uru...Evaluating the prevalence of kidney damage according to population-based studies in different communities has been limited in developing countries.We conducted a population-based screening study in Uygur people of Urumqi, aiming to identify the prevalence and associated risk factors of chronic kidney disease (CKD) in Uygur populations.A total of 2576 residents (】18 years) from four districts of Urumqi were interviewed from June 2007 to January 2009 and tested for haematuria, albuminuria and reduced renal function.Associations between age, gender, smoking, diabetes mellitus, hypertension, hyperuricaemia and kidney damage were examined.There were 2576 subjects enrolled in this study.After age correction, the prevalence of albuminuria, haematuria and reduced estimated glomerular filtration rate (eGFR) was 3.58%, 2.26% and 1.03%, respectively.Approximately 5.65% of the sample population had at least one indicator of kidney damage.Age, diabetes mellitus, hypercholesteremia, hyperuricaemia and hyperlipidaemia were independently associated with CKD.In the general Uygur adult population from Urumqi, 5.65% had either proteinuria, haematuria or reduced eGFR, indicating the presence of kidney damage, with an awareness of only 1.05%.The high prevalence and low awareness of CKD in this population suggest an urgent need for CKD prevention programs in Uygur people.展开更多
AIM： To investigate the glutathione-S-transferase M1 （GSTM1） polymorphisms in three Chinese minorities, Kazakh, Uygur, and Tajik; and the pathological significance of GSTM1 polymorphisms in esophageal carcinogenesi...AIM： To investigate the glutathione-S-transferase M1 （GSTM1） polymorphisms in three Chinese minorities, Kazakh, Uygur, and Tajik; and the pathological significance of GSTM1 polymorphisms in esophageal carcinogenesis in Kazakh.METHODS： A total of 1121 blood samples （442 males and 679 females） were obtained from healthy Kazakh （654）, Uygur （412） and Tajik （55）. Primary esophageal squamous cell cancer （ESCC） tissues from Kazakh were obtained from 116 patients who underwent surgery. GSTM1 polymorphisms were analyzed by a combined approach of PCR and electrophoresis techniques.RESULTS： GSTM1 null genotype was found in 62.63% Uygur, 50.91% Tajik and 47.40% Kazakh. A significantly higher frequency of GSTM1 null genotype in Uygur was observed compared with Kazakh （OR： 1.859, 95% CI： 1.445 -2.391, χ^2 = 23.71, P = 0.000）. In addition, GSTM1 null genotype was found in 23.53% of welldifferentiated ESCC in Kazakh, in 49.23% of poorly differentiated ESCC, with a significant difference （OR： 3.152, 95% CI： 1.403-7.080, χ^2 = 8.018, P = 0.007）.CONCLUSION： There is a marked difference in the frequency of common GSTM1 null genotype between Uygur and Kazakh. GSTM1 null genotype is associated with differentiation of ESCC in Kazakh.展开更多
Background: To explore the application and reliability of Caprini thromboembolism risk assessment scale in the risk assessment of venous thromboembolism in acute and severe uygur patients. Methods: 160 cases of acute ...Background: To explore the application and reliability of Caprini thromboembolism risk assessment scale in the risk assessment of venous thromboembolism in acute and severe uygur patients. Methods: 160 cases of acute and severe Uighur patients with venous thrombo embolism (VTE) that were treated in our hospital from December 2017 to December 2018 were selected as the research group. 160 cases of acute and severe uygur patients without VTE admitted to our hospital in the same period were selected as the control group. Caprini thrombus risk assessment scale and Padua thrombus risk assessment scale were used to evaluate in both groups. The general data of the two groups were compared. The results of the two groups were consistent using Caprini and Padua blood clot risk assessment scales. Clinical efficacy of two different thrombosis risk assessment scales in risk assessment of VTE. Results: Group and control group in the gender distribution, backlog of red blood cells and platelet count have no significant difference (P > 0.05), the team average age, average hospitalization days were significantly less than control group (P P P 2 = 6.956, P P (P P > 0.05). Conclusion: The sensitivity, negative predictive value and positive predictive value of Caprini thrombosis risk assessment scale in VTE risk assessment of acute and severe uygur patients are very prominent, and the clinical efficacy is better, which is worthy of application.展开更多
Gold,iron,copper,lead-zinc and other mineral exploration in West Tianshan,Xinjiang Uygur Autonomous Region,has made remarkable progress in recent years.However,due to the dispute on the tectonic division of West Tians...Gold,iron,copper,lead-zinc and other mineral exploration in West Tianshan,Xinjiang Uygur Autonomous Region,has made remarkable progress in recent years.However,due to the dispute on the tectonic division of West Tianshan,the ore-controlling factors and the regional metallogenic laws are controversial.The authors analyze regional gravity data and notice that the high-value region corresponds to the Yili ancient continent,thus the southeastern boundary of the Yili ancient continent is delineated.Comparative analysis of gravity,aeromagnetic and geologic data reveals that the Tulasu basin,where some medium to large epithermal gold deposits locate,lies above the Yili ancient continent;the Yili Carboniferous-Permian rift extends in E-W direction,numbers of copper deposits have been found in the mid-west section of the rift which lies above the Yili ancient continent,whereas few copper deposits have been discovered in the east section which is outside the Yili ancient continent.Accordingly,the Yili ancient continent may be rich in gold,copper and other metal elements;the metal-bearing hydrothermal solution moves up with the activity of magmatism,and deposits in the favorable places(the Tulasu basin and the Yili Carboniferous-Permian rift),forming numerous small and medium gold,copper deposits,as well as some large and super-large gold deposits.Therefore,the tectonic-magmatic hydrothermal zone above the Yili ancient continent should be the prospective area for epithermal gold and copper polymetallic deposits.展开更多
Xinjiang is a good place, with pastureland to the north and south of the Tianshan MountainThe Gobi Desert has been changed into fertile fields, irrigated by melting snows.
Objective To assess the risk factors for prehypertension in Xinjiang Uygur population. Methods A cross-section study was conducted in a Xinjiang Uygur population（438 males and 716 females,aged 30 to 70 years）.The fa...Objective To assess the risk factors for prehypertension in Xinjiang Uygur population. Methods A cross-section study was conducted in a Xinjiang Uygur population（438 males and 716 females,aged 30 to 70 years）.The fasting lipid profiles,serum glucose,insulin,and uric acid were determined.Homeostasis model assessment of insulin resistance（HOMA-IR）index was used to assess insulin resistance（IR）.Binary logistic regression analysis was performed to determine risk factors for prehypertension.Blood pressure levels ofnormotensives and prehypertensives in different body mass index（BMI）categories were compared. Results Binary logistic regression analysis performed after adjustment for gender,lipids profiles,waist-to-hip ratio,uric acid,HOMA-IR,and lifestyle（alcohol drinking and smoking）showed a significantly increasing prevalence of prehypertension with BMI.The odds ratios for prehypertension against the lowest BMI group（separated by 24 and 28）were 1.934 and 2.490（95% confidence interval：1.435-2.606 and 1.825-3.399,respectively）.Age was independently correlated to the increasing prevalence of prehypertension.HOMA-IR was not associated with prehypertensive.The mean diastolic blood pressure（DBP）was significantly increased with BMI categories in either normotensives or prehypertensives（P〈0.001）while the mean systolic blood pressure（SBP）was significantly increased with BMI only in normotensives（P〈0.001）. Conclusions In Xinjiang Uygurs,BMI and age was the risk factors for prehypertension.DBP is significantly increased with BMI.IR is not associated with prehypertension.These findings emphasize the importance of management of obesity for the control of blood pressure and other cardiovascular complications.展开更多
Objective:To study the association of ABCB1 gene with epilepsy in the Uygur population of Xinjiang region.Methods: In this case-control study, 232 confirmed epilepsy patients from Xinjiang affiliated Medical Universit...Objective:To study the association of ABCB1 gene with epilepsy in the Uygur population of Xinjiang region.Methods: In this case-control study, 232 confirmed epilepsy patients from Xinjiang affiliated Medical University from January 2017 to June 2018, and 116 were recruited in the case group and 116 healthy individuals were selected as the control group. 2 mL of the blood sample was collected from each subject, from which the DNA was extracted. The polymorphism gene was determined by polymerase chain reaction followed by restriction fragment length polymorphism.Results: No significant association was observed in C3435T alleles and genotypes with epilepsy between the case and the control groups (P>0.05), G2677T/A genotypes with epilepsy was the same as GG in both of the groups.Conclusions:The polymorphisms of C3435T gene may not be associated with epilepsy in the Uygur population from the Xinjiang region.展开更多
基金Supported by Central Government Guide Local Science and Technology Development Special Fund Project,No.ZYYD2024JD11 and No.ZYYD2022A06Natural Science Foundation of Xinjiang Uygur Autonomous Region,No.2024D01C76.
文摘BACKGROUND Helicobacter pylori(H.pylori)infection rates have been changing with different populations and geographic areas.Currently,there is still a lack of comprehensive survey data on the H.pylori infection rate and its risk factors in the natural population of Xinjiang Uygur Autonomous Region.AIM To understand the H.pylori infection and risk factors in Xinjiang Uygur Autonomous Region for the prevention and control strategies.METHODS This study comprehensively collected the survey data on H.pylori infection in 15 regions of Xinjiang Uygur Autonomous Region by using the method of stratified random cluster sampling.A total of 4361 individuals from the general population were selected as research subjects,and questionnaire surveys and blood tests for H.pylori antibodies were conducted.RESULTS The overall H.pylori infection rate in Xinjiang Uygur Autonomous Region was 70.79%(3087/4361).The H.pylori infection rate showed a trend of first increasing and then decreasing with the increase of age,and the difference was statistically significant(P<0.05).The analysis of the H.pylori infection rates among different ethnic groups showed that the infection rates of ethnic minorities such as Uyghur,Kirgiz,and Tajik were significantly higher than those of Han and Hui ethnic groups,and the difference was statistically significant(P<0.01).Multivariate analysis showed that altitude,regular consumption of beef,mutton,dried nuts,barbecue foods,and drinking river water were positively correlated with the H.pylori infection rate.CONCLUSION This study indicates that the overall H.pylori infection rate in Xinjiang Uygur Autonomous Region is relatively high,with obvious regional and ethnic differences,which are closely related to the sanitation conditions and eating habits.
基金supported by the National Natural Science Foundation of China, No. 81060097
文摘We sought to investigate the correlation between the -455G/A and -148C/T polymorphisms of the β-fibrinogen gene and plasma fibrinogen levels in patients with cerebral infarction and in healthy subjects among the Xinjiang Uygur and Han Chinese populations, by using polymerase chain reaction-restriction enzyme digestion analysis. Results showed that there were no statistically significant differences in the distributions of the -455G/A genotype and allele frequency between the Uygurs and the Han. Plasma fibrinogen levels in cerebral infarction patients among the Uygurs and the Han were higher than those among healthy subjects. In particular, the frequencies of the -455G/A AA and -148C/T TT genotypes were significantly higher than in healthy subjects. Individuals carrying the A or T allele had a higher incidence of cerebral infarction compared with those carrying the G or C allele. Our experimental findings indicate that the -148C/T and -455G/A polymorphisms are associated with cerebral infarction in Xinjiang Uygur and Han Chinese subjects. The susceptibility- conferring alleles are -148T and -455A, and the susceptibility-conferring genotype is -455G/A ＋ AA.
基金supported by the National Program on Key Research Project of China(2018YFD0500104 and 2018YFD0500803)Technologies for Prevention and Control of Virus Zoonoses,Chinese Academy of Medical Sciences(2020-12M-5-001)。
文摘The Getah virus(GETV),a mosquito-borne RNA virus,is widely distributed in Oceania and Asia.GETV is not the only pathogenic to horses,pigs,cattle,foxes and boars,but it can also cause fever in humans.Since its first reported case in Chinese mainland in 2017,the number of GETV-affected provinces has increased to seventeen till now.Therefore,we performed an epidemiologic investigation of GETV in the Xinjiang region,located in northwestern China,during the period of 2017-2020.ELISA was used to analyze 3299 serum samples collected from thoroughbred horse,local horse,sheep,goat,cattle,and pigs,with thoroughbred horse(74.8%),local horse(67.3%),goat(11.7%),sheep(10.0%),cattle(25.1%)and pigs(51.1%)being positive for anti-GETV antibodies.Interestingly,the neutralizing antibody titer in horses was much higher than in other species.Four samples from horses and pigs were positive for GETV according to RT-PCR.Furthermore,from the serum of a local horse,we isolated GETV which was designated as strain XJ-2019-07,and determined its complete genome sequence.From the phylogenetic relationships,it belongs to the Group III lineage.This is the first evidence of GETV associated to domestic animals in Xinjiang.Overall,GETV is prevalent in Xinjiang and probably has been for several years.Since no vaccine against GETV is available in China,detection and monitoring strategies should be improved in horses and pigs,especially imported and farmed,in order to prevent economic losses.
基金supported by research grants from the National Natural Science Foundation of China (U1603117 81560473+5 种基金 81560442)Doctoral Foundation Technology Research and Achievements Transformation Program of Xinjiang production and Construction Corps (2014BB021 2015AD003)the United States National Institutes of Health Fogarty International Center (D43 TW001492)NCI (CA75903)NCRR COBRE (RR15635) to C. Wood
文摘Kaposi's sarcoma-associated herpesvirus(KSHV) is the infectious etiologic agent associated with Kaposi's sarcoma(KS), primary effusion lymphoma, and multicentric Castleman disease. It has been shown that high KSHV prevalence and high incidence of both classic KS and AIDSassociated KS are found mostly among people of Uygur ethnicity in Xinjiang, while people of Han ethnicity in Xinjiang have a higher KSHV seroprevalence than those of other Han populations in China's Mainland. However, it is still unclear why there is such geographical and population variation in KSHV distribution in China. In this work, we focused on the populations in the Kashgar region and Urumqi area, where a total of 1294 research subjects were randomly selected to investigate the potential correlation between KSHV prevalence and different ethnicities in endemic areas of Xinjiang, and to determine risk factors that may affect KSHV infection rates or KS incidence. We identified a high seroprevalence of KSHV and high peripheral blood DNA infection in the general Uygur and Han populations in both Urumqi and Kashgar regions of Xinjiang, and determined that advancing age, low education level, and stationary population status affect KSHV infection rates. Further, KSHV-positive Uygur participants were shown to have higher prevalence of neutralizing antibodies and neutralizing antibody titers than KSHV-positive Han participants.
文摘It is not clear how HPV infection is prevalent among Uygur women in Xinjiang Uygur Autonomous Region, China and whether the distribution of HPV infection is related with cervical intraepithelial neoplasia （CIN） incidence among them. A study including 883 Uygur women were conducted from 2006 to 2007 in Hetian Prefecture, Xinjiang Uygur Autonomous Region, China.
基金the National Natural Science Foundation of China(No.81560153 and No.81760169)the Natural Science Foundation of the Xinjiang Uygur Autonomous Region(No.2017D01C234)the Open Project of Shanghai Six People,Hospital and Shanghai Key Laboratory of Diabetes Mellitus(No.SHKLD-KF-1502).
文摘This study aimed to test the effects of five single nucleotide polymorphisms within SLC2A9 on uric acid level in a special ethnic population,the Uygurs in Xinjiang,China.According to our inclusion and exclusion criteria,Uygur adults from Xinjiang constituted the study population.There were 1053 Uygur adults with hyperuricemia and 1373 normal Uygur adults who served as controls.Five single nucleotide polymorphisms within SLC2A9(rs938557,rs7679916,rs7349721,rsl3101785,and rs 13137343)were selected with the HapMap dataset and TaqMan assays.We found that,in normouricemia group,rs938557 was significantly correlated with uric acid(β=11.39±3.74,P=0.0024)adjusting for age,gender and BMI;rs7679916 and rsl3137343 were marginally associated with uric acid concentration(β=5.77±3.O9,P=0.0626;p=-5.99±3.08,P=0.0520).In the hyperuricemia group,no SNP was found to possibly influence uric acid concentration.None of these SNPs showed significant association with hyperuricemia after controlling for age,gender and BMI.There were significant or marginal correlations between certain single nucleotide polymorphisms in the SLC2A9 region and uric acid concentration in Uygur normouricemia samples.In turn,some of these single nucleotide polymorphisms in SLC2A9 may increase the risk of hyperuricemia.
文摘BACKGROUND：Matrix metalloproteinase-9 （MMP-9） plays a pivotal role in early atherosclerosis, vascular remodeling and development of atherosclerotic lesion. The potentially functional MMP-9 gene polymorphism may contribute to the susceptibility of acute coronary syndrome （ACS）. This study aimed to investigate the association between two single nucleotide polymorphisms （-1562C〉T, R279Q） of the MMP-9 gene in patients with ACS in the Uygur population of China. METHODS：This case-control study was composed of 361 ACS patients and 432 control subjects, who had undergone coronary angiography. Among the ACS patients, 162 （44.9%） had single-vessel disease, 145 （40.2%） had two-vessel disease, and 54 （14.9%） had three-vessel disease. The genotypes of the two selected SNPs were determined by the method of polymerase chain reaction and restriction fragment length polymorphism （RFLP-PCR）. The relationship between the polymorphism of the MMP-9 gene and the severity of coronary arterial stenosis was analyzed.RESULTS： Analysis of the two SNPs showed that the frequency of CT and TT genotypes in patients with ACS was significantly higher than that in the control group （ACS vs. controls; CT＋TT： 25.5% vs. 15.8%, P=0.001）. And the -1562 gene allele （C/T） was significantly associated with acute coronary syndrome （ACS vs. controls; C allele： 85.7% vs. 91.5%, T allele： 14.3% vs. 8.5%, P〈0.001）. But the frequencies of CT＋TT and CC genotypes were not statistically different among ACS patients with one, two and three or more significantly diseased vessels （P=0.55）. The R279Q polymorphism site with regard to the association with ACS was not significant （P〉0.05）. The presence of CT or TT genotypes, assuming codominant effect of the T allele, was independently associated with increased risk of coronary artery disease when adjustment was made for age, body mass index, smoking, hypertension and diabetes mellitus [odds ratio=1.737 （95% confidence interval, 1.337-2.257）, P=0.018]. CONCLUSIONS： MMP-9-1562C〉T polymorphism is associated with the susceptibility to ACS in the Uygur population of China. However, this mutation apparently is not related to the severity of coronary arterial stenosis. Another SNP （R279Q） polymorphism of MMP-9 is not significantly associated with the risk of ACS.
文摘Spatial interpolation methods are frequently used to estimate values of meteorological data in locations where they are not measured. However, very little research has been investigated the relative performance of different interpolation methods in meteorological data of Xinjiang Uygur Autonomous Region (Xinjiang). Actually, it has importantly practical significance to as far as possibly improve the accuracy of interpolation results for meteorological data, especially in mountainous Xinjiang. There- fore, this paper focuses on the performance of different spatial interpolation methods for monthly temperature data in Xinjiang. The daily observed data of temperature are collected from 38 meteorological stations for the period 1960- 2004. Inverse distance weighting (IDW), ordinary kriging (OK), temperature lapse rate method (TLR) and multiple linear regressions (MLR) are selected as interpolated methods. Two rasterized methods, multiple regression plus space residual error and directly interpolated observed temperature (DIOT) data, are used to analyze and compare the performance of these interpolation methods respectively. Moreover, cross-validation is used to evaluate the performance of different spatial interpolation methods. The results are as follows: 1) The method of DIOT is unsuitable for the study area in this paper. 2) It is important to process the observed data by local regression model before the spatial interpolation. 3) The MLR-IDW is the optimum spatial interpolation method for the monthly mean temperature based on cross-validation. For the authors, the reliability of results and the influence of measurement accuracy, density, distribution and spatial variability on the accuracy of the interpolation methods will be tested and analyzed in the future.
基金Supported by Research Fund of the Education Department of Shaanxi Province,China,No. 09JK710
文摘AIM:To investigate the incidence of gastroesophageal reflux disease(GERD) and its related risk factors in Uygur and Han Chinese adult in Urumqi,China.METHODS:A population-based cross-sectional survey was undertaken in a total of 972 Uygur(684 male and 288 female) aged from 24 to 61 and 1023 Han Chinese(752 male and 271 female) aged from 23 to 63 years.All participants were recruited from the residents who visited hospital for health examination from November 2011 to May 2012.Each participant signed an informed consent and completed a GERD questionnaire(GerdQ) and a lifestyle-food frequency questionnaire survey.Participants whose Gerd Q score was ≥ 8 and met one of the following requirements would be enrolled into this research:(1) being diagnosed with erosive esophagitis(EE) or Barrett's esophagus(BE) by endoscopy;(2) negative manifestation under endoscopy(non-erosive reflux disease,NERD) with abnormal acid reflux revealed by 24-h esophageal pH monitoring;and(3) suffering from typical heartburn and regurgitation with positive result of proton pump inhibitor test.RESULTS:According to Gerd Q scoring criteria,340 cases of Uygur and 286 cases of Han Chinese were defined as GERD.GERD incidence in Uygur was significantly higher than in Han Chinese(35% vs 28%,χ2 = 11.09,P < 0.005),Gerd Q score in Uygur was higher than in Han Chinese(7.85 ± 3.1 vs 7.15 ± 2.9,P < 0.005),and Gerd Q total score in Uygur male was higher than in female(8.15 ± 2.8 vs 6.85 ± 2.5,P < 0.005).According to normalized methods,304(31%) cases of Uygur were diagnosed with GERD,including 89 cases of EE,185 cases of NERD and 30 cases of BE;256(25%) cases of Han Chinese were diagnosed with GERD,including 90 cases of EE,140 cases of NERD and 26 cases of BE.GERD incidence in Uygur was significantly higher than in Han Chinese(31% vs 25%,χ2 = 9.34,P < 0.005) while the incidences were higher in males of both groups than in females(26% vs 5% in Uygur,χ2 = 35.95,P < 0.005,and 19.8% vs 5.2% in Han,χ2 = 5.48,P < 0.025).GERD incidence in Uygur male was higher than in Han Chinese male(26% vs 19.8%,χ2 = 16.51,P < 0.005),and incidence of NERD in Uygur was higher than in Han Chinese(χ2 = 10.06,P < 0.005).Occupation(r = 0.623),gender(r = 0.839),smoking(r = 0.322),strong tea(r = 0.658),alcohol drinking(r = 0.696),meat-based diet(mainly meat)(r = 0.676) and body mass index(BMI)(r = 0.567) were linearly correlated with GERD in Uygur(r = 0.833,P = 0.000);while gender(r = 0.957),age(r = 0.016),occupation(r = 0.482),strong tea(r = 1.124),alcohol drinking(r = 0.558),meat diet(r = 0.591) and BMI(r = 0.246) were linearly correlated with GERD in Han Chinese(r = 0.786,P = 0.01).There was no significant difference between Gerd Q scoring and three normalized methods for the diagnosis of GERD.CONCLUSION:GERD is highly prevalent in adult in Urumqi,especially in Uygur.Male,civil servant,smoking,strong tea,alcohol drinking,meat diet and BMI are risk factors correlated to GERD.
基金supported by grants from Scientific and Technologic Committee of Urumqi,China (No.Y06231006)from frontier supporting science and technology projects of Xinjiang Uygur Autonomous Region,China (No.200840102-38)
文摘Evaluating the prevalence of kidney damage according to population-based studies in different communities has been limited in developing countries.We conducted a population-based screening study in Uygur people of Urumqi, aiming to identify the prevalence and associated risk factors of chronic kidney disease (CKD) in Uygur populations.A total of 2576 residents (】18 years) from four districts of Urumqi were interviewed from June 2007 to January 2009 and tested for haematuria, albuminuria and reduced renal function.Associations between age, gender, smoking, diabetes mellitus, hypertension, hyperuricaemia and kidney damage were examined.There were 2576 subjects enrolled in this study.After age correction, the prevalence of albuminuria, haematuria and reduced estimated glomerular filtration rate (eGFR) was 3.58%, 2.26% and 1.03%, respectively.Approximately 5.65% of the sample population had at least one indicator of kidney damage.Age, diabetes mellitus, hypercholesteremia, hyperuricaemia and hyperlipidaemia were independently associated with CKD.In the general Uygur adult population from Urumqi, 5.65% had either proteinuria, haematuria or reduced eGFR, indicating the presence of kidney damage, with an awareness of only 1.05%.The high prevalence and low awareness of CKD in this population suggest an urgent need for CKD prevention programs in Uygur people.
基金Supported by a grant from the Xinjiang Science and TechnologyBureau, No. XJKJT200511113 and a grant for 100 YoungExcellent Returned Overseas Chinese Scholars Program, ChineseAcademy of Sciences
文摘AIM： To investigate the glutathione-S-transferase M1 （GSTM1） polymorphisms in three Chinese minorities, Kazakh, Uygur, and Tajik; and the pathological significance of GSTM1 polymorphisms in esophageal carcinogenesis in Kazakh.METHODS： A total of 1121 blood samples （442 males and 679 females） were obtained from healthy Kazakh （654）, Uygur （412） and Tajik （55）. Primary esophageal squamous cell cancer （ESCC） tissues from Kazakh were obtained from 116 patients who underwent surgery. GSTM1 polymorphisms were analyzed by a combined approach of PCR and electrophoresis techniques.RESULTS： GSTM1 null genotype was found in 62.63% Uygur, 50.91% Tajik and 47.40% Kazakh. A significantly higher frequency of GSTM1 null genotype in Uygur was observed compared with Kazakh （OR： 1.859, 95% CI： 1.445 -2.391, χ^2 = 23.71, P = 0.000）. In addition, GSTM1 null genotype was found in 23.53% of welldifferentiated ESCC in Kazakh, in 49.23% of poorly differentiated ESCC, with a significant difference （OR： 3.152, 95% CI： 1.403-7.080, χ^2 = 8.018, P = 0.007）.CONCLUSION： There is a marked difference in the frequency of common GSTM1 null genotype between Uygur and Kazakh. GSTM1 null genotype is associated with differentiation of ESCC in Kazakh.
文摘Background: To explore the application and reliability of Caprini thromboembolism risk assessment scale in the risk assessment of venous thromboembolism in acute and severe uygur patients. Methods: 160 cases of acute and severe Uighur patients with venous thrombo embolism (VTE) that were treated in our hospital from December 2017 to December 2018 were selected as the research group. 160 cases of acute and severe uygur patients without VTE admitted to our hospital in the same period were selected as the control group. Caprini thrombus risk assessment scale and Padua thrombus risk assessment scale were used to evaluate in both groups. The general data of the two groups were compared. The results of the two groups were consistent using Caprini and Padua blood clot risk assessment scales. Clinical efficacy of two different thrombosis risk assessment scales in risk assessment of VTE. Results: Group and control group in the gender distribution, backlog of red blood cells and platelet count have no significant difference (P > 0.05), the team average age, average hospitalization days were significantly less than control group (P P P 2 = 6.956, P P (P P > 0.05). Conclusion: The sensitivity, negative predictive value and positive predictive value of Caprini thrombosis risk assessment scale in VTE risk assessment of acute and severe uygur patients are very prominent, and the clinical efficacy is better, which is worthy of application.
基金This research is financially supported by China Geological Survey project“Comprehensive Monitoring of Resources and Environment Bearing Capacity and Digital Platform Construction of Xiongan New Area”(121201003000172401)“Aero Geophysical Survey of Qinling and Tianshan metallogenetic belt”(121201003000150006).
文摘Gold,iron,copper,lead-zinc and other mineral exploration in West Tianshan,Xinjiang Uygur Autonomous Region,has made remarkable progress in recent years.However,due to the dispute on the tectonic division of West Tianshan,the ore-controlling factors and the regional metallogenic laws are controversial.The authors analyze regional gravity data and notice that the high-value region corresponds to the Yili ancient continent,thus the southeastern boundary of the Yili ancient continent is delineated.Comparative analysis of gravity,aeromagnetic and geologic data reveals that the Tulasu basin,where some medium to large epithermal gold deposits locate,lies above the Yili ancient continent;the Yili Carboniferous-Permian rift extends in E-W direction,numbers of copper deposits have been found in the mid-west section of the rift which lies above the Yili ancient continent,whereas few copper deposits have been discovered in the east section which is outside the Yili ancient continent.Accordingly,the Yili ancient continent may be rich in gold,copper and other metal elements;the metal-bearing hydrothermal solution moves up with the activity of magmatism,and deposits in the favorable places(the Tulasu basin and the Yili Carboniferous-Permian rift),forming numerous small and medium gold,copper deposits,as well as some large and super-large gold deposits.Therefore,the tectonic-magmatic hydrothermal zone above the Yili ancient continent should be the prospective area for epithermal gold and copper polymetallic deposits.
文摘Xinjiang is a good place, with pastureland to the north and south of the Tianshan MountainThe Gobi Desert has been changed into fertile fields, irrigated by melting snows.
基金This study was supported by the National Natural Science Foundation of China （30260038） and the National Supporting Programs for Critical Illness of China （2002BA711A0B）. We are very grateful for the participants from Hetian region. We would also like to thank all the staff of the Center of Diagnosis, Treatment and Research of Hypertension in Xinjiang for support with the medical examination and demographic data collection.
文摘Objective To assess the risk factors for prehypertension in Xinjiang Uygur population. Methods A cross-section study was conducted in a Xinjiang Uygur population（438 males and 716 females,aged 30 to 70 years）.The fasting lipid profiles,serum glucose,insulin,and uric acid were determined.Homeostasis model assessment of insulin resistance（HOMA-IR）index was used to assess insulin resistance（IR）.Binary logistic regression analysis was performed to determine risk factors for prehypertension.Blood pressure levels ofnormotensives and prehypertensives in different body mass index（BMI）categories were compared. Results Binary logistic regression analysis performed after adjustment for gender,lipids profiles,waist-to-hip ratio,uric acid,HOMA-IR,and lifestyle（alcohol drinking and smoking）showed a significantly increasing prevalence of prehypertension with BMI.The odds ratios for prehypertension against the lowest BMI group（separated by 24 and 28）were 1.934 and 2.490（95% confidence interval：1.435-2.606 and 1.825-3.399,respectively）.Age was independently correlated to the increasing prevalence of prehypertension.HOMA-IR was not associated with prehypertensive.The mean diastolic blood pressure（DBP）was significantly increased with BMI categories in either normotensives or prehypertensives（P〈0.001）while the mean systolic blood pressure（SBP）was significantly increased with BMI only in normotensives（P〈0.001）. Conclusions In Xinjiang Uygurs,BMI and age was the risk factors for prehypertension.DBP is significantly increased with BMI.IR is not associated with prehypertension.These findings emphasize the importance of management of obesity for the control of blood pressure and other cardiovascular complications.
文摘Objective:To study the association of ABCB1 gene with epilepsy in the Uygur population of Xinjiang region.Methods: In this case-control study, 232 confirmed epilepsy patients from Xinjiang affiliated Medical University from January 2017 to June 2018, and 116 were recruited in the case group and 116 healthy individuals were selected as the control group. 2 mL of the blood sample was collected from each subject, from which the DNA was extracted. The polymorphism gene was determined by polymerase chain reaction followed by restriction fragment length polymorphism.Results: No significant association was observed in C3435T alleles and genotypes with epilepsy between the case and the control groups (P>0.05), G2677T/A genotypes with epilepsy was the same as GG in both of the groups.Conclusions:The polymorphisms of C3435T gene may not be associated with epilepsy in the Uygur population from the Xinjiang region.
