In recent years, electric vehicles have become popular among national governments, sectors and the general public. During January to October of 2017, the production output of China＇s new energy vehicles had surpasse...In recent years, electric vehicles have become popular among national governments, sectors and the general public. During January to October of 2017, the production output of China＇s new energy vehicles had surpassed 0.5 million units,展开更多
The city-state of Singapore has seen remarkable growth since being founded just over half a century ago.By upholding the best of Asian values,Singapore continues to lead the way in an increasingly globalized world.Man...The city-state of Singapore has seen remarkable growth since being founded just over half a century ago.By upholding the best of Asian values,Singapore continues to lead the way in an increasingly globalized world.Many Southeast Asian countries are blessed with an abundance of natural resources.Singapore has positioned itself as one of the region’s largest commodity trading hubs offering tax-friendly incentives,transparent financial and legal sectors,excellent infrastructure and a skilled workforce.These factors have enabled Singa-展开更多
On the eve of the 60th anniversary of the peaceful liberation of Tibet, Zhu Weiqun, Executive Vice Minister of the United Front Work Department of the Central Committee of the Communist Party of China, elaborated on t...On the eve of the 60th anniversary of the peaceful liberation of Tibet, Zhu Weiqun, Executive Vice Minister of the United Front Work Department of the Central Committee of the Communist Party of China, elaborated on the historic importance of the event in an exclusive interview with China Tibet magazine. Excerpts follow:展开更多
IH&RA and its members worldwide extend solidarity and support to all those affected by the 26 December Indian Ocean Disaster in Southeast Asia, so many of whom represent members of the IH&RA family - hotel and...IH&RA and its members worldwide extend solidarity and support to all those affected by the 26 December Indian Ocean Disaster in Southeast Asia, so many of whom represent members of the IH&RA family - hotel and restaurant employees, employers, valued customers and the local people who make travel and tourism possible. The hotel and restaurant industry is united in its support of a rapid recovery and seeks ways of identifying展开更多
Hearing loss is one of the most prevalent sensory disorders affecting the human nervous system.Liquid–liquid phase separation(LLPS)is a physiological process that facilitates the reversible and dynamic assembly of bi...Hearing loss is one of the most prevalent sensory disorders affecting the human nervous system.Liquid–liquid phase separation(LLPS)is a physiological process that facilitates the reversible and dynamic assembly of biomolecular condensates.Increasing evidence suggests that LLPS plays a significant role in the pathogenesis of hereditary hearing loss.Nevertheless,there is a conspicuous lack of systematic investigations exploring the impact of LLPS abnormalities on the etiology of hereditary hearing loss.In this review,we examine the mechanisms by which dysfunctions in LLPS contribute to hereditary hearing loss,specifically focusing on its effects on mechanoelectrical transduction in hair bundles,transcriptional regulation,post-transcriptional modifications,the actin cytoskeleton,ion homeostasis within the inner ear,and energy and redox homeostasis.Furthermore,we evaluate the considerable potential of targeting LLPS as a therapeutic approach for hearing loss and propose innovative perspectives on LLPS that may guide future research initiatives in the field of auditory disorders.展开更多
Usher syndrome(USH)should no longer be considered a fixed diagnosis limited to syndromic early-onset sensorineural hearing loss and progressive vision decline due to rod-cone retinal dystrophy.Patients increasingly pr...Usher syndrome(USH)should no longer be considered a fixed diagnosis limited to syndromic early-onset sensorineural hearing loss and progressive vision decline due to rod-cone retinal dystrophy.Patients increasingly present with partial or delayed retinal manifestations,often lacking a clinically relevant audiological history.Concurrently,genomic testing uncovers variants that challenge the practical relevance of the traditional definition of type I,II,and III subclassifications.This review argues for a paradigm shift toward genotype-first diagnosis led by ophthalmologists,integrating retinal findings and audiological evaluations with comprehensive genetic information.The rise of gene-specific molecular therapies,including antisense oligonucleotides and CRISPR-mediated gene editing for USH2A and MYO7A,demands timely and accurate molecular categorization for each patient.Delays in precise molecular diagnosis may risk excluding patients from potentially vision-saving trials.Diagnostic gaps persist,including limited variant interpretation tools,underrepresentation of non-Caucasian populations in reference databases,and a lack of standardized retinal imaging protocols.The establishment of centralized,real-time Usher registries and interdisciplinary diagnostic models is essential.The future of USH management lies in anticipatory,individualized care that begins in the retina clinic.展开更多
文摘In recent years, electric vehicles have become popular among national governments, sectors and the general public. During January to October of 2017, the production output of China＇s new energy vehicles had surpassed 0.5 million units,
文摘The city-state of Singapore has seen remarkable growth since being founded just over half a century ago.By upholding the best of Asian values,Singapore continues to lead the way in an increasingly globalized world.Many Southeast Asian countries are blessed with an abundance of natural resources.Singapore has positioned itself as one of the region’s largest commodity trading hubs offering tax-friendly incentives,transparent financial and legal sectors,excellent infrastructure and a skilled workforce.These factors have enabled Singa-
文摘On the eve of the 60th anniversary of the peaceful liberation of Tibet, Zhu Weiqun, Executive Vice Minister of the United Front Work Department of the Central Committee of the Communist Party of China, elaborated on the historic importance of the event in an exclusive interview with China Tibet magazine. Excerpts follow:
文摘IH&RA and its members worldwide extend solidarity and support to all those affected by the 26 December Indian Ocean Disaster in Southeast Asia, so many of whom represent members of the IH&RA family - hotel and restaurant employees, employers, valued customers and the local people who make travel and tourism possible. The hotel and restaurant industry is united in its support of a rapid recovery and seeks ways of identifying
基金supported by the National Natural Science Foundation of China(82430035)the Foundation for Innovative Research Groups of Hubei Province(2023AFA038)+1 种基金the National Key Research and Development Program of China(2021YFF0702303,2024YFC2511101,and 2023YFE0203200)the Fundamental Research Funds for the Central Universities(2024BRA019).
文摘Hearing loss is one of the most prevalent sensory disorders affecting the human nervous system.Liquid–liquid phase separation(LLPS)is a physiological process that facilitates the reversible and dynamic assembly of biomolecular condensates.Increasing evidence suggests that LLPS plays a significant role in the pathogenesis of hereditary hearing loss.Nevertheless,there is a conspicuous lack of systematic investigations exploring the impact of LLPS abnormalities on the etiology of hereditary hearing loss.In this review,we examine the mechanisms by which dysfunctions in LLPS contribute to hereditary hearing loss,specifically focusing on its effects on mechanoelectrical transduction in hair bundles,transcriptional regulation,post-transcriptional modifications,the actin cytoskeleton,ion homeostasis within the inner ear,and energy and redox homeostasis.Furthermore,we evaluate the considerable potential of targeting LLPS as a therapeutic approach for hearing loss and propose innovative perspectives on LLPS that may guide future research initiatives in the field of auditory disorders.
文摘Usher syndrome(USH)should no longer be considered a fixed diagnosis limited to syndromic early-onset sensorineural hearing loss and progressive vision decline due to rod-cone retinal dystrophy.Patients increasingly present with partial or delayed retinal manifestations,often lacking a clinically relevant audiological history.Concurrently,genomic testing uncovers variants that challenge the practical relevance of the traditional definition of type I,II,and III subclassifications.This review argues for a paradigm shift toward genotype-first diagnosis led by ophthalmologists,integrating retinal findings and audiological evaluations with comprehensive genetic information.The rise of gene-specific molecular therapies,including antisense oligonucleotides and CRISPR-mediated gene editing for USH2A and MYO7A,demands timely and accurate molecular categorization for each patient.Delays in precise molecular diagnosis may risk excluding patients from potentially vision-saving trials.Diagnostic gaps persist,including limited variant interpretation tools,underrepresentation of non-Caucasian populations in reference databases,and a lack of standardized retinal imaging protocols.The establishment of centralized,real-time Usher registries and interdisciplinary diagnostic models is essential.The future of USH management lies in anticipatory,individualized care that begins in the retina clinic.
