In order to provide direct evidence for the use of fire by humans at Locality 1,Zhoukoudian,we examine the burnt and unburnt sediments of newly excavated area in Layer 4 by detailed measurements of magnetic susceptibi...In order to provide direct evidence for the use of fire by humans at Locality 1,Zhoukoudian,we examine the burnt and unburnt sediments of newly excavated area in Layer 4 by detailed measurements of magnetic susceptibility,color,and diffuse reflectance spectrum.Results show that the magnetic susceptibility and redness of the burnt sediments are remarkably higher than those of other areas on the same level:up to*22 times for magnetic susceptibility and*3 times for redness of those of the adjacent unburnt sediments.Fine-grained(superparamagnetic/stable single-domain)magnetite and hematite grains make dominant contributions to the distinctly high values of magnetic susceptibility and redness in the burnt sediments.Diffuse reflectance spectroscopy results show that the burnt sediments contain more hematite than those of other areas and localities 2 and 3.High-temperature magnetic susceptibility measurements demonstrate that the burnt sediments have been heated above 700°C.Those changes in low-frequency magnetic susceptibility and redness are impossibly resulted from natural fires,thus most likely signaling the human activities of controlled use of fire.However,further work is needed to confirm whether or not these heat-affected sediments were produced in situ.展开更多
Water use efficiency(WUE),as a pivotal indicator of the coupling degree within the carbon–water cycle of ecosystems,holds considerable importance in assessment of the carbon–water balance within terrestrial ecosyste...Water use efficiency(WUE),as a pivotal indicator of the coupling degree within the carbon–water cycle of ecosystems,holds considerable importance in assessment of the carbon–water balance within terrestrial ecosystems.However,in the context of global warming,WUE evolution and its primary drivers on the Tibetan Plateau remain unclear.This study employed the ensemble empirical mode decomposition method and the random forest algorithm to decipher the nonlinear trends and drivers of WUE on the Tibetan Plateau in 2001–2020.Results indicated an annual mean WUE of 0.8088 gC/mm·m^(2)across the plateau,with a spatial gradient reflecting decrease from the southeast toward the northwest.Areas manifesting monotonous trends of increase or decrease in WUE accounted for 23.64%and 9.69%of the total,respectively.Remarkably,66.67%of the region exhibited trend reversals,i.e.,39.94%of the area of the Tibetan Plateau showed transition from a trend of increase to a trend of decrease,and 26.73%of the area demonstrated a shift from a trend of decrease to a trend of increase.Environmental factors accounted for 70.79%of the variability in WUE.The leaf area index and temperature served as the major driving forces of WUE variation.展开更多
Background:Weight-related self-stigma(WRSS)is prevalent among individuals with different types of weight status and is associated with a range of negative health outcomes.Social support and coping models explain how i...Background:Weight-related self-stigma(WRSS)is prevalent among individuals with different types of weight status and is associated with a range of negative health outcomes.Social support and coping models explain how individuals may use different coping methods to deal with their mental health needs.Psychological distress(e.g.,depression and stress)could lead to overuse of social media and smartphones.When using social media or smartphones,individuals are likely to be exposed to negative comments regarding weight/shape/size posted on the social media.Consequently,individuals who experience problematic social media use(PSMU)or problematic smartphone use(PSPU)may develop WRSS.Therefore,the present study examined the roles of PSMU and PSPU as mediators in the relationship between psychological distress and WRSS.Methods:Using convenience sampling via an online survey,622 participants with a mean age of 23.70 years(SD=4.33)completed questions assessing sociodemographic variables,psychological distress,PSMU,PSPU,WRSS,and self-reported weight and height.Results:The hierarchical regression models showed that sex(β=0.08,p=0.01),BMI(β=0.39,p<0.001),depression(β=0.21,p=0.001),stress(β=0.18,p=0.01),PSMU(β=0.09,p=0.045),and PSPU(β=0.14,p=0.001)were significant factors for WRSS.Conclusion:The mediation models showed that both PSMU and PSPU were significant mediators in the relationships between depression and stress with WRSS.The present findings provide some evidence for understanding WRSS and has important implications for developing interventions to reduce its negative impact on individuals’health and well-being.展开更多
Land use transformations in Sonipat District,Haryana,driven by urbanization,industrialization,and land acquisitions,have posed significant ecological and socio-economic challenges,particularly concerning food security...Land use transformations in Sonipat District,Haryana,driven by urbanization,industrialization,and land acquisitions,have posed significant ecological and socio-economic challenges,particularly concerning food security.This study investigates the interplay between these land use changes and their environmental implications at macro(district)and micro(village)levels,focusing on agricultural productivity and resource sustainability.The study employs a mixed-method approach,integrating secondary data from official datasets and primary data gathered through structured household surveys,focus group discussions,and visual analysis techniques.Data from 20 villages,selected based on predominant land use characteristics,were analysed using statistical and geospatial tools,including ArcGIS and STATA,to quantify food grain losses and evaluate environmental degradation.Findings of this study reveal a 19%reduction in agricultural land over two decades(2000-2024),correlating with increased residential and industrial areas.Groundwater resources face severe overexploitation,with pollution from industrial clusters further degrading water and soil quality.The study estimates a total food grain loss of 1.5 million kilograms across surveyed villages due to land acquisitions.A strong positive correlation(R^(2)=0.98)between land acquisition and food loss underscores the direct impact of urbanization on agricultural output.The research underscores the urgency of sustainable land management practices,including preserving agricultural lands,optimizing groundwater usage,and enhancing community involvement in planning.By addressing these challenges,the study advocates for balanced urban expansion and food security to ensure ecological and economic resilience in the region.展开更多
Human well-being and livelihoods depend on natural ecosystem services(ESs).Following the increment of population,ESs have been deteriorated over time.Ultimately,land use/land cover(LULC)changes have a profound impact ...Human well-being and livelihoods depend on natural ecosystem services(ESs).Following the increment of population,ESs have been deteriorated over time.Ultimately,land use/land cover(LULC)changes have a profound impact on the change of ecosystem.The primary goal of this study is to determine the impacts of LULC changes on ecosystem service values(ESVs)in the upper Gilgel Abbay watershed,Ethiopia.Changes in LULC types were studied using three Landsat images representing 1986,2003,and 2021.The Landsat images were classified using a supervised image classification technique in Earth Resources Data Analysis System(ERDAS)Imagine 2014.We classified ESs in this study into four categories(including provisioning,regulating,supporting,and cultural services)based on global ES classification scheme.The adjusted ESV coefficient benefit approach was employed to measure the impacts of LULC changes on ESVs.Five LULC types were identified in this study,including cultivated land,forest,shrubland,grassland,and water body.The result revealed that the area of cultivated land accounted for 64.50%,71.50%,and 61.50%of the total area in 1986,2003,and 2021,respectively.The percentage of the total area covered by forest was 9.50%,5.90%,and 14.80%in 1986,2003,and 2021,respectively.Result revealed that the total ESV decreased from 7.42×10^(7) to 6.44×10^(7) USD between 1986 and 2003.This is due to the expansion of cultivated land at the expense of forest and shrubland.However,the total ESV increased from 6.44×10^(7) to 7.76×10^(7) USD during 2003-2021,because of the increment of forest and shrubland.The expansion of cultivated land and the reductions of forest and shrubland reduced most individual ESs during 1986-2003.Nevertheless,the increase in forest and shrubland at the expense of cultivated land enhanced many ESs during 2003-2021.Therefore,the findings suggest that appropriate land use practices should be scaled-up to sustainably maintain ESs.展开更多
The implementation of long-term shelterbelt programs in the middle reaches of the Yellow River(MRYR),China not only has improved the overall ecological environment,but also has led to the changes of land use pattern,c...The implementation of long-term shelterbelt programs in the middle reaches of the Yellow River(MRYR),China not only has improved the overall ecological environment,but also has led to the changes of land use pattern,causing carbon storage exchanges.However,the relationship between carbon storage and land use change in the MRYR is not concerned,which results in the uncertainty in the simulation of carbon storage in this area.Land use changes directly affect the carbon storage capacity of ecosystems,and as an indicator reflecting the overall state of land use,land use degree has an important relationship with carbon storage.In this study,land use data and the integrated valuation of ecosystem services and trade-offs(InVEST)model were used to assess the trends in land use degree and carbon storage in the MRYR during 1980-2020.The potential impact index and the standard deviation ellipse(SDE)algorithm were applied to quantify and analyze the characteristics of the impact of land use changes on carbon storage.Subsequently,land use transitions that led to carbon storage variations and their spatial variations were determined.The results showed that:(1)the most significant periods of carbon storage changes and land use transitions were observed during 1990-1995 and 1995-2020,with the most changed areas locating in the east of Fenhe River and in northwestern Henan Province;(2)the positive impact of land use degree on carbon storage may be related to the environmental protection measures implemented along the Yellow River,while the negative impact may be associated with the expansion of construction land in plain areas;and(3)the conversion of other land use types to grassland was the primary factor affecting carbon storage changes during 1980-2020.In future land use planning,attention should be given to the direction of grassland conversion,and focus on reasonably limiting the development of construction land.To enhance carbon storage,it will be crucial to increase the area of high-carbon-density land types,such as forest land and grassland under the condition that the area of permanent farmland does not decrease.展开更多
[Objectives]This study was conducted to promote the rational use of special use level of antibiotics in clinic and delay the emergence of drug resistance.[Methods]The application of antibiotics for special use among i...[Objectives]This study was conducted to promote the rational use of special use level of antibiotics in clinic and delay the emergence of drug resistance.[Methods]The application of antibiotics for special use among inpatients of a hospital in 2019 was analyzed.The data in the drug information management system of the hospital were queried,and the collected expert consultation records of special-use antibiotics were sorted out.Indicators including the use rate of special-use antibiotics,antibiotic use density(AUD),defined daily dose system(DDDs)and defined daily dose system cost(DDDc)of each drug,the annual pathogen detection rate,disease distribution and pathogenic microorganism detection were summarized and analyzed for inpatients in the hospital retrospectively.[Results]In 2019,the average annual use rate of special-use antibiotics in the hospital was 1.53%,and the average annual use density was 1.59 DDDs.The antibiotics with the top three DDDs were imipenem and cilastatin,meropenem and cefepime.The antibiotics with the top three DDDc were voriconazole dispersible tablets,voriconazole for injection,and meropenem for injection.The average annual detection rate of microorganisms was 85.77%.The diseases were mainly diagnosed as respiratory infections such as pneumonia and secondary infections after radiotherapy and chemotherapy before medication,and the detected pathogens were mainly Candida and its subspecies,Escherichia coli,and Klebsiella and its subspecies.[Conclusions]The clinical use of special-use antibiotics in the hospital was basically reasonable,but there were still some problems.It is necessary to increase management efforts,strengthen training for relevant medical personnel,and provide management ideas for further standardizing the use of antibiotics in the hospital.展开更多
Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and ...Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and the third ventricle,is implicated in various psychiatric disorders.In addition,personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging.Hb segmentation was performed using a deep learning technique.The Internet Addiction Test(IAT)and the NEO Five-Factor Inventory were used to assess the PIU level and personality,respectively.Partial Spearman's correlation analyses were performed to explore the reiationships between Hb volumetry,IAT and NEO.Multiple regression analysis was applied to identify personality traits that predict IAT scores.The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.Results Relative Hb volume was negatively correlated with IAT scores(partial rho=-0.142,p=0.009).The IAT score was positively correlated with neuroticism(partial rho=0.430,p<0.001)and negatively correlated with extraversion,agreeableness and conscientiousness(partial rho=-0.213,p<0.001;partial rho=-0.279,p<0.001;and partial rho=-0.327,p<0.001).There was a significant indirect effect of Hb volume on this model(β=-0.061,p=0.048,boot 95%confidence interval:-0.149 to-0.001).Conclusions This study uncovered a crucial link between reduced Hb volume and heightened PIU.Our findings highlight neuroticism as a key risk factor for developing PIU.Moreover,neuroticism was shown to mediate the relationship between Hb volume and PIU tendency,offering valuable insight into the complexities of this interaction.展开更多
The introduction of the digital renminbi(eCNY)by the People’s Bank of China serves as a means for the central bank to effectively comprehend macroeconomic dynamics and enhance payment infrastructure within the domest...The introduction of the digital renminbi(eCNY)by the People’s Bank of China serves as a means for the central bank to effectively comprehend macroeconomic dynamics and enhance payment infrastructure within the domestic market.Among the pioneering digital currencies,the eCNY is at the forefront of technological research and development,pilot implementation,and the establishment of a robust system.Thus,employing the unified theory of acceptance and use of technology,this study aims to explore the factors shaping the adoption of the eCNY and to determine the mediating effects of intention toward the eCNY and the moderating role of age and gender among various relationships.A cross-sectional survey methodology was deployed to collect data from pilot communities situated within the Yangtze River Delta,Pearl River Delta,and Beijing–Tianjin–Hebei regions.The empirical analysis comprised 809 valid online questionnaires,and the examination was conducted through structural equation modeling employing the partial least squares technique,ultimately subjecting the conceptual model to a comprehensive assessment.The results for intention to use the eCNY indicate that performance expectancy,effort expectancy,social influence,and perceived government policy have significant effects.Facilitating conditions and intentions toward the eCNY positively influenced its actual use.According to the findings of this study,age and sex did not moderate the effect of each hypothesis on the intention to use in the research model.This study breaks new ground by investigating the adoption of the eCNY,a novel form of currency,highlighting its multifaceted nature and providing empirical evidence for a comprehensive model encompassing psychological,social,and contextual factors.This study employs social surveys to identify obstacles in the process of promoting the widespread adoption of the eCNY and offers suggestions to the central bank and government to increase user enthusiasm and decrease user perceptions of risk,thereby promoting its widespread adoption.展开更多
Background Both medication and non-medication therapies are effective approaches to control blood pressure (BP) in hypertension patients.However,the association of joint changes in antihypertensive medication use and ...Background Both medication and non-medication therapies are effective approaches to control blood pressure (BP) in hypertension patients.However,the association of joint changes in antihypertensive medication use and healthy lifestyle index (HLI)with BP control among hypertension patients is seldom reported,which needs to provide more evidence by prospective intervention studies.We examined the association of antihypertensive medication use and HLI with BP control among employees with hypertension in China based on a workplace-based multicomponent intervention program.Methods Between January 2013 and December 2014,a cluster randomized clinical trial of a workplace-based multicomponent intervention program was conducted in 60 workplaces across 20 urban areas in China.Workplaces were randomly divided into intervention (n=40) and control (n=20) groups.Basic information on employees at each workplace was collected by trained professionals,including sociodemographic characteristics,medical history,family history,lifestyle behaviors,medication status and physical measurements.After baseline,the intervention group received a 2-year intervention to achieve BP control,which included:(1) a workplace wellness program for all employees;(2) a guidelines-oriented hypertension management protocol.HLI including nonsmoking,nondrinking,adequate physical activity,weight within reference range and balanced diet,were coded on a 5-point scale (range:0-5,with higher score indicating a healthier lifestyle).Antihypertensive medication use was defined as taking drug within the last 2 weeks.Changes in HLI,antihypertensive medication use and BP control from baseline to 24 months were measured after the intervention.Results Overall,4655 employees were included (age:46.3±7.6 years,men:3547 (82.3%)).After 24 months of the intervention,there was a significant improvement in lifestyle[smoking (OR=0.65,95%CI:0.43-0.99;P=0.045),drinking (OR=0.52,95%CI:0.40-0.68;P<0.001),regular exercise (OR=3.10,95%CI:2.53-3.78;P<0.001),excessive intake of fatty food (OR=0.17,95%CI:0.06-0.52;P=0.002),restrictive use of salt (OR=0.26,95%CI:0.12-0.56;P=0.001)].Compare to employees with a deteriorating lifestyle after the intervention,those with an improved lifestyle had a higher BP control.In the intervention group,compared with employees not using antihypertensive medication,those who consistent used (OR=2.34;95%CI:1.16-4.72;P=0.017) or changed from not using to using antihypertensive medication (OR=2.24;95%CI:1.08-4.62;P=0.030) had higher BP control.Compared with those having lower HLI,participants with a same (OR=1.38;95%CI:0.99-1.93;P=0.056) or high (OR=1.79;95%CI:1.27~2.53;P<0.001) HLI had higher BP control.Those who used antihypertensive medication and had a high HLI had the highest BP control (OR=1.88;95%CI:1.32-2.67,P<0.001).Subgroup analysis also showed the consistent effect as the above.Conclusion These findings suggest that adherence to antihypertensive medication treatment and healthy lifestyle were associated with a significant improvement in BP control among employees with hypertension.展开更多
Nitrogen(N)and phosphorus(P)are mineral nutrients essential for plant growth and development,playing a crucial role throughout the plant life cycle.Cotton,a globally significant textile crop,has a particularly high de...Nitrogen(N)and phosphorus(P)are mineral nutrients essential for plant growth and development,playing a crucial role throughout the plant life cycle.Cotton,a globally significant textile crop,has a particularly high demand for N fertilizer across its developmental stages.This review explores the effects of adequate or deficient N and P levels on cotton growth phases,focusing on their influence on physiological processes and molecular mechanisms.Key topics include the regulation of N-and P-related enzymes,hormones,and genes,as well as the complex interplay of N-and P-related signaling pathways from the aspects of N-P signaling integration to regulate root development,N-P signaling integration to regulate nutrient uptake,and regulation of N-P interactions—a frontier in current research.Strategies for improving N and P use efficiency are also discussed,including developing high-efficiency cotton cultivars and identifying functional genes to enhance productivity.Generally speaking,we take model plants as a reference in the hope of coming up with new strategies for the efficient utilization of N and P in cotton.展开更多
The purpose of this paper is to look into how reliable and valid the Persian version of the Cannabis Use Disorder Identification Test-Revised (CUDIT-R-Pr) is. It will also compare the screening features of the CUDIT-R...The purpose of this paper is to look into how reliable and valid the Persian version of the Cannabis Use Disorder Identification Test-Revised (CUDIT-R-Pr) is. It will also compare the screening features of the CUDIT-R with those of the DSM-5 criteria for cannabis use disorder (CUD) based on the SCID-5-CT in a group of university students in Tehran, Iran. The study used the stratified random sampling technique to collect data from 541 students (19 to 24 years old) who used cannabis in Tehran universities in 2024. Confirmatory factor analysis confirmed the uni-dimensionality of the CUDIT-R-Pr. We checked the reliability of the CUDIT-R-Pr using Cronbach Alpha, split-half, inter-rater, test-retest stability over time, and parallel testing equivalence. The results indicated that CUDIT-R-Pr is reliable, reproducible, and responsive, with substantial agreement and adequate interpretability. The CUDIT-R shows that it can tell the difference between different levels of cannabis use severity, which is known as discriminant validity. Receiver operating characteristic analyses confirmed this, using an area under the receiver operating characteristics curve (AUC = 0.95) at a cutoff of ten or less. This allowed CUDIT-R-Pr to accurately predict any DSM-5 based on the highest correctly classified value (0.89), demonstrating high levels of sensitivity (0.96), specificity (0.69), and Youden value (0.65). The exact maximum Youden index (0.72) showed that CUDIT-R-Pr could also predict moderate DSM-5 with a cutoff of twelve or less. To validate and generalize the CUDIT-R-Pr for use among Iranian cannabis users, we need more research.展开更多
Purpose:The aim was to synthesize quantitative and qualitative research that identified the most effective educational strategies for nurse-led inhaler technique(IT)education in Chronic Obstructive Pulmonary Disease(C...Purpose:The aim was to synthesize quantitative and qualitative research that identified the most effective educational strategies for nurse-led inhaler technique(IT)education in Chronic Obstructive Pulmonary Disease(COPD)patients,as perceived by patients,healthcare providers,and nurses.Methods:A systematic literature search in Embase,PubMed,Cochrane Library,Web of Science,and CINAHL from 2018 to 30 June 2024 was conducted.In total,327 articles were identified.The results of 14 studies that met the inclusion criteria were synthesized.Data were analyzed with des-criptive and semi-quantitative methods to yield summarizing findings on the effectiveness of different educational strate-gies.All investigations had assessed patient adherence to IT.Results:Data indicated that nurse-led IT teaching strategies are effective in promoting IT adherence and correctness in COPD patients utilizing the personalized Teach-Back method.However,studies in disease control and comparison of patient IT satisfaction and self-efficacy need further investigation.Conclusion:The results of this study may contribute to the understanding of the most effective educational strategies in nurse-led IT education for COPD patients.The synthesized findings can be used for the development of new educational interventions and assessment instruments for IT adherence.展开更多
Land use and precipitation are two major factors affecting phosphorus(P)pollution of watershed runoff.However,molecular characterization of dissolved organic phosphorus(DOP)in runoff under the joint influences of land...Land use and precipitation are two major factors affecting phosphorus(P)pollution of watershed runoff.However,molecular characterization of dissolved organic phosphorus(DOP)in runoff under the joint influences of land use and precipitation remains limited.This study used Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR-MS)to study the molecular characteristics of DOP in a typical P-polluted watershed with spatially variable land use and precipitation.The results showed that low precipitation and intense human activity,including phosphate mining and associated industries,resulted in the accumulation of aliphatic DOP compounds in the upper reaches,characterized by low aromaticity and low biological stability.Higher precipitation and widespread agriculture in the middle and lower reaches resulted in highly unsaturated DOP compounds with high biological stability constituting a higher proportion,compared to in the upper reaches.While,under similar precipitation,more aliphatic DOP compounds characterized by lower aromaticity and higher saturation were enriched in the lower reaches due to more influence from urban runoff relative to the middle reaches.Photochemical and/or microbial processes did result in changes in the characteristics of DOP compounds during runoff processes due to the prevalence of low molecular weight and low O/C bioavailable aliphatic DOP molecules in the upper reaches,which were increasingly transformed into refractory compounds from the upper tomiddle reaches.The results of this study can increase the understanding of the joint impacts of land use and precipitation on DOP compounds in watershed runoff.展开更多
Burundi faces major agricultural constraints, including land fragmentation, soil erosion, limited access to inputs, inadequate infrastructure and demographic pressures that exacerbate food insecurity. In order to addr...Burundi faces major agricultural constraints, including land fragmentation, soil erosion, limited access to inputs, inadequate infrastructure and demographic pressures that exacerbate food insecurity. In order to address the multiple challenges faced by farmers in rural areas, a study on improving agricultural productivity and food security in Burundi through optimized land use and diversified farming practices in agroforestry systems has been carried out. The study area is the communes of Giheta and Rutegama, all located in Burundi’s humid plateau livelihood zone, and involved 164 households grouped in coffee growing cooperatives supervised by the cooperative consortium COCOCA. The study uses a mathematical programming model to determine optimal crop selection based on factors such as production costs, yields and market demand. The findings of the study revealed significant insights into the demographic and socio-economic characteristics of the sampled population. Notably, 98.8% of respondents were engaged in agriculture, confirming the predominantly agricultural nature of Burundi. The results indicated that maize is the most important crop, occupying 33.9% of the average total cultivated area, followed by cassava at 26.5% and bananas at 19.4%. Together, these three crops accounted for a substantial portion of the total cultivated area, highlighting their significance in local agriculture. Beans and potatoes also play a role, occupying 14.4% and smaller areas, respectively. In terms of profitability, the study provides a detailed analysis of profit margins by crop. Bananas emerges as the most profitable crop, with a profit margin of 97.3%, followed closely by cassava at 96.1% and rice at 90.5%. These crops not only offered substantial yields relative to their production costs but also benefited from strong market demand. Other crops, such as beans (71.3%), coffee (70.3%), and vegetables (54.5%), also demonstrated considerable profitability, although they occupied smaller cultivated areas. Conversely, crops like pigeon peas (4.1%), potatoes (7.6%), and sweet potatoes (7.6%) exhibited the lowest profit margins, which may discourage farmers from investing in them unless other incentives, such as ecological benefits or local consumption needs, are present. Regarding the results, we therefore recommend to promote policies supporting agroforestry, improve market access and develop infrastructure to exploit these benefits.展开更多
Jaipur,India,is experiencing rapid urbanization that is significantly altering its land use and land cover(LULC)patterns,presenting both challenges and opportunities for sustainable development and socio-economic adva...Jaipur,India,is experiencing rapid urbanization that is significantly altering its land use and land cover(LULC)patterns,presenting both challenges and opportunities for sustainable development and socio-economic advancement.This study utilizes advanced geospatial and remote sensing technologies to assess these changes and project future scenarios.Specifically,satellite data were processed using Google Earth Engine,land cover was accurately classified using the Random Forest algorithm,and future projections were modeled through QGIS-MOLUSCE using a polynomial-based Cellular Automata–Artificial Neural Network(CA-ANN)approach.Analysis of Landsat imagery for the years 2000 and 2020 reveals a dramatic 188.59%increase in urban built-up areas and a 145.44%rise in vegetation cover,largely due to successful afforestation efforts.Meanwhile,barren land declined by 47.37%,and water bodies exhibited fluctuating trends,reflecting the intricate interplay between urban development and climatic variability.Looking ahead to 2045,model projections estimate that built-up areas will expand to approximately 1303.08 square kilometres,potentially threatening the integrity of vital green spaces and aquatic ecosystems.These findings highlight the urgent need for integrated policy interventions aimed at mitigating environmental risks such as urban heat island effects and biodiversity loss.By providing a detailed account of past and present LULC dynamics,this research delivers actionable,data-driven insights to support sustainable urban planning.Moreover,the integration of urban growth models with climate resilience strategies offers a replicable framework for managing urban expansion in other rapidly developing cities,particularly those situated in semi-arid regions.展开更多
This study examines the effects of rapid land use changes in India,with a specific focus on Sonipat District in Haryana—a region undergoing significant urban expansion.Over the past two decades,rural landscapes in So...This study examines the effects of rapid land use changes in India,with a specific focus on Sonipat District in Haryana—a region undergoing significant urban expansion.Over the past two decades,rural landscapes in Sonipat have undergone notable transformation,as open spaces and agricultural lands are increasingly converted into residential colonies,commercial hubs,and industrial zones.While such changes reflect economic development and urban growth,they also raise critical concerns about sustainability,especially in terms of food security,groundwater depletion,and environmental degradation.The study examines land use changes between 2000 and 2024 using remote sensing techniques and spatial analysis.It further incorporates secondary data and insights from community-level interactions to assess the socio-economic and ecological impacts of this transformation.The findings indicate rising land fragmentation,loss of agricultural livelihoods,pressure on civic infrastructure,and increasing pollution—factors that threaten long-term regional sustainability.The study underscores the urgent need to reconcile urban development with environmental and social sustainability.By offering a detailed case study of Sonipat,this research contributes to the broader discourse on India’s urbanisation pathways.It aims to provide policymakers,planners,and researchers with evidence-based recommendations to manage land transitions more responsibly,promoting urban growth models that ensure ecological integrity,equitable development,and long-term resilience.展开更多
Background: The irrational use of medicines remains a key health problem in many developing countries. The overuse of antibiotics is a key driver of antimicrobial resistance (AMR). This study surveyed antibiotic use a...Background: The irrational use of medicines remains a key health problem in many developing countries. The overuse of antibiotics is a key driver of antimicrobial resistance (AMR). This study surveyed antibiotic use and adherence to the World Health Organization (WHO) prescribing indicators at the Request Muntanga Hospital in the Kalomo District of Southern Province, Zambia. Materials and Methods: This cross-sectional study was conducted from July 2023 to September 2023 at Request Muntanga Hospital in Zambia and reviewed 600 medical record prescriptions which were issued from July 1, 2022 to June 30, 2023 using the WHO prescribing indicators. The collected data were analyzed using Statistical Package for Social Sciences version 23.0. Results: From the 600 prescriptions sampled, 1246 medicines were prescribed, with antibiotics making up 86.7% of the encounters. Additionally, the average number of drugs prescribed per encounter was 2.1 and the prevalence of polypharmacy was 61.3%. Further, 17.8% of medicines were prescribed as injectables. Furthermore, 76.7% of the drugs were prescribed from the Zambia Essential Medicines List and 38.9% by generic names. Conclusions: This study found a high use of antibiotics and deviations from the WHO/International Network of Rational Use of Drugs (INRUD) core prescribing indicators at the Request Muntanga Hospital indicating non-adherence to the prescribing indicators. There is a need to promote adherence to the WHO/INRUD core prescribing indicators to promote the rational use of antibiotics and prevent the emergence and spread of AMR.展开更多
Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery betwe...Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery between March and June 2023 were selected as the control group,receiving routine medication management.Another 115 patients who underwent ophthalmological surgery between July and October 2023 were selected as the observation group,receiving pharmaceutical care.The rationality of medication use,mastery of medication knowledge,medication compliance,and adverse reaction rates were compared between the two groups.Results:The observation group had higher rationality of medication use,higher scores for mastery of medication knowledge,higher medication compliance,and a lower adverse reaction rate compared to the control group(P<0.05).Conclusion:The combination of antibiotic therapy and pharmaceutical care in the ophthalmology perioperative period can improve the rationality of medication use,enhance patients’mastery of medication knowledge,increase their medication compliance,and prevent adverse reactions to antibiotics.展开更多
基金supported by the Ministry of Science and Technology of China(2007FY110200)
文摘In order to provide direct evidence for the use of fire by humans at Locality 1,Zhoukoudian,we examine the burnt and unburnt sediments of newly excavated area in Layer 4 by detailed measurements of magnetic susceptibility,color,and diffuse reflectance spectrum.Results show that the magnetic susceptibility and redness of the burnt sediments are remarkably higher than those of other areas on the same level:up to*22 times for magnetic susceptibility and*3 times for redness of those of the adjacent unburnt sediments.Fine-grained(superparamagnetic/stable single-domain)magnetite and hematite grains make dominant contributions to the distinctly high values of magnetic susceptibility and redness in the burnt sediments.Diffuse reflectance spectroscopy results show that the burnt sediments contain more hematite than those of other areas and localities 2 and 3.High-temperature magnetic susceptibility measurements demonstrate that the burnt sediments have been heated above 700°C.Those changes in low-frequency magnetic susceptibility and redness are impossibly resulted from natural fires,thus most likely signaling the human activities of controlled use of fire.However,further work is needed to confirm whether or not these heat-affected sediments were produced in situ.
基金National Nonprofit Institute Research Grant of CAF,No.CAFYBB2018ZA004,No.CAFYBB2023ZA009Fengyun Application Pioneering Project,No.FY-APP-ZX-2023.02。
文摘Water use efficiency(WUE),as a pivotal indicator of the coupling degree within the carbon–water cycle of ecosystems,holds considerable importance in assessment of the carbon–water balance within terrestrial ecosystems.However,in the context of global warming,WUE evolution and its primary drivers on the Tibetan Plateau remain unclear.This study employed the ensemble empirical mode decomposition method and the random forest algorithm to decipher the nonlinear trends and drivers of WUE on the Tibetan Plateau in 2001–2020.Results indicated an annual mean WUE of 0.8088 gC/mm·m^(2)across the plateau,with a spatial gradient reflecting decrease from the southeast toward the northwest.Areas manifesting monotonous trends of increase or decrease in WUE accounted for 23.64%and 9.69%of the total,respectively.Remarkably,66.67%of the region exhibited trend reversals,i.e.,39.94%of the area of the Tibetan Plateau showed transition from a trend of increase to a trend of decrease,and 26.73%of the area demonstrated a shift from a trend of decrease to a trend of increase.Environmental factors accounted for 70.79%of the variability in WUE.The leaf area index and temperature served as the major driving forces of WUE variation.
基金supported in part by(received funding from)the Ministry of Science and Technology,Taiwan(MOST 110-2410-H-006-115,MOST 111-2410-H-006-100)the National Science and Technology Council,Taiwan(NSTC 112-2410-H-006-089-SS2)+1 种基金the Higher Education Sprout Project,the Ministry of Education at the Headquarters of University Advancement at the National Cheng Kung University(NCKU)the 2021 Southeast and South Asia and Taiwan Universities Joint Research Scheme(NCKU 31).
文摘Background:Weight-related self-stigma(WRSS)is prevalent among individuals with different types of weight status and is associated with a range of negative health outcomes.Social support and coping models explain how individuals may use different coping methods to deal with their mental health needs.Psychological distress(e.g.,depression and stress)could lead to overuse of social media and smartphones.When using social media or smartphones,individuals are likely to be exposed to negative comments regarding weight/shape/size posted on the social media.Consequently,individuals who experience problematic social media use(PSMU)or problematic smartphone use(PSPU)may develop WRSS.Therefore,the present study examined the roles of PSMU and PSPU as mediators in the relationship between psychological distress and WRSS.Methods:Using convenience sampling via an online survey,622 participants with a mean age of 23.70 years(SD=4.33)completed questions assessing sociodemographic variables,psychological distress,PSMU,PSPU,WRSS,and self-reported weight and height.Results:The hierarchical regression models showed that sex(β=0.08,p=0.01),BMI(β=0.39,p<0.001),depression(β=0.21,p=0.001),stress(β=0.18,p=0.01),PSMU(β=0.09,p=0.045),and PSPU(β=0.14,p=0.001)were significant factors for WRSS.Conclusion:The mediation models showed that both PSMU and PSPU were significant mediators in the relationships between depression and stress with WRSS.The present findings provide some evidence for understanding WRSS and has important implications for developing interventions to reduce its negative impact on individuals’health and well-being.
文摘Land use transformations in Sonipat District,Haryana,driven by urbanization,industrialization,and land acquisitions,have posed significant ecological and socio-economic challenges,particularly concerning food security.This study investigates the interplay between these land use changes and their environmental implications at macro(district)and micro(village)levels,focusing on agricultural productivity and resource sustainability.The study employs a mixed-method approach,integrating secondary data from official datasets and primary data gathered through structured household surveys,focus group discussions,and visual analysis techniques.Data from 20 villages,selected based on predominant land use characteristics,were analysed using statistical and geospatial tools,including ArcGIS and STATA,to quantify food grain losses and evaluate environmental degradation.Findings of this study reveal a 19%reduction in agricultural land over two decades(2000-2024),correlating with increased residential and industrial areas.Groundwater resources face severe overexploitation,with pollution from industrial clusters further degrading water and soil quality.The study estimates a total food grain loss of 1.5 million kilograms across surveyed villages due to land acquisitions.A strong positive correlation(R^(2)=0.98)between land acquisition and food loss underscores the direct impact of urbanization on agricultural output.The research underscores the urgency of sustainable land management practices,including preserving agricultural lands,optimizing groundwater usage,and enhancing community involvement in planning.By addressing these challenges,the study advocates for balanced urban expansion and food security to ensure ecological and economic resilience in the region.
文摘Human well-being and livelihoods depend on natural ecosystem services(ESs).Following the increment of population,ESs have been deteriorated over time.Ultimately,land use/land cover(LULC)changes have a profound impact on the change of ecosystem.The primary goal of this study is to determine the impacts of LULC changes on ecosystem service values(ESVs)in the upper Gilgel Abbay watershed,Ethiopia.Changes in LULC types were studied using three Landsat images representing 1986,2003,and 2021.The Landsat images were classified using a supervised image classification technique in Earth Resources Data Analysis System(ERDAS)Imagine 2014.We classified ESs in this study into four categories(including provisioning,regulating,supporting,and cultural services)based on global ES classification scheme.The adjusted ESV coefficient benefit approach was employed to measure the impacts of LULC changes on ESVs.Five LULC types were identified in this study,including cultivated land,forest,shrubland,grassland,and water body.The result revealed that the area of cultivated land accounted for 64.50%,71.50%,and 61.50%of the total area in 1986,2003,and 2021,respectively.The percentage of the total area covered by forest was 9.50%,5.90%,and 14.80%in 1986,2003,and 2021,respectively.Result revealed that the total ESV decreased from 7.42×10^(7) to 6.44×10^(7) USD between 1986 and 2003.This is due to the expansion of cultivated land at the expense of forest and shrubland.However,the total ESV increased from 6.44×10^(7) to 7.76×10^(7) USD during 2003-2021,because of the increment of forest and shrubland.The expansion of cultivated land and the reductions of forest and shrubland reduced most individual ESs during 1986-2003.Nevertheless,the increase in forest and shrubland at the expense of cultivated land enhanced many ESs during 2003-2021.Therefore,the findings suggest that appropriate land use practices should be scaled-up to sustainably maintain ESs.
基金funded by the National Natural Science Foundation of China(52079103)the Outstanding Youth Science Fund of Xi'an University of Science and Technology(2024YQ2-02).
文摘The implementation of long-term shelterbelt programs in the middle reaches of the Yellow River(MRYR),China not only has improved the overall ecological environment,but also has led to the changes of land use pattern,causing carbon storage exchanges.However,the relationship between carbon storage and land use change in the MRYR is not concerned,which results in the uncertainty in the simulation of carbon storage in this area.Land use changes directly affect the carbon storage capacity of ecosystems,and as an indicator reflecting the overall state of land use,land use degree has an important relationship with carbon storage.In this study,land use data and the integrated valuation of ecosystem services and trade-offs(InVEST)model were used to assess the trends in land use degree and carbon storage in the MRYR during 1980-2020.The potential impact index and the standard deviation ellipse(SDE)algorithm were applied to quantify and analyze the characteristics of the impact of land use changes on carbon storage.Subsequently,land use transitions that led to carbon storage variations and their spatial variations were determined.The results showed that:(1)the most significant periods of carbon storage changes and land use transitions were observed during 1990-1995 and 1995-2020,with the most changed areas locating in the east of Fenhe River and in northwestern Henan Province;(2)the positive impact of land use degree on carbon storage may be related to the environmental protection measures implemented along the Yellow River,while the negative impact may be associated with the expansion of construction land in plain areas;and(3)the conversion of other land use types to grassland was the primary factor affecting carbon storage changes during 1980-2020.In future land use planning,attention should be given to the direction of grassland conversion,and focus on reasonably limiting the development of construction land.To enhance carbon storage,it will be crucial to increase the area of high-carbon-density land types,such as forest land and grassland under the condition that the area of permanent farmland does not decrease.
基金Supported by National TCM Advantage Speciality Construction Project:Clinical Pharmacy(GZYYYZH[2024]90)Guizhou Provincial Key Discipline Construction Project of Traditional Chinese Medicine and Ethnic Medicine:Clinical Traditional Chinese pharmacy(QZYYZDXK(JS)-2023-04).
文摘[Objectives]This study was conducted to promote the rational use of special use level of antibiotics in clinic and delay the emergence of drug resistance.[Methods]The application of antibiotics for special use among inpatients of a hospital in 2019 was analyzed.The data in the drug information management system of the hospital were queried,and the collected expert consultation records of special-use antibiotics were sorted out.Indicators including the use rate of special-use antibiotics,antibiotic use density(AUD),defined daily dose system(DDDs)and defined daily dose system cost(DDDc)of each drug,the annual pathogen detection rate,disease distribution and pathogenic microorganism detection were summarized and analyzed for inpatients in the hospital retrospectively.[Results]In 2019,the average annual use rate of special-use antibiotics in the hospital was 1.53%,and the average annual use density was 1.59 DDDs.The antibiotics with the top three DDDs were imipenem and cilastatin,meropenem and cefepime.The antibiotics with the top three DDDc were voriconazole dispersible tablets,voriconazole for injection,and meropenem for injection.The average annual detection rate of microorganisms was 85.77%.The diseases were mainly diagnosed as respiratory infections such as pneumonia and secondary infections after radiotherapy and chemotherapy before medication,and the detected pathogens were mainly Candida and its subspecies,Escherichia coli,and Klebsiella and its subspecies.[Conclusions]The clinical use of special-use antibiotics in the hospital was basically reasonable,but there were still some problems.It is necessary to increase management efforts,strengthen training for relevant medical personnel,and provide management ideas for further standardizing the use of antibiotics in the hospital.
基金funded by a Grant-in-Aid for Scientific Research(B)(Japan Society for The Promotion of Science,21H02849)Grant-in-Aid for Scientific Research(C)(Japan Society for The Promotion of Science,23K07013)+2 种基金Grant-in-Aid for Transformative Research Areas(A)(Japan Society for The Promotion of Science,JP21H05173)Grant-in-Aid by the Smoking Research FoundationGrant-in-Aid by the Telecommunications Advancement Foundation.
文摘Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and the third ventricle,is implicated in various psychiatric disorders.In addition,personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging.Hb segmentation was performed using a deep learning technique.The Internet Addiction Test(IAT)and the NEO Five-Factor Inventory were used to assess the PIU level and personality,respectively.Partial Spearman's correlation analyses were performed to explore the reiationships between Hb volumetry,IAT and NEO.Multiple regression analysis was applied to identify personality traits that predict IAT scores.The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.Results Relative Hb volume was negatively correlated with IAT scores(partial rho=-0.142,p=0.009).The IAT score was positively correlated with neuroticism(partial rho=0.430,p<0.001)and negatively correlated with extraversion,agreeableness and conscientiousness(partial rho=-0.213,p<0.001;partial rho=-0.279,p<0.001;and partial rho=-0.327,p<0.001).There was a significant indirect effect of Hb volume on this model(β=-0.061,p=0.048,boot 95%confidence interval:-0.149 to-0.001).Conclusions This study uncovered a crucial link between reduced Hb volume and heightened PIU.Our findings highlight neuroticism as a key risk factor for developing PIU.Moreover,neuroticism was shown to mediate the relationship between Hb volume and PIU tendency,offering valuable insight into the complexities of this interaction.
基金funded by Jiangsu Education Department(Ref.No.2022SJYB0750).
文摘The introduction of the digital renminbi(eCNY)by the People’s Bank of China serves as a means for the central bank to effectively comprehend macroeconomic dynamics and enhance payment infrastructure within the domestic market.Among the pioneering digital currencies,the eCNY is at the forefront of technological research and development,pilot implementation,and the establishment of a robust system.Thus,employing the unified theory of acceptance and use of technology,this study aims to explore the factors shaping the adoption of the eCNY and to determine the mediating effects of intention toward the eCNY and the moderating role of age and gender among various relationships.A cross-sectional survey methodology was deployed to collect data from pilot communities situated within the Yangtze River Delta,Pearl River Delta,and Beijing–Tianjin–Hebei regions.The empirical analysis comprised 809 valid online questionnaires,and the examination was conducted through structural equation modeling employing the partial least squares technique,ultimately subjecting the conceptual model to a comprehensive assessment.The results for intention to use the eCNY indicate that performance expectancy,effort expectancy,social influence,and perceived government policy have significant effects.Facilitating conditions and intentions toward the eCNY positively influenced its actual use.According to the findings of this study,age and sex did not moderate the effect of each hypothesis on the intention to use in the research model.This study breaks new ground by investigating the adoption of the eCNY,a novel form of currency,highlighting its multifaceted nature and providing empirical evidence for a comprehensive model encompassing psychological,social,and contextual factors.This study employs social surveys to identify obstacles in the process of promoting the widespread adoption of the eCNY and offers suggestions to the central bank and government to increase user enthusiasm and decrease user perceptions of risk,thereby promoting its widespread adoption.
基金supported by grant 2011BAI11B01 from the Projects in the Chinese National Science and Technology Pillar Program during the 12th Five-year Plan Periodby grant 2017-I2M-1-004 from the Chinese Academy of Medical Science Innovation Fund for Medical Sciencesby the Major science and technology special plan project of Yunnan Province (202302AA310045)。
文摘Background Both medication and non-medication therapies are effective approaches to control blood pressure (BP) in hypertension patients.However,the association of joint changes in antihypertensive medication use and healthy lifestyle index (HLI)with BP control among hypertension patients is seldom reported,which needs to provide more evidence by prospective intervention studies.We examined the association of antihypertensive medication use and HLI with BP control among employees with hypertension in China based on a workplace-based multicomponent intervention program.Methods Between January 2013 and December 2014,a cluster randomized clinical trial of a workplace-based multicomponent intervention program was conducted in 60 workplaces across 20 urban areas in China.Workplaces were randomly divided into intervention (n=40) and control (n=20) groups.Basic information on employees at each workplace was collected by trained professionals,including sociodemographic characteristics,medical history,family history,lifestyle behaviors,medication status and physical measurements.After baseline,the intervention group received a 2-year intervention to achieve BP control,which included:(1) a workplace wellness program for all employees;(2) a guidelines-oriented hypertension management protocol.HLI including nonsmoking,nondrinking,adequate physical activity,weight within reference range and balanced diet,were coded on a 5-point scale (range:0-5,with higher score indicating a healthier lifestyle).Antihypertensive medication use was defined as taking drug within the last 2 weeks.Changes in HLI,antihypertensive medication use and BP control from baseline to 24 months were measured after the intervention.Results Overall,4655 employees were included (age:46.3±7.6 years,men:3547 (82.3%)).After 24 months of the intervention,there was a significant improvement in lifestyle[smoking (OR=0.65,95%CI:0.43-0.99;P=0.045),drinking (OR=0.52,95%CI:0.40-0.68;P<0.001),regular exercise (OR=3.10,95%CI:2.53-3.78;P<0.001),excessive intake of fatty food (OR=0.17,95%CI:0.06-0.52;P=0.002),restrictive use of salt (OR=0.26,95%CI:0.12-0.56;P=0.001)].Compare to employees with a deteriorating lifestyle after the intervention,those with an improved lifestyle had a higher BP control.In the intervention group,compared with employees not using antihypertensive medication,those who consistent used (OR=2.34;95%CI:1.16-4.72;P=0.017) or changed from not using to using antihypertensive medication (OR=2.24;95%CI:1.08-4.62;P=0.030) had higher BP control.Compared with those having lower HLI,participants with a same (OR=1.38;95%CI:0.99-1.93;P=0.056) or high (OR=1.79;95%CI:1.27~2.53;P<0.001) HLI had higher BP control.Those who used antihypertensive medication and had a high HLI had the highest BP control (OR=1.88;95%CI:1.32-2.67,P<0.001).Subgroup analysis also showed the consistent effect as the above.Conclusion These findings suggest that adherence to antihypertensive medication treatment and healthy lifestyle were associated with a significant improvement in BP control among employees with hypertension.
基金supported by Supported by National Key Laboratory of Cotton Bio-breeding and Integrated Utilization(CB2023C07)Xinjiang Autonomous Region"Three Agricultural"Backbone Talent Training Program(2022SNGGNT024)Xinjiang Huyanghe City Science and Technology Program(2023C08).
文摘Nitrogen(N)and phosphorus(P)are mineral nutrients essential for plant growth and development,playing a crucial role throughout the plant life cycle.Cotton,a globally significant textile crop,has a particularly high demand for N fertilizer across its developmental stages.This review explores the effects of adequate or deficient N and P levels on cotton growth phases,focusing on their influence on physiological processes and molecular mechanisms.Key topics include the regulation of N-and P-related enzymes,hormones,and genes,as well as the complex interplay of N-and P-related signaling pathways from the aspects of N-P signaling integration to regulate root development,N-P signaling integration to regulate nutrient uptake,and regulation of N-P interactions—a frontier in current research.Strategies for improving N and P use efficiency are also discussed,including developing high-efficiency cotton cultivars and identifying functional genes to enhance productivity.Generally speaking,we take model plants as a reference in the hope of coming up with new strategies for the efficient utilization of N and P in cotton.
文摘The purpose of this paper is to look into how reliable and valid the Persian version of the Cannabis Use Disorder Identification Test-Revised (CUDIT-R-Pr) is. It will also compare the screening features of the CUDIT-R with those of the DSM-5 criteria for cannabis use disorder (CUD) based on the SCID-5-CT in a group of university students in Tehran, Iran. The study used the stratified random sampling technique to collect data from 541 students (19 to 24 years old) who used cannabis in Tehran universities in 2024. Confirmatory factor analysis confirmed the uni-dimensionality of the CUDIT-R-Pr. We checked the reliability of the CUDIT-R-Pr using Cronbach Alpha, split-half, inter-rater, test-retest stability over time, and parallel testing equivalence. The results indicated that CUDIT-R-Pr is reliable, reproducible, and responsive, with substantial agreement and adequate interpretability. The CUDIT-R shows that it can tell the difference between different levels of cannabis use severity, which is known as discriminant validity. Receiver operating characteristic analyses confirmed this, using an area under the receiver operating characteristics curve (AUC = 0.95) at a cutoff of ten or less. This allowed CUDIT-R-Pr to accurately predict any DSM-5 based on the highest correctly classified value (0.89), demonstrating high levels of sensitivity (0.96), specificity (0.69), and Youden value (0.65). The exact maximum Youden index (0.72) showed that CUDIT-R-Pr could also predict moderate DSM-5 with a cutoff of twelve or less. To validate and generalize the CUDIT-R-Pr for use among Iranian cannabis users, we need more research.
文摘Purpose:The aim was to synthesize quantitative and qualitative research that identified the most effective educational strategies for nurse-led inhaler technique(IT)education in Chronic Obstructive Pulmonary Disease(COPD)patients,as perceived by patients,healthcare providers,and nurses.Methods:A systematic literature search in Embase,PubMed,Cochrane Library,Web of Science,and CINAHL from 2018 to 30 June 2024 was conducted.In total,327 articles were identified.The results of 14 studies that met the inclusion criteria were synthesized.Data were analyzed with des-criptive and semi-quantitative methods to yield summarizing findings on the effectiveness of different educational strate-gies.All investigations had assessed patient adherence to IT.Results:Data indicated that nurse-led IT teaching strategies are effective in promoting IT adherence and correctness in COPD patients utilizing the personalized Teach-Back method.However,studies in disease control and comparison of patient IT satisfaction and self-efficacy need further investigation.Conclusion:The results of this study may contribute to the understanding of the most effective educational strategies in nurse-led IT education for COPD patients.The synthesized findings can be used for the development of new educational interventions and assessment instruments for IT adherence.
基金supported by the Three Gorges Corporation (No.HBHB2023018)the Project of Hubei Provincial Key Research and Development (No.2022BCA074)the National Key Research and Development Program of China (No.2022YFC3705002).
文摘Land use and precipitation are two major factors affecting phosphorus(P)pollution of watershed runoff.However,molecular characterization of dissolved organic phosphorus(DOP)in runoff under the joint influences of land use and precipitation remains limited.This study used Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR-MS)to study the molecular characteristics of DOP in a typical P-polluted watershed with spatially variable land use and precipitation.The results showed that low precipitation and intense human activity,including phosphate mining and associated industries,resulted in the accumulation of aliphatic DOP compounds in the upper reaches,characterized by low aromaticity and low biological stability.Higher precipitation and widespread agriculture in the middle and lower reaches resulted in highly unsaturated DOP compounds with high biological stability constituting a higher proportion,compared to in the upper reaches.While,under similar precipitation,more aliphatic DOP compounds characterized by lower aromaticity and higher saturation were enriched in the lower reaches due to more influence from urban runoff relative to the middle reaches.Photochemical and/or microbial processes did result in changes in the characteristics of DOP compounds during runoff processes due to the prevalence of low molecular weight and low O/C bioavailable aliphatic DOP molecules in the upper reaches,which were increasingly transformed into refractory compounds from the upper tomiddle reaches.The results of this study can increase the understanding of the joint impacts of land use and precipitation on DOP compounds in watershed runoff.
文摘Burundi faces major agricultural constraints, including land fragmentation, soil erosion, limited access to inputs, inadequate infrastructure and demographic pressures that exacerbate food insecurity. In order to address the multiple challenges faced by farmers in rural areas, a study on improving agricultural productivity and food security in Burundi through optimized land use and diversified farming practices in agroforestry systems has been carried out. The study area is the communes of Giheta and Rutegama, all located in Burundi’s humid plateau livelihood zone, and involved 164 households grouped in coffee growing cooperatives supervised by the cooperative consortium COCOCA. The study uses a mathematical programming model to determine optimal crop selection based on factors such as production costs, yields and market demand. The findings of the study revealed significant insights into the demographic and socio-economic characteristics of the sampled population. Notably, 98.8% of respondents were engaged in agriculture, confirming the predominantly agricultural nature of Burundi. The results indicated that maize is the most important crop, occupying 33.9% of the average total cultivated area, followed by cassava at 26.5% and bananas at 19.4%. Together, these three crops accounted for a substantial portion of the total cultivated area, highlighting their significance in local agriculture. Beans and potatoes also play a role, occupying 14.4% and smaller areas, respectively. In terms of profitability, the study provides a detailed analysis of profit margins by crop. Bananas emerges as the most profitable crop, with a profit margin of 97.3%, followed closely by cassava at 96.1% and rice at 90.5%. These crops not only offered substantial yields relative to their production costs but also benefited from strong market demand. Other crops, such as beans (71.3%), coffee (70.3%), and vegetables (54.5%), also demonstrated considerable profitability, although they occupied smaller cultivated areas. Conversely, crops like pigeon peas (4.1%), potatoes (7.6%), and sweet potatoes (7.6%) exhibited the lowest profit margins, which may discourage farmers from investing in them unless other incentives, such as ecological benefits or local consumption needs, are present. Regarding the results, we therefore recommend to promote policies supporting agroforestry, improve market access and develop infrastructure to exploit these benefits.
文摘Jaipur,India,is experiencing rapid urbanization that is significantly altering its land use and land cover(LULC)patterns,presenting both challenges and opportunities for sustainable development and socio-economic advancement.This study utilizes advanced geospatial and remote sensing technologies to assess these changes and project future scenarios.Specifically,satellite data were processed using Google Earth Engine,land cover was accurately classified using the Random Forest algorithm,and future projections were modeled through QGIS-MOLUSCE using a polynomial-based Cellular Automata–Artificial Neural Network(CA-ANN)approach.Analysis of Landsat imagery for the years 2000 and 2020 reveals a dramatic 188.59%increase in urban built-up areas and a 145.44%rise in vegetation cover,largely due to successful afforestation efforts.Meanwhile,barren land declined by 47.37%,and water bodies exhibited fluctuating trends,reflecting the intricate interplay between urban development and climatic variability.Looking ahead to 2045,model projections estimate that built-up areas will expand to approximately 1303.08 square kilometres,potentially threatening the integrity of vital green spaces and aquatic ecosystems.These findings highlight the urgent need for integrated policy interventions aimed at mitigating environmental risks such as urban heat island effects and biodiversity loss.By providing a detailed account of past and present LULC dynamics,this research delivers actionable,data-driven insights to support sustainable urban planning.Moreover,the integration of urban growth models with climate resilience strategies offers a replicable framework for managing urban expansion in other rapidly developing cities,particularly those situated in semi-arid regions.
文摘This study examines the effects of rapid land use changes in India,with a specific focus on Sonipat District in Haryana—a region undergoing significant urban expansion.Over the past two decades,rural landscapes in Sonipat have undergone notable transformation,as open spaces and agricultural lands are increasingly converted into residential colonies,commercial hubs,and industrial zones.While such changes reflect economic development and urban growth,they also raise critical concerns about sustainability,especially in terms of food security,groundwater depletion,and environmental degradation.The study examines land use changes between 2000 and 2024 using remote sensing techniques and spatial analysis.It further incorporates secondary data and insights from community-level interactions to assess the socio-economic and ecological impacts of this transformation.The findings indicate rising land fragmentation,loss of agricultural livelihoods,pressure on civic infrastructure,and increasing pollution—factors that threaten long-term regional sustainability.The study underscores the urgent need to reconcile urban development with environmental and social sustainability.By offering a detailed case study of Sonipat,this research contributes to the broader discourse on India’s urbanisation pathways.It aims to provide policymakers,planners,and researchers with evidence-based recommendations to manage land transitions more responsibly,promoting urban growth models that ensure ecological integrity,equitable development,and long-term resilience.
文摘Background: The irrational use of medicines remains a key health problem in many developing countries. The overuse of antibiotics is a key driver of antimicrobial resistance (AMR). This study surveyed antibiotic use and adherence to the World Health Organization (WHO) prescribing indicators at the Request Muntanga Hospital in the Kalomo District of Southern Province, Zambia. Materials and Methods: This cross-sectional study was conducted from July 2023 to September 2023 at Request Muntanga Hospital in Zambia and reviewed 600 medical record prescriptions which were issued from July 1, 2022 to June 30, 2023 using the WHO prescribing indicators. The collected data were analyzed using Statistical Package for Social Sciences version 23.0. Results: From the 600 prescriptions sampled, 1246 medicines were prescribed, with antibiotics making up 86.7% of the encounters. Additionally, the average number of drugs prescribed per encounter was 2.1 and the prevalence of polypharmacy was 61.3%. Further, 17.8% of medicines were prescribed as injectables. Furthermore, 76.7% of the drugs were prescribed from the Zambia Essential Medicines List and 38.9% by generic names. Conclusions: This study found a high use of antibiotics and deviations from the WHO/International Network of Rational Use of Drugs (INRUD) core prescribing indicators at the Request Muntanga Hospital indicating non-adherence to the prescribing indicators. There is a need to promote adherence to the WHO/INRUD core prescribing indicators to promote the rational use of antibiotics and prevent the emergence and spread of AMR.
文摘Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery between March and June 2023 were selected as the control group,receiving routine medication management.Another 115 patients who underwent ophthalmological surgery between July and October 2023 were selected as the observation group,receiving pharmaceutical care.The rationality of medication use,mastery of medication knowledge,medication compliance,and adverse reaction rates were compared between the two groups.Results:The observation group had higher rationality of medication use,higher scores for mastery of medication knowledge,higher medication compliance,and a lower adverse reaction rate compared to the control group(P<0.05).Conclusion:The combination of antibiotic therapy and pharmaceutical care in the ophthalmology perioperative period can improve the rationality of medication use,enhance patients’mastery of medication knowledge,increase their medication compliance,and prevent adverse reactions to antibiotics.
