BACKGROUND Cytomegalovirus(CMV)infections can cause significant morbidity and mortality in immunocompromised individuals.CMV targets dysfunctional lymphocytes.Chronic rituximab(RTX)therapy can cause B-lymphocyte dysfu...BACKGROUND Cytomegalovirus(CMV)infections can cause significant morbidity and mortality in immunocompromised individuals.CMV targets dysfunctional lymphocytes.Chronic rituximab(RTX)therapy can cause B-lymphocyte dysfunction,increasing CMV risk.Rarely,CMV infections present with critical illness such as septic shock.CASE SUMMARY A 64-year-old African American woman presented with generalized weakness and non-bloody watery diarrhea of 4-6 weeks duration.She did not have nausea,vomiting or,abdominal pain.She had been on monthly RTX infusions for neuromyelitis optica.She was admitted for septic shock due to pancolitis.Blood investigations suggested pancytopenia and serology detected significantly elevated CMV DNA.Valganciclovir treatment led to disease resolution.CONCLUSION This case illustrates an extremely rare case of CMV colitis associated with RTX use presenting with septic shock.High suspicion for rare opportunistic infections is imperative in individuals with long-term RTX use.展开更多
With the artificial alder and cypress mixed forest being planted, there has been a marked land use change since 1970s' in Hilly Area of Central Sichuan Basin, China. Data from meteorological observations or posts ...With the artificial alder and cypress mixed forest being planted, there has been a marked land use change since 1970s' in Hilly Area of Central Sichuan Basin, China. Data from meteorological observations or posts operated over long time, measurement and calculation of NPP (net primary production) and biomass of biological community, and analysis of soil organic matter content show that the artificial alder and cypress mixed forest has outstanding eco-environmental effect: adjusting local climate, raising soil fertility, alleviating menace of drought, and raising NPP and biomass of biological community. It is very beneficial for improving ecological environment to afforest artificial alder and cypress mixed forest in populous Hilly Area of Central Sichuan Basin, China. Key Words: land use/land cover change (LUCC); eco-environmental effect; Hilly Area of Central Sichuan Basin; the artificial alder and cypress mixed forest展开更多
Domain analysis is essential to core assets development in software product line engineering. Most existing approaches, however, depend on domain experts’ experience to analyze the commonality and variability of syst...Domain analysis is essential to core assets development in software product line engineering. Most existing approaches, however, depend on domain experts’ experience to analyze the commonality and variability of systems in a domain, which remains a manual and intensive process. This paper addresses the issue by proposing a model-driven approach to automating the domain requirements derivation process. The paper focuses on the match between the use cases of existing individual products and the domain functional requirements of a product line. By introducing a set of linguistic description dimensions to differentiate the sub-variations in a use case, the use case template is extended to model variability. To this end, a transformation process is formulated to sustain and deduce the information in use cases, and to match it to domain functional requirements. This paper also presents a prototype which implements the derivation as a model transformation described in a graphical model transformation language MOLA. This approach complements existing domain analysis techniques with less manual operation cost and more efficiency by automating the domain functional requirements development.展开更多
In order to inquire into the therapeutic effects of Xiao Shi Xiong Huang San (硝石雄黄散the Nitrum and Realgar Powder), one of the Dunhuang Prescription, on angina pectoris due to coronary heart disease (APCHD), the a...In order to inquire into the therapeutic effects of Xiao Shi Xiong Huang San (硝石雄黄散the Nitrum and Realgar Powder), one of the Dunhuang Prescription, on angina pectoris due to coronary heart disease (APCHD), the authors have treated 61 cases of APCHD by externally applying paste of the powder on Zhiyang (GV 9), with another 30 cases of APCHD treated with the nitroglycerin paste on Zhiyang as the controls. The results showed that the total effective rate was 82% and markedly effective rate 31.2% in the treatment group (the Paste of Nitrum and Realgar Powder), and the total effective rate was 46.6% and markedly effective rate 23.2% in the control group (the nitroglycerin paste). The difference in therapeutic effects between the two groups was very significant (P<0.01), indicating that the therapeutic effect of the former was significantly superior to that of the latter.展开更多
The emergence of various technologies such as terahertz communications,Reconfigurable Intelligent Surfaces(RIS),and AI-powered communication services will burden network operators with rising infrastructure costs.Rece...The emergence of various technologies such as terahertz communications,Reconfigurable Intelligent Surfaces(RIS),and AI-powered communication services will burden network operators with rising infrastructure costs.Recently,the Open Radio Access Network(O-RAN)has been introduced as a solution for growing financial and operational burdens in Beyond 5G(B5G)and 6G networks.O-RAN promotes openness and intelligence to overcome the limitations of traditional RANs.By disaggregating conventional Base Band Units(BBUs)into O-RAN Distributed Units(O-DU)and O-RAN Centralized Units(O-CU),O-RAN offers greater flexibility for upgrades and network automation.However,this openness introduces new security challenges compared to traditional RANs.Many existing studies overlook these security requirements of the O-RAN networks.To gain deeper insights into the O-RAN system and security,this paper first provides an overview of the general O-RAN architecture and its diverse use cases relevant to B5G and 6G applications.We then delve into specifications of O-RAN security threats and requirements,aiming to mitigate security vulnerabilities effectively.By providing a comprehensive understanding of O-RAN architecture,use cases,and security considerations,thisworkserves as a valuable resource for future research in O-RAN and its security.展开更多
A software security testing behavior model,SETAM,was proposed in our previous work as the integrated model for describing software security testing requirements behavior,which is not only compatible with security func...A software security testing behavior model,SETAM,was proposed in our previous work as the integrated model for describing software security testing requirements behavior,which is not only compatible with security functions and latent typical misuse behaviors,but also with the interaction of them.In this paper,we analyze the differences between SETAM with security use case and security misuse case in different types of security test requirements.To illustrate the effectiveness of SETAM,we compare them in a practical case study by the number of test cases and the number of faults detected by them.The results show that SETAM could decrease about 34.87%use cases on average,and the number of faults detected by SETAM increased by 71.67%in average,which means that our model can detect more faults with fewer test cases for software security testing.展开更多
Semantic representation of evidence-based medical guidelines provides the support for the data inter-operability and has been found many applications in the medical domain. In this paper, we describe a semantic repres...Semantic representation of evidence-based medical guidelines provides the support for the data inter-operability and has been found many applications in the medical domain. In this paper, we describe a semantic representation approach of evidence-based medical guidelines, which is based on the Semantic Web Technology standards. We discuss several use cases of that semantic representation of evidence-based medical guideline, and show that they are potentially useful for medical applications.展开更多
文摘BACKGROUND Cytomegalovirus(CMV)infections can cause significant morbidity and mortality in immunocompromised individuals.CMV targets dysfunctional lymphocytes.Chronic rituximab(RTX)therapy can cause B-lymphocyte dysfunction,increasing CMV risk.Rarely,CMV infections present with critical illness such as septic shock.CASE SUMMARY A 64-year-old African American woman presented with generalized weakness and non-bloody watery diarrhea of 4-6 weeks duration.She did not have nausea,vomiting or,abdominal pain.She had been on monthly RTX infusions for neuromyelitis optica.She was admitted for septic shock due to pancolitis.Blood investigations suggested pancytopenia and serology detected significantly elevated CMV DNA.Valganciclovir treatment led to disease resolution.CONCLUSION This case illustrates an extremely rare case of CMV colitis associated with RTX use presenting with septic shock.High suspicion for rare opportunistic infections is imperative in individuals with long-term RTX use.
基金Supported by the Knowledge Innovation Program of Chinese Academy of Sciences(KZCX1-SW-01-01B)Cultivatlon Foundation of Institute of Mountain Hazards and Environment,CAS
文摘With the artificial alder and cypress mixed forest being planted, there has been a marked land use change since 1970s' in Hilly Area of Central Sichuan Basin, China. Data from meteorological observations or posts operated over long time, measurement and calculation of NPP (net primary production) and biomass of biological community, and analysis of soil organic matter content show that the artificial alder and cypress mixed forest has outstanding eco-environmental effect: adjusting local climate, raising soil fertility, alleviating menace of drought, and raising NPP and biomass of biological community. It is very beneficial for improving ecological environment to afforest artificial alder and cypress mixed forest in populous Hilly Area of Central Sichuan Basin, China. Key Words: land use/land cover change (LUCC); eco-environmental effect; Hilly Area of Central Sichuan Basin; the artificial alder and cypress mixed forest
文摘Domain analysis is essential to core assets development in software product line engineering. Most existing approaches, however, depend on domain experts’ experience to analyze the commonality and variability of systems in a domain, which remains a manual and intensive process. This paper addresses the issue by proposing a model-driven approach to automating the domain requirements derivation process. The paper focuses on the match between the use cases of existing individual products and the domain functional requirements of a product line. By introducing a set of linguistic description dimensions to differentiate the sub-variations in a use case, the use case template is extended to model variability. To this end, a transformation process is formulated to sustain and deduce the information in use cases, and to match it to domain functional requirements. This paper also presents a prototype which implements the derivation as a model transformation described in a graphical model transformation language MOLA. This approach complements existing domain analysis techniques with less manual operation cost and more efficiency by automating the domain functional requirements development.
文摘In order to inquire into the therapeutic effects of Xiao Shi Xiong Huang San (硝石雄黄散the Nitrum and Realgar Powder), one of the Dunhuang Prescription, on angina pectoris due to coronary heart disease (APCHD), the authors have treated 61 cases of APCHD by externally applying paste of the powder on Zhiyang (GV 9), with another 30 cases of APCHD treated with the nitroglycerin paste on Zhiyang as the controls. The results showed that the total effective rate was 82% and markedly effective rate 31.2% in the treatment group (the Paste of Nitrum and Realgar Powder), and the total effective rate was 46.6% and markedly effective rate 23.2% in the control group (the nitroglycerin paste). The difference in therapeutic effects between the two groups was very significant (P<0.01), indicating that the therapeutic effect of the former was significantly superior to that of the latter.
基金supported by the Research Program funded by the SeoulTech(Seoul National University of Science and Technology).
文摘The emergence of various technologies such as terahertz communications,Reconfigurable Intelligent Surfaces(RIS),and AI-powered communication services will burden network operators with rising infrastructure costs.Recently,the Open Radio Access Network(O-RAN)has been introduced as a solution for growing financial and operational burdens in Beyond 5G(B5G)and 6G networks.O-RAN promotes openness and intelligence to overcome the limitations of traditional RANs.By disaggregating conventional Base Band Units(BBUs)into O-RAN Distributed Units(O-DU)and O-RAN Centralized Units(O-CU),O-RAN offers greater flexibility for upgrades and network automation.However,this openness introduces new security challenges compared to traditional RANs.Many existing studies overlook these security requirements of the O-RAN networks.To gain deeper insights into the O-RAN system and security,this paper first provides an overview of the general O-RAN architecture and its diverse use cases relevant to B5G and 6G applications.We then delve into specifications of O-RAN security threats and requirements,aiming to mitigate security vulnerabilities effectively.By providing a comprehensive understanding of O-RAN architecture,use cases,and security considerations,thisworkserves as a valuable resource for future research in O-RAN and its security.
基金Supported by the National High Technology Research and Development Program of China(863 Program)(2009AA01Z402)the PLA University of Science and Technology Pre-research Project(20110202,20110210)+1 种基金the Natural Science Foundation of Jiangsu Province of China(BK2012059,BK2012060)the PLAUST Outstanding Graduate Student Thesis Fund(2012)
文摘A software security testing behavior model,SETAM,was proposed in our previous work as the integrated model for describing software security testing requirements behavior,which is not only compatible with security functions and latent typical misuse behaviors,but also with the interaction of them.In this paper,we analyze the differences between SETAM with security use case and security misuse case in different types of security test requirements.To illustrate the effectiveness of SETAM,we compare them in a practical case study by the number of test cases and the number of faults detected by them.The results show that SETAM could decrease about 34.87%use cases on average,and the number of faults detected by SETAM increased by 71.67%in average,which means that our model can detect more faults with fewer test cases for software security testing.
基金Supported by the European Commission under the 7th Framework EURECA Project(FP7-ICT-2011-7,288048)the Key Projects of National Social Science Foundation of China(11ZD&189)the Natural Science Foundation of Hubei Province(2014CFB247)
文摘Semantic representation of evidence-based medical guidelines provides the support for the data inter-operability and has been found many applications in the medical domain. In this paper, we describe a semantic representation approach of evidence-based medical guidelines, which is based on the Semantic Web Technology standards. We discuss several use cases of that semantic representation of evidence-based medical guideline, and show that they are potentially useful for medical applications.
