Objective:To explore the predictive value of the combined test of urinary sodium,urinary potassium excretion fraction(FEK),and urinary potassium concentration/urine creatinine concentration(UK/UCr)in sepsis-induced ea...Objective:To explore the predictive value of the combined test of urinary sodium,urinary potassium excretion fraction(FEK),and urinary potassium concentration/urine creatinine concentration(UK/UCr)in sepsis-induced early acute kidney injury(AKI).Methods:Sixty sepsis patients admitted to the Northern Hospital of National Pharmaceuticals from 2022.4 to 2024.4 were selected and divided into the AKI group(n=21)and the non-AKI group(n=39)according to whether AKI occurred or not,and another 20 health check-up subjects from our hospital were selected to be included in the control group during the same period of time,and we compared the urinary sodium,urinary FEK,and urinary UK/UCr tests of the three groups,and analysed the urinary potassium concentration/urine creatinine concentration(UK/UCr)in the early stage of sepsis-induced acute kidney injury(AKI)by plotting the working characteristics of the subjects(ROC)curve graph to analyse the predictive value of the combined detection of urinary sodium,urinary FEK and urinary UK/UCr in sepsis-induced early AKI.Results:The levels of urinary FEK and urinary UK/UCr in the non-AKI group were higher than those in the control group,and the levels of urinary sodium were lower than those in the control group(P<0.05),while the levels of urinary FEK and urinary UK/UCr in the AKI group were higher than those in the non-AKI group,and the levels of urinary sodium were lower than those in the non-AKI group(P<0.05);the ROC was plotted and found that the combined test of urinary sodium,urinary FEK,and urinary UK/UCr was useful for the prediction of early AKI caused by sepsis.The area under the curve(AUC)values ranged from 0.694-0.940,with high sensitivity and specificity,and the value of predicting sepsis-induced early AKI was high.Conclusion:Urinary sodium,urinary FEK and urinary UK/UCr can be used as effective biomarkers for the early prediction of AKI,and the combined test has high value in predicting early AKI caused by sepsis.展开更多
Most studies assessing urine biochemistry for acute kidney injury(AKI)monitoring rely on paradigms from the 1970s.It was proposed that a single measurement of urinary parameters in the presence of increased serum crea...Most studies assessing urine biochemistry for acute kidney injury(AKI)monitoring rely on paradigms from the 1970s.It was proposed that a single measurement of urinary parameters in the presence of increased serum creatinine(sCr)could help understand AKI pathophysiology and predict its duration.However,those studies produced variable and controversial results.Recently,an alternative“urine biochemical approach”has been proposed.In contrast with the traditional approach,it includes sequential urine electrolyte assessment,evaluation before AKI diagnosis,and interpretation of avid sodium retention as a marker of renal microcirculatory stress instead of low renal perfusion.This review highlights the rationale of this alternative approach,which is focused on early urinary biochemical changes that precede increases in sCr as well as signs of renal recovery before decreases in sCr.The relevance of urine composition in conjunction with urine volume for a proper evaluation of renal function is emphasized.This new approach aims to enhance the utility of urinary biochemical parameters in AKI monitoring,particularly in patients who are critically ill.展开更多
Adequate vegetable intake is important in reducing the risk of lifestyle-related diseases;however, intake amongst young Japanese adults is poor. This study aimed to assess the effect of daily intake of a commercially ...Adequate vegetable intake is important in reducing the risk of lifestyle-related diseases;however, intake amongst young Japanese adults is poor. This study aimed to assess the effect of daily intake of a commercially available vegetable juice on nutritional status and metabolic syndrome-related markers in healthy young adults. Fifty-one healthy adults (14 men, 37 women), age 20 - 22 years were recruited, and their food and nutritional intake was surveyed using an FFQ based on Food Groups. Subjects were divided into either a control group, who were not administered vegetable juice, or an intervention group, who consumed 200 mL vegetable juice daily for 2 months. Anthropometric data, serum carotenoid concentrations, blood and urinary parameters were measured at baseline and at 2 months. The average intake of vegetables in all subjects at baseline was approximately 140 g/day, less than half the dose recommended by the Japanese government. Total serum carotenoid concentration in the intervention group doubled from baseline after 2 months. In particular, serum concentrations of α-carotene, β-carotene, and lycopene were increased. In the intervention group, 24-hour urinary potassium excretion increased significantly, and 24-hour urinary sodium to potassium ratio decreased significantly. Waist circumference and systolic blood pressure also decreased significantly. Daily intake of a commercial vegetable juice for 2 months improved nutritional status in young adults with inadequate vegetable intake, shown by improved serum carotenoid and urine potassium levels. In addition, intake of vegetable juice may be beneficial in reducing the risk of metabolic syndrome.展开更多
文摘Objective:To explore the predictive value of the combined test of urinary sodium,urinary potassium excretion fraction(FEK),and urinary potassium concentration/urine creatinine concentration(UK/UCr)in sepsis-induced early acute kidney injury(AKI).Methods:Sixty sepsis patients admitted to the Northern Hospital of National Pharmaceuticals from 2022.4 to 2024.4 were selected and divided into the AKI group(n=21)and the non-AKI group(n=39)according to whether AKI occurred or not,and another 20 health check-up subjects from our hospital were selected to be included in the control group during the same period of time,and we compared the urinary sodium,urinary FEK,and urinary UK/UCr tests of the three groups,and analysed the urinary potassium concentration/urine creatinine concentration(UK/UCr)in the early stage of sepsis-induced acute kidney injury(AKI)by plotting the working characteristics of the subjects(ROC)curve graph to analyse the predictive value of the combined detection of urinary sodium,urinary FEK and urinary UK/UCr in sepsis-induced early AKI.Results:The levels of urinary FEK and urinary UK/UCr in the non-AKI group were higher than those in the control group,and the levels of urinary sodium were lower than those in the control group(P<0.05),while the levels of urinary FEK and urinary UK/UCr in the AKI group were higher than those in the non-AKI group,and the levels of urinary sodium were lower than those in the non-AKI group(P<0.05);the ROC was plotted and found that the combined test of urinary sodium,urinary FEK,and urinary UK/UCr was useful for the prediction of early AKI caused by sepsis.The area under the curve(AUC)values ranged from 0.694-0.940,with high sensitivity and specificity,and the value of predicting sepsis-induced early AKI was high.Conclusion:Urinary sodium,urinary FEK and urinary UK/UCr can be used as effective biomarkers for the early prediction of AKI,and the combined test has high value in predicting early AKI caused by sepsis.
文摘Most studies assessing urine biochemistry for acute kidney injury(AKI)monitoring rely on paradigms from the 1970s.It was proposed that a single measurement of urinary parameters in the presence of increased serum creatinine(sCr)could help understand AKI pathophysiology and predict its duration.However,those studies produced variable and controversial results.Recently,an alternative“urine biochemical approach”has been proposed.In contrast with the traditional approach,it includes sequential urine electrolyte assessment,evaluation before AKI diagnosis,and interpretation of avid sodium retention as a marker of renal microcirculatory stress instead of low renal perfusion.This review highlights the rationale of this alternative approach,which is focused on early urinary biochemical changes that precede increases in sCr as well as signs of renal recovery before decreases in sCr.The relevance of urine composition in conjunction with urine volume for a proper evaluation of renal function is emphasized.This new approach aims to enhance the utility of urinary biochemical parameters in AKI monitoring,particularly in patients who are critically ill.
文摘Adequate vegetable intake is important in reducing the risk of lifestyle-related diseases;however, intake amongst young Japanese adults is poor. This study aimed to assess the effect of daily intake of a commercially available vegetable juice on nutritional status and metabolic syndrome-related markers in healthy young adults. Fifty-one healthy adults (14 men, 37 women), age 20 - 22 years were recruited, and their food and nutritional intake was surveyed using an FFQ based on Food Groups. Subjects were divided into either a control group, who were not administered vegetable juice, or an intervention group, who consumed 200 mL vegetable juice daily for 2 months. Anthropometric data, serum carotenoid concentrations, blood and urinary parameters were measured at baseline and at 2 months. The average intake of vegetables in all subjects at baseline was approximately 140 g/day, less than half the dose recommended by the Japanese government. Total serum carotenoid concentration in the intervention group doubled from baseline after 2 months. In particular, serum concentrations of α-carotene, β-carotene, and lycopene were increased. In the intervention group, 24-hour urinary potassium excretion increased significantly, and 24-hour urinary sodium to potassium ratio decreased significantly. Waist circumference and systolic blood pressure also decreased significantly. Daily intake of a commercial vegetable juice for 2 months improved nutritional status in young adults with inadequate vegetable intake, shown by improved serum carotenoid and urine potassium levels. In addition, intake of vegetable juice may be beneficial in reducing the risk of metabolic syndrome.
