Indolizine is a nitrogen-containing heterocycle with strong aromaticity,possessing a delocalized 10π-electron system.Based on the indolizine scaffolds,numerous molecules with biological activity and organic functiona...Indolizine is a nitrogen-containing heterocycle with strong aromaticity,possessing a delocalized 10π-electron system.Based on the indolizine scaffolds,numerous molecules with biological activity and organic functional materials have been synthesized.Since 2016,over 110 papers have been published on the synthesis of indolizine scaffolds,but the reviews on synthesizing indolizine scaffolds have been incomplete and not up-to-date.Herein,from the perspective of the structure of indolizine with the combination of pyrrole and pyridine ring,we focus on the construction of indolizine scaffolds through the diversity of starting substrates,including pyridine derivatives(N1-substituted pyridinium salt derivatives,C2-substituted pyridine derivatives,N1-and C2-free substituted pyridine derivatives),pyrrole derivatives and unoriginal ring substrates.Furthermore,the corresponding reaction mechanisms of synthetic methodologies are also elaborated.Therefore,this review not only paves the way for indolizine synthesis but also provides insight into exploring new reaction modes for constructing nitrogen-containing heterocycles.展开更多
基金supported by the National Natural Science Foundation of China(22361003)Jiangxi Provincial Science Foundation for Distinguished Young Scholars(20212ACB216002)+2 种基金the Youth JinggangScholars Program in JiangxiProvince(QNJG2019089)the Jiangxi Provincial Natural Science Foundation(20224BAB216005,20242BAB25591)the Yunnan Revitalization Talent Support Program“Young Talent”Project and the Research Foundation of Zhaoqing University(ZD202413).
文摘Indolizine is a nitrogen-containing heterocycle with strong aromaticity,possessing a delocalized 10π-electron system.Based on the indolizine scaffolds,numerous molecules with biological activity and organic functional materials have been synthesized.Since 2016,over 110 papers have been published on the synthesis of indolizine scaffolds,but the reviews on synthesizing indolizine scaffolds have been incomplete and not up-to-date.Herein,from the perspective of the structure of indolizine with the combination of pyrrole and pyridine ring,we focus on the construction of indolizine scaffolds through the diversity of starting substrates,including pyridine derivatives(N1-substituted pyridinium salt derivatives,C2-substituted pyridine derivatives,N1-and C2-free substituted pyridine derivatives),pyrrole derivatives and unoriginal ring substrates.Furthermore,the corresponding reaction mechanisms of synthetic methodologies are also elaborated.Therefore,this review not only paves the way for indolizine synthesis but also provides insight into exploring new reaction modes for constructing nitrogen-containing heterocycles.
