Cells of the central nervous system(CNS)are privileged in lying behind the blood-brain barrier(BBB).Unlike blood vessels in other organs,CNS blood vessels are unique in displaying high electrical resistance and low pe...Cells of the central nervous system(CNS)are privileged in lying behind the blood-brain barrier(BBB).Unlike blood vessels in other organs,CNS blood vessels are unique in displaying high electrical resistance and low permeability.With this unique structure and function,the BBB prevents potentially harmful blood components such as serum proteins,inflammatory cytokines,and inflammatory leukocytes from entering the hallowed space of the CNS and wreaking havoc.In addition to these“tightness”properties,the BBB has an array of specialized transporters designed to import essential nutrients.展开更多
An extended series of Mn-based cage-like phenylsilsesquioxanes were obtained via convenient selfassembly reactions and complexations with 1,10-phenanthroline.The structural features of these cage complexes such as(i)v...An extended series of Mn-based cage-like phenylsilsesquioxanes were obtained via convenient selfassembly reactions and complexations with 1,10-phenanthroline.The structural features of these cage complexes such as(i)various nuclearities and types of silsesquioxane ligands.展开更多
Developing wide-temperature and high-safety lithium-ion batteries(LIBs)presents significant challenges attributed to the absence of suitable solvents possessing broad liquid range and non-flammability properties.γ-Bu...Developing wide-temperature and high-safety lithium-ion batteries(LIBs)presents significant challenges attributed to the absence of suitable solvents possessing broad liquid range and non-flammability properties.γ-Butyrolactone(GBL)has emerged as a promising solvent;however,its incompatibility with graphite anode has hindered its application.This limitation necessitates a comprehensive investigation into the underlying mechanisms and potential solutions.In this study,we achieve a molecular-level understanding of the perplexing interphase formation process by employing in-situ spectroelectrochemical techniques and density function calculations.Our findings reveal that,even at high salt concentrations,GBL consistently occupies the primary Li^(+)solvation sheath,leading to extensive GBL decomposition and the formation of a high-impedance and inorganic-poor solid-electrolyte interphase(SEI)layer.Contrary to manipulating solvation structures,our research demonstrates that the utilization of filmforming additives with higher reduction potential facilitates the pre-establishment of a robust SEI film on the graphite anode.This approach effectively inhibits GBL decomposition and significantly enhances the battery's lifespan.This study provides the first reported intrinsic understanding of the unique GBLgraphite incompatibility and offers valuable insights for the development of wide-temperature and high-safety LIBs.展开更多
We consider a modified Markov branching process incorporating with both state-independent immigration-migration and resurrection. The effect of state-independent immigration-migration is firstly in- vestigated in deta...We consider a modified Markov branching process incorporating with both state-independent immigration-migration and resurrection. The effect of state-independent immigration-migration is firstly in- vestigated in detail. The explicit expressions for the extinction probabilities and mean extinction times are presented. The ergodicity and stability properties of the process incorporating with resurrection structure are then investigated. The conditions for recurrence, ergodicity and exponential ergodicity are obtained. An explicit expression for the equilibrium distribution is also presented. As a preparation, the criteria for regularity and uniqueness for such structure are firstly established.展开更多
Marine animal polysaccharides represent some of the most crucial and effective active compounds found within these creatures.They have garnered significant attention due to their distinct structural traits and diverse...Marine animal polysaccharides represent some of the most crucial and effective active compounds found within these creatures.They have garnered significant attention due to their distinct structural traits and diverse biological activities,including anti-obesity,anti-enteritis,antioxidant,anti-diabetic,and anti-coagulant properties.An increasing number of novel active polysaccharides with unique structures and effects have been isolated from marine animals.These compounds hold promise as a new resource for enhancing human health and addressing various diseases.Consequently,our review aims to consolidate the latest discoveries regarding the characteristics of marine animal polysaccharides,the factors influencing their diverse nutritional functions,and the mechanisms underlying their actions.The goal is to offer insights for exploiting and utilizing marine animal polysaccharide resources,laying a scientific foundation for comprehensive research into organism health and balanced dietary practices.展开更多
基金supported by the NIH RF1 grant NS119477 jointly funded by NINDS and NIA(to RM).
文摘Cells of the central nervous system(CNS)are privileged in lying behind the blood-brain barrier(BBB).Unlike blood vessels in other organs,CNS blood vessels are unique in displaying high electrical resistance and low permeability.With this unique structure and function,the BBB prevents potentially harmful blood components such as serum proteins,inflammatory cytokines,and inflammatory leukocytes from entering the hallowed space of the CNS and wreaking havoc.In addition to these“tightness”properties,the BBB has an array of specialized transporters designed to import essential nutrients.
基金financially supported by the Russian Science Foundation(project no.22-13-00250)Elemental analysis data were collected using the equipment of the Center for Molecular Composition Studies of INEOS RAS with the support from the Ministry of Science and Higher Education of the Russian Federation.D.G.acknowledges the RUDN University Scientific Projects Grant System,project no.025239-2-174+1 种基金Israel Science Foundation(ISF)grant no.370/20the Esther K.and M.Mark Watkins Chair for Synthetic Organic Chemistry.XANES experiment was supported by the Ministry of Education of the Russian Federation:No.075-15-2022-1107.We dedicate this article to the memory of our dear friend and colleague Dr.M.M.Levitsky(INEOS RAS,Moscow,Russia).
文摘An extended series of Mn-based cage-like phenylsilsesquioxanes were obtained via convenient selfassembly reactions and complexations with 1,10-phenanthroline.The structural features of these cage complexes such as(i)various nuclearities and types of silsesquioxane ligands.
基金financially supported by the National Natural Science Foundation of China(21972049,22272175)the National Key R&D Program of China(2022YFA1504002)+3 种基金the“Scientist Studio Funding”from Tianmu Lake Institute of Advanced Energy Storage Technologies Co.,Ltd.Dalian Supports High-Level Talent Innovation and Entrepreneurship Projects(2021RD14)the Dalian Institute of Chemical Physics(DICP I202213)the 21C Innovation Laboratory,Contemporary Ampere Technology Ltd.by project No.21C-OP-202208。
文摘Developing wide-temperature and high-safety lithium-ion batteries(LIBs)presents significant challenges attributed to the absence of suitable solvents possessing broad liquid range and non-flammability properties.γ-Butyrolactone(GBL)has emerged as a promising solvent;however,its incompatibility with graphite anode has hindered its application.This limitation necessitates a comprehensive investigation into the underlying mechanisms and potential solutions.In this study,we achieve a molecular-level understanding of the perplexing interphase formation process by employing in-situ spectroelectrochemical techniques and density function calculations.Our findings reveal that,even at high salt concentrations,GBL consistently occupies the primary Li^(+)solvation sheath,leading to extensive GBL decomposition and the formation of a high-impedance and inorganic-poor solid-electrolyte interphase(SEI)layer.Contrary to manipulating solvation structures,our research demonstrates that the utilization of filmforming additives with higher reduction potential facilitates the pre-establishment of a robust SEI film on the graphite anode.This approach effectively inhibits GBL decomposition and significantly enhances the battery's lifespan.This study provides the first reported intrinsic understanding of the unique GBLgraphite incompatibility and offers valuable insights for the development of wide-temperature and high-safety LIBs.
基金supported by National Natural Science Foundations of China (Grant Nos. 10771216 and 11071259)
文摘We consider a modified Markov branching process incorporating with both state-independent immigration-migration and resurrection. The effect of state-independent immigration-migration is firstly in- vestigated in detail. The explicit expressions for the extinction probabilities and mean extinction times are presented. The ergodicity and stability properties of the process incorporating with resurrection structure are then investigated. The conditions for recurrence, ergodicity and exponential ergodicity are obtained. An explicit expression for the equilibrium distribution is also presented. As a preparation, the criteria for regularity and uniqueness for such structure are firstly established.
基金supported by the National Natural Science Foundation of China[NO.32302093]Liaoning Provincial Education Department Basic Research Project[NO.LJKQZ20222401]+3 种基金Liaoning Provincial Natural Science Foundation Program Project[NO.2022-BS-275]Key Science and Technology Program of Liaoning Province[NO.2020JH1/10200001]Liaoning Provincial Education Department Key Tackling Project[NO.LJKZZ20220090]the Central Government Subsidy Project for Liaoning Fisheries(2023)[No grant number].
文摘Marine animal polysaccharides represent some of the most crucial and effective active compounds found within these creatures.They have garnered significant attention due to their distinct structural traits and diverse biological activities,including anti-obesity,anti-enteritis,antioxidant,anti-diabetic,and anti-coagulant properties.An increasing number of novel active polysaccharides with unique structures and effects have been isolated from marine animals.These compounds hold promise as a new resource for enhancing human health and addressing various diseases.Consequently,our review aims to consolidate the latest discoveries regarding the characteristics of marine animal polysaccharides,the factors influencing their diverse nutritional functions,and the mechanisms underlying their actions.The goal is to offer insights for exploiting and utilizing marine animal polysaccharide resources,laying a scientific foundation for comprehensive research into organism health and balanced dietary practices.
