Phase singularities(PSs)in topological darkness-based sensors have received significant attention in optical sensing due to their rapid,ultra-sensitive,and label-free detection capabilities.Here,we present both experi...Phase singularities(PSs)in topological darkness-based sensors have received significant attention in optical sensing due to their rapid,ultra-sensitive,and label-free detection capabilities.Here,we present both experimental and theoretical investigations of an ultrasensitive and multiplexed phase-sensitive sensor utilizing dual topological PSs in the visible and near-infrared regions.This sensor uses a simple structure,which consists of an ultra-thin highly absorbing film deposited on a metal substrate.We demonstrate the achievement of dual-polarization darkness points for s-and p-polarizations at different incident angles.Furthermore,we theoretically explain the double topological PSs accompanied by a perfect±π-jump near a zero-reflection point,based on the temporal coupled-mode formalism.To validate its multifunctional capabilities,humidity sensing tests were carried out.The results demonstrate that the sensor has a detection limit reaching the level of 0.12‰.These findings go beyond the scope of conventional interference optical coatings and highlight the potential applications of this technology in gas sensing and biosensing domains.展开更多
Gastric cancer(GC)is a prevalent malignant tumor within the digestive system,with over 40%of new cases and deaths related to GC globally occurring in China.Despite advancements in treatment modalities,such as surgery ...Gastric cancer(GC)is a prevalent malignant tumor within the digestive system,with over 40%of new cases and deaths related to GC globally occurring in China.Despite advancements in treatment modalities,such as surgery supplemented by adjuvant radiotherapy or chemotherapeutic agents,the prognosis for GC remains poor.New targeted therapies and immunotherapies are currently under invest-igation,but no significant breakthroughs have been achieved.Studies have indicated that GC is a heterogeneous disease,encompassing multiple subtypes with distinct biological characteristics and roles.Consequently,personalized treatment based on clinical features,pathologic typing,and molecular typing is crucial for the diagnosis and management of precancerous lesions of gastric cancer(PLGC).Current research has categorized GC into four subtypes:Epstein-Barr virus-positive,microsatellite instability,genome stability,and chromosome instability(CIN).Technologies such as multi-omics analysis and gene sequencing are being employed to identify more suitable novel testing methods in these areas.Among these,ultrasensitive chromosomal aneuploidy detection(UCAD)can detect CIN at a genome-wide level in subjects using low-depth whole genome sequencing technology,in conjunction with bioinformatics analysis,to achieve qualitative and quantitative detection of chromosomal stability.This editorial reviews recent research advancements in UCAD technology for the diagnosis and management of PLGC.展开更多
Urothelial carcinoma(UC)is a common malignant tumor in the urinary system with high recurrence rate and low survival rate 5 years after surgery.At present,imaging examination and other diagnostic methods have some sho...Urothelial carcinoma(UC)is a common malignant tumor in the urinary system with high recurrence rate and low survival rate 5 years after surgery.At present,imaging examination and other diagnostic methods have some shortcomings such as invasiveness and non-specificity.Therefore,it is urgent to develop a simple,rapid,noninvasive,highly sensitive and highly specific strategy to diagnose UC.Herein,a high-performance fluorescence sensor was constructed by the plasmonic gold nanorods(AuNRs)-enhanced near-infrared(NIR)fluorescence of silver sulfide quantum dots(Ag_(2)S QDs).The designed sensor can be used for the fast and accurate detection of small molecule single-transmembrane protein(FXYD3),which is overexpressed in 90%of ureteral cancers and 84%of high-grade bladder cancers.Due to its high specificity,the NIR fluorescence sensor achieves the detection of FXYD3 in the range of 0.25-150 ng·ml^(-1)with a detection limit of 0.2 ng·ml^(-1).Importantly,it also can be used for accurate diagnosis of FXYD3 in the urine of patients with relevant cancers,and the results are consistent with clinical cystoscopy and pathological analysis.The proposed fluorescence sensor provides a simple,ultrasensitive,reliable method for UC screening,tumor-grade classification and postoperative monitoring and will have great potential for clinical applications.展开更多
In this manuscript,we first report an ultrasensitive detection assay of microRNA by combing asymmetric polymerase chain reaction(A-PCR)and loop-mediated isothermal amplification(LAMP)technology.Using A-PCR obtained an...In this manuscript,we first report an ultrasensitive detection assay of microRNA by combing asymmetric polymerase chain reaction(A-PCR)and loop-mediated isothermal amplification(LAMP)technology.Using A-PCR obtained an extended single strand to form LAMP stem-loop structure under isothermal amplification conditions.We used miRNAs as a loop primer probe in LAMP reaction and completed its ultrasensitive and rapid detection.The established method furnished a fast,specific and efficient detection of target miRNA with a detection limit as low as 10 amol/L in 90 min.展开更多
Two-dimensional covalent organic framework(COF)has distinctive properties that offer potential opportunities for developing advanced electrode materials.In this work,a core-shell material composed of TAPB-DMTP-COF(TAP...Two-dimensional covalent organic framework(COF)has distinctive properties that offer potential opportunities for developing advanced electrode materials.In this work,a core-shell material composed of TAPB-DMTP-COF(TAPB,1,3,5-tris(4-aminophenyl)benzene;DMTP,2,5-dimethoxyterephaldehyde)core and conducting polymer shell,TAPB-DMTP-COF@PANI,was synthesized solvothermally using a polymerization method.The structural cha racteristics of the prepared composite were revealed by X-ray diffraction patterns(XRD),fourier transform infrared spectra(FTIR),X-ray photoelectron spectroscopy(XPS),transmission electron microscopy(TEM).The electrochemical analyses were verified by subsequent monitoring of trace levels of acetaminophen.This resultant composite not only facilitated acetaminophen to interact with absorption sites byπ-πstacking effect and hydrogen bonding but also overcame the poor conductivity of COF.Under the optimal conditions,a low limit of detection of 0.032μmol/L and wide linear range of 0.10-500μmol/L were obtained.The electrochemical platform was almost unaffected by other interfering substances,and successfully applied for the practical detection of acetaminophen in commercial tablet,human blood serum and urine.The enhanced performance makes this COF based core-shell composite a promising material in electrochemical senso r.展开更多
Rapid and accurate detection of immunoglobulin E(Ig E) in serum and reduction of serum dosage are of great significance for clinical detection. Herein, we described a rapid magnetic separation of Ig E from patient ser...Rapid and accurate detection of immunoglobulin E(Ig E) in serum and reduction of serum dosage are of great significance for clinical detection. Herein, we described a rapid magnetic separation of Ig E from patient serum based on Fe3 O4@Si O2-NTA@026 sdab as the capture probe and multiple horseradish peroxidase(HRP)-labeled antibodies linked gold nanoparticles(Au NPs) as chemiluminescence(CL) signal amplifier for ultrasensitive detection of total Ig E. Results showed that the limit of detection of our immunosensor system in serum samples was 0.03 k U/L, which is lowest in comparison with current methods, and far lower than that of Immuno CAP for Ig E detection(0.1 k U/L). Furthermore, our immunosensor possessed satisfied repeatability and accuracy, as well as good stability. In comparison with the Immuno CAP for the quantitative detection of Ig E, highly consistent results were achieved in 20 serum samples. Specially, this method was also successfully utilized for assessing the Ig E traces in breast cancer patients,which provides a new idea for the diagnosis of early cancer. Therefore, we believe that such versatile immunosensor will offer an alternative method for the on-site monitoring and determination of various Ig E-related diseases.展开更多
An ultrasensitive detection and effective removal material was successfully developed by using a pillar[n]arene-based supramolecular polymer gel(MTP5?HB).The MTP5?HB can ultrasensitively recognize Cu^2+and Fe^3+,and t...An ultrasensitive detection and effective removal material was successfully developed by using a pillar[n]arene-based supramolecular polymer gel(MTP5?HB).The MTP5?HB can ultrasensitively recognize Cu^2+and Fe^3+,and the limits of detection(LODs)for Cu^2+and Fe^3+are 1.55 and 2.68 nmol/L,respectively.Additionally,the in-situ generated metallogel MTP5?HB-Cu can exclusively detect CN,and the LOD for CN is 1.13 nmol/L.Noticeably,the xerogel of MTP5?HB-Cu can effectively remove CN from aqueous solution with 94.40%removal rate.Test kit based on MTP5?HB-Cu is also prepared for convenient detection of CN.展开更多
Advanced sensing devices based on metasurfaces have emerged as a revolutionary platform for innovative label-free biosensors,holding promise for early diagnostics and the detection of low-concentration analytes.Here,w...Advanced sensing devices based on metasurfaces have emerged as a revolutionary platform for innovative label-free biosensors,holding promise for early diagnostics and the detection of low-concentration analytes.Here,we developed a chip-based ultrasensitive terahertz(THz)metasensor,leveraging a quasi-bound state in the continuum(q-BIC)to address the challenges associated with intricate operations in trace biochemical detection.The metasensor design features an open-ring resonator metasurface,which supports magnetic dipole q-BIC combining functionalized gold nanoparticles(AuNPs)bound with a specific antibody.The substantial enhancement in THz–analyte interactions,facilitated by the potent near-field enhancement enabled by the q-BICs,results in a substantial boost in biosensor sensitivity by up to 560 GHz/refractive index units.This methodology allows for the detection of conjugated antibody–AuNPs for cardiac troponin I at concentrations as low as 0.5 pg/ml.These discoveries deliver valuable insight for AuNP-based trace biomolecule sensing and pave the path for the development of chip-scale biosensors with profound light–matter interactions.展开更多
The localized surface plasmon resonance metasurface is a research hotspot in the sensing field since it can enhance the light-matter interaction in the nanoscale,but the wavelength sensitivity is far from comparable w...The localized surface plasmon resonance metasurface is a research hotspot in the sensing field since it can enhance the light-matter interaction in the nanoscale,but the wavelength sensitivity is far from comparable with that of prism-coupled surface plasmon polariton(SPP).Herein,we propose and demonstrate an ultrasensitive angular interrogation sensor based on the transverse electric mode surface lattice resonance(SLR)mechanism in an all-metal metasurface.In theory,we derive the sensitivity function in detail and emphasize the refraction effect at the air-solution interface,which influences the SLR position and improves the sensitivity performance greatly in the wide-angle.In the measurement,a broadband light source substitutes the single-wavelength laser generally used in traditional angular sensing,and the measured SLR wavelength of broadband illuminant at normal incidence is defined as the single wavelength,avoiding the sensitivity loss from the large angle.The experimental sensitivity can reach 4304.35°/RIU,promoting an order of magnitude compared to those of SPP-sensors.This research provides a novel theory as well as the corresponding crucial approach to achieving ultrasensitive angular sensing.展开更多
Flexible wearables have attracted extensive interests for personal human motion sensing,intelligent disease diagnosis,and multifunctional electronic skins.How-ever,the reported flexible sensors,mostly exhibited narrow...Flexible wearables have attracted extensive interests for personal human motion sensing,intelligent disease diagnosis,and multifunctional electronic skins.How-ever,the reported flexible sensors,mostly exhibited narrow detection range,low sensitivity,limited degradability to aggravate environmental pollution from vast electronic wastes,and poor antibacterial performance to hardly improve skin dis-comfort and skin inflammation from bacterial growth under long-term wearing.Herein,bioinspired from human skin featuring highly sensitive tactile sensation with spinous microstructures for amplifying sensing sensitivity between epidermis and dermis,a wearable antibacterial degradable electronics is prepared from degrad-able elastomeric substrate with MXene-coated spinous microstructures templated from lotus leaf assembled with the interdigitated electrode.The degradable elas-tomer is facilely obtained with tunable modulus to match the modulus of human skin with improved hydrophilicity for rapid degradation.The as-obtained sensor displays ultra-low detection limit(0.2 Pa),higher sensitivity(up to 540.2 kPa^(-1)),outstand-ing cycling stability(>23,000 cycles),a wide detection range,robust degradability,and excellent antibacterial capability.Facilitated by machine learning,the collected sensing signals from the integrated sensors on volunteer's fingers to the related American Sign Language are effectively recognized with an accuracy up to 99%,showing excellent potential in wireless human movement sensing and smart machine learning-enabled human-machine interaction.展开更多
Multiplex ultrasensitive detection of low abundance proteins remains a significant challenge in clinical applications,necessitating the development of innovative solutions.The integration of bead-based microfluidic ch...Multiplex ultrasensitive detection of low abundance proteins remains a significant challenge in clinical applications,necessitating the development of innovative solutions.The integration of bead-based microfluidic chip platforms with their efficient target capture and separation capabilities,along with the advantages of miniaturization and low reagent consumption,holds great promise for building an integrated point-of-care testing(POCT)system that enables seamless sample input-result output.This review presents a comprehensive overview of recent advancements in bead-based microfluidic platforms for multiplex and ultrasensitive immunoassays,along with their potential applications in clinical diagnosis and treatment,which is organized into four sections:encoding techniques,the role of microfluidic platforms,applications,and future prospects.展开更多
Nowadays,high-stable and ultrasensitive heavy metal detection is of utmost importance in water quality monitoring.Nanoparticle-enhanced laser-induced breakdown spectroscopy(NELIBS)shows high potential in hazardous met...Nowadays,high-stable and ultrasensitive heavy metal detection is of utmost importance in water quality monitoring.Nanoparticle-enhanced laser-induced breakdown spectroscopy(NELIBS)shows high potential in hazardous metal detection,however,encounters unstable and weak signals due to nonuniform distribution of analytes.Herein,we developed an interface self-assembly(ISA)method to create a uniformly distributed gold nanolayer at a liquid-liquid interface for positive heavy metal ions capture and NELIBS analysis.The electrostatically selfassembled Au nanoparticles(NPs)-analytes membrane was prepared at the oil-water interface by injecting ethanol into the mixture of cyclohexane and Au NPs-analytes water solution.Then,the interface self-assembled Au NPs-analytes membrane was transformed onto a laser-processed superhydrophilic Si slide for detection.Three heavy metals(cadmium(Cd),barium(Ba),and chromium(Cr))were analyzed to evaluate the stability and sensitivity of the ISA method for NELIBS.The results(Cd:RSD=3.6%,LoD=0.654 mg/L;Ba:RSD=3.4%,LoD=0.236 mg/L;Cr:RSD=7.7%,LoD=1.367 mg/L)demonstrated signal enhancement and high-stable and ultrasensitive detection.The actual sample detection(Cd:RE=7.71%,Ba:RE=6.78%)illustrated great reliability.The ISA method,creating a uniform distribution of NP-analytes at the interface,has promising prospects in NELIBS.展开更多
Vibrational strong coupling(VSC)provides a promising way towards not only enhanced control of infrared light but also reshaping of molecular properties,which opens up unprecedented opportunities in ultrasensitive infr...Vibrational strong coupling(VSC)provides a promising way towards not only enhanced control of infrared light but also reshaping of molecular properties,which opens up unprecedented opportunities in ultrasensitive infrared spectroscopy,modification of chemical reactions,and exploration of nonlinear quantum effects.Surface plasmon resonance,excited on simple plasmonic resonators in the infrared,has been demonstrated as a means to realize VSC,but suffers from either limited quality factor for realizing large Rabi splitting or poor reconfigurability for precise detuning control.Here we propose and experimentally demonstrate,for the first time,an on-chip plasmonic resonator based on degeneracy breaking of Wood’s anomaly for VSC.Leveraging the low damping rate of the surface state induced by this degeneracy breaking,we achieve a plasmonic resonance with a high-Q factor exceeding~110,resulting in a Rabi splitting up to~112 cm^(-1) with a subwavelength molecular layer.Additionally,the dispersion of the surface state allows for precise control over VSC detuning by simply adjusting the incident angle of excitation light,even in the absence of photons,enabling a broad detuning range up to 300 cm^(-1).These experimental results align well with our analytical model and numerical simulation.This work provides a promising integrated platform for VSC,with various potential applications in on-chip spectroscopy,polariton chemistry,and polariton devices.展开更多
Active control of metamaterial properties with high tunability of both resonant intensity and frequency is essential for advanced terahertz(THz) applications, ranging from spectroscopy and sensing to communications.Am...Active control of metamaterial properties with high tunability of both resonant intensity and frequency is essential for advanced terahertz(THz) applications, ranging from spectroscopy and sensing to communications.Among varied metamaterials, plasmon-induced transparency(PIT) has enabled active control with giant sensitivity by embedding semiconducting materials. However, there is still a stringent challenge to achieve dynamic responses in both intensity and frequency modulation. Here, an anisotropic THz active metamaterial device with an ultrasensitive modulation feature is proposed and experimentally studied. A radiative-radiative-coupled PIT system is established, with a frequency shift of 0.26 THz in its sharp transparent windows by polarization rotation. Enabled by high charge-carrier mobility and longer diffusion lengths, we utilize a straightforwardly spincoated MAPbI3 film acting as a photoactive medium to endow the device with high sensitivity and ultrafast speed.When the device is pumped by an ultralow laser fluence, the PIT transmission windows at 0.86 and 1.12 THz demonstrate a significant reduction for two polarizations, respectively, with a full recovery time of 561 ps. In addition, we numerically prove the validity that the investigated resonator structure is sensitive to the optically induced conductivity. The hybrid system not only achieves resonant intensity and frequency modulations simultaneously, but also preserves the all-optical-induced switching merits with high sensitivity and speed, which enriches multifunctional subwavelength metamaterial devices at THz frequencies.展开更多
An ultrasensitive magnetic field sensor based on a compact in-fiber Mach–Zehnder interferometer(MZI) created in twin-core fiber(TCF) is proposed, and its performance is experimentally demonstrated. A section of TCF w...An ultrasensitive magnetic field sensor based on a compact in-fiber Mach–Zehnder interferometer(MZI) created in twin-core fiber(TCF) is proposed, and its performance is experimentally demonstrated. A section of TCF was spliced between two sections of standard single-mode fibers, and then a microchannel was drilled through one core of the TCF by means of femtosecond laser micromachining. The TCF with one microchannel was then immersed in a water-based Fe_3O_4 magnetic fluid(MF), forming a direct component of the light propagation path,and then sealed in a capillary tube, achieving a magnetic sensing element, which merges the advantages of an MZI with an MF. Experiments were conducted to investigate the magnetic response of the proposed sensor. The developed magnetic field sensor exhibits a linear response within a measurement range from 5 to 9.5 m T and an ultrahigh sensitivity of 20.8 nm/m T, which, to our best knowledge, is 2 orders of magnitude greater than other previously reported magnetic sensors. The proposed sensor is expected to offer significant potential for detecting weak magnetic fields.展开更多
Aptamer serves as a potential candidate for the micro-detection of cocaine due to its high specificity,high affinity and good stability.Although cocaine aptasensors have been extensively studied,the binding mechanism ...Aptamer serves as a potential candidate for the micro-detection of cocaine due to its high specificity,high affinity and good stability.Although cocaine aptasensors have been extensively studied,the binding mechanism of cocaine-aptamer interactions is still unknown,which limits the structural refinement in the design of an aptamer to improve the performance of cocaine aptasensors.Herein,we report a label-free,ultrasensitive detection of single-molecule cocaine-aptamer interaction by using an electrical nanocircuit based on graphene-moleculegraphene single-molecule junctions (GMG-SMJs).Real-time recordings of cocaine-aptamer interactions have exhibited distinct current oscillations before and after cocaine treatment,revealing the dynamic mechanism of the conformational changes of aptamer upon binding with cocaine.Further concentration-dependent experiments have proved that these devices can act as a single-molecule biosensor with at least a limit of detection as low as 1 nmol·L^-1.The method demonstrated in this work provides a novel strategy for shedding light on the interaction mechanism of biomolecules as well as constructing new types of aptasensors toward practical applications.展开更多
The fabrication of sensitive sensors with high selectivity is highly desirable for the detection of some important biomarkers,such as nucleic acids,proteins,small molecules and ions.DNA hybridization chain reaction(HC...The fabrication of sensitive sensors with high selectivity is highly desirable for the detection of some important biomarkers,such as nucleic acids,proteins,small molecules and ions.DNA hybridization chain reaction(HCR) and DNA supersandwich self-assembly(SSA) are two prevalent enzyme-free signal amplification strategies to improve sensitivity of the sensors.In this review,we firstly describe the characteristics about DNA HCR and DNA SSA,and then summarize the advances in the one-dimensional DNA nanostructures assisted by HCR and SSA.This review has been divided into three parts according to the two signal amplification methods and highlights recent progress in these two strategies to improve the detection sensitivity of proteins,nucleic acids,small molecules and ions.展开更多
Ion-conductive hydrogels with intrinsic biocompatibility,stretchability,and stimuli-responsive capability have attracted considerable attention because of their extensive application potential in wearable sensing devi...Ion-conductive hydrogels with intrinsic biocompatibility,stretchability,and stimuli-responsive capability have attracted considerable attention because of their extensive application potential in wearable sensing devices.The miniaturization and integration of hydrogel-based devices are currently expected to achieve breakthroughs in device performance and promote their practical application.However,currently,hydrogel film is rarely reported because it can be easily wrinkled,torn,and dehydrated,which severely hinders its development in microelectronics.Herein,thin,stretchable,and transparent ion-conductive double-network hydrogel films with controllable thickness are integrated with stretchable elastomer substrates,which show good environmental stability and ultrahigh sensitivity to humidity(78,785.5%/% relative humidity(RH)).Benefiting from the ultrahigh surface-area-to-volume ratio,abundant active sites,and short diffusion distance,the hydrogel film humidity sensor exhibits2×10^(5)times increased response to 98% RH,as well as 5.9 and7.6 times accelerated response and recovery speeds compared with the bulk counterpart,indicating its remarkable thicknessdependent humidity-sensing properties.The humidity-sensing mechanism reveals that the adsorption of water improves the ion migration and dielectric constant,as well as establishes the electrical double layer.Furthermore,the noncontact human-machine interaction and real-time respiratory frequency detection are enabled by the sensors.This work provides an innovative strategy to achieve further breakthroughs in device performance and promote the development of hydrogel-based miniaturized and integrated electronics.展开更多
An ultrasensitive metamaterial sensor based on double-slot vertical split ring resonators(DVSRRs) is designed and numerically calculated in the terahertz frequency. This DVSRR design produces a fundament LC resonance ...An ultrasensitive metamaterial sensor based on double-slot vertical split ring resonators(DVSRRs) is designed and numerically calculated in the terahertz frequency. This DVSRR design produces a fundament LC resonance with a quality factor of about 20 when the incidence magnetic field component normal to the DVSRR array. The resonant characteristics and sensing performance of the DVSRR array design are systematically analyzed employing a contrast method among three similar vertical split ring resonator(SRRs) structures. The research results show that the elimination of bianisotropy, induced by the structural symmetry of the DVSRR design, helps to achieve LC resonance of a high quality factor. Lifting the SRRs up from the substrate sharply reduces the dielectric loss introduced by the substrate. All these factors jointly result in superior sensitivity of the DVSRR to the attributes of analytes. The maximum refractive index sensitivity is 788 GHz/RIU or 1.04 × 10~5 nm∕RIU.Also, the DVSRR sensor maintains its superior sensing performance for fabrication tolerance ranging from -4% to 4% and wide range incidence angles up to 50° under both TE and TM illuminations.展开更多
Metamaterials have proven their ability to possess extraordinary physical properties distinct from naturally available materials,leading to exciting sensing functionalities and applications.However,metamaterial-based ...Metamaterials have proven their ability to possess extraordinary physical properties distinct from naturally available materials,leading to exciting sensing functionalities and applications.However,metamaterial-based sensing applications suffer from severe performance limitations due to noise interference and design constraints.Here,we propose a dual-phase strategy that leverages loss-induced different Fano-resonant phases to access both destructive and constructive signals of molecular vibration.When the two reverse signals are innovatively combined,the noise in the detection system is effectively suppressed,thereby breaking through the noise-related limitations.Additionally,by utilizing loss optimization of the plasmon-molecule coupling system,our dual-phase strategy enhances the efficiency of infrared energy transfer into the molecule without any additional fabrication complex,thereby overcoming the trade-off dilemma between performance and fabrication cost.Thanks to the pioneering breakthroughs in the limitations,our dual-phase strategy possesses an overwhelming competitive advantage in ultrasensitive vibrational spectroscopy over traditional metamaterial technology,including strong signal strength(×4),high sensitivity(×4.2),effective noise suppression(30%),low detection limit(13 ppm),and excellent selectivity among CO_(2),NH_(3),and CH_(4) mixtures.This work not only opens the door to various emerging ultrasensitive detection applications,including ultrasensitive in-breath diagnostics and high-information analysis of molecular information in dynamic reactions,but also gains new insights into the plasmon-molecule interactions in advanced metamaterials.展开更多
基金supported by the National Key R&D Program of China(2022YFA1404701)Program of Shanghai Academic Research Leader under Grant(22XD1422100)+4 种基金National Natural Science Foundation of China(62075231,12141303,12073018)Shanghai Science and Technology Committee(20JC1414603,23dz2260100)Shanghai Pujiang Program(21PJ1411400)China Postdoctoral Science Foundation(2021M703335)Young Elite Scientists Sponsorship Program by CAST(YESS20220355).
文摘Phase singularities(PSs)in topological darkness-based sensors have received significant attention in optical sensing due to their rapid,ultra-sensitive,and label-free detection capabilities.Here,we present both experimental and theoretical investigations of an ultrasensitive and multiplexed phase-sensitive sensor utilizing dual topological PSs in the visible and near-infrared regions.This sensor uses a simple structure,which consists of an ultra-thin highly absorbing film deposited on a metal substrate.We demonstrate the achievement of dual-polarization darkness points for s-and p-polarizations at different incident angles.Furthermore,we theoretically explain the double topological PSs accompanied by a perfect±π-jump near a zero-reflection point,based on the temporal coupled-mode formalism.To validate its multifunctional capabilities,humidity sensing tests were carried out.The results demonstrate that the sensor has a detection limit reaching the level of 0.12‰.These findings go beyond the scope of conventional interference optical coatings and highlight the potential applications of this technology in gas sensing and biosensing domains.
文摘Gastric cancer(GC)is a prevalent malignant tumor within the digestive system,with over 40%of new cases and deaths related to GC globally occurring in China.Despite advancements in treatment modalities,such as surgery supplemented by adjuvant radiotherapy or chemotherapeutic agents,the prognosis for GC remains poor.New targeted therapies and immunotherapies are currently under invest-igation,but no significant breakthroughs have been achieved.Studies have indicated that GC is a heterogeneous disease,encompassing multiple subtypes with distinct biological characteristics and roles.Consequently,personalized treatment based on clinical features,pathologic typing,and molecular typing is crucial for the diagnosis and management of precancerous lesions of gastric cancer(PLGC).Current research has categorized GC into four subtypes:Epstein-Barr virus-positive,microsatellite instability,genome stability,and chromosome instability(CIN).Technologies such as multi-omics analysis and gene sequencing are being employed to identify more suitable novel testing methods in these areas.Among these,ultrasensitive chromosomal aneuploidy detection(UCAD)can detect CIN at a genome-wide level in subjects using low-depth whole genome sequencing technology,in conjunction with bioinformatics analysis,to achieve qualitative and quantitative detection of chromosomal stability.This editorial reviews recent research advancements in UCAD technology for the diagnosis and management of PLGC.
基金financially supported in part by the National Natural Science Foundation of China(Nos.22005081,51873222 and 52111530128)Zhejiang Provincial Natural Science Foundation of China(Nos.LY22B050003 and LZ22B050001)+1 种基金the Funding for the Scientific Research Foundation for Scholars of Hangzhou Normal University(Nos.4095C5021920467 and 4095C5021920452)the Key Research and Development Projects of Anhui Province(Nos.202004g01020016 and 202104g01020009)。
文摘Urothelial carcinoma(UC)is a common malignant tumor in the urinary system with high recurrence rate and low survival rate 5 years after surgery.At present,imaging examination and other diagnostic methods have some shortcomings such as invasiveness and non-specificity.Therefore,it is urgent to develop a simple,rapid,noninvasive,highly sensitive and highly specific strategy to diagnose UC.Herein,a high-performance fluorescence sensor was constructed by the plasmonic gold nanorods(AuNRs)-enhanced near-infrared(NIR)fluorescence of silver sulfide quantum dots(Ag_(2)S QDs).The designed sensor can be used for the fast and accurate detection of small molecule single-transmembrane protein(FXYD3),which is overexpressed in 90%of ureteral cancers and 84%of high-grade bladder cancers.Due to its high specificity,the NIR fluorescence sensor achieves the detection of FXYD3 in the range of 0.25-150 ng·ml^(-1)with a detection limit of 0.2 ng·ml^(-1).Importantly,it also can be used for accurate diagnosis of FXYD3 in the urine of patients with relevant cancers,and the results are consistent with clinical cystoscopy and pathological analysis.The proposed fluorescence sensor provides a simple,ultrasensitive,reliable method for UC screening,tumor-grade classification and postoperative monitoring and will have great potential for clinical applications.
基金supported by the National Key R&D Program of China (Nos.2017YFA0208100,2016YFA0602900)National Natural Science Foundation of China (Nos.91853124,21778057 and 21420102003)Chinese Academy of Sciences
文摘In this manuscript,we first report an ultrasensitive detection assay of microRNA by combing asymmetric polymerase chain reaction(A-PCR)and loop-mediated isothermal amplification(LAMP)technology.Using A-PCR obtained an extended single strand to form LAMP stem-loop structure under isothermal amplification conditions.We used miRNAs as a loop primer probe in LAMP reaction and completed its ultrasensitive and rapid detection.The established method furnished a fast,specific and efficient detection of target miRNA with a detection limit as low as 10 amol/L in 90 min.
基金supported by the National Natural Science Foundation of China(No.21205103)Jiangsu Provincial Natural Science Foundation(No.BK2012258)+2 种基金Young and Middle-aged Academic Leaders Foundation of Yangzhou UniversityTop-notch Academic Programs Project of Jiangsu Higher Education Institutions(TAPP)funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
文摘Two-dimensional covalent organic framework(COF)has distinctive properties that offer potential opportunities for developing advanced electrode materials.In this work,a core-shell material composed of TAPB-DMTP-COF(TAPB,1,3,5-tris(4-aminophenyl)benzene;DMTP,2,5-dimethoxyterephaldehyde)core and conducting polymer shell,TAPB-DMTP-COF@PANI,was synthesized solvothermally using a polymerization method.The structural cha racteristics of the prepared composite were revealed by X-ray diffraction patterns(XRD),fourier transform infrared spectra(FTIR),X-ray photoelectron spectroscopy(XPS),transmission electron microscopy(TEM).The electrochemical analyses were verified by subsequent monitoring of trace levels of acetaminophen.This resultant composite not only facilitated acetaminophen to interact with absorption sites byπ-πstacking effect and hydrogen bonding but also overcame the poor conductivity of COF.Under the optimal conditions,a low limit of detection of 0.032μmol/L and wide linear range of 0.10-500μmol/L were obtained.The electrochemical platform was almost unaffected by other interfering substances,and successfully applied for the practical detection of acetaminophen in commercial tablet,human blood serum and urine.The enhanced performance makes this COF based core-shell composite a promising material in electrochemical senso r.
基金supported by the National Key Research and Development Project (No.2020YFA0709900)the National Natural Science Foundation of China (Nos.81871265,81672508,81702617)+4 种基金Key University Science Research Project of Jiangsu Province (No.19KJA520005)Natural Science Basic Research Program of Shaanxi Province (No.2019JM-016)National Natural Science Foundation of Jiangxi Province (No.20202BABL206043)Science and Technology Project of Jiangxi Provincial Health Commission (No.20204495)Open Research Fund of Anhui Key Laboratory of Tobacco。
文摘Rapid and accurate detection of immunoglobulin E(Ig E) in serum and reduction of serum dosage are of great significance for clinical detection. Herein, we described a rapid magnetic separation of Ig E from patient serum based on Fe3 O4@Si O2-NTA@026 sdab as the capture probe and multiple horseradish peroxidase(HRP)-labeled antibodies linked gold nanoparticles(Au NPs) as chemiluminescence(CL) signal amplifier for ultrasensitive detection of total Ig E. Results showed that the limit of detection of our immunosensor system in serum samples was 0.03 k U/L, which is lowest in comparison with current methods, and far lower than that of Immuno CAP for Ig E detection(0.1 k U/L). Furthermore, our immunosensor possessed satisfied repeatability and accuracy, as well as good stability. In comparison with the Immuno CAP for the quantitative detection of Ig E, highly consistent results were achieved in 20 serum samples. Specially, this method was also successfully utilized for assessing the Ig E traces in breast cancer patients,which provides a new idea for the diagnosis of early cancer. Therefore, we believe that such versatile immunosensor will offer an alternative method for the on-site monitoring and determination of various Ig E-related diseases.
基金supported by the National Natural Science Foundation of China(Nos.21661028,21662031,21574104)the Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China(No.IRT 15R56)。
文摘An ultrasensitive detection and effective removal material was successfully developed by using a pillar[n]arene-based supramolecular polymer gel(MTP5?HB).The MTP5?HB can ultrasensitively recognize Cu^2+and Fe^3+,and the limits of detection(LODs)for Cu^2+and Fe^3+are 1.55 and 2.68 nmol/L,respectively.Additionally,the in-situ generated metallogel MTP5?HB-Cu can exclusively detect CN,and the LOD for CN is 1.13 nmol/L.Noticeably,the xerogel of MTP5?HB-Cu can effectively remove CN from aqueous solution with 94.40%removal rate.Test kit based on MTP5?HB-Cu is also prepared for convenient detection of CN.
基金supported by the Young Scientists Fund of the National Natural Science Foundation of China(grant nos.62305394 and 62205380)the National Science Fund for Distinguished Young Scholar(grant no.12225511)the National Science Fund of China Major Project(grant no.T2241002).
文摘Advanced sensing devices based on metasurfaces have emerged as a revolutionary platform for innovative label-free biosensors,holding promise for early diagnostics and the detection of low-concentration analytes.Here,we developed a chip-based ultrasensitive terahertz(THz)metasensor,leveraging a quasi-bound state in the continuum(q-BIC)to address the challenges associated with intricate operations in trace biochemical detection.The metasensor design features an open-ring resonator metasurface,which supports magnetic dipole q-BIC combining functionalized gold nanoparticles(AuNPs)bound with a specific antibody.The substantial enhancement in THz–analyte interactions,facilitated by the potent near-field enhancement enabled by the q-BICs,results in a substantial boost in biosensor sensitivity by up to 560 GHz/refractive index units.This methodology allows for the detection of conjugated antibody–AuNPs for cardiac troponin I at concentrations as low as 0.5 pg/ml.These discoveries deliver valuable insight for AuNP-based trace biomolecule sensing and pave the path for the development of chip-scale biosensors with profound light–matter interactions.
基金supported by the National Key R&D Program of China(Grant No.2021YFB3200100)the National Natural Science Foundation of China(Grant No.61931018 and 61974004)。
文摘The localized surface plasmon resonance metasurface is a research hotspot in the sensing field since it can enhance the light-matter interaction in the nanoscale,but the wavelength sensitivity is far from comparable with that of prism-coupled surface plasmon polariton(SPP).Herein,we propose and demonstrate an ultrasensitive angular interrogation sensor based on the transverse electric mode surface lattice resonance(SLR)mechanism in an all-metal metasurface.In theory,we derive the sensitivity function in detail and emphasize the refraction effect at the air-solution interface,which influences the SLR position and improves the sensitivity performance greatly in the wide-angle.In the measurement,a broadband light source substitutes the single-wavelength laser generally used in traditional angular sensing,and the measured SLR wavelength of broadband illuminant at normal incidence is defined as the single wavelength,avoiding the sensitivity loss from the large angle.The experimental sensitivity can reach 4304.35°/RIU,promoting an order of magnitude compared to those of SPP-sensors.This research provides a novel theory as well as the corresponding crucial approach to achieving ultrasensitive angular sensing.
基金National Natural Science Foundation of China,Grant/Award Numbers:52222303,51973008Joint Project of BRC-BC(Biomedical Translational Engineering Research Center of BUCT-CJFH),Grant/Award Number:XK2022-03Fundamental Research Funds for the Central Universities。
文摘Flexible wearables have attracted extensive interests for personal human motion sensing,intelligent disease diagnosis,and multifunctional electronic skins.How-ever,the reported flexible sensors,mostly exhibited narrow detection range,low sensitivity,limited degradability to aggravate environmental pollution from vast electronic wastes,and poor antibacterial performance to hardly improve skin dis-comfort and skin inflammation from bacterial growth under long-term wearing.Herein,bioinspired from human skin featuring highly sensitive tactile sensation with spinous microstructures for amplifying sensing sensitivity between epidermis and dermis,a wearable antibacterial degradable electronics is prepared from degrad-able elastomeric substrate with MXene-coated spinous microstructures templated from lotus leaf assembled with the interdigitated electrode.The degradable elas-tomer is facilely obtained with tunable modulus to match the modulus of human skin with improved hydrophilicity for rapid degradation.The as-obtained sensor displays ultra-low detection limit(0.2 Pa),higher sensitivity(up to 540.2 kPa^(-1)),outstand-ing cycling stability(>23,000 cycles),a wide detection range,robust degradability,and excellent antibacterial capability.Facilitated by machine learning,the collected sensing signals from the integrated sensors on volunteer's fingers to the related American Sign Language are effectively recognized with an accuracy up to 99%,showing excellent potential in wireless human movement sensing and smart machine learning-enabled human-machine interaction.
基金supported by the National Natural Science Foundation of China[grant numbers 32001067,82272122,and 31927803]Inter-disciplinary Program of Shanghai Jiao Tong University[grant number YG2022ZD028]Major Projects of Special Development Funds for Shanghai Zhangjiang National Innovation Demonstration Zone[grant number ZJ2021-ZD-007].
文摘Multiplex ultrasensitive detection of low abundance proteins remains a significant challenge in clinical applications,necessitating the development of innovative solutions.The integration of bead-based microfluidic chip platforms with their efficient target capture and separation capabilities,along with the advantages of miniaturization and low reagent consumption,holds great promise for building an integrated point-of-care testing(POCT)system that enables seamless sample input-result output.This review presents a comprehensive overview of recent advancements in bead-based microfluidic platforms for multiplex and ultrasensitive immunoassays,along with their potential applications in clinical diagnosis and treatment,which is organized into four sections:encoding techniques,the role of microfluidic platforms,applications,and future prospects.
基金supported by the National Natural Science Foundation of China(No.62075069 and 52303092)the Water Conservancy Technology project of Hunan Province,China(XSKJ2021000-32)+1 种基金the City University of Hong Kong(#7005507)the Open Project of Yunnan Precious Metals Laboratory Co.,Ltd(grant number YPML-2023050278).
文摘Nowadays,high-stable and ultrasensitive heavy metal detection is of utmost importance in water quality monitoring.Nanoparticle-enhanced laser-induced breakdown spectroscopy(NELIBS)shows high potential in hazardous metal detection,however,encounters unstable and weak signals due to nonuniform distribution of analytes.Herein,we developed an interface self-assembly(ISA)method to create a uniformly distributed gold nanolayer at a liquid-liquid interface for positive heavy metal ions capture and NELIBS analysis.The electrostatically selfassembled Au nanoparticles(NPs)-analytes membrane was prepared at the oil-water interface by injecting ethanol into the mixture of cyclohexane and Au NPs-analytes water solution.Then,the interface self-assembled Au NPs-analytes membrane was transformed onto a laser-processed superhydrophilic Si slide for detection.Three heavy metals(cadmium(Cd),barium(Ba),and chromium(Cr))were analyzed to evaluate the stability and sensitivity of the ISA method for NELIBS.The results(Cd:RSD=3.6%,LoD=0.654 mg/L;Ba:RSD=3.4%,LoD=0.236 mg/L;Cr:RSD=7.7%,LoD=1.367 mg/L)demonstrated signal enhancement and high-stable and ultrasensitive detection.The actual sample detection(Cd:RE=7.71%,Ba:RE=6.78%)illustrated great reliability.The ISA method,creating a uniform distribution of NP-analytes at the interface,has promising prospects in NELIBS.
基金supported by the National Key Research and Development Program of China(Grant No.2024YFE0105200)the National Nature Science Foundation of China(Grant No.62405284)+2 种基金the Key Research and Development Program of Henan Province(Grant No.241111220600)the JSPS KAKENHI(Grant No.JP20K14785)the Murata Science Foundation.
文摘Vibrational strong coupling(VSC)provides a promising way towards not only enhanced control of infrared light but also reshaping of molecular properties,which opens up unprecedented opportunities in ultrasensitive infrared spectroscopy,modification of chemical reactions,and exploration of nonlinear quantum effects.Surface plasmon resonance,excited on simple plasmonic resonators in the infrared,has been demonstrated as a means to realize VSC,but suffers from either limited quality factor for realizing large Rabi splitting or poor reconfigurability for precise detuning control.Here we propose and experimentally demonstrate,for the first time,an on-chip plasmonic resonator based on degeneracy breaking of Wood’s anomaly for VSC.Leveraging the low damping rate of the surface state induced by this degeneracy breaking,we achieve a plasmonic resonance with a high-Q factor exceeding~110,resulting in a Rabi splitting up to~112 cm^(-1) with a subwavelength molecular layer.Additionally,the dispersion of the surface state allows for precise control over VSC detuning by simply adjusting the incident angle of excitation light,even in the absence of photons,enabling a broad detuning range up to 300 cm^(-1).These experimental results align well with our analytical model and numerical simulation.This work provides a promising integrated platform for VSC,with various potential applications in on-chip spectroscopy,polariton chemistry,and polariton devices.
基金National Natural Science Foundation of China(NSFC)(11802339,11804387,11805276,61801498,61805282)Scientific Researches Foundation of National University of Defense Technology(ZK16-03-59,ZK18-01-03,ZK18-03-22,ZK18-03-36)+4 种基金Natural Science Foundation of Hunan Province(2016JJ1021)Open Director Fund of State Key Laboratory of Pulsed Power Laser Technology(SKL2018ZR05)Open Research Fund of Hunan Provincial Key Laboratory of High Energy Technology(GNJGJS03)Opening Foundation of State Key Laboratory of Laser Interaction with Matter(SKLLIM1702)Youth Talent Lifting Project(17-JCJQ-QT-004)
文摘Active control of metamaterial properties with high tunability of both resonant intensity and frequency is essential for advanced terahertz(THz) applications, ranging from spectroscopy and sensing to communications.Among varied metamaterials, plasmon-induced transparency(PIT) has enabled active control with giant sensitivity by embedding semiconducting materials. However, there is still a stringent challenge to achieve dynamic responses in both intensity and frequency modulation. Here, an anisotropic THz active metamaterial device with an ultrasensitive modulation feature is proposed and experimentally studied. A radiative-radiative-coupled PIT system is established, with a frequency shift of 0.26 THz in its sharp transparent windows by polarization rotation. Enabled by high charge-carrier mobility and longer diffusion lengths, we utilize a straightforwardly spincoated MAPbI3 film acting as a photoactive medium to endow the device with high sensitivity and ultrafast speed.When the device is pumped by an ultralow laser fluence, the PIT transmission windows at 0.86 and 1.12 THz demonstrate a significant reduction for two polarizations, respectively, with a full recovery time of 561 ps. In addition, we numerically prove the validity that the investigated resonator structure is sensitive to the optically induced conductivity. The hybrid system not only achieves resonant intensity and frequency modulations simultaneously, but also preserves the all-optical-induced switching merits with high sensitivity and speed, which enriches multifunctional subwavelength metamaterial devices at THz frequencies.
基金National Natural Science Foundation of China(NSFC)(61425007,61377090,61575128)Guangdong Science and Technology Department(2014A030308007,2014B050504010,2015B010105007,2015A030313541)+1 种基金Science and Technology Innovation Commission of Shenzhen(ZDSYS20140430164957664,GJHZ20150313093755757,KQCX20140512172532195,JCYJ20150324141711576)Pearl River Scholar Fellowships
文摘An ultrasensitive magnetic field sensor based on a compact in-fiber Mach–Zehnder interferometer(MZI) created in twin-core fiber(TCF) is proposed, and its performance is experimentally demonstrated. A section of TCF was spliced between two sections of standard single-mode fibers, and then a microchannel was drilled through one core of the TCF by means of femtosecond laser micromachining. The TCF with one microchannel was then immersed in a water-based Fe_3O_4 magnetic fluid(MF), forming a direct component of the light propagation path,and then sealed in a capillary tube, achieving a magnetic sensing element, which merges the advantages of an MZI with an MF. Experiments were conducted to investigate the magnetic response of the proposed sensor. The developed magnetic field sensor exhibits a linear response within a measurement range from 5 to 9.5 m T and an ultrahigh sensitivity of 20.8 nm/m T, which, to our best knowledge, is 2 orders of magnitude greater than other previously reported magnetic sensors. The proposed sensor is expected to offer significant potential for detecting weak magnetic fields.
基金The authors ack no wledge primary fin ancial support from the National Key R&D Program of China (No. 2017YFA0204901)the National Natural Science Foundation of China (No. 21727806)the Natural Science Foundation of Beijing (No. Z181100004418003) and the Interdisciplinary Medicine Seed Fund of Peking University.
文摘Aptamer serves as a potential candidate for the micro-detection of cocaine due to its high specificity,high affinity and good stability.Although cocaine aptasensors have been extensively studied,the binding mechanism of cocaine-aptamer interactions is still unknown,which limits the structural refinement in the design of an aptamer to improve the performance of cocaine aptasensors.Herein,we report a label-free,ultrasensitive detection of single-molecule cocaine-aptamer interaction by using an electrical nanocircuit based on graphene-moleculegraphene single-molecule junctions (GMG-SMJs).Real-time recordings of cocaine-aptamer interactions have exhibited distinct current oscillations before and after cocaine treatment,revealing the dynamic mechanism of the conformational changes of aptamer upon binding with cocaine.Further concentration-dependent experiments have proved that these devices can act as a single-molecule biosensor with at least a limit of detection as low as 1 nmol·L^-1.The method demonstrated in this work provides a novel strategy for shedding light on the interaction mechanism of biomolecules as well as constructing new types of aptasensors toward practical applications.
基金supported by the National Basic Research Program of China(2015CB932600,2013CB933000)the National Natural Science Foundation of China(21505101,21375042,21405054, 21404097)1000 Young Talent(to Fan Xia) and Zhejiang Provincial Natural Science Foundation of China(LQ16B050003)
文摘The fabrication of sensitive sensors with high selectivity is highly desirable for the detection of some important biomarkers,such as nucleic acids,proteins,small molecules and ions.DNA hybridization chain reaction(HCR) and DNA supersandwich self-assembly(SSA) are two prevalent enzyme-free signal amplification strategies to improve sensitivity of the sensors.In this review,we firstly describe the characteristics about DNA HCR and DNA SSA,and then summarize the advances in the one-dimensional DNA nanostructures assisted by HCR and SSA.This review has been divided into three parts according to the two signal amplification methods and highlights recent progress in these two strategies to improve the detection sensitivity of proteins,nucleic acids,small molecules and ions.
基金supported by the National Natural Science Foundation of China(61801525)Guangdong Basic and Applied Basic Research Foundation(2020A1515010693)+1 种基金the Science and Technology Program of Guangzhou(201904010456)the Fundamental Research Funds for the Central Universities,Sun Yat-sen University(22lgqb17)。
文摘Ion-conductive hydrogels with intrinsic biocompatibility,stretchability,and stimuli-responsive capability have attracted considerable attention because of their extensive application potential in wearable sensing devices.The miniaturization and integration of hydrogel-based devices are currently expected to achieve breakthroughs in device performance and promote their practical application.However,currently,hydrogel film is rarely reported because it can be easily wrinkled,torn,and dehydrated,which severely hinders its development in microelectronics.Herein,thin,stretchable,and transparent ion-conductive double-network hydrogel films with controllable thickness are integrated with stretchable elastomer substrates,which show good environmental stability and ultrahigh sensitivity to humidity(78,785.5%/% relative humidity(RH)).Benefiting from the ultrahigh surface-area-to-volume ratio,abundant active sites,and short diffusion distance,the hydrogel film humidity sensor exhibits2×10^(5)times increased response to 98% RH,as well as 5.9 and7.6 times accelerated response and recovery speeds compared with the bulk counterpart,indicating its remarkable thicknessdependent humidity-sensing properties.The humidity-sensing mechanism reveals that the adsorption of water improves the ion migration and dielectric constant,as well as establishes the electrical double layer.Furthermore,the noncontact human-machine interaction and real-time respiratory frequency detection are enabled by the sensors.This work provides an innovative strategy to achieve further breakthroughs in device performance and promote the development of hydrogel-based miniaturized and integrated electronics.
基金National Natural Science Foundation of China(NSFC)(61327006,61620106014)
文摘An ultrasensitive metamaterial sensor based on double-slot vertical split ring resonators(DVSRRs) is designed and numerically calculated in the terahertz frequency. This DVSRR design produces a fundament LC resonance with a quality factor of about 20 when the incidence magnetic field component normal to the DVSRR array. The resonant characteristics and sensing performance of the DVSRR array design are systematically analyzed employing a contrast method among three similar vertical split ring resonator(SRRs) structures. The research results show that the elimination of bianisotropy, induced by the structural symmetry of the DVSRR design, helps to achieve LC resonance of a high quality factor. Lifting the SRRs up from the substrate sharply reduces the dielectric loss introduced by the substrate. All these factors jointly result in superior sensitivity of the DVSRR to the attributes of analytes. The maximum refractive index sensitivity is 788 GHz/RIU or 1.04 × 10~5 nm∕RIU.Also, the DVSRR sensor maintains its superior sensing performance for fabrication tolerance ranging from -4% to 4% and wide range incidence angles up to 50° under both TE and TM illuminations.
基金National Key Research and Development Program of China,Grant/Award Number:2019YFB2004800Advanced Research and Technology Innovation Center(ARTIC)Project,Grant/Award Number:A-0005947-20-00+2 种基金National Natural Science Foundation of China,Grant/Award Number:52072041Ministry of Education(MOE)of Singapore Tier 1 grants,Grant/Award Number:A-0005138-01-00China Postdoctoral Science Foundation,Grant/Award Number:2021M693746。
文摘Metamaterials have proven their ability to possess extraordinary physical properties distinct from naturally available materials,leading to exciting sensing functionalities and applications.However,metamaterial-based sensing applications suffer from severe performance limitations due to noise interference and design constraints.Here,we propose a dual-phase strategy that leverages loss-induced different Fano-resonant phases to access both destructive and constructive signals of molecular vibration.When the two reverse signals are innovatively combined,the noise in the detection system is effectively suppressed,thereby breaking through the noise-related limitations.Additionally,by utilizing loss optimization of the plasmon-molecule coupling system,our dual-phase strategy enhances the efficiency of infrared energy transfer into the molecule without any additional fabrication complex,thereby overcoming the trade-off dilemma between performance and fabrication cost.Thanks to the pioneering breakthroughs in the limitations,our dual-phase strategy possesses an overwhelming competitive advantage in ultrasensitive vibrational spectroscopy over traditional metamaterial technology,including strong signal strength(×4),high sensitivity(×4.2),effective noise suppression(30%),low detection limit(13 ppm),and excellent selectivity among CO_(2),NH_(3),and CH_(4) mixtures.This work not only opens the door to various emerging ultrasensitive detection applications,including ultrasensitive in-breath diagnostics and high-information analysis of molecular information in dynamic reactions,but also gains new insights into the plasmon-molecule interactions in advanced metamaterials.
