Oral ulcers(OUs)are among the most common lesions of the oral mucosa,typically associated with pain and burning sensations,and remain clinically challenging due to the scarcity of effective treatment options.Cy_(RL-QN...Oral ulcers(OUs)are among the most common lesions of the oral mucosa,typically associated with pain and burning sensations,and remain clinically challenging due to the scarcity of effective treatment options.Cy_(RL-QN15),a novel ultra-short cyclic heptapeptide recently shown to promote skin repair,diabetic wound healing,and follicle neogenesis,was evaluated for its therapeutic potential in mucosal repair.Using a rat OU model and a primary oral epithelial cell inflammation model,Cy_(RL-QN15)significantly accelerated wound closure through coordinated modulation of immune-epithelial crosstalk,including suppression of inflammatory cytokine release from macrophages and neutrophils,reduction of pro-inflammatory factor secretion by oral epithelial cells,and enhancement of their proliferation and migration.Mechanistic studies employing alanine scanning mutagenesis and microscale thermophoresis revealed that Cy_(RL-QN15)directly interacted with Toll-like receptor 4(TLR4)via a methionine-dependent binding interface(K_(d)=2.64μmol/L),thereby inhibiting downstream MyD88/NF-κB signaling.As the first ultra-short cyclic heptapeptide identified to antagonize TLR4,Cy_(RL-QN15)represents a mechanistically distinct immunomodulatory scaffold that restores mucosal homeostasis and offers a promising therapeutic candidate for TLR4-based OU intervention.展开更多
Based on the kinetic theoretical Vlasov-Poisson equation, a surface Coulomb explosion model of SiO2 material induced by ultra-short pulsed laser radiation is established. The non-equilibrium free electron distribution...Based on the kinetic theoretical Vlasov-Poisson equation, a surface Coulomb explosion model of SiO2 material induced by ultra-short pulsed laser radiation is established. The non-equilibrium free electron distribution resulting from the two mechanisms of multi-photon ionization and avalanche ionization is computed. A quantitative analysis is given to describe the Coulomb explosion induced by the self-consistent electric field, and the impact of the parameters of laser pulses on the surface ablation is also discussed. The results show that the electron relaxation time is not constant, but it is related to the microscopic state of the electrons, so the relaxation time approximation is not available on the femtosecond time scale. The ablation depths computed by the theoretical model are in good agreement with the experimental results in the range of pulse durations from 0 to 1 ps.展开更多
Ultra-short laser pulses possess many advantages for materials processing.Ultrafast laser has a significantly low thermal effect on the areas surrounding the focal point;therefore,it is a promising tool for micro-and ...Ultra-short laser pulses possess many advantages for materials processing.Ultrafast laser has a significantly low thermal effect on the areas surrounding the focal point;therefore,it is a promising tool for micro-and submicro-sized precision processing.In addition,the nonlinear multiphoton absorption phenomenon of focused ultra-short pulses provides a promising method for the fabrication of various structures on transparent material,such as glass and transparent polymers.A laser direct writing process was applied in the fabrication of high-performance three-dimensional(3D)structured multilayer microsupercapacitors(MSCs)on polymer substrates exhibiting a peak specific capacitance of 42.6 mF·cm^-2 at a current density of 0.1 mA·cm^-12.Furthermore,a flexible smart sensor array on a polymer substrate was fabricated for multi-flavor detection.Different surface treatments such as gold plating,reducedgraphene oxide(rGO)coating,and polyaniline(PANI)coating were accomplished for different measurement units.By applying principal component analysis(PCA),this sensing system showed a promising result for flavor detection.In addition,two-dimensional(2D)periodic metal nanostructures inside 3D glass microfluidic channels were developed by all-femtosecond-laser processing for real-time surfaceenhanced Raman spectroscopy(SERS).The processing mechanisms included laser ablation,laser reduction,and laser-induced surface nano-engineering.These works demonstrate the attractive potential of ultra-short pulsed laser for surface precision manufacturing.展开更多
Starting from the extended nonlinear Schrodinger equation in which the self-steepening effect is included, the evolution and the splitting processes of continuous optical wave whose amplitude is perturbed into time re...Starting from the extended nonlinear Schrodinger equation in which the self-steepening effect is included, the evolution and the splitting processes of continuous optical wave whose amplitude is perturbed into time related ultra-short optical pulse trains in an optical fibre are numerically simulated by adopting the split-step Fourier algorithm. The results show that the self-steepening effect can cause the characteristic of the pulse trains to vary with time, which is different from the self-steepening-free case where the generated pulse trains consist of single pulses which are identical in width, intensity, and interval, namely when pulses move a certain distance, they turn into the pulse trains within a certain time range. Moreover, each single pulse may split into several sub-pulses. And as time goes on, the number of the sub-pulses will decrease gradually and the pulse width and the pulse intensity will change too. With the increase of the self-steepening parameter, the distance needed to generate time-dependent pulse trains will shorten. In addition, for a large self-steepening parameter and at the distance where more sub-pulses appear, the corresponding frequency spectra of pulse trains are also wider.展开更多
We present a nonlinear ytterbium-doped fiber amplifier based on enhanced nonlinear effects that can produce a flat broadband spectrum ranging from 1050–1225 nm with a maximum average output power of 7.8 W at 14 W pum...We present a nonlinear ytterbium-doped fiber amplifier based on enhanced nonlinear effects that can produce a flat broadband spectrum ranging from 1050–1225 nm with a maximum average output power of 7.8 W at 14 W pump power.Its repetition rate is 89 MHz. Using a pair of gratings and two knife edges as a filter, wavelength tunable picosecond pulses of tens to hundreds of milliwatts can be obtained in the broadband spectrum range. The output power, pulse width, and spectrum（center wavelength and linewidth） are adjusted by tuning the distance of the grating pair and/or the knife edges.Fixing the distance between the two gratings at 15 mm and keeping the output spectrum linewidth at approximately 20 nm,the shortest pulse width obtained is less than 1 ps centered at 1080 nm. The longest wavelength of the short pulses is around1200 nm, and its output power and pulse width are 40 m W and 5.79 ps, respectively. The generation of a flat broadband spectrum is also discussed in this paper.展开更多
Glass welding by ultra-short pulsed(USP)lasers is a piece of technology that offers high strength joints with hermetic sealing.The joints are typically formed in glass that is transparent to the laser by exploiting no...Glass welding by ultra-short pulsed(USP)lasers is a piece of technology that offers high strength joints with hermetic sealing.The joints are typically formed in glass that is transparent to the laser by exploiting nonlinear absorption effects that occur under extreme conditions.Though the temperature reached during the process is on the order of a few 1000°C,the heat affected zone(HAZ)is confined to only tens of micrometers.It is this controlled confinement of the HAZ during the joining process that makes this technology so appealing to a multitude of applications because it allows the foregoing of a subsequent tempering step that is typically essential in other glass joining techniques,thus making it possible to effectively join highly heat sensitive components.In this work,we give an overview on the process,development and applications of glass welding by USP lasers.展开更多
The objective of this work was to investigate the possibility of taper angle correction in cutting of complex micro-mechanical contours using a TruMicro ultra-short pulse laser in combination with the SCANLAB precSYS ...The objective of this work was to investigate the possibility of taper angle correction in cutting of complex micro-mechanical contours using a TruMicro ultra-short pulse laser in combination with the SCANLAB precSYS micro machining sub system. In a first step, the influence of the process parameters on the kerftaper angle of metallic alloys was systematically investigated without beam inclination. A set of base parameters was derived for the subsequent investigations. In a second step, the kerftaper angle was controlled by static beam inclination. In a third step, the same optics was used in its dynamic precession mode to fabricate micro-mechanical components of complex contours with perpendicular 0~ taper angles. It was found that taper angle adjustments of up to 7.5~ are possible with the used setup for cutting applications. Taper angle control is possible both in the static beam inclination mode and in the dynamic precession mode. The static mode could be interesting for contours with sharp inner radii and for achieving faster cutting times similar to results with fixed optics, but would require excellent synchronization of beam inclination and axis motion. The dynamic precession mode would allow an easier integration of the optics into a laser machine but will result in longer cutting times and limitations with respect to achievable inner radii.展开更多
This paper focuses on the preparation of a new extended set of calibrations of cooling rate(fictive temperature)in fused silica determined by inelastic light scattering and its subsequent use to characterize the local...This paper focuses on the preparation of a new extended set of calibrations of cooling rate(fictive temperature)in fused silica determined by inelastic light scattering and its subsequent use to characterize the local cooling rate distribution in ultra-short pulsed(USP)laser modification.In order to determine the thermal history(e.g.cooling rate and fictive temperature)of fused silica,high-resolution inelastic light-scattering experiments(Raman and Brillouin spectroscopy)were investigated.Calibrations were performed and compared to the existing literature to quantify structural changes due to a change of fictive temperature.Compared to existing calibrations,this paper provides an extension to lower and higher cooling rates.Using this new set of calibrations,we characterized a USP laser modification in fused silica and calculated the local fictive temperature distribution.An equation relating the fictive temperature(Tf)to cooling rates is given.A maximum cooling rate of 3000 K min-1 in the glass transition region around 1200℃ was deduced from the Raman analysis.The Brillouin observations are sensitive to both the thermal history and the residual stress.By comparing the Raman and Brillouin observations,we extracted the local residual stress distribution with high spatial resolution.For the first time,combined Raman and Brillouin inelastic light scattering experiments show the local distribution of cooling rates and residual stresses(detailed behavior of the glass structure)in the interior and the surrounding of an USP laser modified zone.展开更多
Proton acceleration experiments were carried out by a 1.2× 1018 W/cm2 ultra-short laser interaction with solid foil targets. The peak proton energy observed from an optimum target thickness of 7 μm in our experi...Proton acceleration experiments were carried out by a 1.2× 1018 W/cm2 ultra-short laser interaction with solid foil targets. The peak proton energy observed from an optimum target thickness of 7 μm in our experiments was 2.1 MeV. Peak proton energy and proton yield were investigated for different foil target thicknesses. It was shown that proton energy and conversion efficiency increased as the target became thinner, on one condition that the preplasma generated by the laser prepulse did not have enough shock energy and time to influence or destroy the target rear-surface. The existence of optimum foil thickness is due to the effect of the prepulse and hot electron transportation behavior on the foil target.展开更多
The dynamical progresses involved in ultra-short laser pulse ablation of face-centered cubic metals under stress confinement condition are described completely using molecular dynamics method. The laser beam absorptio...The dynamical progresses involved in ultra-short laser pulse ablation of face-centered cubic metals under stress confinement condition are described completely using molecular dynamics method. The laser beam absorption and thermal energy turning into kinetics energy of. atoms are taken into account to give a detailed picture of laser metal interaction. Superheating phenomenon is observed, and the phase change from solid to liquid is characterized by a destroyed atom configuration and a decreased number density. The steep velocity gradients are found in the systems of Cu and Ni after pulse in consequence of located heating and exponential decrease of fluences following the Lambert-Beer expression. The shock wave velocities are predicted to be about 5 000 m/s in Cu and 7 200 m/s in Ni. The higher ablation rates are obtained from simulations compared with experimental data as a result of a well-defined crystalline surface irradiated by a single pulse. Simulation results show that the main mechanisms of ablation are evaporation and thermoelastic stress due to located heating.展开更多
AIM： To investigate the proteins involved in colonic adaptation and molecular mechanisms of colonic adapration in rats with ultra-short bowel syndrome （USBS）. METHODS： Sprague Dawley rats were randomly as- signed ...AIM： To investigate the proteins involved in colonic adaptation and molecular mechanisms of colonic adapration in rats with ultra-short bowel syndrome （USBS）. METHODS： Sprague Dawley rats were randomly as- signed to three groups： USBS group （10 rats） undergoing an approximately 90%-95% small bowel resection; sham-operation group （10 rats） undergoing small bowel transaction and anastomosis; and control group （ten normal rats）. Colon morphology and differential protein expression was analyzed after rats were given postsurgical enteral nutrition for 21 d. Protein expression in the colonic mucosa was analyzed by two-dimensional electrophoresis （2-DE） in all groups. Differential protein spots were detected by ImageMaster 2D Platinum soft-ware and were further analyzed with matrix-assisted laser desorption/ionization-time-of-flight/time-of-flightmass spectrometric （MALDI-TOF/TOF-MS） analysis. RESULTS： The colonic mucosal thickness significantly increased in the USBS group compared with the control group （302.1 ± 16.9 um vs 273.7 ± 16.0 um, P 〈 0.05）. There was no statistically significant difference between the sham-operation group and control group （P 〉 0.05）. The height of colon plica markedly improved in USBS group compared with the control group （998.4 ± 81.2 um vs 883.4 ± 39.0 um, P 〈 0.05）. There was no statistically significant difference between the shamoperation and control groups （P 〉 0.05）. A total of 141 differential protein spots were found in the USBS group. Forty-nine of these spots were down-regulated while 92 protein spots were up-regulated by over 2-folds. There were 133 differential protein spots in USBS group. Thirty of these spots were down-regulated and 103 were upregulated. There were 47 common differential protein spots among the three groups, including 17 down- regulated protein spots and 30 up-regulated spots. Among 47 differential spots, eight up-regulated proteins were identified by MALDI-TOF/TOF-MS. These proteins were previously reported to be involved in sugar and fat metabolism, protein synthesis and oxidation reduction, which are associated with colonic adaption. CONCLUSION： Eight proteins found in this study play important roles in colonic compensation and are associated with sugar and fat metabolism, protein synthesis, and molecular chaperoning展开更多
Focusing on the extending length restriction of the completion screen pipe resistance running into ultra-short radius horizontal well,this paper proposed technology of hydraulic drive completion tubular string running...Focusing on the extending length restriction of the completion screen pipe resistance running into ultra-short radius horizontal well,this paper proposed technology of hydraulic drive completion tubular string running into ultra-short radius horizontal well.Innovative hydraulic drive tools and string structure are designed,which are composed of guide tubing,hydraulic drive tubing and non-metallic completion screen pipe from inside to outside.A novel mechanical-hydraulic coupling model is established.Based on the wellbore structure of an ultra-short radius horizontal well for deep coalbed methane,the numerical calculations of force and hydraulic load on tubular strings were accomplished by the mechanical-hydraulic coupling model.The results show that the extending length of completion tubular string with the hydraulic drive is 17 times that of conventional completion technology under the same conditions.The multi-factor orthogonal design is adopted to analyze the numerical calculations,and the results show that the extending length of the completion tubular string is mainly affected by the completion tubular string structure and the friction coefficient between the non-metallic composite continuous screen pipe and the wellbore.Two series of hydraulic drive completion tubular string structures suitable for ultra-short radius horizontal wells under different conditions are optimized,with the extending limits of 381 m and 655 m,respectively.These researches will provide theoretical guidance for design and control of hydraulic drive non-metallic composite continuous completion screen pipe running into ultra-short radius horizontal wells.展开更多
The power systems economic and safety operation considering large-scale wind power penetration are now facing great challenges, which are based on reliable power supply and predictable load demands in the past. A roll...The power systems economic and safety operation considering large-scale wind power penetration are now facing great challenges, which are based on reliable power supply and predictable load demands in the past. A rolling generation dispatch model based on ultra-short-term wind power forecast was proposed. In generation dispatch process, the model rolling correct not only the conventional units power output but also the power from wind farm, simultaneously. Second order Markov chain model was utilized to modify wind power prediction error state (WPPES) and update forecast results of wind power over the remaining dispatch periods. The prime-dual affine scaling interior point method was used to solve the proposed model that taken into account the constraints of multi-periods power balance, unit output adjustment, up spinning reserve and down spinning reserve.展开更多
To improve the drill pipe fracture failure phenomenon in deflecting drills with ultra-short radius flexible drill pipes,this study establishes a mechanical model of a deflecting drill with an ultra-short radius flexib...To improve the drill pipe fracture failure phenomenon in deflecting drills with ultra-short radius flexible drill pipes,this study establishes a mechanical model of a deflecting drill with an ultra-short radius flexible drill pipe,numerically simulates the mechanical characteristics of the flexible drill pipe under the conventional drilling process using the finite element analysis method,performs mechanical performance tests on the flexible drill pipe,and optimizes and improves its structure.The results show that,with the gradual increase in the bending angle of the flexible drill pipe unit section,the upper drilling pressure of the flexible drill pipe unit section decreases rapidly and its friction increases approximately linearly.The tensile strength of the optimized ultra-short radius flexible drill pipe is increased by 24.7%,and the minimum threshold of its torsional strength is doubled.This effectively improves the overall strength of the ultra-short radius flexible drill pipe and provides a theoretical basis for downhole drilling stability studies of flexible drill pipes.展开更多
基金supported by the National Natural Science Foundation of China(32301054,82404582,32360138,32060212)First-Class Discipline Team of Skin&Mucosal Regenerative Medicine of Kunming Medical University(2024XKTDTS10)+2 种基金Key Program of Yunnan Fundamental Research Project(202301AS070036)Open Research Fund of Yunnan Characteristic Plant Extraction Laboratory(YKKF2024003)Project of Yunnan Applied Basic Research Project-Kunming Medical University Union Foundation(202301AY070001-301,202401AY070001-028,202301AY070001-012,202401AY070001-068,202301AY070001-169)。
文摘Oral ulcers(OUs)are among the most common lesions of the oral mucosa,typically associated with pain and burning sensations,and remain clinically challenging due to the scarcity of effective treatment options.Cy_(RL-QN15),a novel ultra-short cyclic heptapeptide recently shown to promote skin repair,diabetic wound healing,and follicle neogenesis,was evaluated for its therapeutic potential in mucosal repair.Using a rat OU model and a primary oral epithelial cell inflammation model,Cy_(RL-QN15)significantly accelerated wound closure through coordinated modulation of immune-epithelial crosstalk,including suppression of inflammatory cytokine release from macrophages and neutrophils,reduction of pro-inflammatory factor secretion by oral epithelial cells,and enhancement of their proliferation and migration.Mechanistic studies employing alanine scanning mutagenesis and microscale thermophoresis revealed that Cy_(RL-QN15)directly interacted with Toll-like receptor 4(TLR4)via a methionine-dependent binding interface(K_(d)=2.64μmol/L),thereby inhibiting downstream MyD88/NF-κB signaling.As the first ultra-short cyclic heptapeptide identified to antagonize TLR4,Cy_(RL-QN15)represents a mechanistically distinct immunomodulatory scaffold that restores mucosal homeostasis and offers a promising therapeutic candidate for TLR4-based OU intervention.
文摘Based on the kinetic theoretical Vlasov-Poisson equation, a surface Coulomb explosion model of SiO2 material induced by ultra-short pulsed laser radiation is established. The non-equilibrium free electron distribution resulting from the two mechanisms of multi-photon ionization and avalanche ionization is computed. A quantitative analysis is given to describe the Coulomb explosion induced by the self-consistent electric field, and the impact of the parameters of laser pulses on the surface ablation is also discussed. The results show that the electron relaxation time is not constant, but it is related to the microscopic state of the electrons, so the relaxation time approximation is not available on the femtosecond time scale. The ablation depths computed by the theoretical model are in good agreement with the experimental results in the range of pulse durations from 0 to 1 ps.
基金the University of Tennessee Research Foundation and a grant from the National Natural Science Foundation of China(51575016).
文摘Ultra-short laser pulses possess many advantages for materials processing.Ultrafast laser has a significantly low thermal effect on the areas surrounding the focal point;therefore,it is a promising tool for micro-and submicro-sized precision processing.In addition,the nonlinear multiphoton absorption phenomenon of focused ultra-short pulses provides a promising method for the fabrication of various structures on transparent material,such as glass and transparent polymers.A laser direct writing process was applied in the fabrication of high-performance three-dimensional(3D)structured multilayer microsupercapacitors(MSCs)on polymer substrates exhibiting a peak specific capacitance of 42.6 mF·cm^-2 at a current density of 0.1 mA·cm^-12.Furthermore,a flexible smart sensor array on a polymer substrate was fabricated for multi-flavor detection.Different surface treatments such as gold plating,reducedgraphene oxide(rGO)coating,and polyaniline(PANI)coating were accomplished for different measurement units.By applying principal component analysis(PCA),this sensing system showed a promising result for flavor detection.In addition,two-dimensional(2D)periodic metal nanostructures inside 3D glass microfluidic channels were developed by all-femtosecond-laser processing for real-time surfaceenhanced Raman spectroscopy(SERS).The processing mechanisms included laser ablation,laser reduction,and laser-induced surface nano-engineering.These works demonstrate the attractive potential of ultra-short pulsed laser for surface precision manufacturing.
基金supported by Key Program of Natural Science Foundation of Educational Commission of Sichuan Province, China (GrantNo 2006A124)the Fundamental Application Research Project of the Department of Science and Technology of Sichuan Province,China (Grant No 05JY029-084)the Foundation of Science and Technology Development of Chengdu University of Information Technology, China (Grant No KYTZ20060604)
文摘Starting from the extended nonlinear Schrodinger equation in which the self-steepening effect is included, the evolution and the splitting processes of continuous optical wave whose amplitude is perturbed into time related ultra-short optical pulse trains in an optical fibre are numerically simulated by adopting the split-step Fourier algorithm. The results show that the self-steepening effect can cause the characteristic of the pulse trains to vary with time, which is different from the self-steepening-free case where the generated pulse trains consist of single pulses which are identical in width, intensity, and interval, namely when pulses move a certain distance, they turn into the pulse trains within a certain time range. Moreover, each single pulse may split into several sub-pulses. And as time goes on, the number of the sub-pulses will decrease gradually and the pulse width and the pulse intensity will change too. With the increase of the self-steepening parameter, the distance needed to generate time-dependent pulse trains will shorten. In addition, for a large self-steepening parameter and at the distance where more sub-pulses appear, the corresponding frequency spectra of pulse trains are also wider.
基金supported by the National Basic Research Program of China(Grant No.2013CB922404)the National Scientific Research Project of China(Grant No.61177047)the National Natural Science Foundation of China(Grant No.61575011)
文摘We present a nonlinear ytterbium-doped fiber amplifier based on enhanced nonlinear effects that can produce a flat broadband spectrum ranging from 1050–1225 nm with a maximum average output power of 7.8 W at 14 W pump power.Its repetition rate is 89 MHz. Using a pair of gratings and two knife edges as a filter, wavelength tunable picosecond pulses of tens to hundreds of milliwatts can be obtained in the broadband spectrum range. The output power, pulse width, and spectrum（center wavelength and linewidth） are adjusted by tuning the distance of the grating pair and/or the knife edges.Fixing the distance between the two gratings at 15 mm and keeping the output spectrum linewidth at approximately 20 nm,the shortest pulse width obtained is less than 1 ps centered at 1080 nm. The longest wavelength of the short pulses is around1200 nm, and its output power and pulse width are 40 m W and 5.79 ps, respectively. The generation of a flat broadband spectrum is also discussed in this paper.
基金The authors gratefully acknowledge support by the Graduate School in Advanced Optical Technologies(SAOT)of the Friedrich–Alexander-University of Erlangen–Nürnberg,and the Bayerisches Laserzentrum GmbH.
文摘Glass welding by ultra-short pulsed(USP)lasers is a piece of technology that offers high strength joints with hermetic sealing.The joints are typically formed in glass that is transparent to the laser by exploiting nonlinear absorption effects that occur under extreme conditions.Though the temperature reached during the process is on the order of a few 1000°C,the heat affected zone(HAZ)is confined to only tens of micrometers.It is this controlled confinement of the HAZ during the joining process that makes this technology so appealing to a multitude of applications because it allows the foregoing of a subsequent tempering step that is typically essential in other glass joining techniques,thus making it possible to effectively join highly heat sensitive components.In this work,we give an overview on the process,development and applications of glass welding by USP lasers.
文摘The objective of this work was to investigate the possibility of taper angle correction in cutting of complex micro-mechanical contours using a TruMicro ultra-short pulse laser in combination with the SCANLAB precSYS micro machining sub system. In a first step, the influence of the process parameters on the kerftaper angle of metallic alloys was systematically investigated without beam inclination. A set of base parameters was derived for the subsequent investigations. In a second step, the kerftaper angle was controlled by static beam inclination. In a third step, the same optics was used in its dynamic precession mode to fabricate micro-mechanical components of complex contours with perpendicular 0~ taper angles. It was found that taper angle adjustments of up to 7.5~ are possible with the used setup for cutting applications. Taper angle control is possible both in the static beam inclination mode and in the dynamic precession mode. The static mode could be interesting for contours with sharp inner radii and for achieving faster cutting times similar to results with fixed optics, but would require excellent synchronization of beam inclination and axis motion. The dynamic precession mode would allow an easier integration of the optics into a laser machine but will result in longer cutting times and limitations with respect to achievable inner radii.
基金The authors gratefully acknowledge support by the Deutsche Forschungsgemeinschaft through the Grant Nos.Ho1691/8-1 I Li2713/4-1 | Schm2115/62-1,the Graduate School in Advanced Optical Technologies(SAOT)of the Friedrich-Alexander-Universitat Erlangen-Nurnberg and the QSIL GmbH Quarzschmelze Ilmenau.
文摘This paper focuses on the preparation of a new extended set of calibrations of cooling rate(fictive temperature)in fused silica determined by inelastic light scattering and its subsequent use to characterize the local cooling rate distribution in ultra-short pulsed(USP)laser modification.In order to determine the thermal history(e.g.cooling rate and fictive temperature)of fused silica,high-resolution inelastic light-scattering experiments(Raman and Brillouin spectroscopy)were investigated.Calibrations were performed and compared to the existing literature to quantify structural changes due to a change of fictive temperature.Compared to existing calibrations,this paper provides an extension to lower and higher cooling rates.Using this new set of calibrations,we characterized a USP laser modification in fused silica and calculated the local fictive temperature distribution.An equation relating the fictive temperature(Tf)to cooling rates is given.A maximum cooling rate of 3000 K min-1 in the glass transition region around 1200℃ was deduced from the Raman analysis.The Brillouin observations are sensitive to both the thermal history and the residual stress.By comparing the Raman and Brillouin observations,we extracted the local residual stress distribution with high spatial resolution.For the first time,combined Raman and Brillouin inelastic light scattering experiments show the local distribution of cooling rates and residual stresses(detailed behavior of the glass structure)in the interior and the surrounding of an USP laser modified zone.
基金supported by the Key Project of Chinese National Programs for Fundamental Research(973 Program)(No.2011CB808104)National Natural Science Foundation of China(Nos.11335013,11375276,11105234)
文摘Proton acceleration experiments were carried out by a 1.2× 1018 W/cm2 ultra-short laser interaction with solid foil targets. The peak proton energy observed from an optimum target thickness of 7 μm in our experiments was 2.1 MeV. Peak proton energy and proton yield were investigated for different foil target thicknesses. It was shown that proton energy and conversion efficiency increased as the target became thinner, on one condition that the preplasma generated by the laser prepulse did not have enough shock energy and time to influence or destroy the target rear-surface. The existence of optimum foil thickness is due to the effect of the prepulse and hot electron transportation behavior on the foil target.
基金the Ministerial Level Advanced Research Foundation (ABAQ440261)
文摘The dynamical progresses involved in ultra-short laser pulse ablation of face-centered cubic metals under stress confinement condition are described completely using molecular dynamics method. The laser beam absorption and thermal energy turning into kinetics energy of. atoms are taken into account to give a detailed picture of laser metal interaction. Superheating phenomenon is observed, and the phase change from solid to liquid is characterized by a destroyed atom configuration and a decreased number density. The steep velocity gradients are found in the systems of Cu and Ni after pulse in consequence of located heating and exponential decrease of fluences following the Lambert-Beer expression. The shock wave velocities are predicted to be about 5 000 m/s in Cu and 7 200 m/s in Ni. The higher ablation rates are obtained from simulations compared with experimental data as a result of a well-defined crystalline surface irradiated by a single pulse. Simulation results show that the main mechanisms of ablation are evaporation and thermoelastic stress due to located heating.
基金Supported by A Grant from the Natural Science Foundation of Guangdong Province, China, No. 07005961
文摘AIM： To investigate the proteins involved in colonic adaptation and molecular mechanisms of colonic adapration in rats with ultra-short bowel syndrome （USBS）. METHODS： Sprague Dawley rats were randomly as- signed to three groups： USBS group （10 rats） undergoing an approximately 90%-95% small bowel resection; sham-operation group （10 rats） undergoing small bowel transaction and anastomosis; and control group （ten normal rats）. Colon morphology and differential protein expression was analyzed after rats were given postsurgical enteral nutrition for 21 d. Protein expression in the colonic mucosa was analyzed by two-dimensional electrophoresis （2-DE） in all groups. Differential protein spots were detected by ImageMaster 2D Platinum soft-ware and were further analyzed with matrix-assisted laser desorption/ionization-time-of-flight/time-of-flightmass spectrometric （MALDI-TOF/TOF-MS） analysis. RESULTS： The colonic mucosal thickness significantly increased in the USBS group compared with the control group （302.1 ± 16.9 um vs 273.7 ± 16.0 um, P 〈 0.05）. There was no statistically significant difference between the sham-operation group and control group （P 〉 0.05）. The height of colon plica markedly improved in USBS group compared with the control group （998.4 ± 81.2 um vs 883.4 ± 39.0 um, P 〈 0.05）. There was no statistically significant difference between the shamoperation and control groups （P 〉 0.05）. A total of 141 differential protein spots were found in the USBS group. Forty-nine of these spots were down-regulated while 92 protein spots were up-regulated by over 2-folds. There were 133 differential protein spots in USBS group. Thirty of these spots were down-regulated and 103 were upregulated. There were 47 common differential protein spots among the three groups, including 17 down- regulated protein spots and 30 up-regulated spots. Among 47 differential spots, eight up-regulated proteins were identified by MALDI-TOF/TOF-MS. These proteins were previously reported to be involved in sugar and fat metabolism, protein synthesis and oxidation reduction, which are associated with colonic adaption. CONCLUSION： Eight proteins found in this study play important roles in colonic compensation and are associated with sugar and fat metabolism, protein synthesis, and molecular chaperoning
基金Supported by the Innovative Research Group Project of China National Natural Science Foundation(51821092)Key Project of China National Natural Science Foundation(U1762214).
文摘Focusing on the extending length restriction of the completion screen pipe resistance running into ultra-short radius horizontal well,this paper proposed technology of hydraulic drive completion tubular string running into ultra-short radius horizontal well.Innovative hydraulic drive tools and string structure are designed,which are composed of guide tubing,hydraulic drive tubing and non-metallic completion screen pipe from inside to outside.A novel mechanical-hydraulic coupling model is established.Based on the wellbore structure of an ultra-short radius horizontal well for deep coalbed methane,the numerical calculations of force and hydraulic load on tubular strings were accomplished by the mechanical-hydraulic coupling model.The results show that the extending length of completion tubular string with the hydraulic drive is 17 times that of conventional completion technology under the same conditions.The multi-factor orthogonal design is adopted to analyze the numerical calculations,and the results show that the extending length of the completion tubular string is mainly affected by the completion tubular string structure and the friction coefficient between the non-metallic composite continuous screen pipe and the wellbore.Two series of hydraulic drive completion tubular string structures suitable for ultra-short radius horizontal wells under different conditions are optimized,with the extending limits of 381 m and 655 m,respectively.These researches will provide theoretical guidance for design and control of hydraulic drive non-metallic composite continuous completion screen pipe running into ultra-short radius horizontal wells.
文摘The power systems economic and safety operation considering large-scale wind power penetration are now facing great challenges, which are based on reliable power supply and predictable load demands in the past. A rolling generation dispatch model based on ultra-short-term wind power forecast was proposed. In generation dispatch process, the model rolling correct not only the conventional units power output but also the power from wind farm, simultaneously. Second order Markov chain model was utilized to modify wind power prediction error state (WPPES) and update forecast results of wind power over the remaining dispatch periods. The prime-dual affine scaling interior point method was used to solve the proposed model that taken into account the constraints of multi-periods power balance, unit output adjustment, up spinning reserve and down spinning reserve.
基金supported by Open Fund of Technology Innovation Center for Directional Drilling Engineering,Ministry of Natural Resources./Innovation Base for Directional Drilling Engineering,Geological Society of China(-No.KF202302)the Geological Survey projects of China Geological Survey(No.DD20221681)+1 种基金Open Found Projects of Sinopec Key Laboratory of Geothermal Resources Exploitation and Utilizatio(No.36650000-23-ZC0607-0054)Open Research Fund Program of Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring(Ministry of Education),Central South University(2023YSJS06).
文摘To improve the drill pipe fracture failure phenomenon in deflecting drills with ultra-short radius flexible drill pipes,this study establishes a mechanical model of a deflecting drill with an ultra-short radius flexible drill pipe,numerically simulates the mechanical characteristics of the flexible drill pipe under the conventional drilling process using the finite element analysis method,performs mechanical performance tests on the flexible drill pipe,and optimizes and improves its structure.The results show that,with the gradual increase in the bending angle of the flexible drill pipe unit section,the upper drilling pressure of the flexible drill pipe unit section decreases rapidly and its friction increases approximately linearly.The tensile strength of the optimized ultra-short radius flexible drill pipe is increased by 24.7%,and the minimum threshold of its torsional strength is doubled.This effectively improves the overall strength of the ultra-short radius flexible drill pipe and provides a theoretical basis for downhole drilling stability studies of flexible drill pipes.
