To the Editor:Aging is characterized by progressive functional decline,with the gradual loss of proteostasis being a widely acknowledged hallmark of the aging process.Direct evidence indicates a reduction in ubiquitin...To the Editor:Aging is characterized by progressive functional decline,with the gradual loss of proteostasis being a widely acknowledged hallmark of the aging process.Direct evidence indicates a reduction in ubiquitination levels in aged worms1.Therefore,the development of therapeutics that target the ubiquitination pathways could offer substantial potential for delaying the onset of aging or age-related diseases.展开更多
基金supported by the Science and Technology Commission of Shanghai Municipality(No.22Y11906200,China)Shanghai First Maternity and Infant Hospital(No.2019RC06,China)the National Natural Science Foundation of China(Nos.32171288 and 32471341).
文摘To the Editor:Aging is characterized by progressive functional decline,with the gradual loss of proteostasis being a widely acknowledged hallmark of the aging process.Direct evidence indicates a reduction in ubiquitination levels in aged worms1.Therefore,the development of therapeutics that target the ubiquitination pathways could offer substantial potential for delaying the onset of aging or age-related diseases.
