世界时与协调世界时差值(difference between universal time and coordinated universal time,UT1-UTC)是地球定向参数(Earth orientation parameters,EOP)的重要组成部分,其高精度和快速预测对全球卫星导航系统气象学、人造卫星精密...世界时与协调世界时差值(difference between universal time and coordinated universal time,UT1-UTC)是地球定向参数(Earth orientation parameters,EOP)的重要组成部分,其高精度和快速预测对全球卫星导航系统气象学、人造卫星精密轨道确定等实时应用领域至关重要。传统UT1-UTC预报方法在中长期预测中精度衰减明显,难以满足北斗导航系统及战争环境的精确制导等高精度需求。提出了一种融合地球流体有效角动量(effective angular momentum,EAM)信息的轴向分量χ_(3)数据与EOP14 C04序列的卷积长短期记忆神经网络(convolutional long short-term memory,ConvLSTM)模型预报UT1-UTC的新方法。实测数据分析结果发现,EAM轴向分量χ^(3)和经跳秒与潮汐改正后的UT1-UTC数据具有强相关性,其振幅和相位具有一致的频谱特性,说明EAM轴向分量χ^(3)是UT1-UTC的主要激发源。与参与第二届EOP预报比赛的各家精度进行对比,在90~360 d的中长期预报跨度中,ConvLSTM模型预报精度最优,改善幅度为30.27%~92.44%。对比公报A,时间跨度为60 d、180 d和360 d的中长期预报精度分别提升41.46%、70.07%和59.43%,证实了ConvLSTM能够显著改善UT1-UTC的中长期预报精度。展开更多
Universal time(UT)1 is an alternative description of the Earth’s rotation angle and is one of the spatial parameters representing the Earth’s orientation that reflects subtle changes in its rotational speed.While ve...Universal time(UT)1 is an alternative description of the Earth’s rotation angle and is one of the spatial parameters representing the Earth’s orientation that reflects subtle changes in its rotational speed.While very long baseline interferometry(VLBI)has recently achieved high-precision measurements of UT1,its prohibitively high equipment costs and complex data processes make it difficult to meet the requirements of users in fields with stringent real-time data requirements,such as astronomical measurement and celestial navigation.Currently,the digital zenith telescope is one of the most accurate ground-based optical astronomical measurement instruments available.This study briefly introduces the digital zenith telescope measurement system and the basic principles of UT1 measurement and data processing.On the basis of more than 400 UT1 measurement experiments conducted at Luonan,Lijiang,and Delingha,the accuracy of UT1 measurements based on the digital zenith telescope is analyzed.The experimental results show that the internal consistency accuracy within 20 min can reach 10 ms and that the internal consistency accuracy of single-day observations can reach 0.05″.Compared with IERS 14C04,the mean absolute error of the UT1 measurements is approximately 3 ms.This indicates that optical astronomical observations based on the digital zenith telescope can be used as an effective regional autonomous monitoring method to supplement VLBI by providing highfrequency UT1,functioning in particular as an emergency backup when satellite navigation fails.展开更多
肠道病毒A71型(Enterovirus A71,EV-A71)是手足口病的重要病原体,为研究EV-A71感染人扁桃体上皮细胞后对细胞凋亡和细胞周期的影响,确定ERK1/2、JNK1/2、PI3K/Akt和含半胱氨酸的天冬氨酸蛋白水解酶(Cysteinyl aspartate specific protei...肠道病毒A71型(Enterovirus A71,EV-A71)是手足口病的重要病原体,为研究EV-A71感染人扁桃体上皮细胞后对细胞凋亡和细胞周期的影响,确定ERK1/2、JNK1/2、PI3K/Akt和含半胱氨酸的天冬氨酸蛋白水解酶(Cysteinyl aspartate specific proteinase,Caspase)的作用,本文以人扁桃体上皮细胞系UT-SCC-60B为细胞模型,CCK-8试剂盒检测EV-A71对UT-SCC-60B的抑制率、流式细胞仪检测EV-A71感染组和抑制剂处理组的凋亡和细胞周期、Caspase活力检测试剂盒测定Caspase-3,Caspase-8,Caspase-9活力。EV-A71以感染剂量和感染时间依赖方式抑制UT-SCC-60B增殖;EV-A71感染致UT-SCC-60B发生细胞凋亡,抑制ERK1/2、JNK1/2和PI3K/Akt能够降低UT-SCC-60B细胞凋亡比例;EV-A71感染UT-SCC-60B后发生S期阻滞,抑制ERK1/2、JNK1/2、PI3K/Akt和Caspase阻止UT-SCC-60B发生S期阻滞;EV-A71感染UT-SCC-60B能够活化Caspase-3,Caspase-8,Caspase-9且ERK1/2、JNK1/2和PI3K/Akt调控Caspase-3,Caspase-8,Caspase-9活力。因此,EV-A71能够导致人扁桃体上皮细胞UT-SCC-60B发生凋亡和S期阻滞,并且ERK1/2、JNK1/2、PI3K/Akt和Caspase参与凋亡和S期阻滞的调控。展开更多
文摘世界时与协调世界时差值(difference between universal time and coordinated universal time,UT1-UTC)是地球定向参数(Earth orientation parameters,EOP)的重要组成部分,其高精度和快速预测对全球卫星导航系统气象学、人造卫星精密轨道确定等实时应用领域至关重要。传统UT1-UTC预报方法在中长期预测中精度衰减明显,难以满足北斗导航系统及战争环境的精确制导等高精度需求。提出了一种融合地球流体有效角动量(effective angular momentum,EAM)信息的轴向分量χ_(3)数据与EOP14 C04序列的卷积长短期记忆神经网络(convolutional long short-term memory,ConvLSTM)模型预报UT1-UTC的新方法。实测数据分析结果发现,EAM轴向分量χ^(3)和经跳秒与潮汐改正后的UT1-UTC数据具有强相关性,其振幅和相位具有一致的频谱特性,说明EAM轴向分量χ^(3)是UT1-UTC的主要激发源。与参与第二届EOP预报比赛的各家精度进行对比,在90~360 d的中长期预报跨度中,ConvLSTM模型预报精度最优,改善幅度为30.27%~92.44%。对比公报A,时间跨度为60 d、180 d和360 d的中长期预报精度分别提升41.46%、70.07%和59.43%,证实了ConvLSTM能够显著改善UT1-UTC的中长期预报精度。
基金supported by the National Natural Science Foundation of China(41704006,42204041,and 42374011)the Natural Science Foundation Outstanding Youth Fund Program of Henan Province(242300421150)the Key Laboratory of Smart Earth(SYS-ZX06-2024-01).
文摘Universal time(UT)1 is an alternative description of the Earth’s rotation angle and is one of the spatial parameters representing the Earth’s orientation that reflects subtle changes in its rotational speed.While very long baseline interferometry(VLBI)has recently achieved high-precision measurements of UT1,its prohibitively high equipment costs and complex data processes make it difficult to meet the requirements of users in fields with stringent real-time data requirements,such as astronomical measurement and celestial navigation.Currently,the digital zenith telescope is one of the most accurate ground-based optical astronomical measurement instruments available.This study briefly introduces the digital zenith telescope measurement system and the basic principles of UT1 measurement and data processing.On the basis of more than 400 UT1 measurement experiments conducted at Luonan,Lijiang,and Delingha,the accuracy of UT1 measurements based on the digital zenith telescope is analyzed.The experimental results show that the internal consistency accuracy within 20 min can reach 10 ms and that the internal consistency accuracy of single-day observations can reach 0.05″.Compared with IERS 14C04,the mean absolute error of the UT1 measurements is approximately 3 ms.This indicates that optical astronomical observations based on the digital zenith telescope can be used as an effective regional autonomous monitoring method to supplement VLBI by providing highfrequency UT1,functioning in particular as an emergency backup when satellite navigation fails.
文摘肠道病毒A71型(Enterovirus A71,EV-A71)是手足口病的重要病原体,为研究EV-A71感染人扁桃体上皮细胞后对细胞凋亡和细胞周期的影响,确定ERK1/2、JNK1/2、PI3K/Akt和含半胱氨酸的天冬氨酸蛋白水解酶(Cysteinyl aspartate specific proteinase,Caspase)的作用,本文以人扁桃体上皮细胞系UT-SCC-60B为细胞模型,CCK-8试剂盒检测EV-A71对UT-SCC-60B的抑制率、流式细胞仪检测EV-A71感染组和抑制剂处理组的凋亡和细胞周期、Caspase活力检测试剂盒测定Caspase-3,Caspase-8,Caspase-9活力。EV-A71以感染剂量和感染时间依赖方式抑制UT-SCC-60B增殖;EV-A71感染致UT-SCC-60B发生细胞凋亡,抑制ERK1/2、JNK1/2和PI3K/Akt能够降低UT-SCC-60B细胞凋亡比例;EV-A71感染UT-SCC-60B后发生S期阻滞,抑制ERK1/2、JNK1/2、PI3K/Akt和Caspase阻止UT-SCC-60B发生S期阻滞;EV-A71感染UT-SCC-60B能够活化Caspase-3,Caspase-8,Caspase-9且ERK1/2、JNK1/2和PI3K/Akt调控Caspase-3,Caspase-8,Caspase-9活力。因此,EV-A71能够导致人扁桃体上皮细胞UT-SCC-60B发生凋亡和S期阻滞,并且ERK1/2、JNK1/2、PI3K/Akt和Caspase参与凋亡和S期阻滞的调控。
