Despite public and private investments in the senior housing sector,an alternative to retirement homes is not yet truly present in Italy,except for a few rare cases.The spots in residential facilities for the elderly ...Despite public and private investments in the senior housing sector,an alternative to retirement homes is not yet truly present in Italy,except for a few rare cases.The spots in residential facilities for the elderly are limited and not enough to fill a demand for spaces that is continuously increasing.Another underlying problem is that the type of user that senior housing is aimed at is not currently considered by the Italian market;the impact of factors that can decrease the quality of life in elderly people,such as loneliness,lack of physical activity or loss of routine is underestimated.This set of negative factors promotes the opposite of what is considered active aging.In recent years senior houses,intended as a residential typology for self-sufficient elderly people,have undergone a significant evolution,reflecting social,demographic and technological changes;this reflects a paradigm shift in the way society approaches care to the elderly,focusing increasingly on autonomy,personalization and well-being.From 2010 to 2024,there has been greater attention towards customization of programs and spaces dedicated to the elderly,with the aim of offering services that meet everyone’s specific needs.Senior houses are becoming more oriented towards a wellbeing-based approach and are starting to focus on social inclusion as well,promoting recreational and cultural activities to improve the quality of life of elderly vips.A strategy used for social inclusion is to dedicate part of the project to functions open to the public(kindergartens,community centers,spaces for associations,etc.)so that the project fits into the urban level of the city by interacting with it.The proposal is to integrate cultural spaces with senior housing in a way that the elderly residents can become the keepers and narrators of local heritage,creating intergenerational communities.展开更多
This study examines the spatial and temporal patterns of wetland degradation in Delhi from 1991 to 2021 using remote sensing and GIS techniques.The Automated Water Extraction Index(AWEI)was applied to pre-monsoon Land...This study examines the spatial and temporal patterns of wetland degradation in Delhi from 1991 to 2021 using remote sensing and GIS techniques.The Automated Water Extraction Index(AWEI)was applied to pre-monsoon Landsat imagery to delineate surface water bodies over the past 30 years accurately.Supervised classification was employed to generate land use maps,while census data was utilized to analyze urbanization trends across the region.Classification accuracy was assessed using Google Earth reference data through a confusion matrix,ensuring the reliability of the land cover analysis.Results reveal a significant decline in wetland extent,especially in densely populated and rapidly urbanizing districts such as North West,South,and East Delhi.During this time,the urban population increased from 52.7% to 97.4%,accompanied by a 70.2% expansion of built-up areas,while wetlands contracted from 32.9 km^(2) to 30.2 km^(2).South Delhi experienced the most severe wetland loss,with water body coverage dropping from 0.800% to 0.025%,whereas North East and Central Delhi maintained higher wetland coverage due to the influence of the Yamuna River and targeted conservation efforts.The study highlights the strong linkage between urban growth and wetland decline,which threatens biodiversity,groundwater recharge,and ecological stability.These findings emphasize the urgent need for integrated urban planning and conservation policies to safeguard wetlands,thereby promoting sustainability and water security in the National Capital Region.展开更多
Objective: To assess antiretroviral therapy (ART) adherence rates and associated factors among people living with HIV in Vietnam. Methods: A cross-sectional study was conducted at the Hospital for Tropical Diseases, H...Objective: To assess antiretroviral therapy (ART) adherence rates and associated factors among people living with HIV in Vietnam. Methods: A cross-sectional study was conducted at the Hospital for Tropical Diseases, Ho Chi Minh City from June to August 2022. Data were collected from 347 people living with HIV using structured questionnaires assessing sociodemographics, substance use, drug side effects, treatment beliefs, treatment satisfaction, and depression. ART adherence was evaluated using a multi-method tool, including self-report, pill count, the Provider Interview Tool, and the Visual Analog Scale. Participants were classified as having high adherence only if they met all four criteria across these methods. Multivariable logistic regression was used to identify factors influencing adherence, with significance set at P<0.05. Results: High ART adherence was observed in 69.5% of the participants. Adherence was significantly lower among tobacco users (OR 0.49, 95% CI 0.30-0.83, P=0.007), those with higher depression scores (per 1-point increase) (OR 0.89, 95% CI 0.84-0.95, P<0.001), frequent substance users (OR 0.50, 95% CI 0.30-0.83, P=0.007), and those experiencing more severe drug side effects (per level increase) (OR 0.64, 95% CI 0.45-0.92, P=0.016). Participants able to afford treatment had nearly three times higher odds of adherence than those unable to pay (OR 2.85, 95% CI 1.48-5.47, P=0.002). Conclusions: ART adherence among people living with HIV in Vietnam remains suboptimal. Interventions should target substance use, drug side effects, financial barriers, and depression screening to improve adherence.展开更多
Predictive maintenance often involves imbalanced multivariate time series datasets with scarce failure events,posing challenges for model training due to the high dimensionality of the data and the need for domain-spe...Predictive maintenance often involves imbalanced multivariate time series datasets with scarce failure events,posing challenges for model training due to the high dimensionality of the data and the need for domain-specific preprocessing,which frequently leads to the development of large and complex models.Inspired by the success of Large Language Models(LLMs),transformer-based foundation models have been developed for time series(TSFM).These models have been proven to reconstruct time series in a zero-shot manner,being able to capture different patterns that effectively characterize time series.This paper proposes the use of TSFM to generate embeddings of the input data space,making them more interpretable for machine learning models.To evaluate the effectiveness of our approach,we trained three classical machine learning algorithms and one neural network using the embeddings generated by the TSFM called Moment for predicting the remaining useful life of aircraft engines.We test the models trained with both the full training dataset and only 10%of the training samples.Our results show that training simple models,such as support vector regressors or neural networks,with embeddings generated by Moment not only accelerates the training process but also enhances performance in few-shot learning scenarios,where data is scarce.This suggests a promising alternative to complex deep learning architectures,particularly in industrial contexts with limited labeled data.展开更多
In L2 content-based classrooms,code-switching or translanguaging seem to be a common practice adopted by teachers.There has been growing research discussing the potentials of L1 in these classrooms.Most of the current...In L2 content-based classrooms,code-switching or translanguaging seem to be a common practice adopted by teachers.There has been growing research discussing the potentials of L1 in these classrooms.Most of the current studies have focused on the analysis of lesson interactions and yet the perception of the content teachers has remained underexplored.This case study investigated the introspective views of a group of content teachers at a secondary school using questionnaires and written accounts.Data analyses showed that these teachers were generally aware of the interpersonal and ideational functions achieved by the use of L1 and they also seemed to have a positive view towards their practices of using L1 in English-medium classrooms.Based on the findings,practical implications for content teachers in relation to making medium of instruction decisions and suggestions for further research are discussed.展开更多
The simultaneous increase in development in Pesawaran Regency is closely correlated with the intense competi-tion for land use.However,low policy implementation effectiveness has led to construction beyond designated ...The simultaneous increase in development in Pesawaran Regency is closely correlated with the intense competi-tion for land use.However,low policy implementation effectiveness has led to construction beyond designated spatial plan.The study used a quantitative survey using Landsat images in 2016,2019,and 2022.The data analysis techniques used geographic information systems integrated with Artificial Neural Network(ANN)and Cellular Automata(CA)models.This study aims to predict land-use change in 2031,evaluate its alignment with spatial planning,and provide guidance for controlling land-use change.The results showed that there has been an increase in land use.In 2019,built-up land reached 7,069.65 Ha.The model shows its ability to predict land simulation and transformation,where it is predicted that built-up land in 2031 will experience an increase of up to 40.10%,so development and change cannot be avoided every year.This study also suggests that decision-makers and local governments should reconsider spatial planning strategies.This study shows that there have been many land use changes from 2016 to 2022.The model shows its ability to predict simulation and land transformation.When using the model,there are many changes in the land use area in 2031.This is due to wet agricultural land turning into built-up land by almost 70%.This study shows that road network influence land-use change.The cellular automata model managed to capture the complexity with simple rules.Predictions for future research should focus on conserving wetlands and primary forests.展开更多
Introduction:Having a primary care usual source of care(USC)is associated with better population health outcomes.However,the percent of adults in the United States(US)with a usual primary care provider is declining.We...Introduction:Having a primary care usual source of care(USC)is associated with better population health outcomes.However,the percent of adults in the United States(US)with a usual primary care provider is declining.We sought to identify factors associated with establishing a USC at an urgent care clinic or emergency department as opposed to primary care.Methods:We analyzed data from 57,152 participants in the All of Us study who reported having a USC.We used the Andersen Behavioral Model of Health Services Use framework and multivariable logistic regression to examine associations among predisposing,enabling,and need factors,according to the source of usual care.Results:An urgent care clinic,minute clinic,or emergency department was the source of usual care for 6.3%of our sample.The odds of seeking care at this type of facility increased with younger age,lower educational attainment,and better health status.Black and Hispanic individuals,as well as those who reported experiencing discrimination in medical settings or that their provider was of a different race and ethnicity,were also less likely to have a primary care USC.Financial concerns,being anxious about seeing a provider,and the inability to take time off from work also increased the likelihood of having a non‐primary care USC.Conclusions:Improving the rates of having a primary care USC among younger and healthy adults may be achievable through policies that can improve access to convenient,affordable primary care.Efforts to improve diversity among primary care providers and reduce discrimination experienced by patients may also improve the USC rates for racial and ethnic minority groups.展开更多
Challenges in land use and land cover(LULC)include rapid urbanization encroaching on agricultural land,leading to fragmentation and loss of natural habitats.However,the effects of urbanization on LULC of different cro...Challenges in land use and land cover(LULC)include rapid urbanization encroaching on agricultural land,leading to fragmentation and loss of natural habitats.However,the effects of urbanization on LULC of different crop types are less concerned.The study assessed the impacts of LULC changes on agriculture and drought vulnerability in the Aguascalientes region,Mexico,from 1994 to 2024,and predicted the LULC in 2034 using remote sensing data,with the goals of sustainable land management and climate resilience strategies.Despite increasing urbanization and drought,the integration of satellite imagery and machine learning models in LULC analysis has been underutilized in this region.Using Landsat imagery,we assessed crop attributes through indices such as normalized difference vegetation index(NDVI),normalized difference water index(NDWI),normalized difference moisture index(NDMI),and vegetation condition index(VCI),alongside watershed delineation and spectral features.The random forest model was applied to classify LULC,providing insights into both historical and future trends.Results indicated a significant decline in vegetation cover(109.13 km^(2))from 1994 to 2024,accompanied by an increase in built-up land(75.11 km^(2))and bare land(67.13 km^(2)).Projections suggested a further decline in vegetation cover(41.51 km^(2))and continued urban land expansion by 2034.The study found that paddy crops exhibited the highest values,while common bean and maize performed poorly.Drought analysis revealed that mildly dry areas in 2004 became severely dry in 2024,highlighting the increasing vulnerability of agriculture to climate change.The study concludes that sustainable land management,improved water resource practices,and advanced monitoring techniques are essential to mitigate the adverse effects of LULC changes on agricultural productivity and drought resilience in the area.These findings contribute to the understanding of how remote sensing can be effectively used for long-term agricultural planning and environmental sustainability.展开更多
Marburg virus disease(MVD)is a highly fatal illness,with a case fatality rate of up to 88%,though this rate can be significantly reduced with prompt and effective patient care.The disease was first identified in 1967 ...Marburg virus disease(MVD)is a highly fatal illness,with a case fatality rate of up to 88%,though this rate can be significantly reduced with prompt and effective patient care.The disease was first identified in 1967 during concurrent outbreaks in Marburg and Frankfurt,Germany,and in Belgrade,Serbia,linked to laboratory use of African green monkeys imported from Uganda.Subsequent outbreaks and isolated cases have been reported in various African countries,including Angola,the Democratic Republic of the Congo,Equatorial Guinea,Ghana,Guinea,Kenya,Rwanda,South Africa(in an individual with recent travel to Zimbabwe),Tanzania,and Uganda.Initial human MVD infections typically occur due to prolonged exposure to mines or caves inhabited by Rousettus aegyptiacus fruit bats,the natural hosts of the virus.展开更多
The reliable,rapid,and accurate Remaining Useful Life(RUL)prognostics of aircraft power supply and distribution system are essential for enhancing the reliability and stability of system and reducing the life-cycle co...The reliable,rapid,and accurate Remaining Useful Life(RUL)prognostics of aircraft power supply and distribution system are essential for enhancing the reliability and stability of system and reducing the life-cycle costs.To achieve the reliable,rapid,and accurate RUL prognostics,the balance between accuracy and computational burden deserves more attention.In addition,the uncertainty is intrinsically present in RUL prognostic process.Due to the limitation of the uncertainty quantification,the point-wise prognostics strategy is not trustworthy.A Dual Adaptive Sliding-window Hybrid(DASH)RUL probabilistic prognostics strategy is proposed to tackle these deficiencies.The DASH strategy contains two adaptive mechanisms,the adaptive Long Short-Term Memory-Polynomial Regression(LSTM-PR)hybrid prognostics mechanism and the adaptive sliding-window Kernel Density Estimation(KDE)probabilistic prognostics mechanism.Owing to the dual adaptive mechanisms,the DASH strategy can achieve the balance between accuracy and computational burden and obtain the trustworthy probabilistic prognostics.Based on the degradation dataset of aircraft electromagnetic contactors,the superiority of DASH strategy is validated.In terms of probabilistic,point-wise and integrated prognostics performance,the proposed strategy increases by 66.89%,81.73% and 25.84%on average compared with the baseline methods and their variants.展开更多
In order to simulate the evolution of affordable housing land use a dynamic model that combines cellular automata CA and a multi-agent system MAS is established.This paper aims to utilize the approach of decision fact...In order to simulate the evolution of affordable housing land use a dynamic model that combines cellular automata CA and a multi-agent system MAS is established.This paper aims to utilize the approach of decision factors on site selection of affordable housing through a literature review to construct a hierarchy model of those factors identifying the weight of each factor by an analytic hierarchy process AHP .Based on those weight factors the CA-MAS model is designed. Nanjing city is taken as an example to verify the feasibility of the model.The results show that the CA-MAS model is pragmatic and effective in simulating evolution of affordable housing land use which also promotes the fundamental understanding and perception of the development of affordable housing and urbanization.展开更多
The present article provides a critical review of Randi Reppen's impressing book Using Corpora in the Language Classroom.It's argued that Randi Reppen's book,despite a few slight flaws,has a strong practic...The present article provides a critical review of Randi Reppen's impressing book Using Corpora in the Language Classroom.It's argued that Randi Reppen's book,despite a few slight flaws,has a strong practical orientation and is a laudable effort to make English language teachers to realize the importance and practicality of bringing corpora into classroom in digital age.The book is particularly worthy of reading for those language teachers(especially beginner teachers) who want to breathe new life into their English teaching.展开更多
We present an experimental demonstration of the rotation measurement using a compact cold atom gyroscope. Atom interference fringes are observed in the stationary frame and the rotating frame, respectively. The phase ...We present an experimental demonstration of the rotation measurement using a compact cold atom gyroscope. Atom interference fringes are observed in the stationary frame and the rotating frame, respectively. The phase shift and contrast of the interference fringe are experimentally investigated. The results show that the contrast of the interference fringe is well held when the platform is rotated, and the phase shift of the interference fringe is linearly proportional to the rotation rate of the platform. The long-term stability, which is evaluated by the overlapped Allan deviation, is 8.5 × 10^-6 rad/s over the integrating time of 1000s.展开更多
Land use transition refers to the changes in land use morphology （both dominant morphology and recessive morphology） of a certain region over a certain period of time driven by socio-economic change and innovation, ...Land use transition refers to the changes in land use morphology （both dominant morphology and recessive morphology） of a certain region over a certain period of time driven by socio-economic change and innovation, and it usually corresponds to the transition of socio-economic development phase. In China, farmland and rural housing land are the two major sources of land use transition. This paper analyzes the spatio-temporal coupling characteristics of farmland and rural housing land transition in China, using high-resolution Landsat TM （Thematic Mapper） data in 2000 and 2008, and the data from the Ministry of Land and Resources of China. The outcomes indicated that： （1） during 2000-2008, the correlation coefficient of farmland vs. rural housing land change is -0.921, and it shows that the change pattern of farmland and rural housing land is uncoordinated; （2） the result of Spearman rank correlation analysis shows that rural housing land change has played a major role in the mutual transformation of farmland and rural housing land; and （3） it shows a high-degree spatial coupling between farmland and rural housing land change in southeast China during 2000-2008. In general, farmland and rural housing land transition in China is driven by socio-economic, bio-physical and managerial three-dimensional driving factors through the interactions among rural population, farmland and rural housing land. However, the spatio-temporal coupling phenomenon and mechanism of farmland and rural housing land transition in China are largely due to the ＂dual-track＂ structure of rural-urban development.展开更多
High grain protein content(GPC) reduces rice eating and cooking quality(ECQ). We generated OsAAP6 and OsAAP10 knockout mutants in three high-yielding japonica varieties and one japonica line using the CRISPR/Cas9 syst...High grain protein content(GPC) reduces rice eating and cooking quality(ECQ). We generated OsAAP6 and OsAAP10 knockout mutants in three high-yielding japonica varieties and one japonica line using the CRISPR/Cas9 system. Mutation efficiency varied with genetic background in the T_0 generation, and GPC in the T_1 generation decreased significantly,owing mainly to a reduction in glutelin content. Amylose content was down-regulated significantly in some Osaap6 and all Osaap10 mutants. The increased taste value of these mutants was supported by Rapid Visco Analysis(RVA) profiles, which showed higher peak viscosity and breakdown viscosity and lower setback viscosity than the wild type. There were no significant deficiencies in agronomic traits of the mutants. Targeted mutagenesis of OsAAP6 and OsAAP10, especially OsAAP10, using the CRISPR/Cas9 system can rapidly reduce GPC and improve ECQ of rice, providing a new strategy for the breeding cultivars with desired ECQ.展开更多
In eukaryotic cells, initiation of protein translation is to recruit the ribosome to a specific mRNA, which is generally dependent on the 5＇ cap structure. However, protein translation can also be initiated in a cap-...In eukaryotic cells, initiation of protein translation is to recruit the ribosome to a specific mRNA, which is generally dependent on the 5＇ cap structure. However, protein translation can also be initiated in a cap-independent manner by using a cis-regulatory element termed the internal ribosome entry site （IRES）. The first experimentally validated IRES was reported in the poliovirus （Pelletier and Sonenberg, 1988）. Then eukaryotic cellular mRNAs were also validated to contain IRES elements.展开更多
Cpf1 is a class 2/type V CRISPR effector that has been recently harnessed for genome editing （Zetsche et al., 2015; Hut et al., 2016; Kim et al., 2016）. Cpff recognizes thymidine-rich sequence as the protospacer-adj...Cpf1 is a class 2/type V CRISPR effector that has been recently harnessed for genome editing （Zetsche et al., 2015; Hut et al., 2016; Kim et al., 2016）. Cpff recognizes thymidine-rich sequence as the protospacer-adjacent motif （PAM） at the 5＇ end of target sequences. In addition, Cpfl requires only a single shorter crRNA and cleaves DNA in a staggered fashion with 5＇ overhangs （Zetsche et al., 2015）.展开更多
Beany flavor induced by three lipoxygenases(LOXs, including LOX1, LOX2, and LOX3)restricts human consumption of soybean. It is desirable to generate lipoxygenase-free new mutant lines to improve the eating quality of ...Beany flavor induced by three lipoxygenases(LOXs, including LOX1, LOX2, and LOX3)restricts human consumption of soybean. It is desirable to generate lipoxygenase-free new mutant lines to improve the eating quality of soybean oil and protein products. In this study, a pooled clustered regularly interspaced short palindromic repeats(CRISPR)-CRISPRassociated protein 9(Cas9) strategy targeting three GmLox genes(GmLox1, GmLox2, and GmLox3) was applied and 60 T_0 positive transgenic plants were generated, carrying combinations of sg RNAs and mutations. Among them, GmLox-28 and GmLox-60 were gmlox1 gmlox2 gmlox3 triple mutants and GmLox-40 was a gmlox1 gmlox2 double mutant.Sequencing of T_1 mutant plants derived from GmLox-28, GmLox-60, and GmLox-40 showed that mutation in the GmLox gene was inherited by the next generation. Colorimetric assay revealed that plants carrying different combinations of mutations lost the corresponding lipoxygenase activities. Transgene-free mutants were obtained by screening the T_2 generation of lipoxygenase-free mutant lines(GmLox-28 and GmLox-60). These transgeneand lipoxygenase-free mutants could be used for soybean beany flavor reduction without restriction by regulatory frameworks governing transgenic organisms.展开更多
The improvement of the seismic resilience of existing reinforced-concrete(RC) frame buildings, which is essential for the seismic resilience of a city, has become a critical issue. Although seismic isolation is an eff...The improvement of the seismic resilience of existing reinforced-concrete(RC) frame buildings, which is essential for the seismic resilience of a city, has become a critical issue. Although seismic isolation is an effective method for improving the resilient performance of such buildings, target-oriented quantitative improvements of the resilient performance of these buildings have been reported rarely. To address this gap, the seismic resilience of two existing RC frame buildings located in a high seismic intensity region of China were assessed based on the Chinese Standard for Seismic Resilience Assessment of Buildings. The critical engineering demand parameters(EDPs) affecting the seismic resilience of such buildings were identified. Subsequently, the seismic resilience of buildings retrofitted with different isolation schemes(i.e., yield ratios) were evaluated and compared, with emphasis on the relationships among yield ratios, EDPs, and levels of seismic resilience. Accordingly, to achieve the highest level of seismic resilience with respect to the Chinese standard, a yield ratio of 3% was recommended and successfully applied to the target-oriented design for the seismic-resilience improvement of an existing RC frame building. The research outcome can provide an important reference for the resilience-based retrofitting of existing RC frame buildings using seismic isolation in urban cities.展开更多
Tomato (Solanum lycopersicum) is the leading vegetable crop worldwide and an essential component of a healthy diet (Lin et al., 2014; Du et al., 2017). Fruit color is regarded as one of the most important commercial t...Tomato (Solanum lycopersicum) is the leading vegetable crop worldwide and an essential component of a healthy diet (Lin et al., 2014; Du et al., 2017). Fruit color is regarded as one of the most important commercial traits in tomato (The Tomato Genome Consortium, 2012). Consumers in different regions have different color preferences. For example, European and American consumers prefer red tomatoes, while pink tomatoes are more pop- ular in Asia countries, particularly in China and Japan (Ballester et al., 2010; Lin et al., 2014). However, most of tomato breeding ma- terials are red-fruited, thus the generation of pink-fruited materials is very important for Asian tomato production. Metabolomics and genetics studies demonstrate that the pink trait results from the absence of yellow-colored flavonoid naringenin chalcone (NarCh) in the peels,and is controlled by the monogenic recessive yellow(y)lOCUS(Adato et a1..2009;Ballester et a1..2OLO).展开更多
文摘Despite public and private investments in the senior housing sector,an alternative to retirement homes is not yet truly present in Italy,except for a few rare cases.The spots in residential facilities for the elderly are limited and not enough to fill a demand for spaces that is continuously increasing.Another underlying problem is that the type of user that senior housing is aimed at is not currently considered by the Italian market;the impact of factors that can decrease the quality of life in elderly people,such as loneliness,lack of physical activity or loss of routine is underestimated.This set of negative factors promotes the opposite of what is considered active aging.In recent years senior houses,intended as a residential typology for self-sufficient elderly people,have undergone a significant evolution,reflecting social,demographic and technological changes;this reflects a paradigm shift in the way society approaches care to the elderly,focusing increasingly on autonomy,personalization and well-being.From 2010 to 2024,there has been greater attention towards customization of programs and spaces dedicated to the elderly,with the aim of offering services that meet everyone’s specific needs.Senior houses are becoming more oriented towards a wellbeing-based approach and are starting to focus on social inclusion as well,promoting recreational and cultural activities to improve the quality of life of elderly vips.A strategy used for social inclusion is to dedicate part of the project to functions open to the public(kindergartens,community centers,spaces for associations,etc.)so that the project fits into the urban level of the city by interacting with it.The proposal is to integrate cultural spaces with senior housing in a way that the elderly residents can become the keepers and narrators of local heritage,creating intergenerational communities.
文摘This study examines the spatial and temporal patterns of wetland degradation in Delhi from 1991 to 2021 using remote sensing and GIS techniques.The Automated Water Extraction Index(AWEI)was applied to pre-monsoon Landsat imagery to delineate surface water bodies over the past 30 years accurately.Supervised classification was employed to generate land use maps,while census data was utilized to analyze urbanization trends across the region.Classification accuracy was assessed using Google Earth reference data through a confusion matrix,ensuring the reliability of the land cover analysis.Results reveal a significant decline in wetland extent,especially in densely populated and rapidly urbanizing districts such as North West,South,and East Delhi.During this time,the urban population increased from 52.7% to 97.4%,accompanied by a 70.2% expansion of built-up areas,while wetlands contracted from 32.9 km^(2) to 30.2 km^(2).South Delhi experienced the most severe wetland loss,with water body coverage dropping from 0.800% to 0.025%,whereas North East and Central Delhi maintained higher wetland coverage due to the influence of the Yamuna River and targeted conservation efforts.The study highlights the strong linkage between urban growth and wetland decline,which threatens biodiversity,groundwater recharge,and ecological stability.These findings emphasize the urgent need for integrated urban planning and conservation policies to safeguard wetlands,thereby promoting sustainability and water security in the National Capital Region.
文摘Objective: To assess antiretroviral therapy (ART) adherence rates and associated factors among people living with HIV in Vietnam. Methods: A cross-sectional study was conducted at the Hospital for Tropical Diseases, Ho Chi Minh City from June to August 2022. Data were collected from 347 people living with HIV using structured questionnaires assessing sociodemographics, substance use, drug side effects, treatment beliefs, treatment satisfaction, and depression. ART adherence was evaluated using a multi-method tool, including self-report, pill count, the Provider Interview Tool, and the Visual Analog Scale. Participants were classified as having high adherence only if they met all four criteria across these methods. Multivariable logistic regression was used to identify factors influencing adherence, with significance set at P<0.05. Results: High ART adherence was observed in 69.5% of the participants. Adherence was significantly lower among tobacco users (OR 0.49, 95% CI 0.30-0.83, P=0.007), those with higher depression scores (per 1-point increase) (OR 0.89, 95% CI 0.84-0.95, P<0.001), frequent substance users (OR 0.50, 95% CI 0.30-0.83, P=0.007), and those experiencing more severe drug side effects (per level increase) (OR 0.64, 95% CI 0.45-0.92, P=0.016). Participants able to afford treatment had nearly three times higher odds of adherence than those unable to pay (OR 2.85, 95% CI 1.48-5.47, P=0.002). Conclusions: ART adherence among people living with HIV in Vietnam remains suboptimal. Interventions should target substance use, drug side effects, financial barriers, and depression screening to improve adherence.
基金Funded by the Spanish Government and FEDER funds(AEI/FEDER,UE)under grant PID2021-124502OB-C42(PRESECREL)the predoctoral program“Concepción Arenal del Programa de Personal Investigador en formación Predoctoral”funded by Universidad de Cantabria and Cantabria’s Government(BOC 18-10-2021).
文摘Predictive maintenance often involves imbalanced multivariate time series datasets with scarce failure events,posing challenges for model training due to the high dimensionality of the data and the need for domain-specific preprocessing,which frequently leads to the development of large and complex models.Inspired by the success of Large Language Models(LLMs),transformer-based foundation models have been developed for time series(TSFM).These models have been proven to reconstruct time series in a zero-shot manner,being able to capture different patterns that effectively characterize time series.This paper proposes the use of TSFM to generate embeddings of the input data space,making them more interpretable for machine learning models.To evaluate the effectiveness of our approach,we trained three classical machine learning algorithms and one neural network using the embeddings generated by the TSFM called Moment for predicting the remaining useful life of aircraft engines.We test the models trained with both the full training dataset and only 10%of the training samples.Our results show that training simple models,such as support vector regressors or neural networks,with embeddings generated by Moment not only accelerates the training process but also enhances performance in few-shot learning scenarios,where data is scarce.This suggests a promising alternative to complex deep learning architectures,particularly in industrial contexts with limited labeled data.
文摘In L2 content-based classrooms,code-switching or translanguaging seem to be a common practice adopted by teachers.There has been growing research discussing the potentials of L1 in these classrooms.Most of the current studies have focused on the analysis of lesson interactions and yet the perception of the content teachers has remained underexplored.This case study investigated the introspective views of a group of content teachers at a secondary school using questionnaires and written accounts.Data analyses showed that these teachers were generally aware of the interpersonal and ideational functions achieved by the use of L1 and they also seemed to have a positive view towards their practices of using L1 in English-medium classrooms.Based on the findings,practical implications for content teachers in relation to making medium of instruction decisions and suggestions for further research are discussed.
基金supported by the Ministry of Education,Culture,Research,and Technology Directorate General of Higher Education,Research,and Technology grant number[2147/UN2621/PN/2022].
文摘The simultaneous increase in development in Pesawaran Regency is closely correlated with the intense competi-tion for land use.However,low policy implementation effectiveness has led to construction beyond designated spatial plan.The study used a quantitative survey using Landsat images in 2016,2019,and 2022.The data analysis techniques used geographic information systems integrated with Artificial Neural Network(ANN)and Cellular Automata(CA)models.This study aims to predict land-use change in 2031,evaluate its alignment with spatial planning,and provide guidance for controlling land-use change.The results showed that there has been an increase in land use.In 2019,built-up land reached 7,069.65 Ha.The model shows its ability to predict land simulation and transformation,where it is predicted that built-up land in 2031 will experience an increase of up to 40.10%,so development and change cannot be avoided every year.This study also suggests that decision-makers and local governments should reconsider spatial planning strategies.This study shows that there have been many land use changes from 2016 to 2022.The model shows its ability to predict simulation and land transformation.When using the model,there are many changes in the land use area in 2031.This is due to wet agricultural land turning into built-up land by almost 70%.This study shows that road network influence land-use change.The cellular automata model managed to capture the complexity with simple rules.Predictions for future research should focus on conserving wetlands and primary forests.
文摘Introduction:Having a primary care usual source of care(USC)is associated with better population health outcomes.However,the percent of adults in the United States(US)with a usual primary care provider is declining.We sought to identify factors associated with establishing a USC at an urgent care clinic or emergency department as opposed to primary care.Methods:We analyzed data from 57,152 participants in the All of Us study who reported having a USC.We used the Andersen Behavioral Model of Health Services Use framework and multivariable logistic regression to examine associations among predisposing,enabling,and need factors,according to the source of usual care.Results:An urgent care clinic,minute clinic,or emergency department was the source of usual care for 6.3%of our sample.The odds of seeking care at this type of facility increased with younger age,lower educational attainment,and better health status.Black and Hispanic individuals,as well as those who reported experiencing discrimination in medical settings or that their provider was of a different race and ethnicity,were also less likely to have a primary care USC.Financial concerns,being anxious about seeing a provider,and the inability to take time off from work also increased the likelihood of having a non‐primary care USC.Conclusions:Improving the rates of having a primary care USC among younger and healthy adults may be achievable through policies that can improve access to convenient,affordable primary care.Efforts to improve diversity among primary care providers and reduce discrimination experienced by patients may also improve the USC rates for racial and ethnic minority groups.
基金supported by the Deanship of Research and Graduate Studies at the King Khalid University(RGP2/287/46)the Princess Nourah bint Abdulrahman University Researchers Supporting Project(PNURSP2025R733)+1 种基金the Princess Nourah bint Abdulrahman University Research Supporting Project(RSPD2025R787)the King Saud University,Saudi Arabia.
文摘Challenges in land use and land cover(LULC)include rapid urbanization encroaching on agricultural land,leading to fragmentation and loss of natural habitats.However,the effects of urbanization on LULC of different crop types are less concerned.The study assessed the impacts of LULC changes on agriculture and drought vulnerability in the Aguascalientes region,Mexico,from 1994 to 2024,and predicted the LULC in 2034 using remote sensing data,with the goals of sustainable land management and climate resilience strategies.Despite increasing urbanization and drought,the integration of satellite imagery and machine learning models in LULC analysis has been underutilized in this region.Using Landsat imagery,we assessed crop attributes through indices such as normalized difference vegetation index(NDVI),normalized difference water index(NDWI),normalized difference moisture index(NDMI),and vegetation condition index(VCI),alongside watershed delineation and spectral features.The random forest model was applied to classify LULC,providing insights into both historical and future trends.Results indicated a significant decline in vegetation cover(109.13 km^(2))from 1994 to 2024,accompanied by an increase in built-up land(75.11 km^(2))and bare land(67.13 km^(2)).Projections suggested a further decline in vegetation cover(41.51 km^(2))and continued urban land expansion by 2034.The study found that paddy crops exhibited the highest values,while common bean and maize performed poorly.Drought analysis revealed that mildly dry areas in 2004 became severely dry in 2024,highlighting the increasing vulnerability of agriculture to climate change.The study concludes that sustainable land management,improved water resource practices,and advanced monitoring techniques are essential to mitigate the adverse effects of LULC changes on agricultural productivity and drought resilience in the area.These findings contribute to the understanding of how remote sensing can be effectively used for long-term agricultural planning and environmental sustainability.
文摘Marburg virus disease(MVD)is a highly fatal illness,with a case fatality rate of up to 88%,though this rate can be significantly reduced with prompt and effective patient care.The disease was first identified in 1967 during concurrent outbreaks in Marburg and Frankfurt,Germany,and in Belgrade,Serbia,linked to laboratory use of African green monkeys imported from Uganda.Subsequent outbreaks and isolated cases have been reported in various African countries,including Angola,the Democratic Republic of the Congo,Equatorial Guinea,Ghana,Guinea,Kenya,Rwanda,South Africa(in an individual with recent travel to Zimbabwe),Tanzania,and Uganda.Initial human MVD infections typically occur due to prolonged exposure to mines or caves inhabited by Rousettus aegyptiacus fruit bats,the natural hosts of the virus.
基金co-supported by the National Natural Science Foundation of China(Nos.52272403,52402506)Natural Science Basic Research Program of Shaanxi,China(Nos.2022JC-27,2023-JC-QN-0599)。
文摘The reliable,rapid,and accurate Remaining Useful Life(RUL)prognostics of aircraft power supply and distribution system are essential for enhancing the reliability and stability of system and reducing the life-cycle costs.To achieve the reliable,rapid,and accurate RUL prognostics,the balance between accuracy and computational burden deserves more attention.In addition,the uncertainty is intrinsically present in RUL prognostic process.Due to the limitation of the uncertainty quantification,the point-wise prognostics strategy is not trustworthy.A Dual Adaptive Sliding-window Hybrid(DASH)RUL probabilistic prognostics strategy is proposed to tackle these deficiencies.The DASH strategy contains two adaptive mechanisms,the adaptive Long Short-Term Memory-Polynomial Regression(LSTM-PR)hybrid prognostics mechanism and the adaptive sliding-window Kernel Density Estimation(KDE)probabilistic prognostics mechanism.Owing to the dual adaptive mechanisms,the DASH strategy can achieve the balance between accuracy and computational burden and obtain the trustworthy probabilistic prognostics.Based on the degradation dataset of aircraft electromagnetic contactors,the superiority of DASH strategy is validated.In terms of probabilistic,point-wise and integrated prognostics performance,the proposed strategy increases by 66.89%,81.73% and 25.84%on average compared with the baseline methods and their variants.
基金The National Social Science Foundation of China(No.14AJY013)the Scientific Innovation Research of College Graduates in Jiangsu Province(No.CXLX13_126)
文摘In order to simulate the evolution of affordable housing land use a dynamic model that combines cellular automata CA and a multi-agent system MAS is established.This paper aims to utilize the approach of decision factors on site selection of affordable housing through a literature review to construct a hierarchy model of those factors identifying the weight of each factor by an analytic hierarchy process AHP .Based on those weight factors the CA-MAS model is designed. Nanjing city is taken as an example to verify the feasibility of the model.The results show that the CA-MAS model is pragmatic and effective in simulating evolution of affordable housing land use which also promotes the fundamental understanding and perception of the development of affordable housing and urbanization.
文摘The present article provides a critical review of Randi Reppen's impressing book Using Corpora in the Language Classroom.It's argued that Randi Reppen's book,despite a few slight flaws,has a strong practical orientation and is a laudable effort to make English language teachers to realize the importance and practicality of bringing corpora into classroom in digital age.The book is particularly worthy of reading for those language teachers(especially beginner teachers) who want to breathe new life into their English teaching.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11227083 and 91536221
文摘We present an experimental demonstration of the rotation measurement using a compact cold atom gyroscope. Atom interference fringes are observed in the stationary frame and the rotating frame, respectively. The phase shift and contrast of the interference fringe are experimentally investigated. The results show that the contrast of the interference fringe is well held when the platform is rotated, and the phase shift of the interference fringe is linearly proportional to the rotation rate of the platform. The long-term stability, which is evaluated by the overlapped Allan deviation, is 8.5 × 10^-6 rad/s over the integrating time of 1000s.
基金National Natural Science Foundation of China, No.41171149 No.41130748 Knowledge Innovation Program of the Chinese Academy of Sciences, No.KZCX2-YW-QN304
文摘Land use transition refers to the changes in land use morphology （both dominant morphology and recessive morphology） of a certain region over a certain period of time driven by socio-economic change and innovation, and it usually corresponds to the transition of socio-economic development phase. In China, farmland and rural housing land are the two major sources of land use transition. This paper analyzes the spatio-temporal coupling characteristics of farmland and rural housing land transition in China, using high-resolution Landsat TM （Thematic Mapper） data in 2000 and 2008, and the data from the Ministry of Land and Resources of China. The outcomes indicated that： （1） during 2000-2008, the correlation coefficient of farmland vs. rural housing land change is -0.921, and it shows that the change pattern of farmland and rural housing land is uncoordinated; （2） the result of Spearman rank correlation analysis shows that rural housing land change has played a major role in the mutual transformation of farmland and rural housing land; and （3） it shows a high-degree spatial coupling between farmland and rural housing land change in southeast China during 2000-2008. In general, farmland and rural housing land transition in China is driven by socio-economic, bio-physical and managerial three-dimensional driving factors through the interactions among rural population, farmland and rural housing land. However, the spatio-temporal coupling phenomenon and mechanism of farmland and rural housing land transition in China are largely due to the ＂dual-track＂ structure of rural-urban development.
基金financially supported by National Key Research and Development Program of China(2016YFD0100501)the National Natural Science Foundation of China(31871241,31371233)+3 种基金the Natural Science Foundation of Jiangsu Province(BE2017345,PZCZ201702,BE2018351)the Research and Innovation Program of Postgraduate in Jiangsu Province(KYCX17_1886)the Priority Academic Program Development of Jiangsu Higher Education Institutionsthe Yangzhou University International Academic Exchange Fund。
文摘High grain protein content(GPC) reduces rice eating and cooking quality(ECQ). We generated OsAAP6 and OsAAP10 knockout mutants in three high-yielding japonica varieties and one japonica line using the CRISPR/Cas9 system. Mutation efficiency varied with genetic background in the T_0 generation, and GPC in the T_1 generation decreased significantly,owing mainly to a reduction in glutelin content. Amylose content was down-regulated significantly in some Osaap6 and all Osaap10 mutants. The increased taste value of these mutants was supported by Rapid Visco Analysis(RVA) profiles, which showed higher peak viscosity and breakdown viscosity and lower setback viscosity than the wild type. There were no significant deficiencies in agronomic traits of the mutants. Targeted mutagenesis of OsAAP6 and OsAAP10, especially OsAAP10, using the CRISPR/Cas9 system can rapidly reduce GPC and improve ECQ of rice, providing a new strategy for the breeding cultivars with desired ECQ.
基金supported by the grants from National Natural Science Foundation of China (Nos. 61571223 and 61171191)
文摘In eukaryotic cells, initiation of protein translation is to recruit the ribosome to a specific mRNA, which is generally dependent on the 5＇ cap structure. However, protein translation can also be initiated in a cap-independent manner by using a cis-regulatory element termed the internal ribosome entry site （IRES）. The first experimentally validated IRES was reported in the poliovirus （Pelletier and Sonenberg, 1988）. Then eukaryotic cellular mRNAs were also validated to contain IRES elements.
基金supported by the National Natural Science Foundation of China(No.3140101312)the Zhejiang Provincial Natural Science Foundation of China(No.LZ14C130003)the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences
文摘Cpf1 is a class 2/type V CRISPR effector that has been recently harnessed for genome editing （Zetsche et al., 2015; Hut et al., 2016; Kim et al., 2016）. Cpff recognizes thymidine-rich sequence as the protospacer-adjacent motif （PAM） at the 5＇ end of target sequences. In addition, Cpfl requires only a single shorter crRNA and cleaves DNA in a staggered fashion with 5＇ overhangs （Zetsche et al., 2015）.
基金supported by funds from the National Key Research and Development Program of China(2016YFD0100700)to Y.G。
文摘Beany flavor induced by three lipoxygenases(LOXs, including LOX1, LOX2, and LOX3)restricts human consumption of soybean. It is desirable to generate lipoxygenase-free new mutant lines to improve the eating quality of soybean oil and protein products. In this study, a pooled clustered regularly interspaced short palindromic repeats(CRISPR)-CRISPRassociated protein 9(Cas9) strategy targeting three GmLox genes(GmLox1, GmLox2, and GmLox3) was applied and 60 T_0 positive transgenic plants were generated, carrying combinations of sg RNAs and mutations. Among them, GmLox-28 and GmLox-60 were gmlox1 gmlox2 gmlox3 triple mutants and GmLox-40 was a gmlox1 gmlox2 double mutant.Sequencing of T_1 mutant plants derived from GmLox-28, GmLox-60, and GmLox-40 showed that mutation in the GmLox gene was inherited by the next generation. Colorimetric assay revealed that plants carrying different combinations of mutations lost the corresponding lipoxygenase activities. Transgene-free mutants were obtained by screening the T_2 generation of lipoxygenase-free mutant lines(GmLox-28 and GmLox-60). These transgeneand lipoxygenase-free mutants could be used for soybean beany flavor reduction without restriction by regulatory frameworks governing transgenic organisms.
基金Beijing Natural Science Foundation under Grant No. 8192008the Scientific Research Foundation of Graduate School of Southeast University under Grant No. YBPY2021+1 种基金the Science and Technology Project of Beijing Municipal Education Commission under Grant No. KM201910016014the Program for Changjiang Scholars and Innovative Research Team in University under Grant No. IRT_17R06。
文摘The improvement of the seismic resilience of existing reinforced-concrete(RC) frame buildings, which is essential for the seismic resilience of a city, has become a critical issue. Although seismic isolation is an effective method for improving the resilient performance of such buildings, target-oriented quantitative improvements of the resilient performance of these buildings have been reported rarely. To address this gap, the seismic resilience of two existing RC frame buildings located in a high seismic intensity region of China were assessed based on the Chinese Standard for Seismic Resilience Assessment of Buildings. The critical engineering demand parameters(EDPs) affecting the seismic resilience of such buildings were identified. Subsequently, the seismic resilience of buildings retrofitted with different isolation schemes(i.e., yield ratios) were evaluated and compared, with emphasis on the relationships among yield ratios, EDPs, and levels of seismic resilience. Accordingly, to achieve the highest level of seismic resilience with respect to the Chinese standard, a yield ratio of 3% was recommended and successfully applied to the target-oriented design for the seismic-resilience improvement of an existing RC frame building. The research outcome can provide an important reference for the resilience-based retrofitting of existing RC frame buildings using seismic isolation in urban cities.
基金supported by the National Key Research and Development Program of China (2016YFD0100500 and 2016YFD0101703)the National Natural Science Foundation of China (Nos. 31601759 and 31471881)+1 种基金the Ministry of Agriculture of China (2016ZX08009-003-001)the Tai-Shan Scholar Program from the Shandong Provincial Government
文摘Tomato (Solanum lycopersicum) is the leading vegetable crop worldwide and an essential component of a healthy diet (Lin et al., 2014; Du et al., 2017). Fruit color is regarded as one of the most important commercial traits in tomato (The Tomato Genome Consortium, 2012). Consumers in different regions have different color preferences. For example, European and American consumers prefer red tomatoes, while pink tomatoes are more pop- ular in Asia countries, particularly in China and Japan (Ballester et al., 2010; Lin et al., 2014). However, most of tomato breeding ma- terials are red-fruited, thus the generation of pink-fruited materials is very important for Asian tomato production. Metabolomics and genetics studies demonstrate that the pink trait results from the absence of yellow-colored flavonoid naringenin chalcone (NarCh) in the peels,and is controlled by the monogenic recessive yellow(y)lOCUS(Adato et a1..2009;Ballester et a1..2OLO).
