MnxNi0.5-xZn0.5Fe2O4 nanorods were successfully synthesized by the thermal treatment of rod-like precursors that were fabricated by the co-precipitation of Mn2＋, Ni2＋, and Fe2＋ in the lye. The phase, morphology, an...MnxNi0.5-xZn0.5Fe2O4 nanorods were successfully synthesized by the thermal treatment of rod-like precursors that were fabricated by the co-precipitation of Mn2＋, Ni2＋, and Fe2＋ in the lye. The phase, morphology, and particle diameter were examined by the X-ray diffraction and transmission electron microscopy. The magnetic properties of the samples were studied using a vibrating sample magnetometer. nanorods with a diameter of 35 nm and an The results indicated that pure Ni0.5-xZn0.5Fe2O4 aspect ratio of 15 were prepared. It was found that the diametei of the MnxNi0.5-xZn0.5Fe2O4（0≤x≤0.5） samples increased, the length and the aspect .ratio decreased, with an increase in x value. When x=0.5, the diameter and the aspect ratio of the sample reached up to 50 nm and 7-8, respectively. The coercivity of the samples first increased and then decreased with the increase in the x value. The coercivity of the samples again increased when the x value was higher than 0.4. When x=0.5, the coercivity of the MnxNi0.5-xZn0.5Fe2O4 sample reached the maximal value （134.3 Oe） at the calcination temperature of 600 ℃. The saturation magnetization of the samples first increased and then. decreased with the increase in the x value. When x=0.2, the saturation magnetizat：ion of the sample reached the maximal value （68.5 emu/g） at the calcination temperature of 800 ℃.展开更多
The aim of this study was to investigate the possible protective effects and mechanisms of 20-hydroxyecdysone, an insect steroid hormone, on HEO2-induced cytotoxicity in human neuroblastoma SH-SYSY cells. Pretreatment...The aim of this study was to investigate the possible protective effects and mechanisms of 20-hydroxyecdysone, an insect steroid hormone, on HEO2-induced cytotoxicity in human neuroblastoma SH-SYSY cells. Pretreatment with 20-hydroxyecdysone significantly elevated the cell viability and decreased LDH leakage in H2O2-treated SH-SY5Y cells. 20-Hydroxyecdysone also dramatically reduced malondialdehyde （MDA） contents and enhanced the superoxide dismutase （SOD） activities under oxidative stress conditions. Furthermore, 20-hydroxyecdysone pretreatment inhibited apoptosis by decreasing the Bax/Bcl-2 ratio and attenuating the activation of caspase-3. These results suggest that 20-hydroxyecdysone can protect SH-SYSY cells against H2O2-induced cytotoxicity and might potentially be used to treat neurodegenerative diseases induced by oxidative stress and anontosis.展开更多
文摘MnxNi0.5-xZn0.5Fe2O4 nanorods were successfully synthesized by the thermal treatment of rod-like precursors that were fabricated by the co-precipitation of Mn2＋, Ni2＋, and Fe2＋ in the lye. The phase, morphology, and particle diameter were examined by the X-ray diffraction and transmission electron microscopy. The magnetic properties of the samples were studied using a vibrating sample magnetometer. nanorods with a diameter of 35 nm and an The results indicated that pure Ni0.5-xZn0.5Fe2O4 aspect ratio of 15 were prepared. It was found that the diametei of the MnxNi0.5-xZn0.5Fe2O4（0≤x≤0.5） samples increased, the length and the aspect .ratio decreased, with an increase in x value. When x=0.5, the diameter and the aspect ratio of the sample reached up to 50 nm and 7-8, respectively. The coercivity of the samples first increased and then decreased with the increase in the x value. The coercivity of the samples again increased when the x value was higher than 0.4. When x=0.5, the coercivity of the MnxNi0.5-xZn0.5Fe2O4 sample reached the maximal value （134.3 Oe） at the calcination temperature of 600 ℃. The saturation magnetization of the samples first increased and then. decreased with the increase in the x value. When x=0.2, the saturation magnetizat：ion of the sample reached the maximal value （68.5 emu/g） at the calcination temperature of 800 ℃.
文摘The aim of this study was to investigate the possible protective effects and mechanisms of 20-hydroxyecdysone, an insect steroid hormone, on HEO2-induced cytotoxicity in human neuroblastoma SH-SYSY cells. Pretreatment with 20-hydroxyecdysone significantly elevated the cell viability and decreased LDH leakage in H2O2-treated SH-SY5Y cells. 20-Hydroxyecdysone also dramatically reduced malondialdehyde （MDA） contents and enhanced the superoxide dismutase （SOD） activities under oxidative stress conditions. Furthermore, 20-hydroxyecdysone pretreatment inhibited apoptosis by decreasing the Bax/Bcl-2 ratio and attenuating the activation of caspase-3. These results suggest that 20-hydroxyecdysone can protect SH-SYSY cells against H2O2-induced cytotoxicity and might potentially be used to treat neurodegenerative diseases induced by oxidative stress and anontosis.
