Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain sciences.In this article,we review the development of terahertz biot...Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain sciences.In this article,we review the development of terahertz biotechnology and its applications in the field of neuropsychiatry.Available evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin deficit.In vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric diseases.Although the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic applications.However,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical applications.This review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.展开更多
建立柱前衍生化-UPLC-MS/MS方法检测达格列净原料药中的潜在的基因毒性杂质5-溴-2-氯苯甲酰氯。以苯胺作为衍生化试剂,采用Acouity UPLC Bed C18柱(50 mm×2.1 mm, 1.7μm)为色谱柱,0.1%甲酸-水体系作为流动相进行梯度洗脱,体积流量...建立柱前衍生化-UPLC-MS/MS方法检测达格列净原料药中的潜在的基因毒性杂质5-溴-2-氯苯甲酰氯。以苯胺作为衍生化试剂,采用Acouity UPLC Bed C18柱(50 mm×2.1 mm, 1.7μm)为色谱柱,0.1%甲酸-水体系作为流动相进行梯度洗脱,体积流量0.3 mL/min,进样量2μL,柱温25℃;在电喷雾离子源、正离子监测下,采用多反应扫描(MRM)模式进行检测。该方法的专属性强;在1~100 ng/mL范围内线性关系良好(r=0.999 3);检测限和定量限分别为0.05 ng/mL和0.10 ng/mL;低、中、高浓度(n=3)的平均加样回收率在95.1%~106.5%之间,RSD均小于3.0%;衍生化产物在室温下12 h内稳定。该方法操作简便,灵敏度高,适用于检测达格列净原料药中5-溴-2-氯苯甲酰氯。展开更多
基金supported by grants from the National Key R&D Program of China,No.2017YFC0909200(to DC)the National Natural Science Foundation of China,No.62075225(to HZ)+1 种基金Zhejiang Provincial Medical Health Science and Technology Project,No.2023XY053(to ZP)Zhejiang Provincial Traditional Chinese Medical Science and Technology Project,No.2023ZL703(to ZP).
文摘Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain sciences.In this article,we review the development of terahertz biotechnology and its applications in the field of neuropsychiatry.Available evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin deficit.In vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric diseases.Although the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic applications.However,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical applications.This review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.
