Colorectal cancer(CRC)is the most frequently diagnosed malignancy of the digestive system and the second leading cause of cancer-related deaths worldwide(1).In China,CRC ranks as the second most common cancer with inc...Colorectal cancer(CRC)is the most frequently diagnosed malignancy of the digestive system and the second leading cause of cancer-related deaths worldwide(1).In China,CRC ranks as the second most common cancer with incidence and mortality rates continuing to rise(2).The Chinese Society of Clinical Oncology(CSCO)first introduced its guidelines in 2017,and since then,they have been updated annually to incorporate the latest clinical research findings,drug availability,and expert consensus(3-8).This article presents the key updates in the 2025 edition compared to the 2024 version.展开更多
We present a gain adaptive tuning method for fiber Raman amplifier(FRA) using two-stage neural networks(NNs) and double weights updates. After training the connection weights of two-stage NNs separately in training ph...We present a gain adaptive tuning method for fiber Raman amplifier(FRA) using two-stage neural networks(NNs) and double weights updates. After training the connection weights of two-stage NNs separately in training phase, the connection weights of the unified NN are updated again in verification phase according to error between the predicted and target gains to eliminate the inherent error of the NNs. The simulation results show that the mean of root mean square error(RMSE) and maximum error of gains are 0.131 d B and 0.281 d B, respectively. It shows that the method can realize adaptive adjustment function of FRA gain with high accuracy.展开更多
The four-dimensional variational （4D-Var） data assimilation systems used in most operational and research centers use initial condition increments as control variables and adjust initial increments to find optimal a...The four-dimensional variational （4D-Var） data assimilation systems used in most operational and research centers use initial condition increments as control variables and adjust initial increments to find optimal analysis solutions. This approach may sometimes create discontinuities in analysis fields and produce undesirable spin ups and spin downs. This study explores using incremental analysis updates （IAU） in 4D-Var to reduce the analysis discontinuities. IAU-based 4D-Var has almost the same mathematical formula as conventional 4D-Var if the initial condition increments are replaced with time-integrated increments as control variables. The IAU technique was implemented in the NASA/GSFC 4D-Var prototype and compared against a control run without IAU. The results showed that the initial precipitation spikes were removed and that other discontinuities were also reduced, especially for the analysis of surface temperature.展开更多
Initialization of tropical cyclones plays an important role in typhoon numerical prediction. This study applied a typhoon initialization scheme based on the incremental analysis updates (IAU) technique in a rapid refr...Initialization of tropical cyclones plays an important role in typhoon numerical prediction. This study applied a typhoon initialization scheme based on the incremental analysis updates (IAU) technique in a rapid refresh system to improve the prediction of Typhoon Lekima (2019). Two numerical sensitivity experiments with or without application of the IAU technique after performing vortex relocation and wind adjustment procedures were conducted for comparison with the control experiment, which did not involve a typhoon initialization scheme. Analysis of the initial fields indicated that the relocation procedure shifted the typhoon circulation to the observed typhoon region, and the wind speeds became closer to the observations following the wind adjustment procedure. Comparison of the results of the sensitivity and control experiments revealed that the vortex relocation and wind adjustment procedures could improve the prediction of typhoon track and intensity in the first 6-h period, and that these improvements were extended throughout the first 12-h period of the prediction by the IAU technique. The new typhoon initialization scheme also improved the simulated typhoon structure in terms of not only the wind speed and warm core prediction but also the organization of the eye of Typhoon Lekima. Diagnosis of the tendencies of variables showed that use of the IAU technique in a typhoon initialization scheme is efficacious in resolving the spurious high-frequency noise problem such that the model is able to reach equilibrium as soon as possible.展开更多
Updates in version 2.2019 of the NCCN guidelines for non-small cell lung cancer from version 1.2019 NSCL-22 ALK rearrangement positive metastatic NSCLC:Lorlatinib added as a treatment option after progression on crizo...Updates in version 2.2019 of the NCCN guidelines for non-small cell lung cancer from version 1.2019 NSCL-22 ALK rearrangement positive metastatic NSCLC:Lorlatinib added as a treatment option after progression on crizotinib and alectinib,brigatinib,or ceritinib.NSCL-23 ALK rearrangement positive metastatic NSCLC:Lorlatinib added as a treatment option,after progression on alectinib,brigatinib,or ceritinib.NSCL-24 ROS1 rearrangement positive metastatic NSCLC:Lorlatinib added as a treatment option,after progression on crizotinib or ceritinib.展开更多
With the expansion of network services,large-scale networks have progressively become common.The network status changes rapidly in response to customer needs and configuration changes,so network configuration changes ...With the expansion of network services,large-scale networks have progressively become common.The network status changes rapidly in response to customer needs and configuration changes,so network configuration changes are also very frequent.However,no matter what changes,the network must ensure the correct conditions,such as isolating tenants from each other or guaranteeing essential services.Once changes occur,it is necessary to verify the after-changed network.Whereas,for the verification of large-scale network configuration changes,many current verifiers show poor efficiency.In order to solve the problem ofmultiple global verifications caused by frequent updates of local configurations in large networks,we present a fast configuration updates verification tool,FastCUV,for distributed control planes.FastCUV aims to enhance the efficiency of distributed control plane verification for medium and large networks while ensuring correctness.This paper presents a method to determine the network range affected by the configuration change.We present a flow model and graph structure to facilitate the design of verification algorithms and speed up verification.Our scheme verifies the network area affected by obtaining the change of the Forwarding Information Base(FIB)before and after.FastCUV supports rich network attributes,meanwhile,has high efficiency and correctness performance.After experimental verification and result analysis,our method outperforms the state-of-the-art method to a certain extent.展开更多
This paper proposes a novel hypersphere support vector machines （HSVMs） based on generalized multiplicative updates. This algorithm can obtain the boundary of hypersphere containing one class of samples by the descr...This paper proposes a novel hypersphere support vector machines （HSVMs） based on generalized multiplicative updates. This algorithm can obtain the boundary of hypersphere containing one class of samples by the description of the training samples from one class and use this boundary to classify the test samples. The generalized multiplicative updates are applied to solving boundary optimization progranmning. Multiplicative updates available are suited for nonnegative quadratic convex programming. The generalized multiplicative updates are derived to box and sum constrained quadratic programming in this paper. They provide an extremely straightforward way to implement support vector machines （SVMs） where all variables are updated in parallel. The generalized multiplicative updates converge monotonically to the solution of the maximum margin hyperplane. The experiments show the superiority of our new algorithm.展开更多
GTD (Gestational Trophoblastic Disease) is a pathology that encompasses benign and malignant clinical forms, affects women of childbearing age, has a variable incidence and is more frequent in developing or underdevel...GTD (Gestational Trophoblastic Disease) is a pathology that encompasses benign and malignant clinical forms, affects women of childbearing age, has a variable incidence and is more frequent in developing or underdeveloped countries, colliding with the economic barrier. The frequent absence of clear protocols and guidelines for the correct diagnosis of the pathology results in inadequate classification, imprecise treatment and failed post-therapeutic observation, increasing the risk of relapses, morbidity and mortality. The present study aims to point out updated national and international practice protocols of diagnosis of GTD, through an integrative review. Seven articles were selected and it was observed that the main international reference centers are agreed with the management suggested by the IFGO (International Federation of Gynecology and Obstetrics), being the conduct in the Hydatidiform Mole (HM): evacuation by suction and curettage under ultrasound guidance, followed by hCG monitoring every 1 - 2 weeks until normalized (usually one month for Partial Hydatidiform Mole six months for Complete Hydatidiform Mole and one year for Gestational Trophoblastic Neoplasia). Unfortunately, regarding the diagnosis of MH, the guidelines of some countries show the absence or difficulty of access to the karyotype test and ploid p57 or pelvic ultrasound accompanying the uterine curettage, contrary to what is proposed by the IFGO guideline. Establishing and complying with consistent guidelines can improve patient care, with early diagnosis of the pathology and its complications, reducing the rate of recurrence, morbidity and mortality, especially in less developed countries.展开更多
CPI Grew Slightly in January Consumer price index(CPI) growth in January of 2009 was 1.0 percent over the same period of the previous year.Of which,urban area and rural area up by 0.7 and 1.5 percent respectively;the ...CPI Grew Slightly in January Consumer price index(CPI) growth in January of 2009 was 1.0 percent over the same period of the previous year.Of which,urban area and rural area up by 0.7 and 1.5 percent respectively;the price of foodstuff,consumable展开更多
Textile Exports may Drop Slightly in 2008The exports of China’s textile and garment will continue its double-digit growth in 2008, but with lower growth rate compared with 2007, according to Xu Kunyuan, the
China’s Inflation to Continue Easing in August China’s consumer price index (CPI), a key measure of inflation, was expected to show a rise of about 5 percent in August from a year earlier, said analysts on Thursday.
FDI Up by 23.58% in 2008 According to the statistics, from January to December 2008, foreign-invested enterprises newly approved for establishment reached
This paper presents a recursive procedure to compute the Moore-Penrose inverse of a matrix A. The method is based on the expression for the Moore-Penrose inverse of rank-one modified matrix. The computational complexi...This paper presents a recursive procedure to compute the Moore-Penrose inverse of a matrix A. The method is based on the expression for the Moore-Penrose inverse of rank-one modified matrix. The computational complexity of the method is analyzed and a numerical example is included. A variant of the algorithm with lower computational complexity is also proposed. Both algorithms are tested on randomly generated matrices. Numerical performance confirms our theoretic results.展开更多
Immunohistochemistry is a technique with an interesting journey.It is one of the well-established and reliable technique in modern pathology and it is extremely useful in diagnosis of sinister pathologies with perplex...Immunohistochemistry is a technique with an interesting journey.It is one of the well-established and reliable technique in modern pathology and it is extremely useful in diagnosis of sinister pathologies with perplexing histopathology.Not only does it enhance the diagnostic abilities of a pathologist,but it also has a huge prognostic potential,a great aid in establishing stage of malignancies,determines phenotypic expressions of lymphoid neoplasms and monitors treatment progress and response to therapy.By employing and integrating the basics of varied branches like immunology,histology,microscopy and hematology,it has emerged as a magnificent tool over last few decades,saving pathologists and patients from the impact of serious diseases inflicting the human body.Furthermore,it has contributed immensely to all aspects of diseases related to oral cavity as well.This review has been thus taken to highlight the wide applications of this technique in General and Oral Pathology with an update.展开更多
The rapid growth of distributed data-centric applications and AI workloads increases demand for low-latency,high-throughput communication,necessitating frequent and flexible updates to network routing configurations.H...The rapid growth of distributed data-centric applications and AI workloads increases demand for low-latency,high-throughput communication,necessitating frequent and flexible updates to network routing configurations.However,maintaining consistent forwarding states during these updates is challenging,particularly when rerouting multiple flows simultaneously.Existing approaches pay little attention to multi-flow update,where improper update sequences across data plane nodes may construct deadlock dependencies.Moreover,these methods typically involve excessive control-data plane interactions,incurring significant resource overhead and performance degradation.This paper presents P4LoF,an efficient loop-free update approach that enables the controller to reroute multiple flows through minimal interactions.P4LoF first utilizes a greedy-based algorithm to generate the shortest update dependency chain for the single-flow update.These chains are then dynamically merged into a dependency graph and resolved as a Shortest Common Super-sequence(SCS)problem to produce the update sequence of multi-flow update.To address deadlock dependencies in multi-flow updates,P4LoF builds a deadlock-fix forwarding model that leverages the flexible packet processing capabilities of the programmable data plane.Experimental results show that P4LoF reduces control-data plane interactions by at least 32.6%with modest overhead,while effectively guaranteeing loop-free consistency.展开更多
In this report we present some new numerical methods for unconstrained optimization. These methods apply update formulae that do not satisfy the quasi-Newton equation. We derive these new formulae by considering diffe...In this report we present some new numerical methods for unconstrained optimization. These methods apply update formulae that do not satisfy the quasi-Newton equation. We derive these new formulae by considering different techniques of approximating the objective function. Theoretical analyses are given to show the advantages of using non-quasi-Newton updates. Under mild conditions we prove that our new update formulae preserve global convergence properties. Numerical results are also presented.展开更多
In the second volume of this special issue, we focus on the activity and function of the mutant p53 proteins. The elegant work of Nakayama and Oshima (2019) uses mouse models of colorectal cancer to directly dem on st...In the second volume of this special issue, we focus on the activity and function of the mutant p53 proteins. The elegant work of Nakayama and Oshima (2019) uses mouse models of colorectal cancer to directly dem on strate the role that expression of the R273H protein has in promoting invasion. Using both animal studies and organotypic cultures, they are able to demonstrate that the gain-of-function (GOF) is driven by high-level nuclear expression of the protein and that this high-level expression requires escaping from Mdm2-depe ndent degradation and environ mental influe nee that are especially see n at the invadi ng front of the tumor. Their studies show that wildtype p53 can inhibit the GOF of the mutant protein providing clear support for the need for loss of the wild-type allele as the tumor progresses. This elegant in vivo work shows that the dominantnegative function of mutant p53 proteins has limited penetrance and helps to clarify this controversial area.展开更多
The significant overhead related to frequent location updates from moving objects often results in poor performance. As most of the location updates do not affect the query results, the network bandwidth and the batte...The significant overhead related to frequent location updates from moving objects often results in poor performance. As most of the location updates do not affect the query results, the network bandwidth and the battery life of moving objects are wasted. Existing solutions propose lazy updates, but such techniques generally avoid only a small fraction of all unnecessary location updates because of their basic approach （e.g., safe regions, time or distance thresholds）. Furthermore, most prior work focuses on a simplified scenario where queries are either static or rarely change their positions. In this study, two novel efficient location update strategies are proposed in a trajectory movement model and an arbitrary movement model, respectively. The first strategy for a trajectory movement environment is the Adaptive Safe Region （ASR） technique that retrieves an adjustable safe region which is continuously reconciled with the surrounding dynamic queries. The communication overhead is reduced in a highly dynamic environment where both queries and data objects change their positions frequently. In addition, we design a framework that supports multiple query types （e.g., range and c-kNN queries）. In this framework, our query re-evaluation algorithms take advantage of ASRs and issue location probes only to the affected data objects, without flooding the system with many unnecessary location update requests. The second proposed strategy for an arbitrary movement environment is the Partition-based Lazy Update （PLU, for short） algorithm that elevates this idea further by adopting Location Information Tables （LITs） which （a） allow each moving object to estimate possible query movements and issue a location update only when it may affect any query results and （b） enable smart server probing that results in fewer messages. We first define the data structure of an LIT which is essentially packed with a set of surrounding query locations across the terrain and discuss the mobile-side and server-side processes in correspondence to the utilization of LITs. Simulation results confirm that both the ASR and PLU concepts improve scalability and efficiency over existing methods.展开更多
Network updates have become increasingly prevalent since the broad adoption of software-defined networks(SDNs)in data centers.Modern TCP designs,including cutting-edge TCP variants DCTCP,CUBIC,and BBR,however,are not ...Network updates have become increasingly prevalent since the broad adoption of software-defined networks(SDNs)in data centers.Modern TCP designs,including cutting-edge TCP variants DCTCP,CUBIC,and BBR,however,are not resilient to network updates that provoke flow rerouting.In this paper,we first demonstrate that popular TCP implementations perform inadequately in the presence of frequent and inconsistent network updates,because inconsistent and frequent network updates result in out-of-order packets and packet drops induced via transitory congestion and lead to serious performance deterioration.We look into the causes and propose a network update-friendly TCP(NUFTCP),which is an extension of the DCTCP variant,as a solution.Simulations are used to assess the proposed NUFTCP.Our findings reveal that NUFTCP can more effectively manage the problems of out-of-order packets and packet drops triggered in network updates,and it outperforms DCTCP considerably.展开更多
基金supported by the National Natural Science Foundation of China(No.82373415)Beijing Xisike Clinical Oncology Research Foundation(No.Ytongshu2021/ms-0003)。
文摘Colorectal cancer(CRC)is the most frequently diagnosed malignancy of the digestive system and the second leading cause of cancer-related deaths worldwide(1).In China,CRC ranks as the second most common cancer with incidence and mortality rates continuing to rise(2).The Chinese Society of Clinical Oncology(CSCO)first introduced its guidelines in 2017,and since then,they have been updated annually to incorporate the latest clinical research findings,drug availability,and expert consensus(3-8).This article presents the key updates in the 2025 edition compared to the 2024 version.
基金supported by the Natural Science Research Project of Colleges and Universities in Anhui Province (No.KJ2021A0479)the Science Research Program of Anhui University of Finance and Economics (No.ACKYC22082)。
文摘We present a gain adaptive tuning method for fiber Raman amplifier(FRA) using two-stage neural networks(NNs) and double weights updates. After training the connection weights of two-stage NNs separately in training phase, the connection weights of the unified NN are updated again in verification phase according to error between the predicted and target gains to eliminate the inherent error of the NNs. The simulation results show that the mean of root mean square error(RMSE) and maximum error of gains are 0.131 d B and 0.281 d B, respectively. It shows that the method can realize adaptive adjustment function of FRA gain with high accuracy.
基金supported by NOAA’s Hurricane Forecast Improvement Project
文摘The four-dimensional variational （4D-Var） data assimilation systems used in most operational and research centers use initial condition increments as control variables and adjust initial increments to find optimal analysis solutions. This approach may sometimes create discontinuities in analysis fields and produce undesirable spin ups and spin downs. This study explores using incremental analysis updates （IAU） in 4D-Var to reduce the analysis discontinuities. IAU-based 4D-Var has almost the same mathematical formula as conventional 4D-Var if the initial condition increments are replaced with time-integrated increments as control variables. The IAU technique was implemented in the NASA/GSFC 4D-Var prototype and compared against a control run without IAU. The results showed that the initial precipitation spikes were removed and that other discontinuities were also reduced, especially for the analysis of surface temperature.
基金Science and Technology Project of Zhejiang Province(LGF20D050001)East China Regional Meteorological Science and Technology Innovation Fund Cooperation Project(QYHZ201805)Meteorological Science and Technology Project of Zhejiang Meteorological Service(2018ZD01,2019ZD11)。
文摘Initialization of tropical cyclones plays an important role in typhoon numerical prediction. This study applied a typhoon initialization scheme based on the incremental analysis updates (IAU) technique in a rapid refresh system to improve the prediction of Typhoon Lekima (2019). Two numerical sensitivity experiments with or without application of the IAU technique after performing vortex relocation and wind adjustment procedures were conducted for comparison with the control experiment, which did not involve a typhoon initialization scheme. Analysis of the initial fields indicated that the relocation procedure shifted the typhoon circulation to the observed typhoon region, and the wind speeds became closer to the observations following the wind adjustment procedure. Comparison of the results of the sensitivity and control experiments revealed that the vortex relocation and wind adjustment procedures could improve the prediction of typhoon track and intensity in the first 6-h period, and that these improvements were extended throughout the first 12-h period of the prediction by the IAU technique. The new typhoon initialization scheme also improved the simulated typhoon structure in terms of not only the wind speed and warm core prediction but also the organization of the eye of Typhoon Lekima. Diagnosis of the tendencies of variables showed that use of the IAU technique in a typhoon initialization scheme is efficacious in resolving the spurious high-frequency noise problem such that the model is able to reach equilibrium as soon as possible.
文摘Updates in version 2.2019 of the NCCN guidelines for non-small cell lung cancer from version 1.2019 NSCL-22 ALK rearrangement positive metastatic NSCLC:Lorlatinib added as a treatment option after progression on crizotinib and alectinib,brigatinib,or ceritinib.NSCL-23 ALK rearrangement positive metastatic NSCLC:Lorlatinib added as a treatment option,after progression on alectinib,brigatinib,or ceritinib.NSCL-24 ROS1 rearrangement positive metastatic NSCLC:Lorlatinib added as a treatment option,after progression on crizotinib or ceritinib.
基金supported by the Fundamental Research Funds for the Central Universities(2021RC239)the Postdoctoral Science Foundation of China(2021 M690338)+3 种基金theHainan Provincial Natural Science Foundation of China(620RC562,2019RC096,620RC560)the Scientific Research Setup Fund of Hainan University(KYQD(ZR)1877)the Program of Hainan Association for Science and Technology Plans to Youth R&D Innovation(QCXM201910)the National Natural Science Foundation of China(61802092,62162021).
文摘With the expansion of network services,large-scale networks have progressively become common.The network status changes rapidly in response to customer needs and configuration changes,so network configuration changes are also very frequent.However,no matter what changes,the network must ensure the correct conditions,such as isolating tenants from each other or guaranteeing essential services.Once changes occur,it is necessary to verify the after-changed network.Whereas,for the verification of large-scale network configuration changes,many current verifiers show poor efficiency.In order to solve the problem ofmultiple global verifications caused by frequent updates of local configurations in large networks,we present a fast configuration updates verification tool,FastCUV,for distributed control planes.FastCUV aims to enhance the efficiency of distributed control plane verification for medium and large networks while ensuring correctness.This paper presents a method to determine the network range affected by the configuration change.We present a flow model and graph structure to facilitate the design of verification algorithms and speed up verification.Our scheme verifies the network area affected by obtaining the change of the Forwarding Information Base(FIB)before and after.FastCUV supports rich network attributes,meanwhile,has high efficiency and correctness performance.After experimental verification and result analysis,our method outperforms the state-of-the-art method to a certain extent.
基金Project supported by the National Natural Science Foundation of China (Grant No.60574075)
文摘This paper proposes a novel hypersphere support vector machines （HSVMs） based on generalized multiplicative updates. This algorithm can obtain the boundary of hypersphere containing one class of samples by the description of the training samples from one class and use this boundary to classify the test samples. The generalized multiplicative updates are applied to solving boundary optimization progranmning. Multiplicative updates available are suited for nonnegative quadratic convex programming. The generalized multiplicative updates are derived to box and sum constrained quadratic programming in this paper. They provide an extremely straightforward way to implement support vector machines （SVMs） where all variables are updated in parallel. The generalized multiplicative updates converge monotonically to the solution of the maximum margin hyperplane. The experiments show the superiority of our new algorithm.
文摘GTD (Gestational Trophoblastic Disease) is a pathology that encompasses benign and malignant clinical forms, affects women of childbearing age, has a variable incidence and is more frequent in developing or underdeveloped countries, colliding with the economic barrier. The frequent absence of clear protocols and guidelines for the correct diagnosis of the pathology results in inadequate classification, imprecise treatment and failed post-therapeutic observation, increasing the risk of relapses, morbidity and mortality. The present study aims to point out updated national and international practice protocols of diagnosis of GTD, through an integrative review. Seven articles were selected and it was observed that the main international reference centers are agreed with the management suggested by the IFGO (International Federation of Gynecology and Obstetrics), being the conduct in the Hydatidiform Mole (HM): evacuation by suction and curettage under ultrasound guidance, followed by hCG monitoring every 1 - 2 weeks until normalized (usually one month for Partial Hydatidiform Mole six months for Complete Hydatidiform Mole and one year for Gestational Trophoblastic Neoplasia). Unfortunately, regarding the diagnosis of MH, the guidelines of some countries show the absence or difficulty of access to the karyotype test and ploid p57 or pelvic ultrasound accompanying the uterine curettage, contrary to what is proposed by the IFGO guideline. Establishing and complying with consistent guidelines can improve patient care, with early diagnosis of the pathology and its complications, reducing the rate of recurrence, morbidity and mortality, especially in less developed countries.
文摘CPI Grew Slightly in January Consumer price index(CPI) growth in January of 2009 was 1.0 percent over the same period of the previous year.Of which,urban area and rural area up by 0.7 and 1.5 percent respectively;the price of foodstuff,consumable
文摘Textile Exports may Drop Slightly in 2008The exports of China’s textile and garment will continue its double-digit growth in 2008, but with lower growth rate compared with 2007, according to Xu Kunyuan, the
文摘China’s Inflation to Continue Easing in August China’s consumer price index (CPI), a key measure of inflation, was expected to show a rise of about 5 percent in August from a year earlier, said analysts on Thursday.
文摘FDI Up by 23.58% in 2008 According to the statistics, from January to December 2008, foreign-invested enterprises newly approved for establishment reached
文摘This paper presents a recursive procedure to compute the Moore-Penrose inverse of a matrix A. The method is based on the expression for the Moore-Penrose inverse of rank-one modified matrix. The computational complexity of the method is analyzed and a numerical example is included. A variant of the algorithm with lower computational complexity is also proposed. Both algorithms are tested on randomly generated matrices. Numerical performance confirms our theoretic results.
文摘Immunohistochemistry is a technique with an interesting journey.It is one of the well-established and reliable technique in modern pathology and it is extremely useful in diagnosis of sinister pathologies with perplexing histopathology.Not only does it enhance the diagnostic abilities of a pathologist,but it also has a huge prognostic potential,a great aid in establishing stage of malignancies,determines phenotypic expressions of lymphoid neoplasms and monitors treatment progress and response to therapy.By employing and integrating the basics of varied branches like immunology,histology,microscopy and hematology,it has emerged as a magnificent tool over last few decades,saving pathologists and patients from the impact of serious diseases inflicting the human body.Furthermore,it has contributed immensely to all aspects of diseases related to oral cavity as well.This review has been thus taken to highlight the wide applications of this technique in General and Oral Pathology with an update.
基金supported by the National Key Research and Development Program of China under Grant 2022YFB2901501in part by the Science and Technology Innovation leading Talents Subsidy Project of Central Plains under Grant 244200510038.
文摘The rapid growth of distributed data-centric applications and AI workloads increases demand for low-latency,high-throughput communication,necessitating frequent and flexible updates to network routing configurations.However,maintaining consistent forwarding states during these updates is challenging,particularly when rerouting multiple flows simultaneously.Existing approaches pay little attention to multi-flow update,where improper update sequences across data plane nodes may construct deadlock dependencies.Moreover,these methods typically involve excessive control-data plane interactions,incurring significant resource overhead and performance degradation.This paper presents P4LoF,an efficient loop-free update approach that enables the controller to reroute multiple flows through minimal interactions.P4LoF first utilizes a greedy-based algorithm to generate the shortest update dependency chain for the single-flow update.These chains are then dynamically merged into a dependency graph and resolved as a Shortest Common Super-sequence(SCS)problem to produce the update sequence of multi-flow update.To address deadlock dependencies in multi-flow updates,P4LoF builds a deadlock-fix forwarding model that leverages the flexible packet processing capabilities of the programmable data plane.Experimental results show that P4LoF reduces control-data plane interactions by at least 32.6%with modest overhead,while effectively guaranteeing loop-free consistency.
文摘In this report we present some new numerical methods for unconstrained optimization. These methods apply update formulae that do not satisfy the quasi-Newton equation. We derive these new formulae by considering different techniques of approximating the objective function. Theoretical analyses are given to show the advantages of using non-quasi-Newton updates. Under mild conditions we prove that our new update formulae preserve global convergence properties. Numerical results are also presented.
文摘In the second volume of this special issue, we focus on the activity and function of the mutant p53 proteins. The elegant work of Nakayama and Oshima (2019) uses mouse models of colorectal cancer to directly dem on strate the role that expression of the R273H protein has in promoting invasion. Using both animal studies and organotypic cultures, they are able to demonstrate that the gain-of-function (GOF) is driven by high-level nuclear expression of the protein and that this high-level expression requires escaping from Mdm2-depe ndent degradation and environ mental influe nee that are especially see n at the invadi ng front of the tumor. Their studies show that wildtype p53 can inhibit the GOF of the mutant protein providing clear support for the need for loss of the wild-type allele as the tumor progresses. This elegant in vivo work shows that the dominantnegative function of mutant p53 proteins has limited penetrance and helps to clarify this controversial area.
基金supported by NSF of USA under Grant Nos. IIS-0534761, CNS-0831502, CNS-0855251NUS AcRF under GrantNo. WBS R-252-050-280-101/133
文摘The significant overhead related to frequent location updates from moving objects often results in poor performance. As most of the location updates do not affect the query results, the network bandwidth and the battery life of moving objects are wasted. Existing solutions propose lazy updates, but such techniques generally avoid only a small fraction of all unnecessary location updates because of their basic approach （e.g., safe regions, time or distance thresholds）. Furthermore, most prior work focuses on a simplified scenario where queries are either static or rarely change their positions. In this study, two novel efficient location update strategies are proposed in a trajectory movement model and an arbitrary movement model, respectively. The first strategy for a trajectory movement environment is the Adaptive Safe Region （ASR） technique that retrieves an adjustable safe region which is continuously reconciled with the surrounding dynamic queries. The communication overhead is reduced in a highly dynamic environment where both queries and data objects change their positions frequently. In addition, we design a framework that supports multiple query types （e.g., range and c-kNN queries）. In this framework, our query re-evaluation algorithms take advantage of ASRs and issue location probes only to the affected data objects, without flooding the system with many unnecessary location update requests. The second proposed strategy for an arbitrary movement environment is the Partition-based Lazy Update （PLU, for short） algorithm that elevates this idea further by adopting Location Information Tables （LITs） which （a） allow each moving object to estimate possible query movements and issue a location update only when it may affect any query results and （b） enable smart server probing that results in fewer messages. We first define the data structure of an LIT which is essentially packed with a set of surrounding query locations across the terrain and discuss the mobile-side and server-side processes in correspondence to the utilization of LITs. Simulation results confirm that both the ASR and PLU concepts improve scalability and efficiency over existing methods.
基金supportted by the King Khalid University through the Large Group Project(No.RGP.2/312/44).
文摘Network updates have become increasingly prevalent since the broad adoption of software-defined networks(SDNs)in data centers.Modern TCP designs,including cutting-edge TCP variants DCTCP,CUBIC,and BBR,however,are not resilient to network updates that provoke flow rerouting.In this paper,we first demonstrate that popular TCP implementations perform inadequately in the presence of frequent and inconsistent network updates,because inconsistent and frequent network updates result in out-of-order packets and packet drops induced via transitory congestion and lead to serious performance deterioration.We look into the causes and propose a network update-friendly TCP(NUFTCP),which is an extension of the DCTCP variant,as a solution.Simulations are used to assess the proposed NUFTCP.Our findings reveal that NUFTCP can more effectively manage the problems of out-of-order packets and packet drops triggered in network updates,and it outperforms DCTCP considerably.
