In Unani medicine,Bawl(urine)is recognized as a key diagnostic tool,with humoural imbalances assessed via parameters like color,consistency,sediment,clarity,froth,odor,and volume.This conceptual review explores how th...In Unani medicine,Bawl(urine)is recognized as a key diagnostic tool,with humoural imbalances assessed via parameters like color,consistency,sediment,clarity,froth,odor,and volume.This conceptual review explores how these classical diagnostic indicators may be contextualized alongside modern urinalysis markers(e.g.,bilirubin,protein,ketones,and sedimentation)and examined through emerging artificial intelligence(AI)frameworks.Potential applications include ResNet-18 for color classification,You Only Look Once version 8(YOLOv8)for sediment detection,long short-term memory(LSTM)for viscosity estimation,and EfficientDet for froth analysis,with standardized urine images/videos forming the basis of future datasets.Additionally,a comparative ontology is proposed to align Unani perspectives with diagnostic approaches in traditional Chinese medicine,encouraging cross-system integration.By synthesizing classical epistemology with computational intelligence,this review highlights pathways for developing AI-based decision support systems to promote personalized,accessible,and telemedicine-enabled healthcare.展开更多
Unani medicine is an oldest system of traditional medicine,where drugs of animal,mineral and herbal origin are used for centuries to cure diseases.Unani remedies are now available not only in drug stores,but also in f...Unani medicine is an oldest system of traditional medicine,where drugs of animal,mineral and herbal origin are used for centuries to cure diseases.Unani remedies are now available not only in drug stores,but also in food stores and super markets.Therefore the efficacy and safety of these drugs is very crucial.One of the most serious risks associated with these remedies is,consumer assumes that they are natural,so they are safe.But biological contamination(bacterial,fungal and insect)of herbal medicines is a serious concern.The Aspergillus flavus and Aspergillus parasiticus are the fungal species that occur naturally,release aflatoxins and is a threat to the natural drugs.The World Health Organization has recommended determination of aflatoxins in natural drugs(Unani)as one of the parameter of their safety studies as Aflatoxin contamination is concerned significantly with health and economic loss affecting humans,animals,and agriculture.Aflatoxin B1 is categorized as a group 1 carcinogen by The International Agency for Research on Cancer that causes a variety of health issues.Thus keeping in mind the deleterious health effects of aflatoxins,here,in this review we have made an attempt to summarize the aflatoxins with respect to their origin,occurrence,structure and properties to generate the awareness among the people dealing mainly with Unani herbal drugs.Besides these their toxicity and effects on health have also been discussed.The analytical methods for their determination and some measures to prevent their contamination are also suggested to improve the efficacy and safety of Unani herbal drugs.展开更多
In an era of globalization and increased global demand for herbal medicines, it is essential to ensure the quality and consistency of drugs. Changes in the quality of an herbal product over time should be detectable. ...In an era of globalization and increased global demand for herbal medicines, it is essential to ensure the quality and consistency of drugs. Changes in the quality of an herbal product over time should be detectable. The assessments of chemical quality and therapeutic efficacy of herbal drugs are necessary to establish their shelf-lives. Thus, stability testing is needed to establish standards for herbal products. Unani medicine has its own conceptual framework for studying health and disease. The mode of treatment includes Ilaj bit Tadbeer(regimental therapy), Ilaj bil Ghiza(dietotherapy), Ilaj bil Dawa(pharmacotherapy) and Ilaj bil Yad/Jarahat(surgery) as a final option. Ilaj bil Dawa is the most used mode of treatment.The drugs include either crude drugs prepared from plant, animal and mineral sources, called Mufrad(single) drugs or various formulations prepared from these crude drugs, called Murakkab(compound)drugs. To date, stability studies have been carried out on compound drugs, whereas only a few single drugs had had their stability tested. These studies are needed to understand how the quality of an herbal drug varies over the time when it is prepared and consumed. This may also help to standardize procedures for manufacturing compound formulations ab initio. The present study reviews the concept of Aamar-e-Advia(shelf-lives) described in the literature of the Unani system of medicine. Further, various factors that are considered important to assess the shelf-life of Unani drugs are discussed in the context of contemporary protocols for shelf-life assessment.展开更多
Hypothyroidism(Qillat-e-Ifraz-e-Darqiyya) is a condition where the thyroid gland is underactive and unable to produce enough thyroid hormone. The description of hypothyroidism as a disease is not directly found in Una...Hypothyroidism(Qillat-e-Ifraz-e-Darqiyya) is a condition where the thyroid gland is underactive and unable to produce enough thyroid hormone. The description of hypothyroidism as a disease is not directly found in Unani texts. However, the signs and symptom of hypothyroidism resemble the clinical manifestation associated with Su-e-Mizaj Barid Maddi(derangement in cold temperament), such as plethora(Imtila), excessive salivation(Kasrat-e-Luabe-e-Dahan), tiredness(Aa'yan), loss of appetite(Zoaf-e-Ishteha), excessive sleeping(Kasrat-e-Naum) and cold skin(Baroodat-e-Jildia). These signs and symptoms are the result of an excess in abnormal phlegm(Ghair Tabayi Balgham) in the body. This review article identifies the observations from Unani literature that describe derangement in cold temperament and relate them to the clinical presentation of primary hypothyroidism in conventional medicine. We also discuss management of these symptoms in Unani medicine.展开更多
Objective:Conventional treatments for benign prostatic hyperplasia(BPH)like 5alpha-reductase inhibitors and invasive surgery are associated with some obvious side effects.Conversely,evidence,though limited,has shown t...Objective:Conventional treatments for benign prostatic hyperplasia(BPH)like 5alpha-reductase inhibitors and invasive surgery are associated with some obvious side effects.Conversely,evidence,though limited,has shown that alternative medicines are safer and have potential to improve the lower urinary tract symptoms(LUTS)and quality of life in addition to improving sexual dysfunction in patients with BPH.The current article aimed to include an overview of BPH,different ways of its management,and particularly its appreciation in Greco-Arab(Unani)system of medicine,one of the alternative medicinal systems.Methods:PubMed,Scopus,ScienceDirect,Web of Sciences,Google Scholar databases and classical texts of Greco-Arab medicine were searched for data collection.Results:In Unani system of medicine,BPH,traced under the headings of Waram unuq al-mathana(bladder neck swelling)and Insidad majra-i-mathana(bladder outlet obstruction),has been managed for centuries with herbal medicines yet demanding a comprehensive scientific validation.Among the herbs,Cucurbita pepo,Tribulus terrestris,Urtica dioica,and Linum usitatissimum are worth mentioning.Conclusion:For achieving the goal of LUTS-free ageing men,and safer and cost-effective future management of BPH,Unani herbal medicine could hopefully prove beneficial.展开更多
Vitiligo is not only a cosmetic problem,but also a social and psychological problem with the prevalence rate between 1–2%and being highest in India.As far as etiopathogenesis of the disease is concerned,out of variou...Vitiligo is not only a cosmetic problem,but also a social and psychological problem with the prevalence rate between 1–2%and being highest in India.As far as etiopathogenesis of the disease is concerned,out of various theories put forward,some accepted hypothesis is the autoimmune destruction of melanocytes,melanocytes adhesion,neurogenic damage,auto-toxicity.Disease is mainly classified in two forms i.e.segmental vitiligo and non-segmental vitiligo.Treatment of this disease is usually cumbersome and time taking,causing significant impact on quality of life.Moreover,modern treatment is only suppressive but not curative.Medicinal plants are the base of many traditional medicine systems throughout the world for thousands of years and continue to provide new remedies to mankind.If used appropriately,they are comparatively more effective,less toxic and easily available at affordable prices.Detailed management consisting of single herbs and compound formulations along with other regimes has been mentioned to treat this disease in the classical Unani literature which is safe and effective.Aim of this paper was to delineate the vitiligo disease and search for evidence in the management of the disease through Unani and herbal medicines.展开更多
A male named Anwer Jamal, age 45 years, married, visited Clinic Rafaheaam Dawakhana Ajmali on March 29, 2013, with history of glomerulonephritis, inherited renal diseases, hypertension and previously hooked on voltare...A male named Anwer Jamal, age 45 years, married, visited Clinic Rafaheaam Dawakhana Ajmali on March 29, 2013, with history of glomerulonephritis, inherited renal diseases, hypertension and previously hooked on voltaren 50 (Diclofenic Sodium, 50 mg) and was not on dialysis. Different diagnostic parameters showed the patient was suffering from acute renal failure according to the RIFLE criteria. AKI is life threatening when kidneys suddenly is unable to filter waste products from blood. The patient was treated and managed with herbal medicines according to Unani system of medicine. Reversal of the parameter such as serum creatinine from 7.90 mg/dl (6.58 fold high) to 0.81mg/dl within two weeks clearly shows the remarkable recovery in a short period of time. During this period the other related parameters e.g. blood urea nitrogen (BUN), serum albumin, albuminuria, blood pressure were also normalized whereas clinical sign and symptom exhibited improvement.展开更多
Qūba(dermatophytoses)is a clinical condition caused by fungal infection of skin in humans.The fungi that cause dermatophytoses feed on keratin,the material found in the outer layer of skin,hair and nails.Many effecti...Qūba(dermatophytoses)is a clinical condition caused by fungal infection of skin in humans.The fungi that cause dermatophytoses feed on keratin,the material found in the outer layer of skin,hair and nails.Many effective synthetic antifungal drugs have been discovered for the treatment of dermatomycoses but their use has remained limited due to various side effects on human systems.Herbal remedies are being used for its treatment.Unani medicines are also being promoted as dermatophytoses treatment.Detailed management consisting of single herbs and compound formulations along with other regimes has been mentioned to treat this disease in the classical Unani literature,which is safe and effective.The aim of this study was to systematically review the evidence for this notion and to discuss different aspects of Qūba(dermatophytoses).Extensive literature searches were carried out to identify drugs reported to be effective in the treatment of Qūba(dermatophytoses).In this review paper author has tried to present few Unani medicines prevalently used for treatment of dermatophytoses.展开更多
Eczema(Nār Fārsī)is characterized by itching,lichenification,scaling,oedema and erythema.Corticosteroids are the mainstay of current management of this disease in modern medicine,which is also limited due to its si...Eczema(Nār Fārsī)is characterized by itching,lichenification,scaling,oedema and erythema.Corticosteroids are the mainstay of current management of this disease in modern medicine,which is also limited due to its side effects.Many herbal remedies are being used for its treatment.Most of the herbal remedies are considered to be very useful and have fewer side effects.Unani medicines are also being promoted as eczema treatment.Detailed management of the disease is mentioned by Unani scholars in their classical literature.These include number of single herbs and compound herbal formulations as well as dieto-therapy and other regimes.The aim of this study was to systematically review the evidence for this notion and to discuss different aspects of Nār Fārsī.Extensive literature searches were carried out to identify drugs reported to be effective in the treatment of Nār Fārsī.In this review paper author has tried to present few herbal/Unani medicines prevalently used for the treatment of eczema.展开更多
Hepatitis is an inflammation of the liver caused by viral infection.Hepatitis B(Serum Hepatitis)is an acute systemic infection.It is transmitted by parenteral route having a long incubation period six weak to six mont...Hepatitis is an inflammation of the liver caused by viral infection.Hepatitis B(Serum Hepatitis)is an acute systemic infection.It is transmitted by parenteral route having a long incubation period six weak to six months.Hepatitis B virus can form a dangerous alliance with Delta virus.Hepatitis B virus was discovered by Blumberg.It is a complex,42 nm,double stranded DNA virus,originally known as Dane-Particle.Hepatitis B is a blood borne infection.It is transmitted by infected blood products.Here in this paper an attempt is made to review the Unani concept,causes,sign and symptoms,management and treatment of hepatitis B virus.Some successful case studies of the hepatitis B management through unani formulations and particular regimen have been incorporated to showcase the efficacy of the unani system of medicine in this chronic disease.展开更多
Background and objectives:Acne vulgaris stands as the prevailing dermatological condition on a global scale,prompting exploration into diverse therapeutic modalities.Hence,this study aimed to assess the efficacy of a ...Background and objectives:Acne vulgaris stands as the prevailing dermatological condition on a global scale,prompting exploration into diverse therapeutic modalities.Hence,this study aimed to assess the efficacy of a formulation comprising Kalonji(Nigella sativa)and Sirka(vinegar)in comparison to benzoyl peroxide 5%for the treatment of acne vulgaris.Methods:In this open-label randomized controlled trial,40 participants with acne in the age bracket of 13–40 years completed the 28-day treatment period.The Unani group received a Nigella sativa seed powder and cane vinegar,while the control group received benzoyl peroxide 5%gel.Both interventions were applied topically at night.Primary outcomes encompassed changes in the Global Acne Grading System(GAGS)and Cook’s Acne Grading Scale using PSAG scores.The secondary outcome was the change in Quality of Life assessed through the Cardiff Acne Disability Index(CADI).Safety evaluations included baseline and post-treatment measurements of hemograms,serum creatinine,serum bilirubin,and random blood sugar levels.Results:The GAGS scores showed a mean difference of−2.600(95%CI:−5.770-0.570,d=0.57,p=0.105),PSAG scores exhibited a mean difference of−0.600(95%CI:−1.793-0.593,d=0.49,p=0.315),and CADI scores displayed a mean difference of−1.500(95%CI:−3.470-0.470,d=0.32,p=0.132)at the trial conclusion.Conclusions:This trial suggests that the formulation may have therapeutic potential as an alternative acne treatment.Further studies with larger sample sizes and extended follow-up periods are recommended.Clinical trial registration:The clinical trial was registered with Clinical Trial Registry–India under the registration number CTRI/2022/05/042368 on May 4,2022.展开更多
Leg ulcers pose a significant burden on morbidity,healthcare costs,and quality of life,despite rarely resulting in limb loss.This underscores the necessity for safe and effective alternative treatments.Unani medicine ...Leg ulcers pose a significant burden on morbidity,healthcare costs,and quality of life,despite rarely resulting in limb loss.This underscores the necessity for safe and effective alternative treatments.Unani medicine offers various therapeutic options for managing ulcers.This case report details the successful treatment of a non-healing venous ulcer using Unani regimens in a 40-year-old male with a history of diabetes mellitus and paralytic polio.The patient sought care at the Regional Research Institute of Unani Medicine,Silchar,Assam,India,for a chronic ulcer in the gaiter region of his right leg,which was associated with mild pain,itching,and hyperpigmentation but notably lacked any signs of varicose veins.Over the years,the patient had undergone various treatments,including topical care and antibiotics;however,frustration with persistent non-healing led him to explore alternative interventions.The Unani treatment included medicinal leech therapy,followed by the application of a grated unripe papaya bandage for 14 days.By the end of this period,the ulcer had completely healed,allowing the discontinuation of the dressing.By the 21st day,symptom resolution was observed,with complete relief from pain and itching and normalization of hyperpigmentation in the surrounding area.This case highlights the potential of Unani therapeutic approaches in effectively managing non-healing venous ulcers.展开更多
Background:Melasma is a prevalent skin disorder affecting a wide range of populations.In Unani system of medicine,a traditional healing system with a rich historical background,there exists a repository of therapeutic...Background:Melasma is a prevalent skin disorder affecting a wide range of populations.In Unani system of medicine,a traditional healing system with a rich historical background,there exists a repository of therapeutic modalities for melasma,elucidated by esteemed scholars and practitioners.Despite its extensive utilization,the scientific substantiation supporting these interventions remains limited.Objective:This study aims to scientifically evaluate and compare the safety and efficacy of topically applied Raphanus sativus seed powder and honey mixture versus hydroquinone(4%w/w)cream for melasma treatment.Methods:In this 8-week open-label,randomized controlled trial,40 participants(20 per group),aged 18–65 years and diagnosed with melasma,successfully completed the study.The test group applied finely powdered Raphanus sativus seeds mixed with honey twice daily,while the control group used hydroquinone(4%w/w)cream twice daily.Primary outcome measure was change in modified Melasma Area and Severity Index(mMASI)at each follow-up.Secondary measures examined subjective nuances using a 100mm visual analogue scale(VAS)and recorded the dermatology life quality index(DLQI)at baseline and the conclusion of the study.Safety was ensured through comprehensive clinical reviews,with documentation of adverse events during bi-weekly follow-ups.Results:Following the conclusion of the study,the mean difference in the mMASI score between the test and control groups was–0.22(95%CI:–0.75 to 0.30,d=0.27,p=0.394).Additionally,post-trial mean differences in VAS and DLQI scores between the test and control groups were determined as–5.25(95%CI:–10.65 to–0.15,d=0.62,p=0.056)and–0.10(95%CI:–1.53 to 1.33,d=0.04,p=0.888),respectively.Conclusion:Based on the investigative findings,the test intervention involving Raphanus sativus and honey demonstrated therapeutic efficacy statistically comparable to conventional hydroquinone treatment for managing melasma,with no reported adverse reactions.Moreover,both groups exhibited statistically comparable improvements in the dermatology life quality index.展开更多
Objective： To assess the knowledge, attitude, perception and practice of Ayurveda, yoga, Unani, Siddha, homeopathy and naturopathy （AYUSH） among allopathic doctors and interns and determine their opin- ion regardin...Objective： To assess the knowledge, attitude, perception and practice of Ayurveda, yoga, Unani, Siddha, homeopathy and naturopathy （AYUSH） among allopathic doctors and interns and determine their opin- ion regarding integration of AYUSH education within the allopathic curriculum. Methods： This prospective, cross sectional study was conducted in a tertiary care teaching Hospital, New Delhi, India, from March 2016 to March 2017. A survey of 500 aUopathic doctors and 150 interns was performed using a structured questionnaire. Results： A majority of doctors （95.2%） were aware of the term AYUSH and had knowledge of yoga （70.6%）, homeopathy （55.6%）, Ayurveda （50.3%）, Siddha （47.8%）, naturopathy （32.9%） and Unani （28.9%）. Most of the participants （63.0%） felt that therapies under AYUSH are effective. A majority （84.0%） of the doctors were of the view that more research is required in the field of AYUSH. While homeopathy （44.0%） was the most common system used by doctors for themselves, yoga was the therapy most commonly （60.0%） recommended to patients. Nearly half of the doctors （46.7%） recommended AYUSH to their patients, mainly for chronic illness （74.0%）. A majority （77.5%） of the respondents agreed that students of allopathic med- icine should be familiarized with AYUSH. The modes of incorporation of AYUSH into the medical curriculum most commonly suggested by respondents were optional courses （54.5%） and introductory lectures （42.3%）. Conclusion： Doctors and interns ofallopathic medicine are aware of AYUSH systems. They use it for them- selves and recommend it to patients. They believe that familiarization of Bachelor of Medicine and Bachelor of Surgery students with AYUSH therapies and their integration with allopathic medicine may help in improving patient care.展开更多
Objective: The study examines the effect of the hydro-alcoholic extract of Cinnamomum zeylanicum Blume bark on crystallization of calcium oxalate. Methods: The antilithiatic effect of various concentrations of the hyd...Objective: The study examines the effect of the hydro-alcoholic extract of Cinnamomum zeylanicum Blume bark on crystallization of calcium oxalate. Methods: The antilithiatic effect of various concentrations of the hydro-alcoholic extract of C. zeylanicum was investigated at various stages of stone formation, using Cystone as a stan da rd refere nee drug. The effect on calcium oxalate crystallization was evaluated by measuring the change in turbidity over time, during crystal nucleation, growth and aggregation, in the metastable solution of calcium chloride and sodium oxalate. The slope from the change in turbidity over time was measured using a spectrophotometer at 620 and 214 nm in respective tests. The inhibition rate was estimated by comparing turbidity in the presence and absence of extract. Crystals formed under experimental conditions were observed under a light microscope, and number and shape of the crystals were assessed in a randomly selected field. Phytochemical analysis and high-performance thin-layer chromatography of the extract was also carried out. Results: C. zeylanicum significantly reduced crystal nucleation at concentrations of 4, 8 and 10 mg/mL (P< 0.001). The inhibition percentage of crystal growth was between 28.30% and 92.46% in the presence of C. zeylanicum extract and from 20.76% to 64.15% with various concentrations of Cystone. The maximum inhibition of crystal growth was obtained from C. zeylanicum at 2 mg/mL (92.46%). Microscopic examination revealed a reduction in the number and size of crystals. In the aggregation assay, the inhibition percentage of C. zeylanicum was between 16.27% and 100%, while Cystone was from -214.68% to 100% at different concentrations. The highest (100%) inhibition of aggregation was found at 4 mg/mL of both the test and standard drugs. Conclusion: We found that C. zeylanicum hydro-alcoholic extract has notable inhibitory effects on various stages of crystallization, in terms of turbidity of solution, as well as the crystal size, number and morphology.展开更多
文摘In Unani medicine,Bawl(urine)is recognized as a key diagnostic tool,with humoural imbalances assessed via parameters like color,consistency,sediment,clarity,froth,odor,and volume.This conceptual review explores how these classical diagnostic indicators may be contextualized alongside modern urinalysis markers(e.g.,bilirubin,protein,ketones,and sedimentation)and examined through emerging artificial intelligence(AI)frameworks.Potential applications include ResNet-18 for color classification,You Only Look Once version 8(YOLOv8)for sediment detection,long short-term memory(LSTM)for viscosity estimation,and EfficientDet for froth analysis,with standardized urine images/videos forming the basis of future datasets.Additionally,a comparative ontology is proposed to align Unani perspectives with diagnostic approaches in traditional Chinese medicine,encouraging cross-system integration.By synthesizing classical epistemology with computational intelligence,this review highlights pathways for developing AI-based decision support systems to promote personalized,accessible,and telemedicine-enabled healthcare.
文摘Unani medicine is an oldest system of traditional medicine,where drugs of animal,mineral and herbal origin are used for centuries to cure diseases.Unani remedies are now available not only in drug stores,but also in food stores and super markets.Therefore the efficacy and safety of these drugs is very crucial.One of the most serious risks associated with these remedies is,consumer assumes that they are natural,so they are safe.But biological contamination(bacterial,fungal and insect)of herbal medicines is a serious concern.The Aspergillus flavus and Aspergillus parasiticus are the fungal species that occur naturally,release aflatoxins and is a threat to the natural drugs.The World Health Organization has recommended determination of aflatoxins in natural drugs(Unani)as one of the parameter of their safety studies as Aflatoxin contamination is concerned significantly with health and economic loss affecting humans,animals,and agriculture.Aflatoxin B1 is categorized as a group 1 carcinogen by The International Agency for Research on Cancer that causes a variety of health issues.Thus keeping in mind the deleterious health effects of aflatoxins,here,in this review we have made an attempt to summarize the aflatoxins with respect to their origin,occurrence,structure and properties to generate the awareness among the people dealing mainly with Unani herbal drugs.Besides these their toxicity and effects on health have also been discussed.The analytical methods for their determination and some measures to prevent their contamination are also suggested to improve the efficacy and safety of Unani herbal drugs.
文摘In an era of globalization and increased global demand for herbal medicines, it is essential to ensure the quality and consistency of drugs. Changes in the quality of an herbal product over time should be detectable. The assessments of chemical quality and therapeutic efficacy of herbal drugs are necessary to establish their shelf-lives. Thus, stability testing is needed to establish standards for herbal products. Unani medicine has its own conceptual framework for studying health and disease. The mode of treatment includes Ilaj bit Tadbeer(regimental therapy), Ilaj bil Ghiza(dietotherapy), Ilaj bil Dawa(pharmacotherapy) and Ilaj bil Yad/Jarahat(surgery) as a final option. Ilaj bil Dawa is the most used mode of treatment.The drugs include either crude drugs prepared from plant, animal and mineral sources, called Mufrad(single) drugs or various formulations prepared from these crude drugs, called Murakkab(compound)drugs. To date, stability studies have been carried out on compound drugs, whereas only a few single drugs had had their stability tested. These studies are needed to understand how the quality of an herbal drug varies over the time when it is prepared and consumed. This may also help to standardize procedures for manufacturing compound formulations ab initio. The present study reviews the concept of Aamar-e-Advia(shelf-lives) described in the literature of the Unani system of medicine. Further, various factors that are considered important to assess the shelf-life of Unani drugs are discussed in the context of contemporary protocols for shelf-life assessment.
文摘Hypothyroidism(Qillat-e-Ifraz-e-Darqiyya) is a condition where the thyroid gland is underactive and unable to produce enough thyroid hormone. The description of hypothyroidism as a disease is not directly found in Unani texts. However, the signs and symptom of hypothyroidism resemble the clinical manifestation associated with Su-e-Mizaj Barid Maddi(derangement in cold temperament), such as plethora(Imtila), excessive salivation(Kasrat-e-Luabe-e-Dahan), tiredness(Aa'yan), loss of appetite(Zoaf-e-Ishteha), excessive sleeping(Kasrat-e-Naum) and cold skin(Baroodat-e-Jildia). These signs and symptoms are the result of an excess in abnormal phlegm(Ghair Tabayi Balgham) in the body. This review article identifies the observations from Unani literature that describe derangement in cold temperament and relate them to the clinical presentation of primary hypothyroidism in conventional medicine. We also discuss management of these symptoms in Unani medicine.
文摘Objective:Conventional treatments for benign prostatic hyperplasia(BPH)like 5alpha-reductase inhibitors and invasive surgery are associated with some obvious side effects.Conversely,evidence,though limited,has shown that alternative medicines are safer and have potential to improve the lower urinary tract symptoms(LUTS)and quality of life in addition to improving sexual dysfunction in patients with BPH.The current article aimed to include an overview of BPH,different ways of its management,and particularly its appreciation in Greco-Arab(Unani)system of medicine,one of the alternative medicinal systems.Methods:PubMed,Scopus,ScienceDirect,Web of Sciences,Google Scholar databases and classical texts of Greco-Arab medicine were searched for data collection.Results:In Unani system of medicine,BPH,traced under the headings of Waram unuq al-mathana(bladder neck swelling)and Insidad majra-i-mathana(bladder outlet obstruction),has been managed for centuries with herbal medicines yet demanding a comprehensive scientific validation.Among the herbs,Cucurbita pepo,Tribulus terrestris,Urtica dioica,and Linum usitatissimum are worth mentioning.Conclusion:For achieving the goal of LUTS-free ageing men,and safer and cost-effective future management of BPH,Unani herbal medicine could hopefully prove beneficial.
文摘Vitiligo is not only a cosmetic problem,but also a social and psychological problem with the prevalence rate between 1–2%and being highest in India.As far as etiopathogenesis of the disease is concerned,out of various theories put forward,some accepted hypothesis is the autoimmune destruction of melanocytes,melanocytes adhesion,neurogenic damage,auto-toxicity.Disease is mainly classified in two forms i.e.segmental vitiligo and non-segmental vitiligo.Treatment of this disease is usually cumbersome and time taking,causing significant impact on quality of life.Moreover,modern treatment is only suppressive but not curative.Medicinal plants are the base of many traditional medicine systems throughout the world for thousands of years and continue to provide new remedies to mankind.If used appropriately,they are comparatively more effective,less toxic and easily available at affordable prices.Detailed management consisting of single herbs and compound formulations along with other regimes has been mentioned to treat this disease in the classical Unani literature which is safe and effective.Aim of this paper was to delineate the vitiligo disease and search for evidence in the management of the disease through Unani and herbal medicines.
文摘A male named Anwer Jamal, age 45 years, married, visited Clinic Rafaheaam Dawakhana Ajmali on March 29, 2013, with history of glomerulonephritis, inherited renal diseases, hypertension and previously hooked on voltaren 50 (Diclofenic Sodium, 50 mg) and was not on dialysis. Different diagnostic parameters showed the patient was suffering from acute renal failure according to the RIFLE criteria. AKI is life threatening when kidneys suddenly is unable to filter waste products from blood. The patient was treated and managed with herbal medicines according to Unani system of medicine. Reversal of the parameter such as serum creatinine from 7.90 mg/dl (6.58 fold high) to 0.81mg/dl within two weeks clearly shows the remarkable recovery in a short period of time. During this period the other related parameters e.g. blood urea nitrogen (BUN), serum albumin, albuminuria, blood pressure were also normalized whereas clinical sign and symptom exhibited improvement.
文摘Qūba(dermatophytoses)is a clinical condition caused by fungal infection of skin in humans.The fungi that cause dermatophytoses feed on keratin,the material found in the outer layer of skin,hair and nails.Many effective synthetic antifungal drugs have been discovered for the treatment of dermatomycoses but their use has remained limited due to various side effects on human systems.Herbal remedies are being used for its treatment.Unani medicines are also being promoted as dermatophytoses treatment.Detailed management consisting of single herbs and compound formulations along with other regimes has been mentioned to treat this disease in the classical Unani literature,which is safe and effective.The aim of this study was to systematically review the evidence for this notion and to discuss different aspects of Qūba(dermatophytoses).Extensive literature searches were carried out to identify drugs reported to be effective in the treatment of Qūba(dermatophytoses).In this review paper author has tried to present few Unani medicines prevalently used for treatment of dermatophytoses.
文摘Eczema(Nār Fārsī)is characterized by itching,lichenification,scaling,oedema and erythema.Corticosteroids are the mainstay of current management of this disease in modern medicine,which is also limited due to its side effects.Many herbal remedies are being used for its treatment.Most of the herbal remedies are considered to be very useful and have fewer side effects.Unani medicines are also being promoted as eczema treatment.Detailed management of the disease is mentioned by Unani scholars in their classical literature.These include number of single herbs and compound herbal formulations as well as dieto-therapy and other regimes.The aim of this study was to systematically review the evidence for this notion and to discuss different aspects of Nār Fārsī.Extensive literature searches were carried out to identify drugs reported to be effective in the treatment of Nār Fārsī.In this review paper author has tried to present few herbal/Unani medicines prevalently used for the treatment of eczema.
文摘Hepatitis is an inflammation of the liver caused by viral infection.Hepatitis B(Serum Hepatitis)is an acute systemic infection.It is transmitted by parenteral route having a long incubation period six weak to six months.Hepatitis B virus can form a dangerous alliance with Delta virus.Hepatitis B virus was discovered by Blumberg.It is a complex,42 nm,double stranded DNA virus,originally known as Dane-Particle.Hepatitis B is a blood borne infection.It is transmitted by infected blood products.Here in this paper an attempt is made to review the Unani concept,causes,sign and symptoms,management and treatment of hepatitis B virus.Some successful case studies of the hepatitis B management through unani formulations and particular regimen have been incorporated to showcase the efficacy of the unani system of medicine in this chronic disease.
文摘Background and objectives:Acne vulgaris stands as the prevailing dermatological condition on a global scale,prompting exploration into diverse therapeutic modalities.Hence,this study aimed to assess the efficacy of a formulation comprising Kalonji(Nigella sativa)and Sirka(vinegar)in comparison to benzoyl peroxide 5%for the treatment of acne vulgaris.Methods:In this open-label randomized controlled trial,40 participants with acne in the age bracket of 13–40 years completed the 28-day treatment period.The Unani group received a Nigella sativa seed powder and cane vinegar,while the control group received benzoyl peroxide 5%gel.Both interventions were applied topically at night.Primary outcomes encompassed changes in the Global Acne Grading System(GAGS)and Cook’s Acne Grading Scale using PSAG scores.The secondary outcome was the change in Quality of Life assessed through the Cardiff Acne Disability Index(CADI).Safety evaluations included baseline and post-treatment measurements of hemograms,serum creatinine,serum bilirubin,and random blood sugar levels.Results:The GAGS scores showed a mean difference of−2.600(95%CI:−5.770-0.570,d=0.57,p=0.105),PSAG scores exhibited a mean difference of−0.600(95%CI:−1.793-0.593,d=0.49,p=0.315),and CADI scores displayed a mean difference of−1.500(95%CI:−3.470-0.470,d=0.32,p=0.132)at the trial conclusion.Conclusions:This trial suggests that the formulation may have therapeutic potential as an alternative acne treatment.Further studies with larger sample sizes and extended follow-up periods are recommended.Clinical trial registration:The clinical trial was registered with Clinical Trial Registry–India under the registration number CTRI/2022/05/042368 on May 4,2022.
文摘Leg ulcers pose a significant burden on morbidity,healthcare costs,and quality of life,despite rarely resulting in limb loss.This underscores the necessity for safe and effective alternative treatments.Unani medicine offers various therapeutic options for managing ulcers.This case report details the successful treatment of a non-healing venous ulcer using Unani regimens in a 40-year-old male with a history of diabetes mellitus and paralytic polio.The patient sought care at the Regional Research Institute of Unani Medicine,Silchar,Assam,India,for a chronic ulcer in the gaiter region of his right leg,which was associated with mild pain,itching,and hyperpigmentation but notably lacked any signs of varicose veins.Over the years,the patient had undergone various treatments,including topical care and antibiotics;however,frustration with persistent non-healing led him to explore alternative interventions.The Unani treatment included medicinal leech therapy,followed by the application of a grated unripe papaya bandage for 14 days.By the end of this period,the ulcer had completely healed,allowing the discontinuation of the dressing.By the 21st day,symptom resolution was observed,with complete relief from pain and itching and normalization of hyperpigmentation in the surrounding area.This case highlights the potential of Unani therapeutic approaches in effectively managing non-healing venous ulcers.
文摘Background:Melasma is a prevalent skin disorder affecting a wide range of populations.In Unani system of medicine,a traditional healing system with a rich historical background,there exists a repository of therapeutic modalities for melasma,elucidated by esteemed scholars and practitioners.Despite its extensive utilization,the scientific substantiation supporting these interventions remains limited.Objective:This study aims to scientifically evaluate and compare the safety and efficacy of topically applied Raphanus sativus seed powder and honey mixture versus hydroquinone(4%w/w)cream for melasma treatment.Methods:In this 8-week open-label,randomized controlled trial,40 participants(20 per group),aged 18–65 years and diagnosed with melasma,successfully completed the study.The test group applied finely powdered Raphanus sativus seeds mixed with honey twice daily,while the control group used hydroquinone(4%w/w)cream twice daily.Primary outcome measure was change in modified Melasma Area and Severity Index(mMASI)at each follow-up.Secondary measures examined subjective nuances using a 100mm visual analogue scale(VAS)and recorded the dermatology life quality index(DLQI)at baseline and the conclusion of the study.Safety was ensured through comprehensive clinical reviews,with documentation of adverse events during bi-weekly follow-ups.Results:Following the conclusion of the study,the mean difference in the mMASI score between the test and control groups was–0.22(95%CI:–0.75 to 0.30,d=0.27,p=0.394).Additionally,post-trial mean differences in VAS and DLQI scores between the test and control groups were determined as–5.25(95%CI:–10.65 to–0.15,d=0.62,p=0.056)and–0.10(95%CI:–1.53 to 1.33,d=0.04,p=0.888),respectively.Conclusion:Based on the investigative findings,the test intervention involving Raphanus sativus and honey demonstrated therapeutic efficacy statistically comparable to conventional hydroquinone treatment for managing melasma,with no reported adverse reactions.Moreover,both groups exhibited statistically comparable improvements in the dermatology life quality index.
文摘Objective： To assess the knowledge, attitude, perception and practice of Ayurveda, yoga, Unani, Siddha, homeopathy and naturopathy （AYUSH） among allopathic doctors and interns and determine their opin- ion regarding integration of AYUSH education within the allopathic curriculum. Methods： This prospective, cross sectional study was conducted in a tertiary care teaching Hospital, New Delhi, India, from March 2016 to March 2017. A survey of 500 aUopathic doctors and 150 interns was performed using a structured questionnaire. Results： A majority of doctors （95.2%） were aware of the term AYUSH and had knowledge of yoga （70.6%）, homeopathy （55.6%）, Ayurveda （50.3%）, Siddha （47.8%）, naturopathy （32.9%） and Unani （28.9%）. Most of the participants （63.0%） felt that therapies under AYUSH are effective. A majority （84.0%） of the doctors were of the view that more research is required in the field of AYUSH. While homeopathy （44.0%） was the most common system used by doctors for themselves, yoga was the therapy most commonly （60.0%） recommended to patients. Nearly half of the doctors （46.7%） recommended AYUSH to their patients, mainly for chronic illness （74.0%）. A majority （77.5%） of the respondents agreed that students of allopathic med- icine should be familiarized with AYUSH. The modes of incorporation of AYUSH into the medical curriculum most commonly suggested by respondents were optional courses （54.5%） and introductory lectures （42.3%）. Conclusion： Doctors and interns ofallopathic medicine are aware of AYUSH systems. They use it for them- selves and recommend it to patients. They believe that familiarization of Bachelor of Medicine and Bachelor of Surgery students with AYUSH therapies and their integration with allopathic medicine may help in improving patient care.
文摘Objective: The study examines the effect of the hydro-alcoholic extract of Cinnamomum zeylanicum Blume bark on crystallization of calcium oxalate. Methods: The antilithiatic effect of various concentrations of the hydro-alcoholic extract of C. zeylanicum was investigated at various stages of stone formation, using Cystone as a stan da rd refere nee drug. The effect on calcium oxalate crystallization was evaluated by measuring the change in turbidity over time, during crystal nucleation, growth and aggregation, in the metastable solution of calcium chloride and sodium oxalate. The slope from the change in turbidity over time was measured using a spectrophotometer at 620 and 214 nm in respective tests. The inhibition rate was estimated by comparing turbidity in the presence and absence of extract. Crystals formed under experimental conditions were observed under a light microscope, and number and shape of the crystals were assessed in a randomly selected field. Phytochemical analysis and high-performance thin-layer chromatography of the extract was also carried out. Results: C. zeylanicum significantly reduced crystal nucleation at concentrations of 4, 8 and 10 mg/mL (P< 0.001). The inhibition percentage of crystal growth was between 28.30% and 92.46% in the presence of C. zeylanicum extract and from 20.76% to 64.15% with various concentrations of Cystone. The maximum inhibition of crystal growth was obtained from C. zeylanicum at 2 mg/mL (92.46%). Microscopic examination revealed a reduction in the number and size of crystals. In the aggregation assay, the inhibition percentage of C. zeylanicum was between 16.27% and 100%, while Cystone was from -214.68% to 100% at different concentrations. The highest (100%) inhibition of aggregation was found at 4 mg/mL of both the test and standard drugs. Conclusion: We found that C. zeylanicum hydro-alcoholic extract has notable inhibitory effects on various stages of crystallization, in terms of turbidity of solution, as well as the crystal size, number and morphology.
