This paper proposes a hybrid vertex-centered fi- nite volume/finite element method for solution of the two di- mensional （2D） incompressible Navier-Stokes equations on unstructured grids. An incremental pressure fra...This paper proposes a hybrid vertex-centered fi- nite volume/finite element method for solution of the two di- mensional （2D） incompressible Navier-Stokes equations on unstructured grids. An incremental pressure fractional step method is adopted to handle the velocity-pressure coupling. The velocity and the pressure are collocated at the node of the vertex-centered control volume which is formed by join- ing the centroid of cells sharing the common vertex. For the temporal integration of the momentum equations, an im- plicit second-order scheme is utilized to enhance the com- putational stability and eliminate the time step limit due to the diffusion term. The momentum equations are discretized by the vertex-centered finite volume method （FVM） and the pressure Poisson equation is solved by the Galerkin finite el- ement method （FEM）. The momentum interpolation is used to damp out the spurious pressure wiggles. The test case with analytical solutions demonstrates second-order accuracy of the current hybrid scheme in time and space for both veloc- ity and pressure. The classic test cases, the lid-driven cavity flow, the skew cavity flow and the backward-facing step flow, show that numerical results are in good agreement with the published benchmark solutions.展开更多
Uveal melanoma(UM)is the most common intraocular cancer,with approximately 5.2 individuals per million affected annually in the United States.It represents approximately 3%of the global malignant melanoma cases,accoun...Uveal melanoma(UM)is the most common intraocular cancer,with approximately 5.2 individuals per million affected annually in the United States.It represents approximately 3%of the global malignant melanoma cases,accounting for 80%of the overall noncutaneous melanomas.Clinically,it remains silent in about 30%of the cases;when symptomatic,it generally causes metamorphopsia(painless loss or distortion of vision)and/or photopsia(flashing or flickering of light in the visual field).Discoloration of the iris,astigmatism,glaucoma,and even blindness are other,less common clinical manifestations.Several pathophysiological mechanisms underlie the development of UM.Genetic mutations,involving especially the G protein subunit alpha q(GNAQ),guanine nucleotide-binding protein subunit alpha-11(GNA11),BRCA1 associated deubiquitinase 1(BAP1),splicing factor 3b subunit 1(SF3B1),and eukaryotic translation initiation factor 1A,X-linked(EIF1AX)genes as well as the MAPK/ERK signaling pathway genes,have been largely associated with the development of UM.Chromosomal aberrations,inflammatory and immunological alterations are often concurrent factors for the development and progression of UM.Therapies targeting specific genetic alterations and immunotherapy agents have been recently developed and introduced in clinical practice for the management of advanced-stage UMs.This review aims to present the latest advances in the clinical molecular pathology of UM,along with the resulting targeted,immunological,and other therapies that have been introduced or are currently under investigation.展开更多
Um Solimate emerald deposit is a unique example for the well-known beryl-related schist type.Where,the Be-mineralization is restricted to NNE-trending quartz veins/lenses and as disseminated emerald grains within the ...Um Solimate emerald deposit is a unique example for the well-known beryl-related schist type.Where,the Be-mineralization is restricted to NNE-trending quartz veins/lenses and as disseminated emerald grains within the altered-metasomatic zones of phlogopite-and graphite-schists.The study of fluid inclusions for the mineralized quartz vein revealed three major groups:(i)aqueous(H_(2)O-NaCl),(ii)aqueous-carbonic(H_(2)O-CO_(2)-[CH_(4)]-NaCl),and(iii)aqueous-hydrocarbonic(H_(2)O-CH_(4))FIs.They have been further classified into five types(namely:types 1,2,3,4 and 5)according to number of phases at the room temperature(20℃)as well as microthermometric measurements.Based upon the study of fluid inclusions,the initial-ore forming fluid was supposed to be of magmatic nature,characterized by a relatively high temperature of homogenization(T_(h,tot):269–485℃)and higher salinity(8.4 wt.%–9.6 wt.%NaCl equiv.),followed by development of aqueous-carbonic inclusions at lower temperature(T_(h,tot):241–355℃)and lower salinity(3.3 wt.%–4.9 wt.%NaCl equiv.)through metamorphic dehydration/decarbonation.Methane-rich FIs were suggested to be formed as a result of local re-equilibration of graphite in reduced environment at the contact aureole of the felsic intrusion.The P-T conditions of ore formation were estimated as modal temperature between(330–370℃)and fluid pressures of about 200 MPa,corresponding to an estimated depth ranges from 7 to 10 km.The formation of emerald is closely associated with multiple events through the ore evolution,the deposition is ascribed to destabilization process of continuous metasomatic interactions and elemental substitutions between felsic-derived Be-bearing fluids with the adjacent mafic-ultramafic rocks at the zone of mineralization.展开更多
A high-order fully actuated(HOFA)control method is developed for underactuated mechanical systems(UMSs)with model uncertainties and external disturbances.First,a model transformation is made from the original to a pse...A high-order fully actuated(HOFA)control method is developed for underactuated mechanical systems(UMSs)with model uncertainties and external disturbances.First,a model transformation is made from the original to a pseudo strict-feedback form,and an HOFA model is established by using the method of variable elimination.Then,a group of high-order extended state observers(ESOs)are designed to deal with model uncertainties and external disturbances.The HOFA model is further classified and decomposed to achieve output constraints within a finite time range,and a barrier function is designed by combining with a shift function.Additionally,an ESO-based HOFA tracking control strategy for UMS is proposed.Finally,a manipulator model is used to verify the effectiveness of the proposed control strategy.展开更多
基金supported by the Natural Science Foundation of China (11061021)the Program of Higher-level talents of Inner Mongolia University (SPH-IMU,Z200901004)the Scientific Research Projection of Higher Schools of Inner Mongolia(NJ10016,NJ10006)
文摘This paper proposes a hybrid vertex-centered fi- nite volume/finite element method for solution of the two di- mensional （2D） incompressible Navier-Stokes equations on unstructured grids. An incremental pressure fractional step method is adopted to handle the velocity-pressure coupling. The velocity and the pressure are collocated at the node of the vertex-centered control volume which is formed by join- ing the centroid of cells sharing the common vertex. For the temporal integration of the momentum equations, an im- plicit second-order scheme is utilized to enhance the com- putational stability and eliminate the time step limit due to the diffusion term. The momentum equations are discretized by the vertex-centered finite volume method （FVM） and the pressure Poisson equation is solved by the Galerkin finite el- ement method （FEM）. The momentum interpolation is used to damp out the spurious pressure wiggles. The test case with analytical solutions demonstrates second-order accuracy of the current hybrid scheme in time and space for both veloc- ity and pressure. The classic test cases, the lid-driven cavity flow, the skew cavity flow and the backward-facing step flow, show that numerical results are in good agreement with the published benchmark solutions.
文摘Uveal melanoma(UM)is the most common intraocular cancer,with approximately 5.2 individuals per million affected annually in the United States.It represents approximately 3%of the global malignant melanoma cases,accounting for 80%of the overall noncutaneous melanomas.Clinically,it remains silent in about 30%of the cases;when symptomatic,it generally causes metamorphopsia(painless loss or distortion of vision)and/or photopsia(flashing or flickering of light in the visual field).Discoloration of the iris,astigmatism,glaucoma,and even blindness are other,less common clinical manifestations.Several pathophysiological mechanisms underlie the development of UM.Genetic mutations,involving especially the G protein subunit alpha q(GNAQ),guanine nucleotide-binding protein subunit alpha-11(GNA11),BRCA1 associated deubiquitinase 1(BAP1),splicing factor 3b subunit 1(SF3B1),and eukaryotic translation initiation factor 1A,X-linked(EIF1AX)genes as well as the MAPK/ERK signaling pathway genes,have been largely associated with the development of UM.Chromosomal aberrations,inflammatory and immunological alterations are often concurrent factors for the development and progression of UM.Therapies targeting specific genetic alterations and immunotherapy agents have been recently developed and introduced in clinical practice for the management of advanced-stage UMs.This review aims to present the latest advances in the clinical molecular pathology of UM,along with the resulting targeted,immunological,and other therapies that have been introduced or are currently under investigation.
基金conducted through post-doctoral fellowship scheme granted by “TüB?TAK 2221 ” fellowship in Turkey
文摘Um Solimate emerald deposit is a unique example for the well-known beryl-related schist type.Where,the Be-mineralization is restricted to NNE-trending quartz veins/lenses and as disseminated emerald grains within the altered-metasomatic zones of phlogopite-and graphite-schists.The study of fluid inclusions for the mineralized quartz vein revealed three major groups:(i)aqueous(H_(2)O-NaCl),(ii)aqueous-carbonic(H_(2)O-CO_(2)-[CH_(4)]-NaCl),and(iii)aqueous-hydrocarbonic(H_(2)O-CH_(4))FIs.They have been further classified into five types(namely:types 1,2,3,4 and 5)according to number of phases at the room temperature(20℃)as well as microthermometric measurements.Based upon the study of fluid inclusions,the initial-ore forming fluid was supposed to be of magmatic nature,characterized by a relatively high temperature of homogenization(T_(h,tot):269–485℃)and higher salinity(8.4 wt.%–9.6 wt.%NaCl equiv.),followed by development of aqueous-carbonic inclusions at lower temperature(T_(h,tot):241–355℃)and lower salinity(3.3 wt.%–4.9 wt.%NaCl equiv.)through metamorphic dehydration/decarbonation.Methane-rich FIs were suggested to be formed as a result of local re-equilibration of graphite in reduced environment at the contact aureole of the felsic intrusion.The P-T conditions of ore formation were estimated as modal temperature between(330–370℃)and fluid pressures of about 200 MPa,corresponding to an estimated depth ranges from 7 to 10 km.The formation of emerald is closely associated with multiple events through the ore evolution,the deposition is ascribed to destabilization process of continuous metasomatic interactions and elemental substitutions between felsic-derived Be-bearing fluids with the adjacent mafic-ultramafic rocks at the zone of mineralization.
基金supported in part by the National Natural Science Foundation of China(62373208,62033003,62273105,U191140)Taishan Scholar Program of Shandong Province of China(tsqn202306218)+1 种基金the National Key Research and Development Program of China(2022YFB4703100)the National Natural Science Foundation of Shandong Province(ZR2024YQ032).
文摘A high-order fully actuated(HOFA)control method is developed for underactuated mechanical systems(UMSs)with model uncertainties and external disturbances.First,a model transformation is made from the original to a pseudo strict-feedback form,and an HOFA model is established by using the method of variable elimination.Then,a group of high-order extended state observers(ESOs)are designed to deal with model uncertainties and external disturbances.The HOFA model is further classified and decomposed to achieve output constraints within a finite time range,and a barrier function is designed by combining with a shift function.Additionally,an ESO-based HOFA tracking control strategy for UMS is proposed.Finally,a manipulator model is used to verify the effectiveness of the proposed control strategy.
