Objective: To study the role of monocytes in the pathogenesis of genital herpes. Methods: TNF- α and IL-6 levels in 27 cases of genital herpes were detected by enzyme linked immunosorbant assay (ELISA). HLA class Ⅱ ...Objective: To study the role of monocytes in the pathogenesis of genital herpes. Methods: TNF- α and IL-6 levels in 27 cases of genital herpes were detected by enzyme linked immunosorbant assay (ELISA). HLA class Ⅱ antigen expression on monocytes were detected by an alkaline phosphatase anti-alkaline phosphatase method. Results: Compared with normal controls, levels of TNF- a and IL - 6 secreted by monocytes responding to LPS mitogen in vitro were significantly decreased [(3.13 ± 0.44ng/ml) vs (4.68 ± 0.54ng/ml), P<0.05 and (3.32 ± 1.06ng/ml) vs (6.46 ± 1.94ng/ ml), P<0.05, respectively]. HLA class Ⅱ antigen expression on monocytes in the genital herpes group was also significantly decreased [HLA-DR (67.48% ± 1.51%) vs (81.03% ± 1.32%), P<0.01 and HLA-DQ (29.54% ± 1.15%) vs (37.63% ± 1.79%), P <0.01 respectively]. Conclusion: These findings suggest that the decreased monocyte function may contribute to the pathogenesis of genital herpes. Augmenting or inducing monocyte function may be important in the prevention, treatment, and reduction of genital herpes cases.展开更多
以均匀线阵(Uniform Linear Array,ULA)为子阵,结合频率分集阵(Frequency Diverse Array,FDA)的思想,构建了一种基于分布式子阵的频率分集阵。针对各子阵按等间距布阵将导致严重的栅瓣问题,提出了一种改进粒子群(Improved Particle Swar...以均匀线阵(Uniform Linear Array,ULA)为子阵,结合频率分集阵(Frequency Diverse Array,FDA)的思想,构建了一种基于分布式子阵的频率分集阵。针对各子阵按等间距布阵将导致严重的栅瓣问题,提出了一种改进粒子群(Improved Particle Swarm Optimization,IPSO)算法来优化分布式FDA中各子阵间的基线距离,以实现高效的栅瓣抑制。同时,从理论上推导了目标距离和角度均未知时参数估计的克拉美罗下界(Cramer-Rao Lower Bound,CRLB)。仿真结果表明,优化后分布式FDA的栅瓣得到有效抑制,而且阵列角度维分辨率和估计性能亦得到大幅度提升,验证了所提算法的有效性。展开更多
A joint Doppler shift and channel estimation method for the millimeter-wave communication system of an unmanned aerial vehicle(UAV) equipped with a large-scale uniform linear antenna(ULA) array has been proposed. Sinc...A joint Doppler shift and channel estimation method for the millimeter-wave communication system of an unmanned aerial vehicle(UAV) equipped with a large-scale uniform linear antenna(ULA) array has been proposed. Since Doppler shift induces intercarrier interference, the parameters of the channel paths have been decomposed into the Doppler shift and the channel information. In order to obtain the Doppler shift, a new estimation algorithm based on a combination of discrete Fourier transform and phase rotation has been proposed, which can determine the appropriate number of antennas. In addition to estimating the channel information, a low-complexity joint Doppler shift and channel estimation method has been designed that can quickly obtain accurate estimates. Furthermore, the achievable sum rate, the theoretical bounds of the mean squared errors, and the Cram?er-Rao lower bounds of the estimation method have been derived. The analysis and simulation results prove that the performance of the proposed approach is close to the theoretical inference.展开更多
Array calibration is important in engineering practice. In this paper, fast calibration methods for a ULA's gain and phase errors both in far and near fields are proposed. In the far field, using a single sound so...Array calibration is important in engineering practice. In this paper, fast calibration methods for a ULA's gain and phase errors both in far and near fields are proposed. In the far field, using a single sound source without exact orientation, this method horizontally rotates the array exactly once, performs eigen value decomposition for the covariance matrix of received data, then computes the gain and phase error according to the formulas. In the near field, using the same single sound source, it is necessary to rotate the array horizontally at most three times, build equations according to geometric relations, then solve them. Using the formula proposed in this paper, spherical waves are modified into plane waves. Then eigen values decomposition is performed. These two calibration methods were shown to be valid by simulation and are fast, accurate and easy to use. Finally, an analysis of factors influencing estimation precision is given.展开更多
A novel Direction-Of-Arrival (DOA) estimation method is proposed in the presence of mutual coupling using the joint sparse recovery. In the proposed method, the eigenvector corresponding to the maximum eigenvalue of c...A novel Direction-Of-Arrival (DOA) estimation method is proposed in the presence of mutual coupling using the joint sparse recovery. In the proposed method, the eigenvector corresponding to the maximum eigenvalue of covariance matrix of array measurement is viewed as the signal to be represented. By exploiting the geometrical property in steering vectors and the symmetric Toeplitz structure of Mutual Coupling Matrix (MCM), the redundant dictionaries containing the DOA information are constructed. Consequently, the optimization model based on joint sparse recovery is built and then is solved through Second Order Cone Program (SOCP) and Interior Point Method (IPM). The DOA estimates are gotten according to the positions of nonzeros elements. At last, computer simulations demonstrate the excellent performance of the proposed method.展开更多
Uniform linear array(ULA)radars are widely used in the collision-avoidance radar systems of small unmanned aerial vehicles(UAVs).In practice,a ULA's multi-target direction of arrival(DOA)estimation performance suf...Uniform linear array(ULA)radars are widely used in the collision-avoidance radar systems of small unmanned aerial vehicles(UAVs).In practice,a ULA's multi-target direction of arrival(DOA)estimation performance suffers from significant performance degradation owing to the limited number of physical elements.To improve the underdetermined DOA estimation performance of a ULA radar mounted on a small UAV platform,we propose a nonuniform linear motion sampling underdetermined DOA estimation method.Using the motion of the UAV platform,the echo signal is sampled at different positions.Then,according to the concept of difference co-array,a virtual ULA with multiple array elements and a large aperture is synthesized to increase the degrees of freedom(DOFs).Through position analysis of the original and motion arrays,we propose a nonuniform linear motion sampling method based on ULA for determining the optimal DOFs.Under the condition of no increase in the aperture of the physical array,the proposed method obtains a high DOF with fewer sampling runs and greatly improves the underdetermined DOA estimation performance of ULA.The results of numerical simulations conducted herein verify the superior performance of the proposed method.展开更多
In this paper, we have proposed a hybrid transmission scheme which involves beam selection and antenna selection techniques over a MIMO system operating with vary antenna array. Optimal subset of transmit antennas are...In this paper, we have proposed a hybrid transmission scheme which involves beam selection and antenna selection techniques over a MIMO system operating with vary antenna array. Optimal subset of transmit antennas are selected via fast successive selection scheme designed to optimize the target eigenbeam. Optimal eigenbeams corresponding to the largest singular values of the new MIMO channel formed by the selected antennas are exploited for data transmission. To evaluate the performance of the proposed scheme, different array structures, including uniform linear array (ULA) and including uniform circular array (UCA) are employed in the simulations. The transmitter is assumed to be surrounded by scattering objects while the receiver is postulated to be free from scattering objects. The Laplacian distribution of angle of arrival (AoA) of a signal reaching the receiver is postulated. The results presented by this paper indicate that the proposed scheme can significantly improve the performance of data transmission in term of symbol error rate (SER).展开更多
This paper reports on investigations into the performance of a Multiple Input Multiple Output (MIMO) wireless communication system employing a uniform linear array (ULA) at the transmitter and either a uni-form linear...This paper reports on investigations into the performance of a Multiple Input Multiple Output (MIMO) wireless communication system employing a uniform linear array (ULA) at the transmitter and either a uni-form linear array (ULA) or a uniform circular array (UCA) antenna at the receiver. The transmitter is as-sumed to be surrounded by scattering objects while the receiver is postulated to be free from scattering ob-jects. The Laplacian distribution of angle of arrival (AOA) of a signal reaching the receiver is postulated. The performance of bit error rate (BER), capacity and channel estimation for a MIMO system are evaluated for the two cases that the receiver is equipped with ULA or with UCA antennas.展开更多
A novel algorithm for the direction of arrival (DOA) estimation based on the fractional Fourier transform (FRFT) is proposed. Firstly, using the properties of FRFT and mask processing, Multi-component LFM sig-nals are...A novel algorithm for the direction of arrival (DOA) estimation based on the fractional Fourier transform (FRFT) is proposed. Firstly, using the properties of FRFT and mask processing, Multi-component LFM sig-nals are filtered and demodulated into a number of stationary single frequency signals. Then the one-dimensional (1-D) direction estimation of LFM signals can be achieved by combining with the tradi-tional spectrum search method in the fractional Fourier (FRF) domain. As for the multi-component LFM signals, there is no cross-term interference, the mean square error (MSE) and Cramer-Rao bound (CRB) are also analyzed which perfects the method theoretically, simulation results are provided to show the validity of our method. The proposed algorithm is also extended to the uniform circular array (UCA), which realizes the two-dimensional (2-D) estimation. Using the characteristics of time-frequency rotation and demodulation of FRFT, the observed LFM signals are demodulated into a series of single frequency ones;secondly, operate the beam-space mapping to the single frequency signals in FRF domain, which UCA in array space is changed into the virtual uniform circular array (ULA) in mode space;finally, the DOA estimation can be realized by the traditional spectral estimation method. Compared with other method, the complex time-frequency cluster and the parameter matching computation are avoided;meanwhile enhances the esti-mation precision by a certain extent. The proposed algorithm can also be used in the multi-path and Doppler frequency shift complex channel, which expands its application scope. In a word, a demodulated DOA esti-mation algorithm is proposed and is applied to 1-D and 2-D angle estimation by dint of ULA and UCA re-spectively. The detailed theoretical analysis and adequate simulations are given to support our proposed al-gorithm, which enriches the theory of the FRFT.展开更多
文摘Objective: To study the role of monocytes in the pathogenesis of genital herpes. Methods: TNF- α and IL-6 levels in 27 cases of genital herpes were detected by enzyme linked immunosorbant assay (ELISA). HLA class Ⅱ antigen expression on monocytes were detected by an alkaline phosphatase anti-alkaline phosphatase method. Results: Compared with normal controls, levels of TNF- a and IL - 6 secreted by monocytes responding to LPS mitogen in vitro were significantly decreased [(3.13 ± 0.44ng/ml) vs (4.68 ± 0.54ng/ml), P<0.05 and (3.32 ± 1.06ng/ml) vs (6.46 ± 1.94ng/ ml), P<0.05, respectively]. HLA class Ⅱ antigen expression on monocytes in the genital herpes group was also significantly decreased [HLA-DR (67.48% ± 1.51%) vs (81.03% ± 1.32%), P<0.01 and HLA-DQ (29.54% ± 1.15%) vs (37.63% ± 1.79%), P <0.01 respectively]. Conclusion: These findings suggest that the decreased monocyte function may contribute to the pathogenesis of genital herpes. Augmenting or inducing monocyte function may be important in the prevention, treatment, and reduction of genital herpes cases.
文摘以均匀线阵(Uniform Linear Array,ULA)为子阵,结合频率分集阵(Frequency Diverse Array,FDA)的思想,构建了一种基于分布式子阵的频率分集阵。针对各子阵按等间距布阵将导致严重的栅瓣问题,提出了一种改进粒子群(Improved Particle Swarm Optimization,IPSO)算法来优化分布式FDA中各子阵间的基线距离,以实现高效的栅瓣抑制。同时,从理论上推导了目标距离和角度均未知时参数估计的克拉美罗下界(Cramer-Rao Lower Bound,CRLB)。仿真结果表明,优化后分布式FDA的栅瓣得到有效抑制,而且阵列角度维分辨率和估计性能亦得到大幅度提升,验证了所提算法的有效性。
基金supported by National Natural Science Foundation of China (No. 62101601, No.61971445)。
文摘A joint Doppler shift and channel estimation method for the millimeter-wave communication system of an unmanned aerial vehicle(UAV) equipped with a large-scale uniform linear antenna(ULA) array has been proposed. Since Doppler shift induces intercarrier interference, the parameters of the channel paths have been decomposed into the Doppler shift and the channel information. In order to obtain the Doppler shift, a new estimation algorithm based on a combination of discrete Fourier transform and phase rotation has been proposed, which can determine the appropriate number of antennas. In addition to estimating the channel information, a low-complexity joint Doppler shift and channel estimation method has been designed that can quickly obtain accurate estimates. Furthermore, the achievable sum rate, the theoretical bounds of the mean squared errors, and the Cram?er-Rao lower bounds of the estimation method have been derived. The analysis and simulation results prove that the performance of the proposed approach is close to the theoretical inference.
文摘Array calibration is important in engineering practice. In this paper, fast calibration methods for a ULA's gain and phase errors both in far and near fields are proposed. In the far field, using a single sound source without exact orientation, this method horizontally rotates the array exactly once, performs eigen value decomposition for the covariance matrix of received data, then computes the gain and phase error according to the formulas. In the near field, using the same single sound source, it is necessary to rotate the array horizontally at most three times, build equations according to geometric relations, then solve them. Using the formula proposed in this paper, spherical waves are modified into plane waves. Then eigen values decomposition is performed. These two calibration methods were shown to be valid by simulation and are fast, accurate and easy to use. Finally, an analysis of factors influencing estimation precision is given.
基金Supported by the Innovation Foundation for Outstanding Postgraduates in the Electronic Engineering Institute of PLA (No. 2009YB005)
文摘A novel Direction-Of-Arrival (DOA) estimation method is proposed in the presence of mutual coupling using the joint sparse recovery. In the proposed method, the eigenvector corresponding to the maximum eigenvalue of covariance matrix of array measurement is viewed as the signal to be represented. By exploiting the geometrical property in steering vectors and the symmetric Toeplitz structure of Mutual Coupling Matrix (MCM), the redundant dictionaries containing the DOA information are constructed. Consequently, the optimization model based on joint sparse recovery is built and then is solved through Second Order Cone Program (SOCP) and Interior Point Method (IPM). The DOA estimates are gotten according to the positions of nonzeros elements. At last, computer simulations demonstrate the excellent performance of the proposed method.
基金National Natural Science Foundation of China(61973037)National 173 Program Project(2019-JCJQ-ZD-324)。
文摘Uniform linear array(ULA)radars are widely used in the collision-avoidance radar systems of small unmanned aerial vehicles(UAVs).In practice,a ULA's multi-target direction of arrival(DOA)estimation performance suffers from significant performance degradation owing to the limited number of physical elements.To improve the underdetermined DOA estimation performance of a ULA radar mounted on a small UAV platform,we propose a nonuniform linear motion sampling underdetermined DOA estimation method.Using the motion of the UAV platform,the echo signal is sampled at different positions.Then,according to the concept of difference co-array,a virtual ULA with multiple array elements and a large aperture is synthesized to increase the degrees of freedom(DOFs).Through position analysis of the original and motion arrays,we propose a nonuniform linear motion sampling method based on ULA for determining the optimal DOFs.Under the condition of no increase in the aperture of the physical array,the proposed method obtains a high DOF with fewer sampling runs and greatly improves the underdetermined DOA estimation performance of ULA.The results of numerical simulations conducted herein verify the superior performance of the proposed method.
文摘In this paper, we have proposed a hybrid transmission scheme which involves beam selection and antenna selection techniques over a MIMO system operating with vary antenna array. Optimal subset of transmit antennas are selected via fast successive selection scheme designed to optimize the target eigenbeam. Optimal eigenbeams corresponding to the largest singular values of the new MIMO channel formed by the selected antennas are exploited for data transmission. To evaluate the performance of the proposed scheme, different array structures, including uniform linear array (ULA) and including uniform circular array (UCA) are employed in the simulations. The transmitter is assumed to be surrounded by scattering objects while the receiver is postulated to be free from scattering objects. The Laplacian distribution of angle of arrival (AoA) of a signal reaching the receiver is postulated. The results presented by this paper indicate that the proposed scheme can significantly improve the performance of data transmission in term of symbol error rate (SER).
文摘This paper reports on investigations into the performance of a Multiple Input Multiple Output (MIMO) wireless communication system employing a uniform linear array (ULA) at the transmitter and either a uni-form linear array (ULA) or a uniform circular array (UCA) antenna at the receiver. The transmitter is as-sumed to be surrounded by scattering objects while the receiver is postulated to be free from scattering ob-jects. The Laplacian distribution of angle of arrival (AOA) of a signal reaching the receiver is postulated. The performance of bit error rate (BER), capacity and channel estimation for a MIMO system are evaluated for the two cases that the receiver is equipped with ULA or with UCA antennas.
文摘A novel algorithm for the direction of arrival (DOA) estimation based on the fractional Fourier transform (FRFT) is proposed. Firstly, using the properties of FRFT and mask processing, Multi-component LFM sig-nals are filtered and demodulated into a number of stationary single frequency signals. Then the one-dimensional (1-D) direction estimation of LFM signals can be achieved by combining with the tradi-tional spectrum search method in the fractional Fourier (FRF) domain. As for the multi-component LFM signals, there is no cross-term interference, the mean square error (MSE) and Cramer-Rao bound (CRB) are also analyzed which perfects the method theoretically, simulation results are provided to show the validity of our method. The proposed algorithm is also extended to the uniform circular array (UCA), which realizes the two-dimensional (2-D) estimation. Using the characteristics of time-frequency rotation and demodulation of FRFT, the observed LFM signals are demodulated into a series of single frequency ones;secondly, operate the beam-space mapping to the single frequency signals in FRF domain, which UCA in array space is changed into the virtual uniform circular array (ULA) in mode space;finally, the DOA estimation can be realized by the traditional spectral estimation method. Compared with other method, the complex time-frequency cluster and the parameter matching computation are avoided;meanwhile enhances the esti-mation precision by a certain extent. The proposed algorithm can also be used in the multi-path and Doppler frequency shift complex channel, which expands its application scope. In a word, a demodulated DOA esti-mation algorithm is proposed and is applied to 1-D and 2-D angle estimation by dint of ULA and UCA re-spectively. The detailed theoretical analysis and adequate simulations are given to support our proposed al-gorithm, which enriches the theory of the FRFT.
